{"id":"https://openalex.org/W4415767659","doi":"https://doi.org/10.21203/rs.3.rs-7761877/v1","title":"Synergistic Inhibition of PI3K and HSP90 Enhanced Antitumorigenic Efficacy in Adrenocortical Carcinoma","display_name":"Synergistic Inhibition of PI3K and HSP90 Enhanced Antitumorigenic Efficacy in Adrenocortical Carcinoma","publication_year":2025,"publication_date":"2025-11-01","ids":{"openalex":"https://openalex.org/W4415767659","doi":"https://doi.org/10.21203/rs.3.rs-7761877/v1","pmid":"https://pubmed.ncbi.nlm.nih.gov/41282100","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12636729"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-7761877/v1","doi":"https://doi.org/10.21203/rs.3.rs-7761877/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7761877/v1","pdf_url":"https://www.researchsquare.com/article/rs-7761877/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-7761877/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Prachi Mishra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prachi Mishra","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052003639","display_name":"Brieann Sobieski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brieann Sobieski","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089943886","display_name":"Dipranjan Laha","orcid":"https://orcid.org/0000-0002-3763-4395","observed_orcids":["https://orcid.org/0000-0002-3763-4395"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dipranjan Laha","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058662053","display_name":"Steven Donald Forsythe","orcid":"https://orcid.org/0000-0003-4099-6642","observed_orcids":["https://orcid.org/0000-0003-4099-6642"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven D. Forsythe","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101340140","display_name":"Min Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Shen","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663308","display_name":"Yaqin Zhang","orcid":"https://orcid.org/0000-0002-0436-9732","observed_orcids":["https://orcid.org/0000-0002-0436-9732"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ya-Qin Zhang","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mathew Hall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mathew Hall","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004993640","display_name":"Bhavishya U. Ramamoorthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bhavishya Ramamoorthy","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087178283","display_name":"Robert C. Grant","orcid":"https://orcid.org/0000-0002-9821-0377","observed_orcids":["https://orcid.org/0000-0002-9821-0377"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rob Grant","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nicholas L. Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas L. Michael","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050780818","display_name":"Samira Mercedes Sadowski","orcid":"https://orcid.org/0000-0002-7538-9431","observed_orcids":["https://orcid.org/0000-0002-7538-9431"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samira M. Sadowski","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027938558","display_name":"Jaydira Del Rivero","orcid":"https://orcid.org/0000-0001-9710-4030","observed_orcids":["https://orcid.org/0000-0001-9710-4030","https://orcid.org/0000-0002-9065-6753"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaydira Rivero","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033639338","display_name":"Jonathan Matthew Hernandez","orcid":"https://orcid.org/0000-0001-7529-0557","observed_orcids":["https://orcid.org/0000-0001-7529-0557"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Hernandez","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006574108","display_name":"Naris Nilubol","orcid":"https://orcid.org/0000-0002-7348-7804","observed_orcids":["https://orcid.org/0000-0002-7348-7804"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Naris Nilubol","raw_affiliation_strings":["National Cancer Institute, National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Institute, National Institutes of Health","institution_ids":["https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006574108"],"corresponding_institution_ids":["https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.01979999989271164,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ganetespib","display_name":"ganetespib","score":0.8669999837875366},{"id":"https://openalex.org/keywords/autophagic-cell-death","display_name":"autophagic cell death","score":0.8640000224113464},{"id":"https://openalex.org/keywords/pi3k-mtor-signaling","display_name":"PI3K/mTOR signaling","score":0.9190000295639038},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9860000014305115},{"id":"https://openalex.org/keywords/patient-derived-organoids","display_name":"patient-derived organoids","score":0.9559999704360962},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7850000262260437},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.7400000095367432},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9629999995231628}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6593000292778015},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.6133000254631042},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5853000283241272},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5375000238418579},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.5016000270843506},{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.47690001130104065},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.4763999879360199},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.47380000352859497},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4496000111103058},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4277999997138977},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4212000072002411},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4189000129699707},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40630000829696655},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39500001072883606},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3693000078201294},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.364300012588501},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.34880000352859497},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.32829999923706055},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C2776735609","wikidata":"https://www.wikidata.org/wiki/Q417465","display_name":"Mitotane","level":3,"score":0.27250000834465027},{"id":"https://openalex.org/C2779559962","wikidata":"https://www.wikidata.org/wiki/Q14905263","display_name":"Hsp27","level":5,"score":0.26840001344680786},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.25519999861717224}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21203/rs.3.rs-7761877/v1","doi":"https://doi.org/10.21203/rs.3.rs-7761877/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7761877/v1","pdf_url":"https://www.researchsquare.com/article/rs-7761877/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:41282100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41282100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research square","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11443838","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12636729","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-7761877/v1","doi":"https://doi.org/10.21203/rs.3.rs-7761877/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-7761877/v1","pdf_url":"https://www.researchsquare.com/article/rs-7761877/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G174775509","display_name":"Investigating the link between DNA damage, chromatin and nuclear dysfunction","funder_award_id":"ZIABC011283","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320313762","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209"},{"id":"https://openalex.org/F4320315952","display_name":"Leidos","ror":"https://ror.org/012cvds63"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415767659.pdf","grobid_xml":"https://content.openalex.org/works/W4415767659.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4362593900","https://openalex.org/W4415450877","https://openalex.org/W4308136001","https://openalex.org/W6977245081","https://openalex.org/W6977522960","https://openalex.org/W2953916556","https://openalex.org/W2151291770","https://openalex.org/W4296828467","https://openalex.org/W2896829483","https://openalex.org/W4280627522"],"abstract_inverted_index":{"Abstract":[0],"Adrenocortical":[1],"cancer":[2],"(ACC)":[3],"is":[4,22],"a":[5,15,136,216],"rare":[6],"and":[7,47,62,78,89,96,103,107,134,152,175,194,206],"aggressive":[8],"malignancy":[9],"with":[10,110,140,197,221],"poor":[11],"survival":[12],"due":[13],"to":[14,24,27,67,119],"lack":[16],"of":[17,72,94,204],"effective":[18,75,211],"treatments;":[19],"therefore,":[20],"it":[21],"important":[23],"identify":[25],"therapies":[26],"be":[28],"readily":[29],"studied":[30],"in":[31,82,114,144,164,189,212,219],"clinical":[32,124,217],"trials.":[33],"Quantitative":[34],"high-throughput":[35],"drug":[36],"combination":[37,81,159,170,188],"screening":[38],"identified":[39],"potent":[40],"synergy":[41],"between":[42],"phosphatidylinositol-3-kinase":[43],"(PI3K)":[44],"inhibitor,":[45,128],"PIK75":[46,95,122],"heat":[48],"shock":[49],"protein":[50],"90":[51],"(HSP90)":[52],"inhibitors,":[53],"Ganetespib":[54],"(STA9090),":[55],"HSP990,":[56],"or":[57],"Luminespib":[58],"(NVP-AUY922).":[59],"Preclinical":[60],"in-vitro":[61],"in-vivo":[63],"studies":[64,154],"were":[65,209],"performed":[66],"validate":[68],"the":[69,73,120,145,157,168,186,202],"synergistic":[70,138],"efficacy":[71,139,182],"most":[74],"HSP90":[76,207],"inhibitor":[77,80],"PI3K":[79,127,205],"ACC":[83,87,146,165,191],"cell":[84,100,105,147,162,177],"lines,":[85],"human":[86,190],"xenografts":[88],"patient-derived":[90],"organoids":[91],"(PDOs).":[92],"Combination":[93],"STA9090,":[97,141],"synergistically":[98],"inhibited":[99],"proliferation":[101],"(monolayer":[102],"3-dimensional),":[104],"migration/invasion":[106],"epithelial-to-mesenchymal":[108],"transition":[109],"decreased":[111],"phosphorylated":[112],"proteins":[113],"PI3K/mTOR":[115],"signaling":[116],"pathway.":[117],"Due":[118],"unavailabilityof":[121],"for":[123],"trial,":[125],"another":[126],"BGT226,":[129],"which":[130,171],"was":[131,142,183],"clinically":[132],"available":[133],"demonstrated":[135],"comparable":[137],"validated":[143],"lines.":[148],"RNA":[149],"sequencing":[150],"analysis":[151],"phenotypic":[153],"revealed":[155],"that":[156],"BGT226-STA9090":[158,187],"induced":[160,172],"autophagy-related":[161],"death":[163],"cells,":[166],"unlike":[167],"PIK75-STA9090":[169],"caspase-dependent":[173],"apoptosis":[174],"G2/M":[176],"cycle":[178],"arrest.":[179],"Further":[180],"antitumor":[181],"confirmed":[184],"by":[185],"xenograft":[192],"model":[193],"five":[195],"PDOs":[196],"different":[198],"pathogenic":[199],"mutations.":[200],"Conclusively,":[201],"combinations":[203],"inhibitors":[208],"highly":[210],"preclinical":[213],"studies,":[214],"warranting":[215],"trial":[218],"patients":[220],"advanced":[222],"ACC.":[223]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-11-01T00:00:00"}