{"id":"https://openalex.org/W4415769800","doi":"https://doi.org/10.1101/2025.07.17.664724","title":"Systematic molecular glue drug discovery with a high-throughput effector protein remodeling platform","display_name":"Systematic molecular glue drug discovery with a high-throughput effector protein remodeling platform","publication_year":2025,"publication_date":"2025-07-18","ids":{"openalex":"https://openalex.org/W4415769800","doi":"https://doi.org/10.1101/2025.07.17.664724"},"language":"en","primary_location":{"id":"doi:10.1101/2025.07.17.664724","doi":"https://doi.org/10.1101/2025.07.17.664724","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.17.664724","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/18/2025.07.17.664724.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/18/2025.07.17.664724.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111976578","display_name":"Jia Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jia Lu","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kate Stuart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kate Stuart","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038656148","display_name":"Rebecca Teague","orcid":"https://orcid.org/0000-0002-7045-3561","observed_orcids":["https://orcid.org/0000-0002-7045-3561","https://orcid.org/0000-0003-2032-6094"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca Teague","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120217400","display_name":"Chloe Tarry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chloe Tarry","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Robert Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Yan","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tabitha Morgan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tabitha Morgan","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120217401","display_name":"Elizabeth Nock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth Nock","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007276747","display_name":"Darcie S Mulhearn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darcie S Mulhearn","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Matt Jones","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matt Jones","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103350877","display_name":"Michael H. Knaggs","orcid":"https://orcid.org/0000-0003-0421-0251","observed_orcids":["https://orcid.org/0000-0003-0421-0251"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael H Knaggs","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ruben Alvarez Fernandez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ruben Alvarez Fernandez","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Willie Yen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Willie Yen","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013842270","display_name":"Aris Aristodemou","orcid":"https://orcid.org/0000-0002-3266-4499","observed_orcids":["https://orcid.org/0000-0002-3266-4499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aris Aristodemou","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Eleanor Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eleanor Thompson","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050077855","display_name":"Penny Hayward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Penny Hayward","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003014556","display_name":"Juliane F. Ripka","orcid":"https://orcid.org/0009-0005-8061-5199","observed_orcids":["https://orcid.org/0009-0005-8061-5199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juliane F Ripka","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":"https://orcid.org/0009-0005-8061-5199","affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bethany C Atkinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bethany C Atkinson","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Abigail Dear","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abigail Dear","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111219273","display_name":"Aruba Farooq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aruba Farooq","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014691356","display_name":"Mat Calder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mat Calder","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057747891","display_name":"Miguel B. Coelho","orcid":"https://orcid.org/0000-0002-5913-149X","observed_orcids":["https://orcid.org/0000-0002-5913-149X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miguel B Coelho","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022508825","display_name":"Laura R. Butler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura R Butler","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alberto Moreno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alberto Moreno","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036776345","display_name":"Christian Dillon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Dillon","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111144536","display_name":"Richard J. Boyce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J Boyce","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011709620","display_name":"Benedict C. S. Cross","orcid":"https://orcid.org/0000-0003-1065-3139","observed_orcids":["https://orcid.org/0000-0003-1065-3139"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Benedict CS Cross","raw_affiliation_strings":["PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-1065-3139","affiliations":[{"raw_affiliation_string":"PhoreMost Ltd, Unit 7 The Works, Cambridge, CB22 9FT, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011709620","https://openalex.org/A5111976578"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-glue-degraders","display_name":"molecular glues","score":0.9150000214576721},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.6819999814033508},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cereblon","display_name":"cereblon","score":0.9200000166893005},{"id":"https://openalex.org/keywords/deep-mutational-scanning","display_name":"deep mutational scanning","score":0.75},{"id":"https://openalex.org/keywords/gspt1","display_name":"GSPT1","score":0.7110000252723694},{"id":"https://openalex.org/keywords/small-molecule-drug-discovery","display_name":"small molecule drug discovery","score":0.5329999923706055},{"id":"https://openalex.org/keywords/oncology-drug-targets","display_name":"oncology drug targets","score":0.6029999852180481}],"concepts":[{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.8783000111579895},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.8217999935150146},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.7831000089645386},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6794000267982483},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.6087999939918518},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5400000214576721},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47519999742507935},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.45399999618530273},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.43619999289512634},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4075999855995178},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.36809998750686646},{"id":"https://openalex.org/C92028520","wikidata":"https://www.wikidata.org/wiki/Q7395025","display_name":"SUPERFAMILY","level":3,"score":0.3386000096797943},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33660000562667847},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32350000739097595},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3203999996185303},{"id":"https://openalex.org/C171852809","wikidata":"https://www.wikidata.org/wiki/Q731154","display_name":"Chemical biology","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.2969000041484833},{"id":"https://openalex.org/C74401373","wikidata":"https://www.wikidata.org/wiki/Q1829843","display_name":"Bromodomain","level":4,"score":0.28839999437332153},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.28119999170303345},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.2802000045776367},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26809999346733093},{"id":"https://openalex.org/C2908868211","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin-Protein Ligases","level":5,"score":0.2547000050544739},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25290000438690186},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.25279998779296875}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2025.07.17.664724","doi":"https://doi.org/10.1101/2025.07.17.664724","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.17.664724","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/18/2025.07.17.664724.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2025.07.17.664724","doi":"https://doi.org/10.1101/2025.07.17.664724","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.07.17.664724","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/07/18/2025.07.17.664724.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320335052","display_name":"Department of Biochemistry, University of Cambridge","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415769800.pdf","grobid_xml":"https://content.openalex.org/works/W4415769800.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W2072753134","https://openalex.org/W2106839391","https://openalex.org/W2146512944","https://openalex.org/W2157881623","https://openalex.org/W2170551349","https://openalex.org/W2179438025","https://openalex.org/W2299508065","https://openalex.org/W2470671857","https://openalex.org/W2516355239","https://openalex.org/W2733066269","https://openalex.org/W2956081100","https://openalex.org/W3087769169","https://openalex.org/W4225923919","https://openalex.org/W4230096730","https://openalex.org/W4308439092","https://openalex.org/W4387492901","https://openalex.org/W4391530535","https://openalex.org/W4391987176","https://openalex.org/W4403428249","https://openalex.org/W4407392239","https://openalex.org/W4407392249","https://openalex.org/W4411983851","https://openalex.org/W4412629733","https://openalex.org/W4413346119","https://openalex.org/W6925356896"],"related_works":["https://openalex.org/W4414691781","https://openalex.org/W3186572052","https://openalex.org/W7133340874","https://openalex.org/W4406569266","https://openalex.org/W3158527646","https://openalex.org/W3046236678","https://openalex.org/W7213664559","https://openalex.org/W7117302492","https://openalex.org/W7211875698","https://openalex.org/W4409630118"],"abstract_inverted_index":{"ABSTRACT":[0],"Realising":[1],"the":[2,22,39,46,96,109,137,141,151,193,207,216,223],"promise":[3],"of":[4,25,50,75,111,136,150,166,195,210],"new":[5,66,86,112,126,145,164,229],"medicines":[6],"that":[7,19,52,91,116],"operate":[8],"through":[9,37],"a":[10,65,122,134,159],"targeted":[11],"molecular":[12,147],"glue-induced":[13],"degradation":[14,110],"mechanism":[15],"requires":[16],"systematic":[17],"tools":[18],"can":[20,100,130,225],"uncover":[21],"relevant":[23],"principles":[24],"neomorphic":[26,105],"protein-protein":[27],"interactions.":[28,88],"Whilst":[29],"some":[30],"monovalent":[31,182],"glue":[32,148],"degraders":[33,129,149],"have":[34],"been":[35,176],"found":[36],"serendipity,":[38],"rules":[40],"for":[41],"small":[42,127,211],"molecule":[43,128,212],"attributes":[44],"and":[45,84,115,162,220],"pairs":[47],"or":[48],"complexes":[49],"proteins":[51,78,114,197],"are":[53,158],"amenable":[54],"to":[55,68,79,103,143,191,205],"drug-induced":[56],"proximity":[57],"control":[58],"remain":[59],"poorly":[60],"articulated.":[61],"Here":[62],"we":[63,139],"introduce":[64],"approach":[67,204],"address":[69],"this":[70,203],"by":[71,107,185],"using":[72,186],"programmed":[73],"libraries":[74],"intramolecularly":[76],"edited":[77],"expand":[80],"protein":[81],"surface":[82],"landscapes":[83],"trigger":[85],"druggable":[87],"We":[89,201],"show":[90,221],"effector":[92,196],"proteins,":[93],"such":[94],"as":[95],"E3":[97,199],"ligase":[98],"Cereblon,":[99],"be":[101,131,226],"engineered":[102],"provoke":[104],"activity":[106],"inducing":[108],"client":[113],"these":[117],"de":[118],"novo":[119],"interactions":[120],"provide":[121],"blueprint":[123],"from":[124],"which":[125,214],"built.":[132],"As":[133],"demonstration":[135],"approach,":[138],"use":[140],"platform":[142],"identify":[144],"non-IMiD":[146],"oncology":[152,217],"target":[153,218],"GSPT1.":[154],"SUMMARY":[155],"Molecular":[156],"glues":[157,213],"highly":[160],"important":[161],"promising":[163],"form":[165],"therapeutic":[167],"agent,":[168],"but":[169],"rationalising":[170],"their":[171],"discovery":[172,184,209],"has":[173],"so":[174],"far":[175],"impossible":[177],"GlueSEEKER":[178],"screening":[179],"enables":[180],"prospective":[181],"drug":[183],"high-throughput":[187],"deep":[188],"mutational":[189],"scanning":[190],"re-engineer":[192],"function":[194],"like":[198],"ligases":[200],"used":[202,227],"enable":[206],"computational":[208],"degrade":[215],"GSPT1":[219],"how":[222],"technology":[224],"across":[228],"targets":[230]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-11-02T00:00:00"}