{"id":"https://openalex.org/W4415832003","doi":"https://doi.org/10.1016/j.identj.2025.105371","title":"Hdac9-Mediated Pyroptosis Promotes Orthodontic Inflammatory Root Resorption","display_name":"Hdac9-Mediated Pyroptosis Promotes Orthodontic Inflammatory Root Resorption","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415832003","doi":"https://doi.org/10.1016/j.identj.2025.105371"},"language":"en","primary_location":{"id":"doi:10.1016/j.identj.2025.105371","doi":"https://doi.org/10.1016/j.identj.2025.105371","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.105371","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.identj.2025.105371","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100443697","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0002-0237-2137","observed_orcids":["https://orcid.org/0000-0002-0237-2137"]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Chen","raw_affiliation_strings":["The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004387257","display_name":"Junhao Huang","orcid":"https://orcid.org/0000-0001-9981-9558","observed_orcids":["https://orcid.org/0000-0001-9981-9558"]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junhao Huang","raw_affiliation_strings":["The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]},{"author_position":"last","author":{"id":null,"display_name":"Bingxue Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146956","display_name":"Third Affiliated Hospital of Sun Yat-sen University","ror":"https://ror.org/04tm3k558","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146956"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingxue Hu","raw_affiliation_strings":["The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","institution_ids":["https://openalex.org/I4210146956"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100443697"],"corresponding_institution_ids":["https://openalex.org/I4210146956"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34639966,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":null,"first_page":"105371","last_page":"105371"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.04439999908208847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.015699999406933784,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac9","display_name":"HDAC9","score":0.949999988079071},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/histone-deacetylation","display_name":"histone deacetylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/periodontal-ligament-fibroblasts","display_name":"periodontal ligament fibroblasts","score":0.9549999833106995},{"id":"https://openalex.org/keywords/osteoclastogenesis","display_name":"osteoclastogenesis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9649999737739563},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.824999988079071},{"id":"https://openalex.org/keywords/h3k9-acetylation","display_name":"H3K9 acetylation","score":0.9039999842643738},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/orthodontic-tooth-movement","display_name":"orthodontic tooth movement","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.8671000003814697},{"id":"https://openalex.org/C41868710","wikidata":"https://www.wikidata.org/wiki/Q540092","display_name":"Periodontal fiber","level":2,"score":0.7516000270843506},{"id":"https://openalex.org/C2778380114","wikidata":"https://www.wikidata.org/wiki/Q143652","display_name":"Periodontium","level":2,"score":0.6241000294685364},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6136999726295471},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.5770000219345093},{"id":"https://openalex.org/C56302369","wikidata":"https://www.wikidata.org/wiki/Q189341","display_name":"Cementoblast","level":4,"score":0.5120999813079834},{"id":"https://openalex.org/C2777894202","wikidata":"https://www.wikidata.org/wiki/Q848382","display_name":"Cementum","level":3,"score":0.49300000071525574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4885999858379364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4717000126838684},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.45089998841285706},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4332999885082245},{"id":"https://openalex.org/C146562846","wikidata":"https://www.wikidata.org/wiki/Q96649518","display_name":"Resorption","level":2,"score":0.41179999709129333},{"id":"https://openalex.org/C2778703501","wikidata":"https://www.wikidata.org/wiki/Q7824277","display_name":"Root resorption","level":3,"score":0.41029998660087585},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4047999978065491},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3856000006198883},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.34360000491142273},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33489999175071716},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.33090001344680786},{"id":"https://openalex.org/C2908931166","wikidata":"https://www.wikidata.org/wiki/Q848382","display_name":"Dental cementum","level":4,"score":0.314300000667572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31360000371932983},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3116999864578247},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30410000681877136},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2809000015258789},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C107793267","wikidata":"https://www.wikidata.org/wiki/Q14908260","display_name":"PCAF","level":4,"score":0.2775999903678894},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27469998598098755},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.26080000400543213},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.25850000977516174},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.257999986410141}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.identj.2025.105371","doi":"https://doi.org/10.1016/j.identj.2025.105371","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.105371","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5893affe9e41442993bd8c6a1ce2d60b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5893affe9e41442993bd8c6a1ce2d60b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Dental Journal, Vol 75, Iss , Pp 105371- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.identj.2025.105371","doi":"https://doi.org/10.1016/j.identj.2025.105371","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.105371","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Orthodontic":[0,85],"inflammatory":[1],"root":[2],"resorption":[3],"(OIIRR)":[4],"is":[5],"a":[6,20,195],"common":[7],"iatrogenic":[8],"outcome":[9],"of":[10,42,90,97,110,129,164],"orthodontic":[11,91],"treatment.":[12],"Both":[13],"epigenetic":[14,31],"modifications":[15,32],"and":[16,46,60,79,94,143,186,191,219,227],"pyroptosis":[17,34,74,142,152,220],"have":[18],"demonstrated":[19],"certain":[21],"role":[22],"in":[23,38,106,122,131,139,161,198,221],"OIIRR.":[24,39],"This":[25],"study":[26],"aims":[27],"to":[28,35,82,113,134],"investigate":[29],"whether":[30],"regulate":[33],"be":[36],"involved":[37],"Rat":[40],"model":[41],"OIIRR":[43,111,132,228],"was":[44,104,120,207],"established,":[45],"the":[47,88,95,107,114,135,178,204],"periodontal":[48,64,108,123],"tissues":[49,109],"were":[50,68,149],"utilized":[51],"for":[52],"H&E":[53],"staining,":[54,56],"TRAP":[55],"immunofluorescence,":[57],"transcriptome":[58],"sequencing,":[59],"RT-qPCR":[61,192],"analysis.":[62],"Human":[63],"ligament":[65,124],"fibroblasts":[66],"(hPDLFs)":[67],"overexpressed":[69],"with":[70,73,77,126],"HDAC9,":[71],"treated":[72],"inhibitor,":[75],"incubated":[76],"osteoclast,":[78],"then":[80],"subjected":[81],"CUT&Tag":[83,154],"sequencing":[84,100],"force":[86],"increased":[87,209],"distance":[89],"tooth":[92],"movement":[93],"abundance":[96],"osteoclast.":[98],"Transcriptome":[99],"identified":[101],"that":[102,118,157],"Hdac9":[103],"upregulated":[105],"compared":[112,133],"control.":[115,136],"Immunofluorescence":[116],"revealed":[117,194],"HDAC9":[119,130,137,158,189,211],"present":[121],"fibroblasts,":[125],"reduced":[127,174],"fluorescence":[128],"overexpression":[138,159],"hPDLFs":[140],"induced":[141],"promoted":[144],"osteoclast":[145,225],"differentiation.":[146],"These":[147],"effects":[148],"reversed":[150],"by":[151,210],"inhibitors.":[153],"analysis":[155,172,193],"showed":[156],"resulted":[160],"an":[162],"enrichment":[163,176],"deacetylated":[165],"genes":[166,181],"on":[167,177],"mitochondrial":[168,179,217],"dysfunction-associated":[169,180],"pathways.":[170],"CUT&Tag-PCR":[171],"confirmed":[173],"H3K9ac":[175],"VPS13D,":[182],"AQP1,":[183],"PEX2,":[184],"CDK1,":[185],"PLEKHA1":[187],"after":[188],"overexpression,":[190],"corresponding":[196],"decrease":[197],"their":[199],"respective":[200],"expression":[201],"levels.":[202],"Accordingly,":[203],"ROS":[205],"level":[206],"also":[208],"overexpression.":[212],"HDAC9-mediated":[213],"histone":[214],"deacetylation":[215],"induces":[216],"dysfunction":[218],"hPDLFs,":[222],"thereby":[223],"promoting":[224],"differentiation":[226],"progression.":[229]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2025-11-04T00:00:00"}