{"id":"https://openalex.org/W4415769474","doi":"https://doi.org/10.7241/ourd.20254.12","title":"Rare multisystemic complications with delayed diagnosis in two cases of leprosy","display_name":"Rare multisystemic complications with delayed diagnosis in two cases of leprosy","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415769474","doi":"https://doi.org/10.7241/ourd.20254.12"},"language":"en","primary_location":{"id":"doi:10.7241/ourd.20254.12","doi":"https://doi.org/10.7241/ourd.20254.12","is_oa":true,"landing_page_url":"https://doi.org/10.7241/ourd.20254.12","pdf_url":"https://www.odermatol.com/odermatology/20254/12.Rare-KhalloukiM.pdf","source":{"id":"https://openalex.org/S4393920031","display_name":"Our Dermatology Online","issn_l":"2956-7904","issn":["2956-7904"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Our Dermatology Online","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.odermatol.com/odermatology/20254/12.Rare-KhalloukiM.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056115258","display_name":"Meryem Khallouki","orcid":"https://orcid.org/0009-0002-5690-2436","observed_orcids":["https://orcid.org/0009-0002-5690-2436"]},"institutions":[{"id":"https://openalex.org/I119856527","display_name":"Cadi Ayyad University","ror":"https://ror.org/04xf6nm78","country_code":"MA","type":"education","lineage":["https://openalex.org/I119856527"]},{"id":"https://openalex.org/I4210091090","display_name":"Centre Hospitalier Universitaire Mohammed VI","ror":"https://ror.org/009nscf91","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210091090"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Meryem Khallouki","raw_affiliation_strings":["Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco","institution_ids":["https://openalex.org/I119856527","https://openalex.org/I4210091090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089554461","display_name":"Layla Bendaoud","orcid":"https://orcid.org/0000-0002-3592-6423","observed_orcids":["https://orcid.org/0000-0002-3592-6423"]},"institutions":[{"id":"https://openalex.org/I119856527","display_name":"Cadi Ayyad University","ror":"https://ror.org/04xf6nm78","country_code":"MA","type":"education","lineage":["https://openalex.org/I119856527"]},{"id":"https://openalex.org/I4210091090","display_name":"Centre Hospitalier Universitaire Mohammed VI","ror":"https://ror.org/009nscf91","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210091090"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Layla Bendaoud","raw_affiliation_strings":["Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco","institution_ids":["https://openalex.org/I119856527","https://openalex.org/I4210091090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120217265","display_name":"Sara Serghini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119856527","display_name":"Cadi Ayyad University","ror":"https://ror.org/04xf6nm78","country_code":"MA","type":"education","lineage":["https://openalex.org/I119856527"]},{"id":"https://openalex.org/I4210091090","display_name":"Centre Hospitalier Universitaire Mohammed VI","ror":"https://ror.org/009nscf91","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210091090"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Sara Serghini","raw_affiliation_strings":["Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco","institution_ids":["https://openalex.org/I119856527","https://openalex.org/I4210091090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120217266","display_name":"Mohamed Houbayeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119856527","display_name":"Cadi Ayyad University","ror":"https://ror.org/04xf6nm78","country_code":"MA","type":"education","lineage":["https://openalex.org/I119856527"]},{"id":"https://openalex.org/I4210091090","display_name":"Centre Hospitalier Universitaire Mohammed VI","ror":"https://ror.org/009nscf91","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210091090"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mohamed Houbayeli","raw_affiliation_strings":["Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco","institution_ids":["https://openalex.org/I119856527","https://openalex.org/I4210091090"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mariem Aboudourib","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119856527","display_name":"Cadi Ayyad University","ror":"https://ror.org/04xf6nm78","country_code":"MA","type":"education","lineage":["https://openalex.org/I119856527"]},{"id":"https://openalex.org/I4210091090","display_name":"Centre Hospitalier Universitaire Mohammed VI","ror":"https://ror.org/009nscf91","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210091090"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Mariem Aboudourib","raw_affiliation_strings":["Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco","institution_ids":["https://openalex.org/I119856527","https://openalex.org/I4210091090"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109982430","display_name":"Ouafa Hocar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I119856527","display_name":"Cadi Ayyad University","ror":"https://ror.org/04xf6nm78","country_code":"MA","type":"education","lineage":["https://openalex.org/I119856527"]},{"id":"https://openalex.org/I4210091090","display_name":"Centre Hospitalier Universitaire Mohammed VI","ror":"https://ror.org/009nscf91","country_code":"MA","type":"healthcare","lineage":["https://openalex.org/I4210091090"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Ouafa Hocar","raw_affiliation_strings":["Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology , Mohammed VI University Hospital , Cadi Ayad University , 4000 Marrakech , Morocco","institution_ids":["https://openalex.org/I119856527","https://openalex.org/I4210091090"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017195302","display_name":"Said Amal","orcid":"https://orcid.org/0000-0003-1512-5220","observed_orcids":["https://orcid.org/0000-0003-1512-5220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Said Amal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11909","display_name":"Histiocytic Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leprosy","display_name":"leprosy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/multibacillary-leprosy","display_name":"multibacillary leprosy","score":0.9679999947547913},{"id":"https://openalex.org/keywords/delayed-diagnosis","display_name":"delayed diagnosis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/multisystem-involvement","display_name":"multisystem involvement","score":0.7960000038146973},{"id":"https://openalex.org/keywords/acro-osteolysis","display_name":"acro-osteolysis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/leonine-facies","display_name":"leonine facies","score":0.7590000033378601},{"id":"https://openalex.org/keywords/paresthesia","display_name":"paresthesia","score":0.7269999980926514},{"id":"https://openalex.org/keywords/hypoesthesia","display_name":"numbness","score":0.7480000257492065},{"id":"https://openalex.org/keywords/neurological-complications","display_name":"neurological complications","score":0.5379999876022339},{"id":"https://openalex.org/keywords/ocular-complications","display_name":"ocular complications","score":0.7910000085830688},{"id":"https://openalex.org/keywords/nasal-complications","display_name":"nasal complications","score":0.8709999918937683},{"id":"https://openalex.org/keywords/bone-involvement","display_name":"bone involvement","score":0.5460000038146973},{"id":"https://openalex.org/keywords/leprosy-screening","display_name":"leprosy screening","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9872000217437744},{"id":"https://openalex.org/C2780695269","wikidata":"https://www.wikidata.org/wiki/Q36956","display_name":"Leprosy","level":2,"score":0.7293000221252441},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.6398000121116638},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.2667999863624573},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.24490000307559967},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.17870000004768372},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.17810000479221344},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.17739999294281006},{"id":"https://openalex.org/C2780801072","wikidata":"https://www.wikidata.org/wiki/Q837512","display_name":"Differential diagnosis","level":2,"score":0.17270000278949738}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7241/ourd.20254.12","doi":"https://doi.org/10.7241/ourd.20254.12","is_oa":true,"landing_page_url":"https://doi.org/10.7241/ourd.20254.12","pdf_url":"https://www.odermatol.com/odermatology/20254/12.Rare-KhalloukiM.pdf","source":{"id":"https://openalex.org/S4393920031","display_name":"Our Dermatology Online","issn_l":"2956-7904","issn":["2956-7904"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Our Dermatology Online","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.7241/ourd.20254.12","doi":"https://doi.org/10.7241/ourd.20254.12","is_oa":true,"landing_page_url":"https://doi.org/10.7241/ourd.20254.12","pdf_url":"https://www.odermatol.com/odermatology/20254/12.Rare-KhalloukiM.pdf","source":{"id":"https://openalex.org/S4393920031","display_name":"Our Dermatology Online","issn_l":"2956-7904","issn":["2956-7904"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Our Dermatology Online","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415769474.pdf","grobid_xml":"https://content.openalex.org/works/W4415769474.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7222969897","https://openalex.org/W2147173766","https://openalex.org/W2989729093","https://openalex.org/W2756858829","https://openalex.org/W4408634468","https://openalex.org/W7220572878","https://openalex.org/W2758254441","https://openalex.org/W2416366610","https://openalex.org/W2081058588","https://openalex.org/W1536644089"],"abstract_inverted_index":{"Leprosy":[0],"is":[1],"a":[2],"multisystem":[3,102],"granulomatous":[4],"disease":[5],"caused":[6],"by":[7],"infection":[8],"with":[9,21,28,57,85],"Mycobacterium":[10],"leprae.Herein,":[11],"we":[12],"report":[13],"two":[14,81],"cases":[15,130],"of":[16,19,36,40,45,60,64,68,76,91,96,131],"delayed":[17],"diagnosis":[18],"leprosy":[20,87,132],"multisystemic":[22],"involvement.A":[23],"48-year-old":[24],"male":[25,54],"patient":[26,55],"presented":[27,56],"leonine":[29],"facies,":[30],"generalized":[31],"infiltrated":[32,58],"plaques,":[33],"paresthesias,":[34,74],"amyotrophy":[35],"the":[37,41,46,61,65,69,89,92,97,111,135],"dorsal":[38],"muscles":[39],"hands,":[42],"and":[43,71,73,107,119,126],"hypoesthesia":[44,63],"lower":[47],"limbs":[48],"evolving":[49],"for":[50],"three":[51],"years.A":[52],"63-year-old":[53],"plaques":[59],"face,":[62],"feet,":[66],"acro-osteolysis":[67],"fingers":[70],"toes,":[72],"all":[75],"an":[77],"undetermined":[78],"chronic":[79],"course.The":[80],"patients":[82,100,109],"were":[83],"diagnosed":[84],"multibacillary":[86],"on":[88,116],"basis":[90],"positive":[93],"bacteriological":[94],"sampling":[95],"ear":[98],"lobe.The":[99],"had":[101],"involvement:":[103],"neurological,":[104],"bone,":[105],"ocular,":[106],"nasal.The":[108],"received":[110],"recommended":[112],"treatment":[113],"regimen":[114],"based":[115],"dapsone,":[117],"clofazimine,":[118],"rifampicin.Physicians":[120],"should":[121],"be":[122],"vigilant":[123],"in":[124,134],"screening":[125],"treating":[127],"new":[128],"active":[129],"even":[133],"post-leprosy":[136],"elimination":[137],"era.":[138]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-11-02T00:00:00"}