{"id":"https://openalex.org/W4415723137","doi":"https://doi.org/10.3389/fimmu.2025.1675114","title":"Regulatory T cell therapies: from patient data to biological insights","display_name":"Regulatory T cell therapies: from patient data to biological insights","publication_year":2025,"publication_date":"2025-10-31","ids":{"openalex":"https://openalex.org/W4415723137","doi":"https://doi.org/10.3389/fimmu.2025.1675114","pmid":"https://pubmed.ncbi.nlm.nih.gov/41246323","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12615433"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2025.1675114","doi":"https://doi.org/10.3389/fimmu.2025.1675114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1675114","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1675114/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1675114/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009791821","display_name":"Kameron B. Rodrigues","orcid":"https://orcid.org/0000-0002-0270-3688","observed_orcids":["https://orcid.org/0000-0002-0270-3688"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kameron B. Rodrigues","raw_affiliation_strings":["Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083636715","display_name":"Peter J. Eggenhuizen","orcid":"https://orcid.org/0000-0002-7102-3547","observed_orcids":["https://orcid.org/0000-0002-7102-3547"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter J. Eggenhuizen","raw_affiliation_strings":["Center for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC,\u00a0Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences, Monash University, Clayton, VIC,\u00a0Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079634281","display_name":"Rosa Bacchetta","orcid":"https://orcid.org/0000-0002-0606-6268","observed_orcids":["https://orcid.org/0000-0002-0606-6268"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I4394709089","display_name":"Institute for Stem Cell Biology and Regenerative Medicine","ror":"https://ror.org/02vbab064","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210137306","https://openalex.org/I4394709089","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Bacchetta","raw_affiliation_strings":["Center for Definitive and Curative Medicine, Stanford University, Stanford, CA,\u00a0United States","Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA,\u00a0United States","Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Definitive and Curative Medicine, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Oncology, Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4394709089","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052742413","display_name":"Zinaida Good","orcid":"https://orcid.org/0000-0003-2343-5771","observed_orcids":["https://orcid.org/0000-0003-2343-5771"]},"institutions":[{"id":"https://openalex.org/I4210109986","display_name":"Parker Institute for Cancer Immunotherapy","ror":"https://ror.org/0184qbg02","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210109986"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zinaida Good","raw_affiliation_strings":["Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","Parker Institute for Cancer Immunotherapy, Stanford University, Stanford, CA,\u00a0United States","Weill Cancer Hub West, Stanford University, Stanford, CA,\u00a0United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Biomedical Informatics Research, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Parker Institute for Cancer Immunotherapy, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I4210109986","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Weill Cancer Hub West, Stanford University, Stanford, CA,\u00a0United States","institution_ids":["https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5052742413"],"corresponding_institution_ids":["https://openalex.org/I4210109986","https://openalex.org/I4210137306","https://openalex.org/I97018004"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.5024,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.83333333,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"16","issue":null,"first_page":"1675114","last_page":"1675114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9574999809265137,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9240000247955322},{"id":"https://openalex.org/keywords/adoptive-t-cell-therapy","display_name":"adoptive T cell therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cd19-car-t-cell-therapy","display_name":"CD19 CAR T-cell therapy","score":0.8529999852180481},{"id":"https://openalex.org/keywords/graft-versus-host-disease-prophylaxis","display_name":"graft-versus-host disease prophylaxis","score":0.921999990940094},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.781000018119812},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/spatial-transcriptomics","display_name":"spatial transcriptomics","score":0.9340000152587891},{"id":"https://openalex.org/keywords/epigenetic-analysis","display_name":"epigenetic analysis","score":0.8489999771118164}],"concepts":[{"id":"https://openalex.org/C3020684253","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Treg cell","level":5,"score":0.621399998664856},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5656999945640564},{"id":"https://openalex.org/C2778296632","wikidata":"https://www.wikidata.org/wiki/Q1550619","display_name":"Regulatory T cell","level":5,"score":0.5439000129699707},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5360000133514404},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.515999972820282},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.510699987411499},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49779999256134033},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4867999851703644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47699999809265137},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4706000089645386},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.46230000257492065},{"id":"https://openalex.org/C90375314","wikidata":"https://www.wikidata.org/wiki/Q3537484","display_name":"Adoptive cell transfer","level":4,"score":0.40220001339912415},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.38609999418258667},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3806999921798706},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.37959998846054077},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.35440000891685486},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.349700003862381},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.3221000134944916},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C2780179540","wikidata":"https://www.wikidata.org/wiki/Q1765748","display_name":"Transplant rejection","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.28519999980926514},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2599000036716461},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.2574999928474426}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006086","descriptor_name":"Graft vs Host Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3389/fimmu.2025.1675114","doi":"https://doi.org/10.3389/fimmu.2025.1675114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1675114","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1675114/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11423709","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12615433","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41246323","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41246323","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in immunology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:e6961c1644f34c379d9c1fded5ae3874","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e6961c1644f34c379d9c1fded5ae3874","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 16 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2025.1675114","doi":"https://doi.org/10.3389/fimmu.2025.1675114","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2025.1675114","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2025.1675114/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1169299836","display_name":"Learning features of optimal CAR T cells for LBCL from patient data","funder_award_id":"1k99ca293149-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4497426766","display_name":null,"funder_award_id":"R00 CA293149","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000858242","display_name":"Learning features of optimal CAR T cells for LBCL from patient data","funder_award_id":"4r00ca293149-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000910426","display_name":"Multimodal AI modeling of T cell therapies to predict patient response and nominate advanced cell design strategies","funder_award_id":"1ot2od038101-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415723137.pdf","grobid_xml":"https://content.openalex.org/works/W4415723137.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W1486722793","https://openalex.org/W1972403935","https://openalex.org/W1977224177","https://openalex.org/W1981690705","https://openalex.org/W1983019708","https://openalex.org/W1996532235","https://openalex.org/W2002726823","https://openalex.org/W2021603971","https://openalex.org/W2033149742","https://openalex.org/W2034621048","https://openalex.org/W2043565262","https://openalex.org/W2050941564","https://openalex.org/W2054326876","https://openalex.org/W2066186103","https://openalex.org/W2067263905","https://openalex.org/W2068238618","https://openalex.org/W2068392572","https://openalex.org/W2073045132","https://openalex.org/W2097811455","https://openalex.org/W2101230909","https://openalex.org/W2102650038","https://openalex.org/W2117757143","https://openalex.org/W2119860862","https://openalex.org/W2123987776","https://openalex.org/W2130822830","https://openalex.org/W2135280067","https://openalex.org/W2139497337","https://openalex.org/W2147557220","https://openalex.org/W2149184543","https://openalex.org/W2153389047","https://openalex.org/W2173141813","https://openalex.org/W2261516588","https://openalex.org/W2284630235","https://openalex.org/W2414226125","https://openalex.org/W2555431842","https://openalex.org/W2563656670","https://openalex.org/W2726575235","https://openalex.org/W2739492614","https://openalex.org/W2766740801","https://openalex.org/W2801024566","https://openalex.org/W2805549191","https://openalex.org/W2900144939","https://openalex.org/W2905370254","https://openalex.org/W2942708362","https://openalex.org/W2944910640","https://openalex.org/W2949177718","https://openalex.org/W2949238013","https://openalex.org/W2965985232","https://openalex.org/W2983615744","https://openalex.org/W3005483243","https://openalex.org/W3023092348","https://openalex.org/W3025676410","https://openalex.org/W3026232934","https://openalex.org/W3089339285","https://openalex.org/W3094128707","https://openalex.org/W3100295827","https://openalex.org/W3107015606","https://openalex.org/W3132274017","https://openalex.org/W3132661792","https://openalex.org/W3134348614","https://openalex.org/W3172794367","https://openalex.org/W3175617087","https://openalex.org/W3185560091","https://openalex.org/W3200101063","https://openalex.org/W3209529397","https://openalex.org/W3214321036","https://openalex.org/W3214530473","https://openalex.org/W4224274171","https://openalex.org/W4281673207","https://openalex.org/W4295454080","https://openalex.org/W4295512323","https://openalex.org/W4307703143","https://openalex.org/W4308038519","https://openalex.org/W4317757307","https://openalex.org/W4320896693","https://openalex.org/W4321480081","https://openalex.org/W4376879090","https://openalex.org/W4381380457","https://openalex.org/W4384818874","https://openalex.org/W4386333061","https://openalex.org/W4387906388","https://openalex.org/W4389166577","https://openalex.org/W4389662503","https://openalex.org/W4391567325","https://openalex.org/W4393043593","https://openalex.org/W4393205384","https://openalex.org/W4401918034","https://openalex.org/W4401932192","https://openalex.org/W4401948126","https://openalex.org/W4402171757","https://openalex.org/W4404488291","https://openalex.org/W4404907041","https://openalex.org/W4405045203","https://openalex.org/W4405446790","https://openalex.org/W4405834605","https://openalex.org/W4406241200","https://openalex.org/W4406298382","https://openalex.org/W4406606850","https://openalex.org/W4406609583","https://openalex.org/W4409218825","https://openalex.org/W4409268374","https://openalex.org/W4410092406","https://openalex.org/W4410955025","https://openalex.org/W4413349976","https://openalex.org/W4413419026"],"related_works":["https://openalex.org/W2974877234","https://openalex.org/W7141254208","https://openalex.org/W35636740","https://openalex.org/W7160540320","https://openalex.org/W7154701034","https://openalex.org/W7202341332","https://openalex.org/W7165964604","https://openalex.org/W4366498158","https://openalex.org/W4286843262","https://openalex.org/W2161981173"],"abstract_inverted_index":{"Regulatory":[0],"T":[1,44,128],"cell":[2,45,129],"(Treg)":[3],"therapies":[4,130,140],"are":[5],"emerging":[6],"as":[7,35,103,144],"powerful":[8],"tools":[9],"for":[10,51,90],"treating":[11],"autoimmune":[12],"and":[13,20,56,65,74,85,109,120,131],"inflammatory":[14],"diseases,":[15],"preventing":[16],"graft-versus-host":[17],"disease":[18],"(GvHD),":[19],"promoting":[21],"organ":[22],"transplant":[23],"tolerance.":[24],"Building":[25],"on":[26,98],"the":[27,87],"identification":[28],"of":[29,38,81,116,148],"chimeric":[30],"antigen":[31],"receptor":[32],"(CAR)-expressing":[33],"Tregs":[34],"a":[36,78],"correlate":[37],"poor":[39],"patient":[40],"outcomes":[41],"in":[42,91],"CD19-CAR":[43],"therapy,":[46],"this":[47,135],"review":[48,136],"examines":[49],"strategies":[50],"learning":[52],"from":[53,126],"clinical":[54,83,154],"samples":[55],"data":[57],"to":[58],"improve":[59],"Treg":[60,67,82,93,117,139],"therapies.":[61],"We":[62],"highlight":[63],"current":[64],"next-generation":[66],"modalities,":[68],"including":[69],"polyclonal,":[70],"antigen-specific,":[71],"converted,":[72],"TCR-engineered,":[73],"CAR-engineered":[75],"Tregs,":[76],"provide":[77],"comprehensive":[79],"overview":[80],"trials,":[84],"evaluate":[86],"evolving":[88],"toolkit":[89],"vivo":[92],"monitoring.":[94],"Emphasis":[95],"is":[96],"placed":[97],"advanced":[99],"immunomonitoring":[100],"technologies,":[101],"such":[102],"single-cell":[104],"multi-omic":[105,133],"profiling,":[106],"epigenetic":[107],"analysis,":[108],"spatial":[110],"transcriptomics,":[111],"which":[112],"enable":[113],"precise":[114],"characterization":[115],"persistence,":[118],"function,":[119],"lineage":[121],"stability.":[122],"By":[123],"integrating":[124],"insights":[125],"adoptive":[127],"cutting-edge":[132],"platforms,":[134],"outlines":[137],"how":[138],"can":[141],"be":[142],"optimized":[143],"\u201cliving":[145],"drugs\u201d":[146],"capable":[147],"establishing":[149],"immune":[150],"tolerance":[151],"across":[152],"diverse":[153],"contexts.":[155]},"counts_by_year":[{"year":2026,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-31T00:00:00"}