{"id":"https://openalex.org/W4415786148","doi":"https://doi.org/10.1158/0008-5472.c.8126120","title":"Data from Gut Microbiota\u2013Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment","display_name":"Data from Gut Microbiota\u2013Mediated Bile Acid Metabolism Regulates Colorectal Cancer Liver Metastasis by Altering Neutrophil Recruitment","publication_year":2025,"publication_date":"2025-11-03","ids":{"openalex":"https://openalex.org/W4415786148","doi":"https://doi.org/10.1158/0008-5472.c.8126120"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.c.8126120","doi":"https://doi.org/10.1158/0008-5472.c.8126120","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.8126120","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.c.8126120","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051630309","display_name":"Zongmei Zheng","orcid":"https://orcid.org/0000-0001-5173-634X","observed_orcids":["https://orcid.org/0000-0001-5173-634X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zongmei Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5173-634X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035281555","display_name":"Fuwen Yuan","orcid":"https://orcid.org/0000-0001-5764-2504","observed_orcids":["https://orcid.org/0000-0001-5764-2504"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fuwen Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5764-2504","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102716877","display_name":"Jinming Li","orcid":"https://orcid.org/0000-0002-4870-9815","observed_orcids":["https://orcid.org/0000-0002-4870-9815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinming Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4870-9815","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101486025","display_name":"Xiaojing Zhu","orcid":"https://orcid.org/0009-0009-5482-3786","observed_orcids":["https://orcid.org/0009-0009-5482-3786","https://orcid.org/0000-0001-9717-387X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangxiang Zhu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-5482-3786","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113138510","display_name":"Ru Jia","orcid":"https://orcid.org/0000-0002-8121-4443","observed_orcids":["https://orcid.org/0000-0002-8121-4443"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ru Jia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8121-4443","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009063034","display_name":"Jiao Wei","orcid":"https://orcid.org/0009-0006-1450-7584","observed_orcids":["https://orcid.org/0009-0006-1450-7584"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiao Wei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0006-1450-7584","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083237764","display_name":"Fengjing Jia","orcid":"https://orcid.org/0000-0001-8115-6442","observed_orcids":["https://orcid.org/0000-0001-8115-6442"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fengjing Jia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8115-6442","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033063791","display_name":"Xinxin Hou","orcid":"https://orcid.org/0000-0001-6055-752X","observed_orcids":["https://orcid.org/0000-0001-6055-752X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinxin Hou","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6055-752X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072057262","display_name":"Zhaozhou Zhang","orcid":"https://orcid.org/0009-0009-4105-6864","observed_orcids":["https://orcid.org/0009-0009-4105-6864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhaozhou Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0009-4105-6864","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100322860","display_name":"Yan Wang","orcid":"https://orcid.org/0000-0003-0191-8115","observed_orcids":["https://orcid.org/0000-0003-0191-8115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Wang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-0191-8115","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075258838","display_name":"Yanlei Ma","orcid":"https://orcid.org/0000-0002-0632-5258","observed_orcids":["https://orcid.org/0000-0002-0632-5258","https://orcid.org/0000-0002-7018-3063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanlei Ma","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0632-5258","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100404644","display_name":"Wei Ping Jia","orcid":"https://orcid.org/0000-0002-3739-8994","observed_orcids":["https://orcid.org/0000-0002-3739-8994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Jia","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3739-8994","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5086339442","display_name":"Ling Zhao","orcid":"https://orcid.org/0000-0003-4932-499X","observed_orcids":["https://orcid.org/0000-0003-4932-499X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Zhao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4932-499X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-liver-metastases","display_name":"colorectal liver metastases","score":0.8889999985694885},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9639999866485596},{"id":"https://openalex.org/keywords/bile-acid-metabolism","display_name":"bile acid metabolism","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bile-salt-hydrolase","display_name":"bile salt hydrolase","score":0.9710000157356262},{"id":"https://openalex.org/keywords/unconjugated-bile-acids","display_name":"unconjugated bile acids","score":0.9959999918937683},{"id":"https://openalex.org/keywords/taurocholic-acid","display_name":"taurocholate","score":0.9700000286102295},{"id":"https://openalex.org/keywords/neutrophil-recruitment","display_name":"neutrophil recruitment","score":0.9729999899864197},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5910000205039978},{"id":"https://openalex.org/keywords/bile-acid-supplementation","display_name":"bile acid supplementation","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.805400013923645},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.659600019454956},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.6158999800682068},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.541700005531311},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4959000051021576},{"id":"https://openalex.org/C2780480987","wikidata":"https://www.wikidata.org/wiki/Q2659931","display_name":"Taurocholic acid","level":3,"score":0.49480000138282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49459999799728394},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46389999985694885},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4323999881744385},{"id":"https://openalex.org/C2780615123","wikidata":"https://www.wikidata.org/wiki/Q1058608","display_name":"Primary sclerosing cholangitis","level":3,"score":0.38440001010894775},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37929999828338623},{"id":"https://openalex.org/C39321552","wikidata":"https://www.wikidata.org/wiki/Q18052005","display_name":"G protein-coupled bile acid receptor","level":3,"score":0.3774999976158142},{"id":"https://openalex.org/C2780749602","wikidata":"https://www.wikidata.org/wiki/Q425680","display_name":"Deoxycholic acid","level":3,"score":0.3531999886035919},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3434999883174896},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.34139999747276306},{"id":"https://openalex.org/C2776279336","wikidata":"https://www.wikidata.org/wiki/Q2701638","display_name":"Glycocholic acid","level":4,"score":0.31029999256134033},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.29510000348091125},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.2919999957084656},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2777999937534332},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.27730000019073486},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.2639999985694885},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.2615000009536743},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.26010000705718994}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.c.8126120","doi":"https://doi.org/10.1158/0008-5472.c.8126120","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.8126120","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.c.8126120","doi":"https://doi.org/10.1158/0008-5472.c.8126120","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.c.8126120","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4413753906","https://openalex.org/W4415786259","https://openalex.org/W4415786147","https://openalex.org/W4415786186","https://openalex.org/W4415786323","https://openalex.org/W4415786307","https://openalex.org/W4415786283","https://openalex.org/W4407619465","https://openalex.org/W4310148218","https://openalex.org/W4415786104"],"abstract_inverted_index":{"Abstract":[0],"The":[1,76],"gut":[2,40,175,209],"microbiome":[3],"is":[4,18],"frequently":[5],"dysregulated":[6,174],"in":[7,39,48,73,78,88,95,128,133,153,163,178],"colorectal":[8,53,97,129,197,202],"cancer.":[9],"Gut":[10],"microbiota":[11,210],"can":[12,226],"modify":[13],"bile":[14,43,206,214,233],"acids":[15,215],"(BA),":[16],"which":[17,132,225],"a":[19,36,102,117,122,169,191],"group":[20],"of":[21,61,69,172,205],"metabolites":[22],"that":[23,181,216],"have":[24],"been":[25],"linked":[26],"to":[27,100,195],"tumorigenesis":[28],"and":[29,66,82,109,139,144,155,160,187],"progression.":[30],"In":[31,201],"this":[32],"study,":[33],"we":[34],"observed":[35],"significant":[37],"deficiency":[38],"bacteria":[41],"with":[42,50,91,231],"salt":[44,207],"hydrolase":[45],"(BSH)":[46],"activity":[47,81],"patients":[49,57,90],"liver":[51,111,161,218],"metastatic":[52],"cancer":[54,98,130,198],"(CRLM).":[55],"These":[56],"exhibited":[58],"elevated":[59],"levels":[60,68,84],"conjugated":[62,186,212],"primary":[63,143,213],"BAs":[64,71,146],"(CPBA)":[65],"decreased":[67],"unconjugated":[70,142,232],"(UBA)":[72],"their":[74],"circulation.":[75],"changes":[77],"bacterial":[79],"BSH":[80],"CPBA":[83],"were":[85],"more":[86],"pronounced":[87],"male":[89],"CRLM.":[92,140],"Microbial":[93],"manipulation":[94],"mouse":[96],"models":[99],"create":[101],"BSH-deficient":[103],"state":[104],"increased":[105],"CPBAs,":[106],"reduced":[107],"UBAs,":[108],"promoted":[110,119],"metastasis.":[112,199],"Specifically,":[113],"taurocholic":[114],"acid":[115],"(TCA),":[116],"CPBA,":[118],"CRLM":[120],"through":[121],"neutrophil-dependent":[123],"mechanism.":[124],"TCA":[125,152],"upregulated":[126],"TIMP1":[127],"cells,":[131],"turn":[134],"stimulated":[135],"CXCL5/CXCR2-mediated":[136],"neutrophil":[137,148,158,223],"recruitment":[138,159],"Alternatively,":[141],"secondary":[145],"counteracted":[147],"migration":[149],"induced":[150],"by":[151,220,229],"vitro":[154],"abolished":[156],"TCA-promoted":[157],"metastasis":[162,219],"vivo.":[164],"Together,":[165],"these":[166],"findings":[167],"elucidate":[168],"mechanistic":[170],"role":[171],"the":[173,183],"microbiota\u2013BA":[176],"axis":[177],"CRLM,":[179],"suggesting":[180],"manipulating":[182],"balance":[184],"between":[185],"UBAs":[188],"could":[189],"be":[190,227],"potential":[192],"therapeutic":[193],"strategy":[194],"suppress":[196],"Significance:":[200],"cancer,":[203],"enrichment":[204],"hydrolase-deficient":[208],"elevates":[211],"promote":[217],"inducing":[221],"TIMP1-mediated":[222],"recruitment,":[224],"reversed":[228],"supplementing":[230],"acids.":[234]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-11-03T00:00:00"}
