{"id":"https://openalex.org/W4415937375","doi":"https://doi.org/10.1101/2025.11.04.686499","title":"Limited Effects of Isolated Congenital Anosmia on Cerebral White Matter Morphology","display_name":"Limited Effects of Isolated Congenital Anosmia on Cerebral White Matter Morphology","publication_year":2025,"publication_date":"2025-11-05","ids":{"openalex":"https://openalex.org/W4415937375","doi":"https://doi.org/10.1101/2025.11.04.686499"},"language":"en","primary_location":{"id":"doi:10.1101/2025.11.04.686499","doi":"https://doi.org/10.1101/2025.11.04.686499","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.04.686499","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/05/2025.11.04.686499.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/05/2025.11.04.686499.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079732586","display_name":"Anja Lundkvist Winter","orcid":"https://orcid.org/0000-0002-4830-8640","observed_orcids":["https://orcid.org/0000-0002-4830-8640"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Anja L. Winter","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":"https://orcid.org/0000-0002-4830-8640","affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005699499","display_name":"Moa G. Peter","orcid":"https://orcid.org/0000-0003-4472-795X","observed_orcids":["https://orcid.org/0000-0003-4472-795X"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Moa Peter","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":"https://orcid.org/0000-0003-4472-795X","affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050507375","display_name":"Evelina Thunell","orcid":"https://orcid.org/0000-0002-9368-4661","observed_orcids":["https://orcid.org/0000-0002-9368-4661"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Evelina Thunell","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":"https://orcid.org/0000-0002-9368-4661","affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077323418","display_name":"Johan N. Lundstr\u00f6m","orcid":"https://orcid.org/0000-0002-3529-8981","observed_orcids":["https://orcid.org/0000-0002-3529-8981"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan N. Lundstr\u00f6m","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":"https://orcid.org/0000-0002-3529-8981","affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042308816","display_name":"Fahimeh Darki","orcid":"https://orcid.org/0000-0002-4739-5180","observed_orcids":["https://orcid.org/0000-0002-4739-5180"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Fahimeh Darki","raw_affiliation_strings":["Karolinska Institutet"],"raw_orcid":"https://orcid.org/0000-0002-4739-5180","affiliations":[{"raw_affiliation_string":"Karolinska Institutet","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079732586"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10914","display_name":"Tactile and Sensory Interactions","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/olfactory-sulcus","display_name":"olfactory sulcus","score":0.9129999876022339},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.7490000128746033},{"id":"https://openalex.org/keywords/olfactory-deprivation","display_name":"olfactory deprivation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/sensory-deprivation","display_name":"sensory deprivation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/brain-structure","display_name":"brain structure","score":0.46000000834465027},{"id":"https://openalex.org/keywords/piriform-cortex","display_name":"piriform cortex","score":0.9380000233650208},{"id":"https://openalex.org/keywords/white-matter-volume","display_name":"white matter volume","score":0.5699999928474426},{"id":"https://openalex.org/keywords/multi-voxel-pattern-analysis","display_name":"multi-voxel pattern analysis","score":0.7200000286102295}],"concepts":[{"id":"https://openalex.org/C2779926200","wikidata":"https://www.wikidata.org/wiki/Q468433","display_name":"Anosmia","level":5,"score":0.7627999782562256},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5845999717712402},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5727999806404114},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.5189999938011169},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.5169000029563904},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.4986000061035156},{"id":"https://openalex.org/C145940234","wikidata":"https://www.wikidata.org/wiki/Q4955830","display_name":"Brain morphometry","level":3,"score":0.47909998893737793},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.4758000075817108},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4575999975204468},{"id":"https://openalex.org/C94487597","wikidata":"https://www.wikidata.org/wiki/Q11101","display_name":"Sensory system","level":2,"score":0.4180999994277954},{"id":"https://openalex.org/C2777831001","wikidata":"https://www.wikidata.org/wiki/Q1981429","display_name":"Neuropil","level":3,"score":0.36970001459121704},{"id":"https://openalex.org/C2777132076","wikidata":"https://www.wikidata.org/wiki/Q2560248","display_name":"Sulcus","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C2776452703","wikidata":"https://www.wikidata.org/wiki/Q1153195","display_name":"Rhinencephalon","level":3,"score":0.34929999709129333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28130000829696655},{"id":"https://openalex.org/C2778013878","wikidata":"https://www.wikidata.org/wiki/Q646150","display_name":"Grey matter","level":4,"score":0.2797999978065491},{"id":"https://openalex.org/C2780374578","wikidata":"https://www.wikidata.org/wiki/Q267641","display_name":"Habenula","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2696000039577484},{"id":"https://openalex.org/C2781377823","wikidata":"https://www.wikidata.org/wiki/Q7086517","display_name":"Olfactory mucosa","level":3,"score":0.26570001244544983},{"id":"https://openalex.org/C200134340","wikidata":"https://www.wikidata.org/wiki/Q845664","display_name":"Voxel-based morphometry","level":4,"score":0.2554999887943268},{"id":"https://openalex.org/C76297474","wikidata":"https://www.wikidata.org/wiki/Q1898737","display_name":"Morphological analysis","level":2,"score":0.2526000142097473},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.2513999938964844}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.11.04.686499","doi":"https://doi.org/10.1101/2025.11.04.686499","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.04.686499","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/05/2025.11.04.686499.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.11.04.686499","doi":"https://doi.org/10.1101/2025.11.04.686499","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.11.04.686499","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/11/05/2025.11.04.686499.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1513587345","display_name":null,"funder_award_id":"2018.0152","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G3426331231","display_name":null,"funder_award_id":"KAW 2018.0152","funder_id":"https://openalex.org/F4320322327","funder_display_name":"Knut och Alice Wallenbergs Stiftelse"},{"id":"https://openalex.org/G7185651825","display_name":"Is there a critical period for olfaction?","funder_award_id":"2017-02325","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320322327","display_name":"Knut och Alice Wallenbergs Stiftelse","ror":"https://ror.org/004hzzk67"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415937375.pdf","grobid_xml":"https://content.openalex.org/works/W4415937375.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1987624575","https://openalex.org/W1998738087","https://openalex.org/W1999670578","https://openalex.org/W2006027205","https://openalex.org/W2013801953","https://openalex.org/W2027137921","https://openalex.org/W2039491891","https://openalex.org/W2045534904","https://openalex.org/W2061108189","https://openalex.org/W2078543629","https://openalex.org/W2083131225","https://openalex.org/W2092701541","https://openalex.org/W2093657829","https://openalex.org/W2119848633","https://openalex.org/W2155298532","https://openalex.org/W2159289603","https://openalex.org/W2168296467","https://openalex.org/W2903978256","https://openalex.org/W2907275067","https://openalex.org/W2952062626","https://openalex.org/W3014919072","https://openalex.org/W3031095025","https://openalex.org/W3128343106","https://openalex.org/W3205245712","https://openalex.org/W3210439159","https://openalex.org/W4221089105","https://openalex.org/W4283796332","https://openalex.org/W4307898741","https://openalex.org/W4309924923","https://openalex.org/W4388227425","https://openalex.org/W4409327484"],"related_works":["https://openalex.org/W7161403099","https://openalex.org/W3031095025","https://openalex.org/W2971994370","https://openalex.org/W2090088693","https://openalex.org/W4410914710","https://openalex.org/W2061108189","https://openalex.org/W2016422227","https://openalex.org/W2168296467","https://openalex.org/W4388227425","https://openalex.org/W4412841331"],"abstract_inverted_index":{"Abstract":[0],"Lack":[1],"of":[2,22,42,48,66,171,180],"sensory":[3,140],"input":[4],"is":[5,189],"associated":[6],"with":[7,84,112,186],"alterations":[8,88,126,149,183],"in":[9,13,28,56,89,117,129,142,184],"brain":[10],"morphology;":[11],"mainly":[12],"or":[14,57],"near":[15,58],"cerebral":[16],"regions":[17,193],"normally":[18],"devoted":[19],"to":[20,94,138,151,168],"processing":[21],"the":[23,33,39,46,59,63,67,69,120,132,162,169,178,191],"missing":[24],"sense.":[25],"We":[26],"have":[27,75],"multiple":[29],"studies":[30,74],"demonstrated":[31],"that":[32,82,110,147,190],"only":[34],"consistent":[35],"morphological":[36,148,182],"finding":[37],"within":[38],"gray":[40],"matter":[41,71],"individuals":[43,83,111,185],"born":[44],"without":[45],"sense":[47],"smell":[49],"(isolated":[50],"congenital":[51,139,187],"anosmia;":[52],"ICA),":[53],"are":[54,155,158],"changes":[55],"olfactory":[60,121,133,153,163,172,192],"sulcus.":[61,122],"For":[62],"connecting":[64],"tissue":[65],"brain,":[68],"white":[70],"(WM),":[72],"previous":[73],"yielded":[76],"inconsistent":[77],"findings.":[78],"Here,":[79],"we":[80,145],"show":[81,114,146],"ICA":[85,113],"(n=49)":[86],"exhibit":[87],"WM":[90,116,125],"volume":[91],"as":[92],"compared":[93],"age-":[95],"and":[96,105,165],"sex-matched":[97],"controls.":[98],"Consistent":[99],"evidence":[100],"from":[101],"both":[102],"voxel-based":[103],"morphometry":[104],"multi-voxel":[106],"pattern":[107],"analysis":[108],"shows":[109],"decreased":[115],"areas":[118,130],"surrounding":[119,131],"Importantly,":[123],"no":[124],"were":[127],"found":[128],"(piriform)":[134],"cortex.":[135],"In":[136],"contrast":[137],"loss":[141],"other":[143],"systems,":[144],"due":[150,167],"lifelong":[152],"deprivation":[154],"limited.":[156],"Alterations":[157],"primarily":[159],"localized":[160],"around":[161],"sulcus":[164],"likely":[166],"absence":[170],"bulbs.":[173],"A":[174],"possible":[175],"explanation":[176],"for":[177,197],"lack":[179],"major":[181],"anosmia":[188],"may":[194],"be":[195],"recruited":[196],"non-olfactory":[198],"functions.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-05T00:00:00"}
