{"id":"https://openalex.org/W4415831709","doi":"https://doi.org/10.1016/j.identj.2025.104061","title":"Apical Periodontitis Exacerbates Ulcerative Colitis Through NETs And Gut Dysbiosis","display_name":"Apical Periodontitis Exacerbates Ulcerative Colitis Through NETs And Gut Dysbiosis","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415831709","doi":"https://doi.org/10.1016/j.identj.2025.104061"},"language":"en","primary_location":{"id":"doi:10.1016/j.identj.2025.104061","doi":"https://doi.org/10.1016/j.identj.2025.104061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.104061","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.identj.2025.104061","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yu Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Zeng","raw_affiliation_strings":["School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030925628","display_name":"Shuai Chen","orcid":"https://orcid.org/0000-0002-4016-8217","observed_orcids":["https://orcid.org/0000-0002-4016-8217"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuai Chen","raw_affiliation_strings":["School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shihan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shihan Lin","raw_affiliation_strings":["School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037987925","display_name":"Yufang Luo","orcid":"https://orcid.org/0000-0002-2883-1960","observed_orcids":["https://orcid.org/0000-0002-2883-1960"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufang Luo","raw_affiliation_strings":["School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091676260","display_name":"Guowu Gan","orcid":"https://orcid.org/0000-0002-3189-9915","observed_orcids":["https://orcid.org/0000-0002-3189-9915"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guowu Gan","raw_affiliation_strings":["School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129708740"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.28720945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"75","issue":null,"first_page":"104061","last_page":"104061"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.0689999982714653,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apical-periodontitis","display_name":"apical periodontitis","score":1.0},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neutrophil-extracellular-traps","display_name":"neutrophil extracellular traps","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gut-dysbiosis","display_name":"gut dysbiosis","score":0.9549999833106995},{"id":"https://openalex.org/keywords/intestinal-barrier-dysfunction","display_name":"intestinal barrier dysfunction","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.8759999871253967},{"id":"https://openalex.org/keywords/goblet-cells","display_name":"goblet cells","score":0.9200000166893005},{"id":"https://openalex.org/keywords/bacteroides","display_name":"Bacteroides","score":0.9390000104904175},{"id":"https://openalex.org/keywords/escherichia","display_name":"Escherichia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8399999737739563},{"id":"https://openalex.org/keywords/oral-health","display_name":"oral health","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.7944999933242798},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.7296000123023987},{"id":"https://openalex.org/C2780385504","wikidata":"https://www.wikidata.org/wiki/Q520127","display_name":"Periodontitis","level":2,"score":0.632099986076355},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.6108999848365784},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.5622000098228455},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5455999970436096},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.503600001335144},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49889999628067017},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.490200012922287},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.4675999879837036},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.4507000148296356},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4447999894618988},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.36820000410079956},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.353300005197525},{"id":"https://openalex.org/C2984894117","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Indirect immunofluorescence","level":3,"score":0.3522000014781952},{"id":"https://openalex.org/C2775941134","wikidata":"https://www.wikidata.org/wiki/Q813622","display_name":"Goblet cell","level":3,"score":0.3483000099658966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32829999923706055},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C2777572184","wikidata":"https://www.wikidata.org/wiki/Q15749161","display_name":"Inflammatory Bowel Diseases","level":4,"score":0.2964000105857849},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2930999994277954},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2800000011920929},{"id":"https://openalex.org/C2776258884","wikidata":"https://www.wikidata.org/wiki/Q3055368","display_name":"Enterocolitis","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C29350253","wikidata":"https://www.wikidata.org/wiki/Q189073","display_name":"Cell junction","level":3,"score":0.265500009059906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2606000006198883},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.26019999384880066},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.2563999891281128}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.identj.2025.104061","doi":"https://doi.org/10.1016/j.identj.2025.104061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.104061","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a142da4d7f324ea58027841ecfcee51b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a142da4d7f324ea58027841ecfcee51b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Dental Journal, Vol 75, Iss , Pp 104061- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.identj.2025.104061","doi":"https://doi.org/10.1016/j.identj.2025.104061","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.identj.2025.104061","pdf_url":null,"source":{"id":"https://openalex.org/S143937555","display_name":"International Dental Journal","issn_l":"0020-6539","issn":["0020-6539","1875-595X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Dental Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Aim":[0],"or":[1],"purpose":[2],"This":[3,158],"study":[4,159],"investigated":[5],"the":[6,20],"causal":[7],"relationship":[8],"between":[9],"apical":[10],"periodontitis":[11],"(AP)":[12],"and":[13,18,29,41,60,69,82,91,117,133,172,175],"ulcerative":[14],"colitis":[15],"(UC)":[16],"exacerbation,":[17],"elucidated":[19],"underlying":[21],"mechanisms,":[22],"focusing":[23],"on":[24],"neutrophil":[25],"extracellular":[26],"traps":[27],"(NETs)":[28],"gut":[30,98],"microbiota":[31,153],"dysbiosis,":[32],"a":[33],"knowledge":[34],"gap":[35],"in":[36,128],"oral-systemic":[37],"inflammation":[38],"research.":[39],"Materials":[40],"methods":[42],"Ethical":[43],"approval":[44],"was":[45,64,74],"obtained.":[46],"Thirty-two":[47],"ICR":[48],"mice":[49,110],"underwent":[50],"8-week":[51],"interventions:":[52],"Control,":[53],"AP":[54,164],"(apical":[55],"periodontitis),":[56],"UC":[57,124,166],"(ulcerative":[58],"colitis),":[59],"AP+UC.":[61],"Disease":[62],"progression":[63],"assessed":[65],"through":[66,168],"clinical":[67],"scoring":[68],"histopathology.":[70],"Intestinal":[71],"barrier":[72,140,182],"integrity":[73],"quantified":[75],"via":[76],"tight":[77,129],"junction":[78,130],"protein":[79],"immunofluorescence":[80,92],"(ZO-1/Claudin1)":[81,132],"goblet":[83,134],"cell":[84,135],"staining.":[85],"NETs":[86,143,173],"were":[87],"measured":[88],"by":[89],"ELISA":[90],"co-localization.":[93],"16S":[94],"rRNA":[95],"sequencing":[96],"analyzed":[97],"microbial":[99],"shifts.":[100],"Statistical":[101],"analyses":[102],"employed":[103],"ANOVA":[104],"with":[105,151],"Tukey's":[106],"test.":[107],"Results":[108],"AP+UC":[109],"exhibited":[111],"significantly":[112],"elevated":[113],"disease":[114],"activity":[115],"(p<0.01)":[116,137],"exacerbated":[118],"histopathological":[119],"damage":[120],"(p<0.05)":[121],"compared":[122],"to":[123],"controls.":[125],"Marked":[126],"reductions":[127],"proteins":[131],"depletion":[136],"confirmed":[138],"intestinal":[139],"impairment.":[141],"Systemic":[142],"elevation":[144],"(serum":[145],"p<0.05;":[146],"colon":[147],"infiltration":[148],"p<0.05)":[149],"coincided":[150],"pathogenic":[152],"dominance":[154],"(Bacteroides/Escherichia,":[155],"FDR<0.05).":[156],"Conclusions":[157],"provides":[160],"experimental":[161],"evidence":[162],"that:":[163],"aggravates":[165],"severity":[167],"oral-gut":[169],"inflammatory":[170],"crosstalk,":[171],"formation":[174],"dysbiotic":[176],"Bacteroides/Escherichia":[177],"expansion":[178],"may":[179],"synergistically":[180],"drive":[181],"dysfunction.":[183],"The":[184],"data":[185],"provide":[186],"compelling":[187],"rationale":[188],"for":[189],"integrating":[190],"oral":[191],"health":[192],"management":[193],"into":[194],"IBD":[195],"therapeutic":[196],"strategies.":[197]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-11-04T00:00:00"}