{"id":"https://openalex.org/W4415831791","doi":"https://doi.org/10.1016/j.identj.2025.105066","title":"Co-Releasing Nanoparticles Accelerate Mandibular Vascularized Bone Regeneration","display_name":"Co-Releasing Nanoparticles Accelerate Mandibular Vascularized Bone Regeneration","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415831791","doi":"https://doi.org/10.1016/j.identj.2025.105066"},"language":"en","primary_location":{"id":"doi:10.1016/j.identj.2025.105066","doi":"https://doi.org/10.1016/j.identj.2025.105066","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.105066","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.identj.2025.105066","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084615025","display_name":"Bang Li","orcid":"https://orcid.org/0000-0002-7254-6569","observed_orcids":["https://orcid.org/0000-0002-7254-6569"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bang Li","raw_affiliation_strings":["College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Kang","raw_affiliation_strings":["College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112587542","display_name":"Xu Jianguang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Jianguang","raw_affiliation_strings":["College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101670414","display_name":"Xiaoxuan Lu","orcid":"https://orcid.org/0000-0003-4760-7523","observed_orcids":["https://orcid.org/0000-0003-4760-7523"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Xiaoxuan","raw_affiliation_strings":["College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120238434","display_name":"Yang Ruiwen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Ruiwen","raw_affiliation_strings":["College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100338368","display_name":"Jingjing Li","orcid":"https://orcid.org/0000-0001-9638-7964","observed_orcids":["https://orcid.org/0000-0001-9638-7964"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Jingjing","raw_affiliation_strings":["College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College & Hospital of Stomatology, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei, China","institution_ids":["https://openalex.org/I197869895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084615025"],"corresponding_institution_ids":["https://openalex.org/I197869895"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18144527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":null,"first_page":"105066","last_page":"105066"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.8353999853134155,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.028999999165534973,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11566","display_name":"Laser Applications in Dentistry and Medicine","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mandibular-bone-regeneration","display_name":"mandibular bone regeneration","score":0.8759999871253967},{"id":"https://openalex.org/keywords/vascularized-bone-regeneration","display_name":"vascularized bone regeneration","score":0.871999979019165},{"id":"https://openalex.org/keywords/ros-scavenging","display_name":"reactive oxygen species scavenging","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hypoxic-microenvironment","display_name":"hypoxic microenvironment","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hif-pathway","display_name":"HIF pathway","score":0.8989999890327454},{"id":"https://openalex.org/keywords/mitochondrial-metabolic-reprogramming","display_name":"mitochondrial metabolic reprogramming","score":0.9070000052452087},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.8569999933242798},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6320000290870667},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.8740000128746033},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/streptococcus-mutans","display_name":"Streptococcus mutans","score":1.0},{"id":"https://openalex.org/keywords/craniofacial-tissue-engineering","display_name":"craniofacial tissue engineering","score":0.9850000143051147}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6757000088691711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6377000212669373},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5055000185966492},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.47909998893737793},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4781000018119812},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.47429999709129333},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.40549999475479126},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.40459999442100525},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.39989998936653137},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.39239999651908875},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.3637999892234802},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.3617999851703644},{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.33739998936653137},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3292999863624573},{"id":"https://openalex.org/C2781245598","wikidata":"https://www.wikidata.org/wiki/Q5182134","display_name":"Craniofacial","level":2,"score":0.3264999985694885},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.303600013256073},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.290800005197525},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C2779886569","wikidata":"https://www.wikidata.org/wiki/Q7168661","display_name":"Periodontal ligament stem cells","level":4,"score":0.27059999108314514},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.26919999718666077},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.2687000036239624},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.2574000060558319}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.identj.2025.105066","doi":"https://doi.org/10.1016/j.identj.2025.105066","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.105066","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2db1dfe433a24b0f948ce6813ba98f79","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2db1dfe433a24b0f948ce6813ba98f79","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Dental Journal, Vol 75, Iss , Pp 105066- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.identj.2025.105066","doi":"https://doi.org/10.1016/j.identj.2025.105066","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.105066","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"This":[0,192],"study":[1],"innovatively":[2],"constructs":[3],"red":[4,21],"light-responsive":[5],"carbon":[6],"monoxide":[7],"(CO)-releasing":[8],"nanoparticles":[9],"(COR-NPs)":[10],"to":[11,73,126,136,143,160],"accelerate":[12],"vascularized":[13,215],"mandibular":[14,200],"regeneration":[15,129,201,217],"through":[16,130,218],"a":[17,41,152,203,222],"triple":[18],"synergistic":[19],"mechanism:":[20],"light-triggered":[22],"ROS":[23,142],"scavenging,":[24],"localized":[25],"oxygen":[26,53],"depletion,":[27],"and":[28,51,64,78,88,97,106,132,164,178,183],"controlled":[29],"CO":[30,48,169],"release,":[31],"thereby":[32],"reconstructing":[33],"the":[34,75,121,157,180,195],"defective":[35],"microenvironment.":[36],"COR-NPs":[37,65,82,138,150,209],"were":[38,71],"synthesized":[39],"via":[40,102],"self-assembly":[42],"method,":[43],"followed":[44],"by":[45,120],"characterization":[46],"of":[47,81,186,199],"release":[49,170],"efficiency":[50],"dissolved":[52],"levels.":[54],"Experimental":[55],"groups":[56],"included":[57],"control":[58],"group,":[59,61,63],"red-light":[60],"blank-NPs":[62],"group.":[66],"In":[67],"vitro":[68],"cellular":[69],"experiments":[70],"performed":[72],"evaluate":[74],"anti-inflammatory,":[76],"pro-angiogenic,":[77],"osteogenic":[79,86,184],"effects":[80],"using":[83],"immunofluorescence":[84],"staining,":[85,105],"induction,":[87],"tube":[89],"formation":[90],"assays.":[91,109],"Antibacterial":[92],"efficacy":[93],"against":[94],"Staphylococcus":[95],"aureus":[96],"Streptococcus":[98],"mutans":[99],"was":[100,124],"assessed":[101],"turbidimetry,":[103],"live/dead":[104],"crystal":[107],"violet":[108],"A":[110],"tooth":[111],"extraction":[112],"model":[113],"in":[114,213],"8-week-old":[115],"male":[116],"Sprague-Dawley":[117],"rats":[118],"(approved":[119],"Ethics":[122],"Committee)":[123],"employed":[125],"analyze":[127],"jawbone":[128],"micro-CT":[131],"immunohistochemical":[133],"staining.":[134],"Compared":[135],"controls,":[137],"effectively":[139],"consumed":[140],"intracellular":[141],"suppress":[144],"neutrophil":[145,175],"extracellular":[146],"trap":[147],"formation.":[148],"Meanwhile,":[149],"established":[151],"transient":[153],"hypoxic":[154],"microenvironment,":[155],"activating":[156],"HIF":[158],"pathway":[159],"enhance":[161],"microvascular":[162],"reconstruction":[163],"mitochondrial":[165],"metabolic":[166],"reprogramming.":[167],"Concurrently,":[168],"inhibited":[171],"bacterial":[172],"proliferation,":[173],"amplified":[174],"phagocytic":[176],"efficiency,":[177],"bolstered":[179],"stress":[181],"resistance":[182],"differentiation":[185],"bone":[187,216],"marrow":[188],"mesenchymal":[189],"stem":[190],"cells.":[191],"work":[193],"elucidates":[194],"dynamic":[196],"regulatory":[197],"principles":[198],"from":[202],"gas":[204],"molecule-microenvironment":[205],"interaction":[206],"perspective.":[207],"The":[208],"demonstrate":[210],"significant":[211],"potential":[212],"accelerating":[214],"remodeling":[219],"microenvironments,":[220],"offering":[221],"novel":[223],"strategy":[224],"for":[225],"craniofacial":[226],"tissue":[227],"engineering.":[228]},"counts_by_year":[],"updated_date":"2026-01-20T17:24:06.736184","created_date":"2025-11-04T00:00:00"}
