{"id":"https://openalex.org/W4415940385","doi":"https://doi.org/10.1016/j.annonc.2025.08.3067","title":"2452P Impact of tumor suppressor gene (TSG) alteration (alt) burden on outcomes in patients (pts) with metastatic castration-sensitive prostate cancer (mCSPC)","display_name":"2452P Impact of tumor suppressor gene (TSG) alteration (alt) burden on outcomes in patients (pts) with metastatic castration-sensitive prostate cancer (mCSPC)","publication_year":2025,"publication_date":"2025-09-01","ids":{"openalex":"https://openalex.org/W4415940385","doi":"https://doi.org/10.1016/j.annonc.2025.08.3067"},"language":"en","primary_location":{"id":"doi:10.1016/j.annonc.2025.08.3067","doi":"https://doi.org/10.1016/j.annonc.2025.08.3067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2025.08.3067","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.annonc.2025.08.3067","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057146540","display_name":"Deepak Kilari","orcid":"https://orcid.org/0000-0002-6999-1901","observed_orcids":["https://orcid.org/0000-0002-6999-1901"]},"institutions":[{"id":"https://openalex.org/I1310546135","display_name":"Froedtert Hospital","ror":"https://ror.org/01nhrc260","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1310546135"]},{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Kilari","raw_affiliation_strings":["Medicine department, Froedtert Hospital & Medical College of Wisconsin, Milwaukee, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine department, Froedtert Hospital & Medical College of Wisconsin, Milwaukee, United States of America","institution_ids":["https://openalex.org/I1310546135","https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033012755","display_name":"Binyam Yilma","orcid":"https://orcid.org/0009-0007-8845-5390","observed_orcids":["https://orcid.org/0009-0007-8845-5390"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Yilma","raw_affiliation_strings":["Medical Affairs Department, Tempus Labs, Inc., Chicago, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Tempus Labs, Inc., Chicago, United States of America","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017279812","display_name":"Stamatina Fragkogianni","orcid":"https://orcid.org/0000-0002-5960-8921","observed_orcids":["https://orcid.org/0000-0002-5960-8921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Fragkogianni","raw_affiliation_strings":["Medical Affairs Department, Tempus AI, Inc., Chicago, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Tempus AI, Inc., Chicago, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008837662","display_name":"Unnati Jariwala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Jariwala","raw_affiliation_strings":["Medical Affairs Department, Tempus AI, Inc., Chicago, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Tempus AI, Inc., Chicago, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"C. Traverso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Traverso","raw_affiliation_strings":["Medical Affairs Department, Tempus Labs, Inc., Chicago, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Tempus Labs, Inc., Chicago, United States of America","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008280493","display_name":"Jacob Mercer","orcid":"https://orcid.org/0000-0001-8548-2800","observed_orcids":["https://orcid.org/0000-0001-8548-2800"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Mercer","raw_affiliation_strings":["Medical Affairs Department, Tempus Labs, Inc., Chicago, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Affairs Department, Tempus Labs, Inc., Chicago, United States of America","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033779189","display_name":"N. Agarwal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I2801159745","display_name":"Huntsman Cancer Institute","ror":"https://ror.org/03v7tx966","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801159745","https://openalex.org/I4210148268"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Agarwal","raw_affiliation_strings":["Oncology, University of Utah Health - Huntsman Cancer Institute, Salt Lake City, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology, University of Utah Health - Huntsman Cancer Institute, Salt Lake City, United States of America","institution_ids":["https://openalex.org/I223532165","https://openalex.org/I2801159745"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042288086","display_name":"E.S. Antonarakis","orcid":"https://orcid.org/0000-0003-3531-3851","observed_orcids":["https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]},{"id":"https://openalex.org/I4390039358","display_name":"Masonic Cancer Center","ror":"https://ror.org/05x083d20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E.S. Antonarakis","raw_affiliation_strings":["Hematology, Oncology and Transplantation, Masonic Cancer Center - University of Minnesota, Minneapolis, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology, Oncology and Transplantation, Masonic Cancer Center - University of Minnesota, Minneapolis, United States of America","institution_ids":["https://openalex.org/I130238516","https://openalex.org/I4390039358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058325420","display_name":"Rana R. McKay","orcid":"https://orcid.org/0000-0002-0581-7963","observed_orcids":["https://orcid.org/0000-0002-0581-7963"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.R. McKay","raw_affiliation_strings":["Medicine, University of California San Diego - UCSD, La Jolla, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, University of California San Diego - UCSD, La Jolla, United States of America","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.37777231,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":null,"first_page":"S1245","last_page":"S1246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-suppressor-gene-alterations","display_name":"tumor suppressor gene alterations","score":0.7929999828338623},{"id":"https://openalex.org/keywords/metastatic-hormone-sensitive-prostate-cancer","display_name":"metastatic hormone-sensitive prostate cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.3720000088214874},{"id":"https://openalex.org/keywords/genetic-burden","display_name":"genetic burden","score":0.36800000071525574},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9592000246047974},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8109999895095825},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6545000076293945},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5777000188827515},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5641999840736389},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5139999985694885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4893999993801117},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3968000113964081},{"id":"https://openalex.org/C2909960190","wikidata":"https://www.wikidata.org/wiki/Q6823243","display_name":"Metastasis Suppressor Gene","level":4,"score":0.35019999742507935},{"id":"https://openalex.org/C205003668","wikidata":"https://www.wikidata.org/wiki/Q17113442","display_name":"Chromoplexy","level":5,"score":0.34610000252723694},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3425000011920929},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.3271999955177307},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.30790001153945923},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.2741999924182892},{"id":"https://openalex.org/C2994223898","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate disease","level":4,"score":0.2689000070095062},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.26750001311302185}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.annonc.2025.08.3067","doi":"https://doi.org/10.1016/j.annonc.2025.08.3067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2025.08.3067","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.annonc.2025.08.3067","doi":"https://doi.org/10.1016/j.annonc.2025.08.3067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.annonc.2025.08.3067","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4399394816","https://openalex.org/W2892364538","https://openalex.org/W4403614303","https://openalex.org/W3187071112","https://openalex.org/W3170594378","https://openalex.org/W2979260721","https://openalex.org/W2904249129","https://openalex.org/W4297995269","https://openalex.org/W4407720246","https://openalex.org/W4391303500"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2025-11-06T00:00:00"}
