{"id":"https://openalex.org/W4415774297","doi":"https://doi.org/10.14218/ge.2025.00058","title":"Exosome-based Therapies for Androgenetic Alopecia: Mechanisms, MicroRNAs, and Clinical Prospects","display_name":"Exosome-based Therapies for Androgenetic Alopecia: Mechanisms, MicroRNAs, and Clinical Prospects","publication_year":2025,"publication_date":"2025-10-30","ids":{"openalex":"https://openalex.org/W4415774297","doi":"https://doi.org/10.14218/ge.2025.00058"},"language":"en","primary_location":{"id":"doi:10.14218/ge.2025.00058","doi":"https://doi.org/10.14218/ge.2025.00058","is_oa":true,"landing_page_url":"https://doi.org/10.14218/ge.2025.00058","pdf_url":"https://publinestorage.blob.core.windows.net/journals/GE.2025.24(4).e00058.00058.Pavel Ivanov.pdf","source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://publinestorage.blob.core.windows.net/journals/GE.2025.24(4).e00058.00058.Pavel Ivanov.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Pavel Ivanov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149643846","display_name":"Immanuel Kant Baltic Federal University","ror":"https://ror.org/0421w8947","country_code":"RU","type":"education","lineage":["https://openalex.org/I149643846"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Pavel Ivanov","raw_affiliation_strings":["Immanuel Kant Baltic Federal University , Kaliningrad , Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immanuel Kant Baltic Federal University , Kaliningrad , Russia","institution_ids":["https://openalex.org/I149643846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081225616","display_name":"\u041d. \u041c. \u0422\u043e\u0434\u043e\u0441\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0001-7468-4861","observed_orcids":["https://orcid.org/0000-0001-7468-4861"]},"institutions":[{"id":"https://openalex.org/I149643846","display_name":"Immanuel Kant Baltic Federal University","ror":"https://ror.org/0421w8947","country_code":"RU","type":"education","lineage":["https://openalex.org/I149643846"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Natalia Todosenko","raw_affiliation_strings":["Immanuel Kant Baltic Federal University , 14 Nevskogo St. , Kaliningrad 236041 , Russia","Immanuel Kant Baltic Federal University , Kaliningrad , Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immanuel Kant Baltic Federal University , 14 Nevskogo St. , Kaliningrad 236041 , Russia","institution_ids":["https://openalex.org/I149643846"]},{"raw_affiliation_string":"Immanuel Kant Baltic Federal University , Kaliningrad , Russia","institution_ids":["https://openalex.org/I149643846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003069421","display_name":"Kristina Alekseevna Yurova","orcid":"https://orcid.org/0000-0001-6146-3330","observed_orcids":["https://orcid.org/0000-0001-6146-3330"]},"institutions":[{"id":"https://openalex.org/I149643846","display_name":"Immanuel Kant Baltic Federal University","ror":"https://ror.org/0421w8947","country_code":"RU","type":"education","lineage":["https://openalex.org/I149643846"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Kristina Yurova","raw_affiliation_strings":["Immanuel Kant Baltic Federal University , Kaliningrad , Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immanuel Kant Baltic Federal University , Kaliningrad , Russia","institution_ids":["https://openalex.org/I149643846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071723040","display_name":"\u041e. \u0413. \u0425\u0430\u0437\u0438\u0430\u0445\u043c\u0430\u0442\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-5525-3529","observed_orcids":["https://orcid.org/0000-0002-5525-3529"]},"institutions":[{"id":"https://openalex.org/I149643846","display_name":"Immanuel Kant Baltic Federal University","ror":"https://ror.org/0421w8947","country_code":"RU","type":"education","lineage":["https://openalex.org/I149643846"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Olga Khaziakhmatova","raw_affiliation_strings":["Immanuel Kant Baltic Federal University , Kaliningrad , Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immanuel Kant Baltic Federal University , Kaliningrad , Russia","institution_ids":["https://openalex.org/I149643846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030121222","display_name":"Larisa Sergeevna Litvinova","orcid":"https://orcid.org/0000-0001-5231-6910","observed_orcids":["https://orcid.org/0000-0001-5231-6910"]},"institutions":[{"id":"https://openalex.org/I149643846","display_name":"Immanuel Kant Baltic Federal University","ror":"https://ror.org/0421w8947","country_code":"RU","type":"education","lineage":["https://openalex.org/I149643846"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Larisa Litvinova","raw_affiliation_strings":["Immanuel Kant Baltic Federal University , Kaliningrad , Russia"],"raw_orcid":"https://orcid.org/0000-0001-5231-6910","affiliations":[{"raw_affiliation_string":"Immanuel Kant Baltic Federal University , Kaliningrad , Russia","institution_ids":["https://openalex.org/I149643846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I149643846"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38377939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"4","first_page":"e00058","last_page":"e00058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/androgenetic-alopecia","display_name":"androgenetic alopecia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8550000190734863},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.984000027179718},{"id":"https://openalex.org/keywords/hair-follicle-morphogenesis","display_name":"hair follicle morphogenesis","score":0.9629999995231628},{"id":"https://openalex.org/keywords/anagen-induction","display_name":"anagen induction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hair-follicle-miniaturization","display_name":"hair follicle miniaturization","score":0.859000027179718},{"id":"https://openalex.org/keywords/hair-cycle","display_name":"hair cycle","score":0.5979999899864197},{"id":"https://openalex.org/keywords/intracellular-signaling","display_name":"intracellular signaling","score":0.8069999814033508},{"id":"https://openalex.org/keywords/exosome-therapy","display_name":"exosome therapy","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4616999924182892},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3790000081062317},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.296099990606308},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.28540000319480896},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.26600000262260437},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.26429998874664307},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2621000111103058},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2485000044107437},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.24729999899864197}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14218/ge.2025.00058","doi":"https://doi.org/10.14218/ge.2025.00058","is_oa":true,"landing_page_url":"https://doi.org/10.14218/ge.2025.00058","pdf_url":"https://publinestorage.blob.core.windows.net/journals/GE.2025.24(4).e00058.00058.Pavel Ivanov.pdf","source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14218/ge.2025.00058","doi":"https://doi.org/10.14218/ge.2025.00058","is_oa":true,"landing_page_url":"https://doi.org/10.14218/ge.2025.00058","pdf_url":"https://publinestorage.blob.core.windows.net/journals/GE.2025.24(4).e00058.00058.Pavel Ivanov.pdf","source":{"id":"https://openalex.org/S134577766","display_name":"Gene Expression","issn_l":"1052-2166","issn":["1052-2166","1555-3884"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-70","russia-white-list-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gene Expression","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415774297.pdf","grobid_xml":"https://content.openalex.org/works/W4415774297.grobid-xml"},"referenced_works_count":136,"referenced_works":["https://openalex.org/W1499456034","https://openalex.org/W1503100469","https://openalex.org/W1568755887","https://openalex.org/W1969021169","https://openalex.org/W1973725190","https://openalex.org/W2002647481","https://openalex.org/W2012675490","https://openalex.org/W2019477867","https://openalex.org/W2020409650","https://openalex.org/W2045305474","https://openalex.org/W2058746018","https://openalex.org/W2071937290","https://openalex.org/W2077477797","https://openalex.org/W2081894598","https://openalex.org/W2097241499","https://openalex.org/W2112914821","https://openalex.org/W2130147528","https://openalex.org/W2132402780","https://openalex.org/W2140692632","https://openalex.org/W2154993767","https://openalex.org/W2155584216","https://openalex.org/W2182221509","https://openalex.org/W2274320155","https://openalex.org/W2284668340","https://openalex.org/W2294967868","https://openalex.org/W2523308681","https://openalex.org/W2539762920","https://openalex.org/W2568092366","https://openalex.org/W2572005835","https://openalex.org/W2606333626","https://openalex.org/W2611974124","https://openalex.org/W2727629609","https://openalex.org/W2728521641","https://openalex.org/W2753878493","https://openalex.org/W2755841822","https://openalex.org/W2763497408","https://openalex.org/W2777711022","https://openalex.org/W2782508195","https://openalex.org/W2786637252","https://openalex.org/W2796519170","https://openalex.org/W2799392361","https://openalex.org/W2803335705","https://openalex.org/W2806757861","https://openalex.org/W2885004395","https://openalex.org/W2900981288","https://openalex.org/W2907481244","https://openalex.org/W2911406017","https://openalex.org/W2918322255","https://openalex.org/W2927886839","https://openalex.org/W2935269181","https://openalex.org/W2947607777","https://openalex.org/W2948150201","https://openalex.org/W2954309910","https://openalex.org/W2957617789","https://openalex.org/W2988755616","https://openalex.org/W2990182803","https://openalex.org/W3007628315","https://openalex.org/W3011167742","https://openalex.org/W3014008006","https://openalex.org/W3014338719","https://openalex.org/W3023922995","https://openalex.org/W3034262180","https://openalex.org/W3040930301","https://openalex.org/W3043126734","https://openalex.org/W3047247216","https://openalex.org/W3092111016","https://openalex.org/W3092630374","https://openalex.org/W3095939776","https://openalex.org/W3102072634","https://openalex.org/W3110806949","https://openalex.org/W3112833379","https://openalex.org/W3112843872","https://openalex.org/W3113803059","https://openalex.org/W3120800958","https://openalex.org/W3128328603","https://openalex.org/W3169734379","https://openalex.org/W3170613622","https://openalex.org/W3175365912","https://openalex.org/W3175992200","https://openalex.org/W3176495630","https://openalex.org/W3187617273","https://openalex.org/W3195550805","https://openalex.org/W3198715869","https://openalex.org/W3205246752","https://openalex.org/W3205480411","https://openalex.org/W3206038043","https://openalex.org/W3210207203","https://openalex.org/W3214599107","https://openalex.org/W4205433535","https://openalex.org/W4206209974","https://openalex.org/W4206375931","https://openalex.org/W4210272134","https://openalex.org/W4280626543","https://openalex.org/W4282970088","https://openalex.org/W4283835368","https://openalex.org/W4286500360","https://openalex.org/W4296661591","https://openalex.org/W4307898205","https://openalex.org/W4308019622","https://openalex.org/W4308471114","https://openalex.org/W4313478542","https://openalex.org/W4313646479","https://openalex.org/W4318315708","https://openalex.org/W4319965195","https://openalex.org/W4321097855","https://openalex.org/W4327715649","https://openalex.org/W4375858539","https://openalex.org/W4377092531","https://openalex.org/W4378908478","https://openalex.org/W4379383182","https://openalex.org/W4382983086","https://openalex.org/W4383270621","https://openalex.org/W4383536349","https://openalex.org/W4385075925","https://openalex.org/W4385408051","https://openalex.org/W4385456671","https://openalex.org/W4386026463","https://openalex.org/W4387079122","https://openalex.org/W4387264885","https://openalex.org/W4387868637","https://openalex.org/W4388595989","https://openalex.org/W4388930256","https://openalex.org/W4389801976","https://openalex.org/W4390618490","https://openalex.org/W4392057380","https://openalex.org/W4392057705","https://openalex.org/W4392438899","https://openalex.org/W4392909633","https://openalex.org/W4396643090","https://openalex.org/W4398252722","https://openalex.org/W4400367085","https://openalex.org/W4401793940","https://openalex.org/W4403475524","https://openalex.org/W4408307753","https://openalex.org/W4409879512","https://openalex.org/W4412825383"],"related_works":["https://openalex.org/W7167460153","https://openalex.org/W7172279051","https://openalex.org/W7166687128","https://openalex.org/W4412677837","https://openalex.org/W3134128582","https://openalex.org/W7214621026","https://openalex.org/W4388210612","https://openalex.org/W4285984821","https://openalex.org/W7128482886","https://openalex.org/W4224251092"],"abstract_inverted_index":{"Characteristic":[0],"signs":[1],"of":[2,8,22,24,43,67,73,83,90,99,129,140],"alopecia":[3,55],"are":[4,62],"gradual":[5],"thinning,":[6],"disruption":[7],"structural":[9],"features,":[10],"and":[11,31,40,47,105,114,149],"the":[12,20,37,65,71,87,97,112,127,138],"hair":[13,25,91,120],"development":[14,39],"cycle":[15],"(anagen,":[16],"catagen,":[17],"telogen)":[18],"against":[19,54],"background":[21],"miniaturization":[23],"follicles,":[26],"which":[27,78],"leads":[28],"to":[29],"baldness":[30],"psychological":[32],"stress":[33],"in":[34,110],"patients.":[35],"Despite":[36],"rapid":[38],"clinical":[41,144],"application":[42],"synthetic":[44],"pharmacological,":[45],"cellular/acellular,":[46],"molecular":[48],"drugs,":[49],"no":[50],"effective":[51],"therapeutic":[52,68],"agent":[53],"has":[56],"yet":[57],"been":[58],"developed.":[59],"Great":[60],"hopes":[61],"pinned":[63],"on":[64,126],"improvement":[66],"strategies":[69],"with":[70],"introduction":[72],"exosomes":[74,133],"into":[75],"practical":[76],"application,":[77],"contain":[79],"a":[80,143],"wide":[81],"array":[82],"active":[84],"substances":[85],"for":[86,137,146],"targeted":[88],"stimulation":[89],"follicle":[92,121],"activity":[93],"(anagen":[94],"inducers)":[95],"through":[96],"regulation":[98],"intracellular":[100,116],"signaling":[101],"cascades,":[102],"growth":[103],"factors,":[104],"microRNAs.":[106],"The":[107],"review":[108],"discusses":[109],"detail":[111],"microRNAs":[113],"their":[115],"targets":[117],"that":[118],"control":[119],"morphogenesis.":[122],"It":[123],"also":[124],"focuses":[125],"prospects":[128],"using":[130],"stem":[131],"cell":[132],"from":[134],"various":[135],"sources":[136],"treatment":[139],"alopecia,":[141],"providing":[142],"rationale":[145],"potential":[147],"benefits":[148],"risks.":[150]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-11-02T00:00:00"}