{"id":"https://openalex.org/W4415899307","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","title":"66 QVT Score, a radiomic biomarker of tumor vascularity, enables immune checkpoint inhibitor (ICI) outcome prediction and early survival assessment in NSCLC","display_name":"66 QVT Score, a radiomic biomarker of tumor vascularity, enables immune checkpoint inhibitor (ICI) outcome prediction and early survival assessment in NSCLC","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4415899307","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0066"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2025-sitc2025.0066","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A77.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/13/Suppl_2/A77.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081588858","display_name":"Young Kwang Chae","orcid":"https://orcid.org/0000-0003-1557-7235","observed_orcids":["https://orcid.org/0000-0003-1557-7235"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Young Kwang Chae","raw_affiliation_strings":["Northwestern University, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100324060","display_name":"Kai Zhang","orcid":"https://orcid.org/0000-0003-4237-3115","observed_orcids":["https://orcid.org/0000-0003-4237-3115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Zhang","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020509902","display_name":"Liam Il\u2010Young Chung","orcid":"https://orcid.org/0000-0001-6541-793X","observed_orcids":["https://orcid.org/0000-0001-6541-793X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liam Il-Young Chung","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071590669","display_name":"Amogh Hiremath","orcid":"https://orcid.org/0000-0001-6937-9141","observed_orcids":["https://orcid.org/0000-0001-6937-9141"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amogh Hiremath","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036982583","display_name":"Haojia Li","orcid":"https://orcid.org/0000-0002-1295-4341","observed_orcids":["https://orcid.org/0000-0002-1295-4341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haojia Li","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023795674","display_name":"Rhea Chitalia","orcid":"https://orcid.org/0000-0001-7880-930X","observed_orcids":["https://orcid.org/0000-0001-7880-930X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rhea Chitalia","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111241390","display_name":"Julianne Jin","orcid":"https://orcid.org/0009-0008-9877-9716","observed_orcids":["https://orcid.org/0009-0008-9877-9716"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julianne Jin","raw_affiliation_strings":["Northwestern University Feinberg School of Medicine, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Northwestern University Feinberg School of Medicine, Chicago, IL, USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014409428","display_name":"Omid Haji Maghsoudi","orcid":"https://orcid.org/0000-0001-9478-8721","observed_orcids":["https://orcid.org/0000-0001-9478-8721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omid Haji Maghsoudi","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113384536","display_name":"Pushkar Mutha","orcid":"https://orcid.org/0000-0002-5961-7131","observed_orcids":["https://orcid.org/0000-0002-5961-7131"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pushkar Mutha","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054397238","display_name":"Trishan Arul","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Trishan Arul","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103127175","display_name":"Vamsidhar Velcheti","orcid":"https://orcid.org/0000-0003-2735-7213","observed_orcids":["https://orcid.org/0000-0003-2735-7213"]},"institutions":[{"id":"https://openalex.org/I4390039310","display_name":"NYU Langone\u2019s Laura and Isaac Perlmutter Cancer Center","ror":"https://ror.org/00sa8g751","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933","https://openalex.org/I4390039310"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vamsidhar Velcheti","raw_affiliation_strings":["Laura and Isaac Perlmutter Cancer Center at NYU, Scarsdale, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laura and Isaac Perlmutter Cancer Center at NYU, Scarsdale, NY, USA","institution_ids":["https://openalex.org/I4390039310","https://openalex.org/I57206974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027642699","display_name":"Anant Madabhushi","orcid":"https://orcid.org/0000-0002-5741-0399","observed_orcids":["https://orcid.org/0000-0002-5741-0399"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anant Madabhushi","raw_affiliation_strings":["Emory University, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087068707","display_name":"Nathaniel M. Braman","orcid":"https://orcid.org/0000-0001-5603-0821","observed_orcids":["https://orcid.org/0000-0001-5603-0821"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nathaniel Braman","raw_affiliation_strings":["Picture Health, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Picture Health, Cleveland, OH, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A77","last_page":"A77"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomic-biomarkers","display_name":"radiomic biomarkers","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tumor-vascularity","display_name":"tumor vascularity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8299999833106995},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/overall-survival-prediction","display_name":"overall survival prediction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/treatment-response-monitoring","display_name":"treatment response monitoring","score":0.621999979019165},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.8640000224113464},{"id":"https://openalex.org/keywords/necrosis","display_name":"necrosis","score":0.7599999904632568},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.7200000286102295},{"id":"https://openalex.org/keywords/immune-resistance","display_name":"immune resistance","score":0.3799999952316284},{"id":"https://openalex.org/keywords/computed-tomography","display_name":"computed tomography","score":0.5950000286102295},{"id":"https://openalex.org/keywords/histopathological-correlation","display_name":"histopathological correlation","score":0.7699999809265137},{"id":"https://openalex.org/keywords/unsupervised-clustering","display_name":"unsupervised clustering","score":0.7599999904632568},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7811999917030334},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5782999992370605},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5723000168800354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49470001459121704},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.40369999408721924},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.3928999900817871},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.39169999957084656},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.36419999599456787},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.3402999937534332},{"id":"https://openalex.org/C148220186","wikidata":"https://www.wikidata.org/wiki/Q7111912","display_name":"Outcome (game theory)","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.30390000343322754},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2025-sitc2025.0066","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A77.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2025-sitc2025.0066","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0066","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A77.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415899307.pdf","grobid_xml":"https://content.openalex.org/works/W4415899307.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7130721985","https://openalex.org/W4410805195","https://openalex.org/W2981607170","https://openalex.org/W4297902017","https://openalex.org/W7148756788","https://openalex.org/W4308538130","https://openalex.org/W7117300481","https://openalex.org/W7213894558","https://openalex.org/W2921452985","https://openalex.org/W4387810035"],"abstract_inverted_index":{"Background":[0],"Predicting":[1],"ICI":[2,44,156,295,408,437],"benefit":[3,296],"relies":[4],"primarily":[5],"on":[6,63,283,385],"PD-L1":[7],"expression,":[8],"which":[9,35,180,302],"is":[10,24,289,326],"a":[11,25,54,72,98,268,274,290],"poor":[12,43,436],"one-dimensional":[13],"measure":[14],"and":[15,78,116,123,140,149,206,239,257,299,365,373,421],"overlooks":[16],"resistance":[17],"mechanisms":[18],"such":[19],"as":[20,71,215,271,344],"tumor":[21,433],"angiogenesis.":[22],"QVT":[23,52,111,136,185,188,263,287,324,332,338,357,380,424,429],"radiomic":[26,291],"approach":[27],"for":[28,79,86,142,237,242,251,297,353,362,416],"measuring":[29],"abnormalities":[30],"of":[31,60,101,109,130,176,234,294,307,311,379],"the":[32,51,58,128,174,199,304],"tumor-associated":[33,413],"vasculature,":[34],"have":[36,435],"been":[37,342],"shown":[38],"to":[39,119,144,172,267,320,440],"be":[40],"associated":[41,194],"with":[42,161,184,195,231,277,382,418,427,442],"outcomes.":[45],"1":[46],"2":[47],"Here,":[48],"we":[49],"introduce":[50],"Score,":[53],"continuous":[55,124],"index":[56],"mapping":[57],"degree":[59,129],"chaotic":[61,432],"vascularity":[62],"standard":[64],"clinical":[65,351,370],"imaging.":[66],"We":[67,88],"validate":[68],"this":[69],"biomarker":[70,292,347],"survival-associated":[73],"predictor":[74],"(from":[75,82],"baseline":[76,200,262,298],"CT)":[77,85],"early":[80,366],"monitoring":[81],"first":[83,150,207],"on-treatment":[84,151,208,300],"ICIs.":[87],"further":[89],"assess":[90],"its":[91],"biological":[92],"basis":[93],"through":[94],"histopathological":[95],"correlation.Methods":[96],"In":[97],"discovery":[99],"cohort":[100],"375":[102],"NSCLC":[103],"patients,":[104],"an":[105,121,345],"unsupervised":[106],"clustering":[107],"model":[108],"interpretable":[110,327],"features\u2014including":[112],"vessel":[113],"curvature,":[114],"twistedness,":[115],"branching\u2014was":[117],"utilized":[118],"create":[120],"automated":[122],"0-to-1":[125],"Score":[126,137,189,264,288,325,358],"indicating":[127,431],"high":[131,422],"risk":[132],"elevated":[133,428],"vascularity.":[134],"The":[135],"was":[138,193,216,265],"computed":[139],"validated":[141],"association":[143,276],"OS":[145,197,228,233],"using":[146],"pre-treatment":[147,162],"(n=266)":[148],"(n=143)":[152],"CT":[153],"from":[154,331],"266":[155],"monotherapy":[157],"recipients.":[158],"For":[159],"patients":[160,222,417],"histopathology":[163,284,386],"samples":[164],"available":[165],"(n=31),":[166],"deep":[167,321],"learning":[168,322],"models":[169],"were":[170,181],"used":[171],"compute":[173],"proportions":[175],"various":[177],"cellular":[178,383],"subpopulations,":[179],"then":[182],"correlated":[183],"Score.Results":[186],"Higher":[187,261],"(":[190],"figure":[191],"1)":[192],"shorter":[196],"at":[198],"(HR:":[201,209],"2.07,":[202],"p":[203,211],"=":[204,212],"0.019)":[205],"4.22,":[210],"0.00083)":[213],"scans,":[214],"longitudinal":[217],"change":[218,224,259],"(HR=2.89,":[219],"p=0.0056).":[220],"Stratifying":[221],"by":[223,273,328,410],"directionality":[225],"also":[226],"stratified":[227],"(HR=1.91,":[229],"p=0.0017)":[230],"median":[232],"10":[235],"months":[236,241],"Increasing":[238],"22":[240],"Decreasing.":[243],"These":[244],"groups":[245],"remained":[246],"independently":[247],"prognostic":[248],"when":[249],"adjusted":[250],"RECIST":[252],"best":[253],"overall":[254],"response":[255,309,367],"(p=0.0340)":[256],"volume":[258],"(p=0.0015).":[260],"linked":[266],"hypoxic":[269],"microenvironment,":[270],"indicated":[272],"significant":[275],"necrotic":[278],"cell":[279],"proportion":[280],"(r=0.40,":[281],"p=0.024)":[282],"(table":[285],"1).Conclusions":[286],"predictive":[293],"assessment,":[301],"captures":[303],"vascular":[305,414],"dynamics":[306],"therapeutic":[308],"independent":[310],"traditional":[312],"imaging":[313],"endpoints.":[314],"Unlike":[315],"post-hoc":[316],"explainability":[317],"methods":[318],"attached":[319],"algorithms,":[323],"design,":[329],"built":[330],"features":[333],"targeting":[334],"tumor-immune":[335],"microenvironment":[336],"biology.":[337],"scoring":[339],"has":[340],"already":[341],"deployed":[343],"exploratory":[346],"in":[348,369],"ongoing":[349],"prospective":[350],"trials":[352],"multiple":[354],"cancer":[355],"indications.":[356],"offers":[359],"valuable":[360],"insight":[361],"patient":[363],"selection":[364],"assessment":[368],"drug":[371],"development":[372],"precision":[374],"oncology.Abstract":[375],"66":[376,403],"Table":[377],"1Association":[378],"score":[381,406],"composition":[384],"Cell":[387],"Type":[388],"Pearson":[389],"Correlation":[390],"(r)":[391],"p-value":[392],"Necrosis":[393],"0.40":[394],"0.024":[395],"Fibroblasts":[396],"0.21":[397,401],"0.25":[398],"Lymphocytes":[399],"0.23":[400],"Abstract":[402],"Figure":[404],"1QVT":[405],"stratifies":[407],"recipients":[409],"OS.":[411],"Visualized":[412],"complexity":[415],"low":[419],"(left)":[420],"(right)":[423],"score.":[425],"Patients":[426],"score,":[430],"angiogenesis,":[434],"outcomes":[438],"compared":[439],"those":[441],"normalized":[443],"vasculature":[444]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2025-11-05T00:00:00"}
