{"id":"https://openalex.org/W4415899176","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","title":"203 Overcoming CART therapy resistance in an immunocompetent model of rhabdomyosarcoma","display_name":"203 Overcoming CART therapy resistance in an immunocompetent model of rhabdomyosarcoma","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4415899176","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0203"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2025-sitc2025.0203","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A221.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/13/Suppl_2/A221.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059801296","display_name":"Erica Lynne Braverman","orcid":"https://orcid.org/0000-0002-5072-5291","observed_orcids":["https://orcid.org/0000-0002-5072-5291"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica Braverman","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033474293","display_name":"Sebastian Hymson","orcid":"https://orcid.org/0009-0001-1823-9680","observed_orcids":["https://orcid.org/0009-0001-1823-9680"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sebastian Hymson","raw_affiliation_strings":["University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh School of Medicine, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alexa Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexa Jones","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042380218","display_name":"Nicole E. Mihalik","orcid":"https://orcid.org/0000-0002-8220-6613","observed_orcids":["https://orcid.org/0000-0002-8220-6613"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Mihalik","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090814221","display_name":"Andrew Baessler","orcid":"https://orcid.org/0000-0002-4572-9001","observed_orcids":["https://orcid.org/0000-0002-4572-9001"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Baessler","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008106149","display_name":"Creg J. Workman","orcid":"https://orcid.org/0000-0002-9964-9509","observed_orcids":["https://orcid.org/0000-0002-9964-9509"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Creg Workman","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001000053","display_name":"Dario A.A. Vignali","orcid":"https://orcid.org/0000-0002-2771-5992","observed_orcids":["https://orcid.org/0000-0002-2771-5992"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dario AA Vignali","raw_affiliation_strings":["University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A221","last_page":"A221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.7179999947547913},{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/b7-h3","display_name":"B7-H3","score":0.8349999785423279},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9480000138282776},{"id":"https://openalex.org/keywords/inhibitory-receptors","display_name":"inhibitory receptors","score":0.800000011920929},{"id":"https://openalex.org/keywords/pd-1","display_name":"PD-1","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.8759999871253967},{"id":"https://openalex.org/keywords/tim-3","display_name":"TIM-3","score":0.7310000061988831},{"id":"https://openalex.org/keywords/pd-l1-upregulation","display_name":"PD-L1 upregulation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.9850000143051147},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pediatric-soft-tissue-sarcoma","display_name":"pediatric soft tissue sarcoma","score":0.7229999899864197},{"id":"https://openalex.org/keywords/immunocompetent-mouse-model","display_name":"immunocompetent mouse model","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8148999810218811},{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.7670999765396118},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.5995000004768372},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.4325999915599823},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35409998893737793},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2847000062465668},{"id":"https://openalex.org/C2908856526","wikidata":"https://www.wikidata.org/wiki/Q16252627","display_name":"Antibody therapy","level":4,"score":0.28299999237060547},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27790001034736633},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2775000035762787},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2745000123977661},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.2736000120639801},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2711000144481659},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2025-sitc2025.0203","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A221.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2025-sitc2025.0203","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0203","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A221.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4415899176.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6990826933","https://openalex.org/W7165625860","https://openalex.org/W4409634726","https://openalex.org/W4393071409","https://openalex.org/W4407977416","https://openalex.org/W7133242269","https://openalex.org/W4409629514","https://openalex.org/W4362541340","https://openalex.org/W4395669355","https://openalex.org/W4308377690"],"abstract_inverted_index":{"Background":[0],"Chimeric":[1],"antigen":[2,160,650],"receptor":[3,651],"(CAR)":[4],"T":[5,27,67,84,232,416,543,652],"therapy":[6,35,77,104,376,398],"has":[7,36,53],"seen":[8,54],"limited":[9,107],"success":[10],"in":[11,57,99,109,181,364,373,387,419,637,642],"patients":[12,400],"with":[13,151,186,323,359,401,550],"solid":[14,101,420,552,643],"tumors,":[15,102,223],"likely":[16],"due":[17],"to":[18,39,73,81,122,205,305,327,390,395,494,581],"a":[19,40,324,355,368],"combination":[20,393],"of":[21,43,94,120,129,209,229,243,263,271,277,286,347,385,414,539,640],"physical":[22],"barriers,":[23],"metabolic":[24],"challenges,":[25,490],"and":[26,126,169,189,200,212,248,290,363,410,491,547,579],"cell":[28,68,139,417],"exhaustion.":[29],"1":[30,537],"As":[31],"such,":[32],"this":[33,92,310],"powerful":[34],"remained":[37],"inaccessible":[38],"large":[41],"cohort":[42],"patients.":[44],"Rhabdomyosarcoma":[45],"(RMS),":[46],"the":[47,60,79,87,124,127,158,170,192,207,227,256,272,348,388,638],"most":[48],"common":[49],"pediatric":[50],"soft-tissue":[51],"sarcoma,":[52],"few":[55],"advances":[56],"therapies":[58,418],"over":[59],"last":[61],"decades.2":[62],"These":[63,238],"tumors":[64,644],"exhibit":[65,240],"low":[66,320],"infiltrate,":[69],"making":[70],"them":[71],"resistant":[72],"checkpoint":[74],"immunotherapy.":[75,583],"CART":[76,103,134,154,215,252,302,312,352,375,397],"offers":[78],"opportunity":[80],"direct":[82],"sarcoma-specific":[83],"cells":[85,155,188,233,280,313,544],"into":[86,146],"tumor":[88,267,291,344],"microenvironment":[89],"(TME),":[90],"overcoming":[91],"lack":[93],"anti-tumor":[95],"response.":[96],"However,":[97],"as":[98,281,283],"other":[100],"is":[105,143,167,259,577],"showing":[106],"efficacy":[108],"sarcoma":[110,159],"clinical":[111],"trials.3":[112],"Here":[113],"we":[114],"use":[115,413],"an":[116,275],"immunocompetent":[117],"preclinical":[118],"model":[119],"RMS":[121,138],"assess":[123,206],"TME":[125,171,273,349,358,389],"role":[128,208,369],"inhibitory":[130],"receptors":[131],"(IR)":[132],"following":[133],"therapy.Methods":[135],"The":[136],"murine":[137,153,198,338],"line":[140],"M39M":[141,187,222,295],"4":[142],"injected":[144,163],"intramuscularly":[145],"C57BL6":[147],"mice.":[148],"Following":[149],"preconditioning":[150],"cyclophosphamide,":[152],"specific":[156],"for":[157,370,399,412,545],"B7-H35":[161],"are":[162,184,226,381],"intravenously.":[164],"Tumor":[165],"growth":[166],"followed":[168],"evaluated":[172],"at":[173,299,319],"predetermined":[174],"time":[175],"points.":[176],"To":[177],"monitor":[178],"killing":[179,318],"capacity":[180],"vitro,":[182,294],"CARTs":[183,219,239,264,334],"mixed":[185],"monitored":[190],"using":[191],"xCELLigence":[193],"RTCA":[194],"eSight":[195],"(Agilent).":[196],"Multiple":[197],"models":[199],"CRISPR/Cas9":[201],"technology":[202],"were":[203],"used":[204],"IRs":[210],"PD1":[211,315],"LAG3":[213],"on":[214,266],"function.Results":[216],"Murine":[217,575],"B7-H3":[218,333,647],"efficiently":[220,336],"infiltrate":[221],"where":[224],"they":[225,340],"majority":[228],"intra-tumoral":[230],"CD8+":[231],"by":[234,288,645],"day":[235],"7":[236],"post-injection.":[237],"high":[241,251,306,360],"expression":[242,285],"IRs,":[244],"including":[245],"PD1,":[246],"LAG3,":[247],"Tim3.":[249],"Despite":[250],"numbers":[253],"isolated":[254],"from":[255],"TME,":[257],"there":[258],"no":[260],"significant":[261],"impact":[262],"alone":[265],"growth.":[268,345],"Preliminary":[269],"analysis":[270],"reveals":[274],"influx":[276],"myeloid-derived":[278],"suppressor":[279],"well":[282],"increased":[284],"PDL1":[287,298,307,361],"immune":[289],"cells.":[292,653],"In":[293,309],"expresses":[296],"little":[297],"baseline,":[300],"whereas":[301],"exposure":[303],"leads":[304],"expression.":[308],"setting,":[311],"without":[314],"demonstrate":[316],"improved":[317],"E:T":[321],"ratios,":[322],"particular":[325],"advantage":[326],"PD1/LAG3":[328],"dual":[329],"deficient":[330],"CARTs.Conclusions":[331],"While":[332],"can":[335],"target":[337],"RMS,":[339],"do":[341],"not":[342],"limit":[343],"Analysis":[346],"suggests":[350],"that":[351],"infiltration":[353],"creates":[354],"more":[356],"immunosuppressive":[357],"expression,":[362],"vitro":[365],"data":[366],"support":[367],"IR":[371],"blockade":[372],"improving":[374],"against":[377],"RMS.":[378],"Ongoing":[379],"studies":[380],"evaluating":[382],"additional":[383],"mechanisms":[384],"resistance":[386],"design":[391],"effective":[392],"strategies":[394],"improve":[396],"sarcoma.References":[402],"Ramakrishna":[403],"S,":[404,438,450,478,482,512,596,632],"Barsan":[405],"V,":[406,520],"Mackall":[407,573],"C.":[408],"Prospects":[409],"challenges":[411],"CAR":[415,542],"tumors.":[421,553],"Expert":[422],"Opin":[423],"Biol":[424],"Ther.":[425],"2020":[426],"May;20(5):503\u2013516.":[427],"PMID:":[428],"32125191Zarrabi":[429],"A,":[430,466,470,474,510],"Perrin":[431],"D,":[432,608],"Kavoosi":[433],"M,":[434,436,456,476,508,570],"Sommer":[435],"Sezen":[437],"Mehrbod":[439],"P,":[440,448,454,518],"Bhushan":[441],"B,":[442,462,472,606,630],"Machaj":[443],"F,":[444],"Rosik":[445],"J,":[446,566],"Kawalec":[447],"Afifi":[449],"Bolandi":[451],"SM,":[452],"Koleini":[453],"Taheri":[455],"Madrakian":[457],"T,":[458],"\u0141os":[459],"MJ,":[460],"Lindsey":[461],"Cakir":[463],"N,":[464],"Zarepour":[465],"Hushmandi":[467],"K,":[468,516,594,604,610],"Fallah":[469],"Koc":[471],"Khosravi":[473],"Ahmadi":[475],"Logue":[477],"Orive":[479],"G,":[480,568],"Pecic":[481],"Gordon":[483],"JW,":[484],"Ghavami":[485],"S.":[486],"Rhabdomyosarcoma:":[487],"current":[488],"therapy,":[489],"future":[492],"approaches":[493],"treatment":[495],"strategies.":[496],"Cancers":[497],"(Basel).":[498],"2023":[499],"Nov":[500],"2;15(21).":[501],"PMCID:":[502,590,659],"PMC10650215Pinto":[503],"NR,":[504],"Albert":[505],"CM,":[506],"Taylor":[507],"Wilson":[509],"Rawlings-Rhea":[511],"Huang":[513],"W,":[514],"Seidel":[515],"Narayanaswany":[517],"Wu":[519],"Brown":[521],"C,":[522,616],"Vitanza":[523],"NA,":[524],"Orentas":[525,571],"R,":[526,628],"Gardner":[527],"RA,":[528],"Jensen":[529],"MC,":[530],"Park":[531],"JR.":[532],"STRIVE-02:":[533],"A":[534],"first-in-human":[535],"phase":[536],"trial":[538],"systemic":[540],"B7H3":[541],"children":[546],"young":[548],"adults":[549],"relapsed/refractory":[551],"JCO.":[554],"2022":[555],"Jun":[556],"1;40(16_suppl):10011\u201310011.Meadors":[557],"JL,":[558],"Cui":[559],"Y,":[560,614,618,624],"Chen":[561,617],"Q-R,":[562],"Song":[563],"YK,":[564],"Khan":[565],"Merlino":[567],"Tsokos":[569],"RJ,":[572],"CL.":[574],"rhabdomyosarcoma":[576],"immunogenic":[578],"responsive":[580],"T-cell-based":[582],"Pediatr":[584],"Blood":[585],"Cancer.":[586],"2011":[587],"Dec":[588],"1;57(6):921\u2013929.":[589],"PMC7401311Du":[591],"H,":[592],"Hirabayashi":[593],"Ahn":[595],"Kren":[597],"NP,":[598],"Montgomery":[599],"SA,":[600],"Wang":[601],"X,":[602,620],"Tiruthani":[603],"Mirlekar":[605],"Michaud":[607],"Greene":[609],"Herrera":[611],"SG,":[612],"Xu":[613],"Sun":[615],"Ma":[619],"Ferrone":[621,631],"CR,":[622],"Pylayeva-Gupta":[623],"Yeh":[625],"JJ,":[626],"Liu":[627],"Savoldo":[629],"Dotti":[633],"G.":[634],"Antitumor":[635],"responses":[636],"absence":[639],"toxicity":[641],"targeting":[646],"via":[648],"chimeric":[649],"Cancer":[654],"Cell.":[655],"2019":[656],"Feb":[657],"11;35(2):221-237.e8.":[658],"PMC6645919":[660]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2025-11-05T00:00:00"}