{"id":"https://openalex.org/W4415748403","doi":"https://doi.org/10.1126/sciadv.aea6817","title":"Unlocking the therapeutic potential of cellular mechanobiology","display_name":"Unlocking the therapeutic potential of cellular mechanobiology","publication_year":2025,"publication_date":"2025-10-31","ids":{"openalex":"https://openalex.org/W4415748403","doi":"https://doi.org/10.1126/sciadv.aea6817","pmid":"https://pubmed.ncbi.nlm.nih.gov/41171907","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12577691"},"language":"en","primary_location":{"id":"doi:10.1126/sciadv.aea6817","doi":"https://doi.org/10.1126/sciadv.aea6817","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aea6817","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1126/sciadv.aea6817","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016860873","display_name":"Yohalie Kalukula","orcid":"https://orcid.org/0000-0002-4429-2995","observed_orcids":["https://orcid.org/0000-0002-4429-2995"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Yohalie Kalukula","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-4429-2995","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062991986","display_name":"Giuseppe Ciccone","orcid":"https://orcid.org/0000-0002-7677-6257","observed_orcids":["https://orcid.org/0000-0002-7677-6257"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]},{"id":"https://openalex.org/I4210132884","display_name":"Barcelona Institute of Science and Technology","ror":"https://ror.org/03kpps236","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210132884"]},{"id":"https://openalex.org/I4210147769","display_name":"Institute for Bioengineering of Catalonia","ror":"https://ror.org/056h71x09","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210147769","https://openalex.org/I4387153040"]}],"countries":["BE","ES"],"is_corresponding":true,"raw_author_name":"Giuseppe Ciccone","raw_affiliation_strings":["Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain","SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-7677-6257","affiliations":[{"raw_affiliation_string":"Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute for Science and Technology (BIST), Barcelona, Spain","institution_ids":["https://openalex.org/I4210132884","https://openalex.org/I4210147769"]},{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045322787","display_name":"Danah\u00e9 Mohammed","orcid":"https://orcid.org/0000-0002-2612-7670","observed_orcids":["https://orcid.org/0000-0002-2612-7670"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]},{"id":"https://openalex.org/I132053463","display_name":"Universit\u00e9 Libre de Bruxelles","ror":"https://ror.org/01r9htc13","country_code":"BE","type":"education","lineage":["https://openalex.org/I132053463"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Danahe Mohammed","raw_affiliation_strings":["Department of Molecular Biology, ULB Neuroscience Institute, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2612-7670","affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, ULB Neuroscience Institute, Universit\u00e9 Libre de Bruxelles (ULB), Gosselies, Belgium","institution_ids":["https://openalex.org/I132053463"]},{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039751454","display_name":"Anthony Proc\u00e8s","orcid":"https://orcid.org/0000-0002-4785-8931","observed_orcids":["https://orcid.org/0000-0002-4785-8931"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210151160","display_name":"Grenoble Institute of Neurosciences","ror":"https://ror.org/04as3rk94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2738703131","https://openalex.org/I4210151160","https://openalex.org/I899635006"]},{"id":"https://openalex.org/I899635006","display_name":"Universit\u00e9 Grenoble Alpes","ror":"https://ror.org/02rx3b187","country_code":"FR","type":"education","lineage":["https://openalex.org/I899635006"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anthony Proc\u00e8s","raw_affiliation_strings":["University Grenoble Alpes, INSERM U1216, Grenoble Alpes, Grenoble Institut Neuroscience, 38000 Grenoble, France"],"raw_orcid":"https://orcid.org/0000-0002-4785-8931","affiliations":[{"raw_affiliation_string":"University Grenoble Alpes, INSERM U1216, Grenoble Alpes, Grenoble Institut Neuroscience, 38000 Grenoble, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210151160","https://openalex.org/I899635006"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024996285","display_name":"Marie Versaevel","orcid":"https://orcid.org/0000-0003-0710-4243","observed_orcids":["https://orcid.org/0000-0003-0710-4243"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marie Versaevel","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0710-4243","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011031308","display_name":"Amandine Deridoux","orcid":"https://orcid.org/0000-0003-0540-1500","observed_orcids":["https://orcid.org/0000-0003-0540-1500"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Amandine Deridoux","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0540-1500","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107017216","display_name":"Lucie Ergot","orcid":"https://orcid.org/0009-0008-8886-1708","observed_orcids":["https://orcid.org/0009-0008-8886-1708"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lucie Ergot","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0009-0008-8886-1708","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120208120","display_name":"Zo\u00e9 Barbier","orcid":"https://orcid.org/0009-0006-4491-2919","observed_orcids":["https://orcid.org/0009-0006-4491-2919"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Zo\u00e9 Barbier","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0009-0006-4491-2919","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039382705","display_name":"Mina Mansy","orcid":"https://orcid.org/0009-0005-8279-6640","observed_orcids":["https://orcid.org/0009-0005-8279-6640"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Maxime Mansy","raw_affiliation_strings":["Laboratory for Chemistry of Novel Materials, CIRMAP, University of Mons\u2013UMONS, Mons, Belgium","SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0009-0005-8279-6640","affiliations":[{"raw_affiliation_string":"Laboratory for Chemistry of Novel Materials, CIRMAP, University of Mons\u2013UMONS, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]},{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120208118","display_name":"Roxane Aucouturier","orcid":"https://orcid.org/0009-0003-6626-2185","observed_orcids":["https://orcid.org/0009-0003-6626-2185"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Roxane Aucouturier","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0009-0003-6626-2185","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120208119","display_name":"R\u00e9mi Tranzer","orcid":"https://orcid.org/0009-0008-6995-0975","observed_orcids":["https://orcid.org/0009-0008-6995-0975"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"R\u00e9mi Tranzer","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0009-0008-6995-0975","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008026363","display_name":"Mathieu Surin","orcid":"https://orcid.org/0000-0001-8950-3437","observed_orcids":["https://orcid.org/0000-0001-8950-3437"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Mathieu Surin","raw_affiliation_strings":["Laboratory for Chemistry of Novel Materials, CIRMAP, University of Mons\u2013UMONS, Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-8950-3437","affiliations":[{"raw_affiliation_string":"Laboratory for Chemistry of Novel Materials, CIRMAP, University of Mons\u2013UMONS, Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010727077","display_name":"Sylvain Gabriele","orcid":"https://orcid.org/0000-0001-8696-8052","observed_orcids":["https://orcid.org/0000-0001-8696-8052"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Sylvain Gabriele","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0001-8696-8052","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003028982","display_name":"Marine Luciano","orcid":"https://orcid.org/0000-0003-0826-9752","observed_orcids":["https://orcid.org/0000-0003-0826-9752"]},"institutions":[{"id":"https://openalex.org/I130929987","display_name":"University of Mons","ror":"https://ror.org/02qnnz951","country_code":"BE","type":"education","lineage":["https://openalex.org/I130929987"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Marine Luciano","raw_affiliation_strings":["SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium"],"raw_orcid":"https://orcid.org/0000-0003-0826-9752","affiliations":[{"raw_affiliation_string":"SYMBIOSE Lab, Research Institute for Biosciences, Research Institute for Materials Science and Engineering, CIRMAP, University of Mons\u2013UMONS, B-7000 Mons, Belgium","institution_ids":["https://openalex.org/I130929987"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5003028982","https://openalex.org/A5010727077","https://openalex.org/A5016860873","https://openalex.org/A5062991986"],"corresponding_institution_ids":["https://openalex.org/I130929987","https://openalex.org/I4210132884","https://openalex.org/I4210147769"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":4.2833,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.96487603,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"11","issue":"44","first_page":"eaea6817","last_page":"eaea6817"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.5540000200271606},{"id":"https://openalex.org/keywords/mechanomedicine","display_name":"mechanomedicine","score":0.9229999780654907},{"id":"https://openalex.org/keywords/engineered-biomaterials","display_name":"engineered biomaterials","score":0.875},{"id":"https://openalex.org/keywords/cellular-microenvironment","display_name":"cell microenvironment","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.906000018119812},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9620000123977661},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tissue-remodeling","display_name":"tissue remodeling","score":0.6389999985694885},{"id":"https://openalex.org/keywords/cell-migration-and-differentiation","display_name":"cell migration and differentiation","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.9793999791145325},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5062000155448914},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.3278999924659729},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.3257000148296356},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.287200003862381},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2858999967575073},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.28529998660087585},{"id":"https://openalex.org/C33276779","wikidata":"https://www.wikidata.org/wiki/Q1943363","display_name":"Design elements and principles","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2808000147342682},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27549999952316284},{"id":"https://openalex.org/C2780609957","wikidata":"https://www.wikidata.org/wiki/Q108887885","display_name":"Biofabrication","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2587999999523163},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.2581000030040741},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.25099998712539673}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001672","descriptor_name":"Biocompatible Materials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044968","descriptor_name":"Regenerative Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1126/sciadv.aea6817","doi":"https://doi.org/10.1126/sciadv.aea6817","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aea6817","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11386958","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12577691","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41171907","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41171907","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science advances","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12577691","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12577691/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Adv","raw_type":"Text"},{"id":"pmh:oai:orbi.umons.ac.be:20.500.12907/53524","doi":null,"is_oa":true,"landing_page_url":"https://orbi.umons.ac.be/handle/20.500.12907/53524","pdf_url":"https://orbi.umons.ac.be/bitstream/20.500.12907/53524/1/_2025_61_ScienceAdvances.pdf","source":{"id":"https://openalex.org/S7407055454","display_name":"ORBi UMONS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science Advances, 11, eaea6817 (2025-10-31)","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:dipot.ulb.ac.be:2013/399426","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/399426","pdf_url":null,"source":{"id":"https://openalex.org/S4306401063","display_name":"D\u00e9p\u00f4t institutionnel de l'Universit\u00e9 libre de Bruxelles (Universit\u00e9 Libre de Bruxelles)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132053463","host_organization_name":"Universit\u00e9 Libre de Bruxelles","host_organization_lineage":["https://openalex.org/I132053463"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Science advances, 11 (44","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1126/sciadv.aea6817","doi":"https://doi.org/10.1126/sciadv.aea6817","is_oa":true,"landing_page_url":"https://doi.org/10.1126/sciadv.aea6817","pdf_url":null,"source":{"id":"https://openalex.org/S2737427234","display_name":"Science Advances","issn_l":"2375-2548","issn":["2375-2548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5450543576","display_name":"Deciphering the Role of Huntingtin in Energy Supply for Axonal Transport in Health and Huntington\u2019s Disease","funder_award_id":"834317","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415748403.pdf","grobid_xml":"https://content.openalex.org/works/W4415748403.grobid-xml"},"referenced_works_count":233,"referenced_works":["https://openalex.org/W974872885","https://openalex.org/W1553861239","https://openalex.org/W1964281587","https://openalex.org/W1972130450","https://openalex.org/W1972554719","https://openalex.org/W1983571130","https://openalex.org/W1992193707","https://openalex.org/W2003069503","https://openalex.org/W2017536526","https://openalex.org/W2032526594","https://openalex.org/W2054635074","https://openalex.org/W2057917964","https://openalex.org/W2064887851","https://openalex.org/W2067106012","https://openalex.org/W2067682780","https://openalex.org/W2068506802","https://openalex.org/W2077035124","https://openalex.org/W2084160691","https://openalex.org/W2092811432","https://openalex.org/W2095026025","https://openalex.org/W2099963452","https://openalex.org/W2100303404","https://openalex.org/W2100454719","https://openalex.org/W2102121146","https://openalex.org/W2109653536","https://openalex.org/W2111412288","https://openalex.org/W2115362391","https://openalex.org/W2121353065","https://openalex.org/W2127202845","https://openalex.org/W2131832714","https://openalex.org/W2134208433","https://openalex.org/W2137034111","https://openalex.org/W2141740654","https://openalex.org/W2159744630","https://openalex.org/W2167243609","https://openalex.org/W2189355713","https://openalex.org/W2270498673","https://openalex.org/W2283405726","https://openalex.org/W2299438807","https://openalex.org/W2320821933","https://openalex.org/W2327893020","https://openalex.org/W2334059699","https://openalex.org/W2345977772","https://openalex.org/W2522174175","https://openalex.org/W2527344026","https://openalex.org/W2554164858","https://openalex.org/W2554968345","https://openalex.org/W2602609341","https://openalex.org/W2606898748","https://openalex.org/W2619683448","https://openalex.org/W2675059502","https://openalex.org/W2728122910","https://openalex.org/W2749615089","https://openalex.org/W2753650690","https://openalex.org/W2768065449","https://openalex.org/W2773729171","https://openalex.org/W2774483419","https://openalex.org/W2782972757","https://openalex.org/W2783103906","https://openalex.org/W2784479902","https://openalex.org/W2784879901","https://openalex.org/W2786431878","https://openalex.org/W2788813648","https://openalex.org/W2792015579","https://openalex.org/W2884435515","https://openalex.org/W2891740951","https://openalex.org/W2892459790","https://openalex.org/W2895293517","https://openalex.org/W2909879980","https://openalex.org/W2910094146","https://openalex.org/W2911973964","https://openalex.org/W2913551921","https://openalex.org/W2920618299","https://openalex.org/W2921114066","https://openalex.org/W2924089686","https://openalex.org/W2936506428","https://openalex.org/W2944782303","https://openalex.org/W2948980593","https://openalex.org/W2951737903","https://openalex.org/W2955324589","https://openalex.org/W2957203663","https://openalex.org/W2966654380","https://openalex.org/W2972250307","https://openalex.org/W2973099177","https://openalex.org/W2978551302","https://openalex.org/W2980104037","https://openalex.org/W2980249731","https://openalex.org/W2982342780","https://openalex.org/W2988665117","https://openalex.org/W2992656734","https://openalex.org/W2998282594","https://openalex.org/W2998356548","https://openalex.org/W3010362802","https://openalex.org/W3014453248","https://openalex.org/W3021494925","https://openalex.org/W3021592636","https://openalex.org/W3029644242","https://openalex.org/W3034141515","https://openalex.org/W3041515747","https://openalex.org/W3043091645","https://openalex.org/W3080362910","https://openalex.org/W3082726941","https://openalex.org/W3086325855","https://openalex.org/W3087286534","https://openalex.org/W3092706534","https://openalex.org/W3093148868","https://openalex.org/W3093443465","https://openalex.org/W3097920809","https://openalex.org/W3110448403","https://openalex.org/W3111033453","https://openalex.org/W3125159299","https://openalex.org/W3130910260","https://openalex.org/W3133812088","https://openalex.org/W3134663270","https://openalex.org/W3136984311","https://openalex.org/W3137124753","https://openalex.org/W3142770345","https://openalex.org/W3152670943","https://openalex.org/W3155636143","https://openalex.org/W3156256523","https://openalex.org/W3164329887","https://openalex.org/W3164932609","https://openalex.org/W3170187881","https://openalex.org/W3172557238","https://openalex.org/W3180636335","https://openalex.org/W3183689901","https://openalex.org/W3183984388","https://openalex.org/W3190217875","https://openalex.org/W3195795111","https://openalex.org/W3197367825","https://openalex.org/W3197477919","https://openalex.org/W3197684602","https://openalex.org/W3200172023","https://openalex.org/W3201957189","https://openalex.org/W3203147843","https://openalex.org/W3207714802","https://openalex.org/W3207883895","https://openalex.org/W3211813782","https://openalex.org/W4200291185","https://openalex.org/W4200331912","https://openalex.org/W4205588463","https://openalex.org/W4205884987","https://openalex.org/W4206159125","https://openalex.org/W4210863305","https://openalex.org/W4211238337","https://openalex.org/W4212811245","https://openalex.org/W4221045674","https://openalex.org/W4224261640","https://openalex.org/W4225100591","https://openalex.org/W4242996780","https://openalex.org/W4280530067","https://openalex.org/W4280540675","https://openalex.org/W4280561446","https://openalex.org/W4281615234","https://openalex.org/W4281748368","https://openalex.org/W4283751102","https://openalex.org/W4285249509","https://openalex.org/W4288051156","https://openalex.org/W4292485618","https://openalex.org/W4294991945","https://openalex.org/W4298109924","https://openalex.org/W4301492333","https://openalex.org/W4310496927","https://openalex.org/W4310777811","https://openalex.org/W4321116321","https://openalex.org/W4321441033","https://openalex.org/W4322719438","https://openalex.org/W4361282756","https://openalex.org/W4362585006","https://openalex.org/W4362673596","https://openalex.org/W4366237310","https://openalex.org/W4366732305","https://openalex.org/W4376872303","https://openalex.org/W4377989539","https://openalex.org/W4379056067","https://openalex.org/W4382931810","https://openalex.org/W4385387988","https://openalex.org/W4385396537","https://openalex.org/W4386529177","https://openalex.org/W4386958139","https://openalex.org/W4387521182","https://openalex.org/W4387771223","https://openalex.org/W4388020343","https://openalex.org/W4388021698","https://openalex.org/W4388135163","https://openalex.org/W4388520401","https://openalex.org/W4388694319","https://openalex.org/W4389732794","https://openalex.org/W4389795617","https://openalex.org/W4390511203","https://openalex.org/W4391383681","https://openalex.org/W4391544135","https://openalex.org/W4391987139","https://openalex.org/W4392589850","https://openalex.org/W4392697730","https://openalex.org/W4393235590","https://openalex.org/W4394676015","https://openalex.org/W4394681352","https://openalex.org/W4395960499","https://openalex.org/W4397044997","https://openalex.org/W4398231451","https://openalex.org/W4399435700","https://openalex.org/W4399470962","https://openalex.org/W4399809875","https://openalex.org/W4400199098","https://openalex.org/W4401047370","https://openalex.org/W4401465198","https://openalex.org/W4401619383","https://openalex.org/W4401724571","https://openalex.org/W4401941215","https://openalex.org/W4402028233","https://openalex.org/W4402423585","https://openalex.org/W4402648742","https://openalex.org/W4402922983","https://openalex.org/W4402945972","https://openalex.org/W4403159590","https://openalex.org/W4403324593","https://openalex.org/W4403770171","https://openalex.org/W4404400091","https://openalex.org/W4404571206","https://openalex.org/W4405439794","https://openalex.org/W4405476548","https://openalex.org/W4405649785","https://openalex.org/W4407562042","https://openalex.org/W4409158236","https://openalex.org/W4409565507","https://openalex.org/W4410267942","https://openalex.org/W4410840955","https://openalex.org/W4410858452","https://openalex.org/W4411728285","https://openalex.org/W4413495530","https://openalex.org/W4415248289","https://openalex.org/W7130650816"],"related_works":["https://openalex.org/W4416952109","https://openalex.org/W4416777927","https://openalex.org/W4415479282","https://openalex.org/W7135105709","https://openalex.org/W4282976493","https://openalex.org/W4411178784","https://openalex.org/W7128158744","https://openalex.org/W4413612199","https://openalex.org/W4411181685","https://openalex.org/W3209291895"],"abstract_inverted_index":{"Mechanobiology":[0],"is":[1,82],"a":[2,87,135],"rapidly":[3],"advancing":[4],"field":[5],"at":[6],"the":[7,59,73],"intersection":[8],"of":[9,42,61,72,98,137],"biology,":[10],"physics,":[11],"and":[12,24,32,47,52,65,100,117,120],"engineering":[13],"that":[14,68,91],"reveals":[15],"how":[16,29,105],"mechanical":[17,34,93],"forces":[18,94],"shape":[19],"cellular":[20,74],"behavior,":[21],"tissue":[22,53],"architecture,":[23],"disease":[25],"progression.":[26],"By":[27,123],"elucidating":[28],"cells":[30],"sense":[31],"transduce":[33],"cues,":[35],"mechanobiology":[36,106,133],"has":[37],"fundamentally":[38],"advanced":[39],"our":[40],"understanding":[41],"processes":[43],"ranging":[44],"from":[45],"migration":[46],"differentiation":[48],"to":[49,85],"immune":[50],"responses":[51],"remodeling.":[54],"These":[55],"advances":[56],"have":[57],"driven":[58],"development":[60],"innovative":[62],"biophysical":[63],"tools":[64],"engineered":[66],"biomaterials":[67],"enable":[69],"precise":[70],"modulation":[71],"microenvironment.":[75],"Translating":[76],"mechanobiological":[77],"principles":[78],"into":[79,144],"clinical":[80,146],"practice":[81],"giving":[83],"rise":[84],"mechanomedicine,":[86],"previously":[88],"unrecognized":[89],"paradigm":[90],"integrates":[92],"as":[95,134],"key":[96],"modulators":[97],"health":[99],"disease.":[101],"This":[102],"review":[103,131],"highlights":[104],"informs":[107],"therapeutic":[108],"strategies":[109],"across":[110],"diverse":[111],"domains,":[112],"including":[113],"cancer":[114],"immunotherapy,":[115],"cardiovascular":[116],"neurodegenerative":[118],"disorders,":[119],"regenerative":[121],"medicine.":[122],"bridging":[124],"fundamental":[125],"discoveries":[126],"with":[127],"translational":[128],"applications,":[129],"this":[130],"positions":[132],"cornerstone":[136],"next-generation":[138],"medical":[139],"innovation,":[140],"translating":[141],"mechanistic":[142],"insights":[143],"impactful":[145],"applications.":[147]},"counts_by_year":[{"year":2026,"cited_by_count":48}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-31T00:00:00"}
