{"id":"https://openalex.org/W4415898757","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","title":"696 Turning metabolic adaptations into immunotherapeutic opportunities: RAS inhibition reshapes the tumor immunopeptidome","display_name":"696 Turning metabolic adaptations into immunotherapeutic opportunities: RAS inhibition reshapes the tumor immunopeptidome","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4415898757","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0696"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2025-sitc2025.0696","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A800.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/13/Suppl_2/A800.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5137667740","display_name":"Christopher A. Polera","orcid":"https://orcid.org/0009-0001-9776-6306","observed_orcids":["https://orcid.org/0009-0001-9776-6306"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher A Polera","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Brennan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Brennan","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034876883","display_name":"Andrew Deonarine","orcid":"https://orcid.org/0000-0001-7852-9674","observed_orcids":["https://orcid.org/0000-0001-7852-9674"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Deonarine","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046030840","display_name":"Emma Adhikari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Adhikari","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044158864","display_name":"Emily Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Paul","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Miguel Xiao Barbero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Xiao Barbero","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000962444","display_name":"Victoria Izumi","orcid":"https://orcid.org/0000-0001-6467-9081","observed_orcids":["https://orcid.org/0000-0001-6467-9081"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victoria Izumi","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046520540","display_name":"Bin Fang","orcid":"https://orcid.org/0000-0003-1955-6626","observed_orcids":["https://orcid.org/0000-0003-1955-6626"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bin Fang","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002876951","display_name":"John M. Koomen","orcid":"https://orcid.org/0000-0002-3818-1762","observed_orcids":["https://orcid.org/0000-0002-3818-1762"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Koomen","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087467089","display_name":"Paul A. Stewart","orcid":"https://orcid.org/0000-0003-0882-308X","observed_orcids":["https://orcid.org/0000-0003-0882-308X"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Stewart","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045716415","display_name":"Alex M. Jaeger","orcid":"https://orcid.org/0000-0002-4319-4330","observed_orcids":["https://orcid.org/0000-0002-4319-4330"]},"institutions":[{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex M Jaeger","raw_affiliation_strings":["H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA","institution_ids":["https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I3019308854"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A800","last_page":"A800"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5360999703407288,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.41819998621940613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ras-inhibition","display_name":"RAS inhibition","score":0.9100000262260437},{"id":"https://openalex.org/keywords/tumor-immunopeptidome","display_name":"tumor immunopeptidome","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.859000027179718},{"id":"https://openalex.org/keywords/mhc-peptide-presentation","display_name":"MHC-peptide presentation","score":0.6119999885559082},{"id":"https://openalex.org/keywords/ras-signaling","display_name":"Ras signaling","score":0.5199999809265137},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6880000233650208},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"iron homeostasis","score":0.9850000143051147},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.996999979019165},{"id":"https://openalex.org/keywords/ribosome-profiling","display_name":"ribosome profiling","score":0.9629999995231628},{"id":"https://openalex.org/keywords/kras-g12d","display_name":"KRAS G12D","score":0.7059999704360962},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9549999833106995},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5091000199317932},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5048999786376953},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3709999918937683},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3125999867916107},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3122999966144562},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31209999322891235},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.2858999967575073},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27459999918937683},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25290000438690186}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2025-sitc2025.0696","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A800.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2025-sitc2025.0696","doi":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2025-sitc2025.0696","pdf_url":"https://jitc.bmj.com/content/13/Suppl_2/A800.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular and Young Investigator Award Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415898757.pdf","grobid_xml":"https://content.openalex.org/works/W4415898757.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7214315268","https://openalex.org/W4403520045","https://openalex.org/W3037180270","https://openalex.org/W4392639138","https://openalex.org/W7204889290","https://openalex.org/W7148865718","https://openalex.org/W7135342151","https://openalex.org/W4403551488","https://openalex.org/W7214380837","https://openalex.org/W4385827573"],"abstract_inverted_index":{"Background":[0],"Oncogenic":[1],"RAS":[2,19,59,78,106,146,174,234,286,290,363],"mutations":[3],"are":[4,89,304],"prevalent":[5],"in":[6,14,25,57,112,172,196,206,209,239,326,374,394,412,432],"solid":[7],"tumors":[8],"and":[9,39,70,86,138,153,184,200,208,258,332,391,438,448,462,476,481,488],"play":[10],"a":[11,64,130,278,306,353],"central":[12],"role":[13],"driving":[15],"immune":[16,68,283,348],"evasion.":[17],"While":[18],"inhibitors":[20,364],"(RASi)":[21],"have":[22],"shown":[23],"promise":[24],"reshaping":[26],"the":[27,101,113,178,217,220,243,368,389,435,441,456,467,482,486],"tumor":[28,94,179,221,311,372],"microenvironment\u2014most":[29],"notably":[30],"by":[31,157,285,455],"enhancing":[32],"T":[33,71],"cell":[34,72],"infiltration\u2014clinical":[35],"responses":[36],"remain":[37],"inconsistent":[38],"often":[40],"transient":[41],"due":[42],"to":[43,100,109,266,337,347,417,466],"rapid":[44],"emergence":[45],"of":[46,53,67,132,219,247,282,309,322,358,370,388,440,478,490],"resistance.":[47],"1":[48],"A":[49,245],"largely":[50],"uncharted":[51],"aspect":[52],"this":[54],"resistance":[55],"lies":[56],"how":[58],"signaling":[60,296],"influences":[61],"antigen":[62,163,224,301,324],"presentation,":[63],"key":[65,230],"determinant":[66],"recognition":[69],"activation.":[73],"Recent":[74],"insights":[75],"reveal":[76],"that":[77,105,121,241,289,361],"interacts":[79],"with":[80,143,165,226,313,365,434],"metabolic":[81,231],"pathways\u2014including":[82],"ferroptosis,":[83],"iron":[84],"homeostasis,":[85],"lipid":[87],"metabolism\u2014that":[88],"not":[90,292],"only":[91,293],"vital":[92],"for":[93,125,355,485],"survival":[95],"but":[96,298],"also":[97,299],"tightly":[98],"linked":[99],"immunopeptidome.2":[102],"We":[103,128,187,303],"hypothesized":[104],"inhibition":[107,175,291],"leads":[108],"distinct":[110],"changes":[111,238],"MHC-presented":[114],"peptide":[115,159,214],"landscape,":[116],"potentially":[117],"unveiling":[118],"immunogenic":[119],"vulnerabilities":[120],"can":[122],"be":[123,267],"exploited":[124],"combination":[126,131,359],"immunotherapy.Methods":[127],"utilized":[129],"cultured":[133],"cells,":[134],"syngeneic":[135],"transplant":[136],"models,":[137],"GEMMs":[139],"(Kras^LSL-G12D;":[140],"p53^fl/fl)":[141],"treated":[142],"clinically":[144],"relevant":[145],"inhibitors.":[147],"Immunopeptidomics":[148],"was":[149],"performed":[150],"via":[151],"MHC-I":[152],"MHC-II":[154],"immunoprecipitation":[155],"followed":[156],"LC-MS/MS":[158],"sequencing.":[160],"To":[161],"integrate":[162],"presentation":[164,254],"translational":[166],"dynamics,":[167],"we":[168],"conducted":[169,431],"ribosome":[170,227],"profiling":[171,228],"parallel.Results":[173],"dramatically":[176],"reshapes":[177],"immunopeptidome,":[180],"revealing":[181],"both":[182,197],"treatment-specific":[183],"treatment-induced":[185],"antigens.":[186],"identified":[188],"unique":[189],"peptides":[190,249,265],"selectively":[191],"presented":[192],"upon":[193],"RASi":[194],"treatment":[195],"LUAD,":[198],"PDAC,":[199],"melanoma":[201],"models.":[202],"Comparative":[203],"analysis":[204],"between":[205],"vitro":[207],"vivo":[210,327],"systems":[211],"revealed":[212,340],"context-dependent":[213],"repertoires,":[215],"underscoring":[216],"influence":[218],"microenvironment":[222],"on":[223,253,473],"presentation.Integration":[225],"uncovered":[229],"adaptations":[232],"following":[233],"inhibition,":[235],"including":[236],"compensatory":[237],"translation":[240],"affect":[242],"immunopeptidome.":[244],"subset":[246],"RASi-induced":[248,310],"were":[250,430,453],"prioritized":[251],"based":[252],"frequency,":[255],"therapeutic":[256,315,418],"window,":[257],"predicted":[259],"immunogenicity.":[260],"Immunological":[261],"assays":[262],"confirmed":[263],"several":[264],"immunogenic,":[268],"supporting":[269],"their":[270],"candidacy":[271],"as":[272],"immunotherapy":[273],"targets.Conclusions":[274],"This":[275],"work":[276],"uncovers":[277],"previously":[279],"underappreciated":[280],"layer":[281],"modulation":[284],"signaling,":[287],"demonstrating":[288],"disrupts":[294],"oncogenic":[295],"pathways":[297],"reprograms":[300],"presentation.":[302],"building":[305],"comprehensive":[307],"database":[308],"antigens":[312],"high":[314],"potential.":[316],"Ongoing":[317],"studies":[318,429],"include":[319],"mechanistic":[320],"dissection":[321],"altered":[323],"processing,":[325],"validation":[328],"through":[329],"peptide-based":[330],"vaccines,":[331],"leveraging":[333],"TCR":[334],"mimetic":[335],"scFvs":[336],"target":[338],"newly":[339],"MHC-bound":[341],"peptides.":[342],"By":[343],"linking":[344],"oncogene-driven":[345],"metabolism":[346],"recognition,":[349],"our":[350],"findings":[351],"offer":[352],"roadmap":[354],"rational":[356],"design":[357],"therapies":[360],"synergize":[362],"precision":[366],"immunotherapies\u2014advancing":[367],"goal":[369],"durable":[371],"regression":[373],"RAS-driven":[375],"cancers.References":[376],"Punekar":[377],"SR,":[378],"Velcheti":[379],"V,":[380],"Neel":[381],"BG,":[382],"et":[383,409],"al.":[384,410],"The":[385],"current":[386],"state":[387],"art":[390],"future":[392],"trends":[393],"RAS-targeted":[395],"cancer":[396],"therapies.":[397],"Nat":[398],"Rev":[399],"Clin":[400],"Oncol":[401],"2022;19:637\u2013655.":[402],"https://doi.org/10.1038/s41571-022-00671-9Zhou":[403],"Q,":[404],"Meng":[405],"Y,":[406],"Li":[407],"D,":[408],"Ferroptosis":[411],"cancer:":[413],"from":[414],"molecular":[415],"mechanisms":[416],"strategies.":[419],"Sig":[420],"Transduct":[421],"Target":[422],"Ther":[423],"2024;9:55.":[424],"https://doi.org/10.1038/s41392-024-01769-5Ethics":[425],"Approval":[426],"All":[427],"animal":[428],"accordance":[433],"ethical":[436],"standards":[437],"guidelines":[439],"Moffitt":[442],"Cancer":[443],"Center\u2018s":[444],"Institutional":[445],"Animal":[446],"Care":[447,475,487],"Use":[449,477,489],"Committee":[450],"(IACUC).":[451],"Protocols":[452],"approved":[454],"IACUC":[457],"under":[458],"protocol":[459],"R":[460],"IS00013155,":[461],"all":[463],"procedures":[464],"adhered":[465],"U.S.":[468],"Public":[469],"Health":[470],"Service":[471],"Policy":[472],"Humane":[474],"Laboratory":[479,491],"Animals":[480],"NIH":[483],"Guide":[484],"Animals.":[492]},"counts_by_year":[],"updated_date":"2026-11-02T09:45:03.842371","created_date":"2025-11-05T00:00:00"}