{"id":"https://openalex.org/W4415711985","doi":"https://doi.org/10.1016/j.sciaf.2025.e03067","title":"A study on the anti-Shigella activity of extracts and constituents from the root bark of Detarium microcarpum (Fabaceae), a plant traditionally used to treat dysentery in Niger","display_name":"A study on the anti-Shigella activity of extracts and constituents from the root bark of Detarium microcarpum (Fabaceae), a plant traditionally used to treat dysentery in Niger","publication_year":2025,"publication_date":"2025-10-30","ids":{"openalex":"https://openalex.org/W4415711985","doi":"https://doi.org/10.1016/j.sciaf.2025.e03067"},"language":"en","primary_location":{"id":"doi:10.1016/j.sciaf.2025.e03067","doi":"https://doi.org/10.1016/j.sciaf.2025.e03067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sciaf.2025.e03067","pdf_url":null,"source":{"id":"https://openalex.org/S4210198261","display_name":"Scientific African","issn_l":"2468-2276","issn":["2468-2276"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific African","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.sciaf.2025.e03067","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035844559","display_name":"Hama Hamadou Habibou","orcid":"https://orcid.org/0009-0008-3669-0150","observed_orcids":["https://orcid.org/0009-0008-3669-0150"]},"institutions":[{"id":"https://openalex.org/I130359222","display_name":"Universit\u00e9 Abdou Moumouni","ror":"https://ror.org/05tj8pb04","country_code":"NE","type":"education","lineage":["https://openalex.org/I130359222"]}],"countries":["NE"],"is_corresponding":true,"raw_author_name":"Hama Hamadou Habibou","raw_affiliation_strings":["Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger"],"raw_orcid":"https://orcid.org/0009-0008-3669-0150","affiliations":[{"raw_affiliation_string":"Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger","institution_ids":["https://openalex.org/I130359222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054353530","display_name":"Amadou Oumarou Fati","orcid":"https://orcid.org/0000-0002-4298-5288","observed_orcids":["https://orcid.org/0000-0002-4298-5288"]},"institutions":[{"id":"https://openalex.org/I130359222","display_name":"Universit\u00e9 Abdou Moumouni","ror":"https://ror.org/05tj8pb04","country_code":"NE","type":"education","lineage":["https://openalex.org/I130359222"]}],"countries":["NE"],"is_corresponding":false,"raw_author_name":"Amadou Oumarou Fati","raw_affiliation_strings":["Laboratory of Energy and Electronics, Electrotechnics, Automation, Industrials Camputing, Abdou Moumouni University, BP 10662 Niamey, Niger"],"raw_orcid":"https://orcid.org/0000-0002-4298-5288","affiliations":[{"raw_affiliation_string":"Laboratory of Energy and Electronics, Electrotechnics, Automation, Industrials Camputing, Abdou Moumouni University, BP 10662 Niamey, Niger","institution_ids":["https://openalex.org/I130359222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077512320","display_name":"Mahamane Idi Issa Abdoulahi","orcid":"https://orcid.org/0009-0008-8785-1292","observed_orcids":["https://orcid.org/0009-0008-8785-1292"]},"institutions":[{"id":"https://openalex.org/I130359222","display_name":"Universit\u00e9 Abdou Moumouni","ror":"https://ror.org/05tj8pb04","country_code":"NE","type":"education","lineage":["https://openalex.org/I130359222"]}],"countries":["NE"],"is_corresponding":false,"raw_author_name":"Mahamane Idi Issa Abdoulahi","raw_affiliation_strings":["Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger","Laboratory of biochemistry of bioctives substances, Abdou Moumouni University, BP 10662 Niamey, Niger"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger","institution_ids":["https://openalex.org/I130359222"]},{"raw_affiliation_string":"Laboratory of biochemistry of bioctives substances, Abdou Moumouni University, BP 10662 Niamey, Niger","institution_ids":["https://openalex.org/I130359222"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119379626","display_name":"Sani Souna Sido Abdelkarim","orcid":"https://orcid.org/0009-0004-1513-5255","observed_orcids":["https://orcid.org/0009-0004-1513-5255"]},"institutions":[{"id":"https://openalex.org/I130359222","display_name":"Universit\u00e9 Abdou Moumouni","ror":"https://ror.org/05tj8pb04","country_code":"NE","type":"education","lineage":["https://openalex.org/I130359222"]}],"countries":["NE"],"is_corresponding":false,"raw_author_name":"Sani Souna Sido Abdelkarim","raw_affiliation_strings":["Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger"],"raw_orcid":"https://orcid.org/0009-0004-1513-5255","affiliations":[{"raw_affiliation_string":"Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger","institution_ids":["https://openalex.org/I130359222"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108989059","display_name":"Khalid Ikhiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130359222","display_name":"Universit\u00e9 Abdou Moumouni","ror":"https://ror.org/05tj8pb04","country_code":"NE","type":"education","lineage":["https://openalex.org/I130359222"]}],"countries":["NE"],"is_corresponding":false,"raw_author_name":"Ikhiri Khalid","raw_affiliation_strings":["Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Natural Substances and Organic Synthesis, Abdou Moumouni University, BP 10662 Niamey, Niger","institution_ids":["https://openalex.org/I130359222"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035844559"],"corresponding_institution_ids":["https://openalex.org/I130359222"],"apc_list":{"value":590,"currency":"USD","value_usd":590},"apc_paid":{"value":590,"currency":"USD","value_usd":590},"fwci":0.4459,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.64049727,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"30","issue":null,"first_page":"e03067","last_page":"e03067"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.21789999306201935,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.21789999306201935,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1965000033378601,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/detarium-microcarpum","display_name":"Detarium microcarpum","score":1.0},{"id":"https://openalex.org/keywords/shigella","display_name":"Shigella","score":0.6790000200271606},{"id":"https://openalex.org/keywords/root-bark","display_name":"root bark","score":0.6959999799728394},{"id":"https://openalex.org/keywords/medicinal-plants","display_name":"medicinal plants","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dysentery","display_name":"dysentery","score":0.8389999866485596},{"id":"https://openalex.org/keywords/shigella-flexneri","display_name":"Shigella flexneri","score":0.8199999928474426},{"id":"https://openalex.org/keywords/shigella-boydii","display_name":"Shigella boydii","score":0.984000027179718},{"id":"https://openalex.org/keywords/shigella-sonnei","display_name":"Shigella sonnei","score":0.9559999704360962},{"id":"https://openalex.org/keywords/triterpenoids","display_name":"triterpenoids","score":0.824999988079071},{"id":"https://openalex.org/keywords/coumarins","display_name":"coumarins","score":0.9490000009536743},{"id":"https://openalex.org/keywords/steroids","display_name":"steroids","score":0.8029999732971191},{"id":"https://openalex.org/keywords/secondary-metabolites","display_name":"secondary metabolites","score":0.6919999718666077},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7260000109672546},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"traditional medicine","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2781217973","wikidata":"https://www.wikidata.org/wiki/Q1644417","display_name":"Shigella flexneri","level":4,"score":0.8353000283241272},{"id":"https://openalex.org/C2779858419","wikidata":"https://www.wikidata.org/wiki/Q407153","display_name":"Ethyl acetate","level":2,"score":0.7684999704360962},{"id":"https://openalex.org/C2776986154","wikidata":"https://www.wikidata.org/wiki/Q131029","display_name":"Shigella","level":4,"score":0.7364000082015991},{"id":"https://openalex.org/C2911111840","wikidata":"https://www.wikidata.org/wiki/Q6382438","display_name":"Shigella sonnei","level":5,"score":0.7203999757766724},{"id":"https://openalex.org/C2776692010","wikidata":"https://www.wikidata.org/wiki/Q4892937","display_name":"Shigella boydii","level":5,"score":0.7110999822616577},{"id":"https://openalex.org/C2780950330","wikidata":"https://www.wikidata.org/wiki/Q19903614","display_name":"Broth microdilution","level":4,"score":0.5461000204086304},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42910000681877136},{"id":"https://openalex.org/C2780610775","wikidata":"https://www.wikidata.org/wiki/Q265094","display_name":"Shigella dysenteriae","level":4,"score":0.42640000581741333},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42149999737739563},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41370001435279846},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.3822000026702881},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3756999969482422},{"id":"https://openalex.org/C2780708024","wikidata":"https://www.wikidata.org/wiki/Q129279","display_name":"Dysentery","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C51724486","wikidata":"https://www.wikidata.org/wiki/Q908955","display_name":"Column chromatography","level":2,"score":0.3352000117301941},{"id":"https://openalex.org/C26381139","wikidata":"https://www.wikidata.org/wiki/Q1158816","display_name":"Minimum bactericidal concentration","level":4,"score":0.3163999915122986},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.29319998621940613},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C2779546430","wikidata":"https://www.wikidata.org/wiki/Q327298","display_name":"Shigellosis","level":5,"score":0.2689000070095062},{"id":"https://openalex.org/C97428945","wikidata":"https://www.wikidata.org/wiki/Q15305109","display_name":"Fractionation","level":2,"score":0.26460000872612},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.2628999948501587},{"id":"https://openalex.org/C133446333","wikidata":"https://www.wikidata.org/wiki/Q38681","display_name":"Bark (sound)","level":2,"score":0.250900000333786}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1016/j.sciaf.2025.e03067","doi":"https://doi.org/10.1016/j.sciaf.2025.e03067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sciaf.2025.e03067","pdf_url":null,"source":{"id":"https://openalex.org/S4210198261","display_name":"Scientific African","issn_l":"2468-2276","issn":["2468-2276"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific African","raw_type":"journal-article"},{"id":"doi:10.2139/ssrn.5398793","doi":"https://doi.org/10.2139/ssrn.5398793","is_oa":true,"landing_page_url":"https://doi.org/10.2139/ssrn.5398793","pdf_url":null,"source":{"id":"https://openalex.org/S4210172589","display_name":"SSRN Electronic Journal","issn_l":"1556-5068","issn":["1556-5068"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1318003438","host_organization_name":"RELX Group (Netherlands)","host_organization_lineage":["https://openalex.org/I1318003438"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmh:oai:doaj.org/article:37788908230042e28c49f0f666398f9a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/37788908230042e28c49f0f666398f9a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific African, Vol 30, Iss , Pp e03067- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.sciaf.2025.e03067","doi":"https://doi.org/10.1016/j.sciaf.2025.e03067","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.sciaf.2025.e03067","pdf_url":null,"source":{"id":"https://openalex.org/S4210198261","display_name":"Scientific African","issn_l":"2468-2276","issn":["2468-2276"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","norway-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific African","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W54884419","https://openalex.org/W238009831","https://openalex.org/W328456720","https://openalex.org/W1222402817","https://openalex.org/W1864367858","https://openalex.org/W1963822376","https://openalex.org/W1970402458","https://openalex.org/W1976657679","https://openalex.org/W1978426194","https://openalex.org/W2008881461","https://openalex.org/W2010675090","https://openalex.org/W2032136302","https://openalex.org/W2040188657","https://openalex.org/W2060014888","https://openalex.org/W2060159650","https://openalex.org/W2061901810","https://openalex.org/W2078597534","https://openalex.org/W2081370954","https://openalex.org/W2083722173","https://openalex.org/W2092680402","https://openalex.org/W2119259412","https://openalex.org/W2150465569","https://openalex.org/W2152886435","https://openalex.org/W2167424604","https://openalex.org/W2169066349","https://openalex.org/W2181407244","https://openalex.org/W2576772148","https://openalex.org/W3018377437","https://openalex.org/W3137345770","https://openalex.org/W4224303261","https://openalex.org/W4233541854","https://openalex.org/W4242451810","https://openalex.org/W4385211003","https://openalex.org/W4402312013"],"related_works":["https://openalex.org/W4413406607","https://openalex.org/W4402312013","https://openalex.org/W4392361225","https://openalex.org/W2969826334","https://openalex.org/W4280540076","https://openalex.org/W4318393843","https://openalex.org/W4397000884","https://openalex.org/W2150657079","https://openalex.org/W3034308501","https://openalex.org/W2521004351"],"abstract_inverted_index":{"Detarium":[0],"microcarpum":[1,29,262],"is":[2],"a":[3,49,102,254],"medicinal":[4,286],"plant":[5,45],"traditionally":[6],"used":[7,91],"to":[8,48,81,101,193,280],"treat":[9],"various":[10],"digestive":[11,274],"disorders":[12],"in":[13,269],"Niger":[14],"including":[15,199],"dysentery.":[16],"This":[17,250],"study":[18,278],"reports":[19],"the":[20,24,41,44,69,82,86,93,122,128,155,158,163,188,211,217,247,258,270,282],"chemical":[21],"constituents":[22],"of":[23,27,43,66,121,144,169,196,237,260,265,273,284,292],"root":[25,42],"bark":[26],"D.":[28,261],"and":[30,56,85,115,147,175,206,223,230,241,263],"evaluate":[31],"their":[32],"anti-Shigella":[33,83,129,165,235,251],"activity.":[34,130],"The":[35,77,95,131,234,276],"methanol":[36,132],"crude":[37],"extract":[38,133],"obtained":[39],"from":[40,187],"was":[46,60,90,99],"subjectted":[47],"liquid-liquid":[50],"fractionation":[51],"using":[52,72],"n-hexane,":[53],"ethyl":[54,96,159,189],"acetate":[55,97,160,190],"n-butanol.":[57],"Anti-Shigella":[58],"activity":[59,84,135,166,219,236,252],"assessed":[61],"against":[62,136,172,178,220],"four":[63],"(04)":[64],"strains":[65],"Shigella":[67,137,148,173,179,221,224],"by":[68,109],"microdilution":[70],"method":[71],"Muller-Hinton":[73],"broth":[74],"as":[75,288],"medium.":[76],"fractions":[78,156],"were":[79,107,125,185],"submitted":[80],"most":[87],"active":[88,267],"fraction":[89,98,161],"for":[92,127,246,257],"isolation.":[94],"subjected":[100],"column":[103],"chromatography.":[104],"Isolated":[105],"compounds":[106,124,184,238,268],"identified":[108],"mass":[110],"spectrometry,":[111],"nuclear":[112],"magnetic":[113],"resonance":[114],"comparison":[116],"with":[117,139,167,226],"literature":[118],"data.":[119],"Some":[120],"isolated":[123,186],"tested":[126,212],"showed":[134,162],"boydii":[138,174],"MIC":[140,168,227],"(Minimum":[141],"Inhibitory":[142],"Concentration)":[143],"500":[145,176,231],"\u03bcg/mL":[146,171,177],"flexneri":[149,222],"(MIC":[150],"=":[151],"1000":[152],"\u03bcg/mL).":[153],"Among":[154,210],"obtained,":[157],"best":[164,218],"250":[170],"flexneri.":[180],"11":[181,242],"known":[182],"(described)":[183],"fraction,":[191],"belonging":[192],"several":[194],"classes":[195],"secondary":[197],"metabolites":[198],"two":[200],"steroids":[201],"(1-2),":[202],"six":[203],"triterpenes":[204],"(3-8)":[205],"three":[207],"coumarins":[208],"(9-11).":[209],"compounds,":[213],"6-hydroxy-4-methoxy-5-methylcoumarin":[214],"(10)":[215],"shows":[216],"sonnei":[225],"at":[228],"62.5":[229],"\u00b5g/mL":[232],"respectively.":[233],"9,":[239],"10":[240],"are":[243],"described":[244],"here":[245],"first":[248],"time.":[249],"indicate":[253],"promising":[255],"basis":[256],"use":[259],"some":[264],"its":[266],"traditional":[271],"treatment":[272],"disorders.":[275],"present":[277],"contributes":[279],"demonstrate":[281],"importance":[283],"African":[285],"plants":[287],"an":[289],"important":[290],"source":[291],"biomolecules.":[293]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-30T00:00:00"}