{"id":"https://openalex.org/W4415794792","doi":"https://doi.org/10.1161/circ.152.suppl_3.4365816","title":"Abstract 4365816: Unmasking Hypertrophic Cardiomyopathy: Ventricular Crypts as the Earliest Clue","display_name":"Abstract 4365816: Unmasking Hypertrophic Cardiomyopathy: Ventricular Crypts as the Earliest Clue","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4415794792","doi":"https://doi.org/10.1161/circ.152.suppl_3.4365816"},"language":"en","primary_location":{"id":"doi:10.1161/circ.152.suppl_3.4365816","doi":"https://doi.org/10.1161/circ.152.suppl_3.4365816","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.152.suppl_3.4365816","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112474022","display_name":"Ahmed Daniyaal Rasheed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed Daniyaal Rasheed","raw_affiliation_strings":["Hartford Hospital, Bloomfield, Connecticut, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartford Hospital, Bloomfield, Connecticut, United States","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065078721","display_name":"Vidya Nadig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vidya Nadig","raw_affiliation_strings":["Hartford Hospital, Bloomfield, Connecticut, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hartford Hospital, Bloomfield, Connecticut, United States","institution_ids":["https://openalex.org/I1302163369"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060903766","display_name":"Antonio B. Fern\u00e1ndez","orcid":"https://orcid.org/0000-0003-4517-9123","observed_orcids":["https://orcid.org/0000-0003-4517-9123"]},"institutions":[{"id":"https://openalex.org/I1302163369","display_name":"Hartford Hospital","ror":"https://ror.org/00gt5xe03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1302163369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Fernandez","raw_affiliation_strings":["HARTFORD HOSPITAL, Hartford, Connecticut, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HARTFORD HOSPITAL, Hartford, Connecticut, United States","institution_ids":["https://openalex.org/I1302163369"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1302163369"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"152","issue":"Suppl_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apical-hypertrophy","display_name":"apical hypertrophy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/late-gadolinium-enhancement","display_name":"late gadolinium enhancement","score":0.9350000023841858},{"id":"https://openalex.org/keywords/pre-participation-screening","display_name":"pre-participation screening","score":0.6759999990463257},{"id":"https://openalex.org/keywords/athletes","display_name":"athletes","score":0.7080000042915344},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.6930000185966492},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.5230000019073486},{"id":"https://openalex.org/keywords/t-wave-inversion","display_name":"T-wave inversion","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.914900004863739},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7771999835968018},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.7473000288009644},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5809999704360962},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48159998655319214},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.48069998621940613},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.4507000148296356},{"id":"https://openalex.org/C2779376020","wikidata":"https://www.wikidata.org/wiki/Q2014808","display_name":"Right ventricular hypertrophy","level":3,"score":0.4140999913215637},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.4027999937534332},{"id":"https://openalex.org/C3018763269","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Myocardial fibrosis","level":3,"score":0.4007999897003174},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.39489999413490295},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3889000117778778},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.2777000069618225},{"id":"https://openalex.org/C2776002628","wikidata":"https://www.wikidata.org/wiki/Q1628627","display_name":"Left ventricular hypertrophy","level":3,"score":0.2689000070095062},{"id":"https://openalex.org/C67139541","wikidata":"https://www.wikidata.org/wiki/Q2858200","display_name":"Apex (geometry)","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2603999972343445}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.152.suppl_3.4365816","doi":"https://doi.org/10.1161/circ.152.suppl_3.4365816","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.152.suppl_3.4365816","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-3","ki-jl-3","medline","norway-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Left":[1],"ventricular":[2],"(LV)":[3],"myocardial":[4,13],"crypts,":[5],"defined":[6],"as":[7,238],"blood-filled":[8],"invaginations":[9],"penetrating":[10],">50%":[11],"of":[12,115,153,215],"thickness,":[14],"remain":[15],"a":[16,138,148,159],"debated":[17],"imaging":[18,186],"finding.":[19],"While":[20],"associated":[21],"with":[22,47,110,236],"hypertrophic":[23],"cardiomyopathy":[24],"(HCM)":[25],"in":[26,32,75,137,165,175,218],"genotype-positive/phenotype-negative":[27],"individuals,":[28],"their":[29],"prognostic":[30],"significance":[31],"asymptomatic":[33,45,219],"patients":[34],"without":[35,64,190],"confirmed":[36],"genetic":[37],"mutations":[38],"is":[39],"unclear.":[40],"Case":[41],"Presentation:":[42],"A":[43],"20-year-old":[44],"female":[46],"inferoseptal":[48],"precordial":[49],"T-wave":[50],"inversions":[51],"underwent":[52],"sports":[53],"pre-participation":[54],"screening.":[55],"Transthoracic":[56],"echocardiography":[57],"(TTE)":[58],"revealed":[59,104],"an":[60],"apical":[61,106,111,120],"LV":[62],"crypt":[63,216],"hypertrophy.":[65,84,121],"Cardiac":[66],"MRI":[67],"(CMR)":[68],"demonstrated":[69],"non-specific":[70,154],"late":[71],"gadolinium":[72],"enhancement":[73],"(LGE)":[74],"the":[76,244],"basilar":[77],"septum":[78],"and":[79,88,93,242],"inferior":[80],"walls":[81],"but":[82],"no":[83,94],"Exercise":[85],"stress":[86],"testing":[87],"ambulatory":[89],"monitoring":[90],"were":[91,97],"normal,":[92],"activity":[95],"restrictions":[96],"imposed.":[98],"Repeat":[99],"CMR":[100],"at":[101],"2":[102,197],"years":[103],"new":[105],"hypertrophy":[107,136],"(12":[108],"mm)":[109],"to":[112,135,162,249],"basal":[113],"ratio":[114],"1.2":[116],"raising":[117],"suspicion":[118],"for":[119,188,233,246],"Discussion:":[122],"This":[123],"case":[124,212],"challenges":[125],"conventional":[126],"paradigms":[127],"by":[128],"demonstrating":[129],"temporal":[130],"progression":[131],"from":[132],"isolated":[133],"crypts":[134,145,189,235],"genotype-negative":[139],"patient,":[140],"supporting":[141],"emerging":[142],"evidence":[143],"that":[144],"may":[146,208],"represent":[147],"\"pre-hypertrophic\"":[149],"marker.":[150],"The":[151,211],"presence":[152],"LGE":[155,237],"on":[156,185],"initial":[157],"CMR,":[158],"pattern":[160],"linked":[161],"early":[163],"fibrosis":[164],"HCM":[166,201],"mutation":[167],"carriers,":[168],"raises":[169],"questions":[170],"about":[171],"whether":[172],"such":[173],"findings":[174],"crypt-bearing":[176],"myocardium":[177],"warrant":[178],"closer":[179],"surveillance.":[180],"Current":[181],"guidelines":[182],"lack":[183],"consensus":[184],"intervals":[187],"hypertrophy;":[191],"this":[192],"rapid":[193],"phenotypic":[194],"evolution":[195],"within":[196],"years\u2014faster":[198],"than":[199],"typical":[200],"trajectories\u2014suggests":[202],"current":[203],"3\u20135":[204],"year":[205],"surveillance":[206,252],"windows":[207],"be":[209],"inadequate.":[210],"compels":[213],"re-examination":[214],"management":[217],"populations,":[220],"particularly":[221],"athletes,":[222],"where":[223],"delayed":[224],"diagnosis":[225],"carries":[226],"sudden":[227],"cardiac":[228],"death":[229],"risks.":[230],"It":[231],"advocates":[232],"reclassifying":[234],"high-risk":[239],"morphological":[240],"markers":[241],"underscores":[243],"need":[245],"prospective":[247],"studies":[248],"define":[250],"optimal":[251],"protocols.":[253]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-11-03T00:00:00"}
