{"id":"https://openalex.org/W4415680902","doi":"https://doi.org/10.1016/j.physbeh.2025.115153","title":"Behavioral standardization and validation of a new model of cancer-induced depression in sarcoma-bearing mice","display_name":"Behavioral standardization and validation of a new model of cancer-induced depression in sarcoma-bearing mice","publication_year":2025,"publication_date":"2025-10-30","ids":{"openalex":"https://openalex.org/W4415680902","doi":"https://doi.org/10.1016/j.physbeh.2025.115153","pmid":"https://pubmed.ncbi.nlm.nih.gov/41173117"},"language":"en","primary_location":{"id":"doi:10.1016/j.physbeh.2025.115153","doi":"https://doi.org/10.1016/j.physbeh.2025.115153","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.physbeh.2025.115153","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & Behavior","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046412587","display_name":"Rayran Walter Ramos de Sousa","orcid":"https://orcid.org/0000-0001-7033-9198","observed_orcids":["https://orcid.org/0000-0001-7033-9198"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rayran Walter Ramos de Sousa","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7033-9198","affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055196484","display_name":"Ingredy Lopes dos Santos","orcid":"https://orcid.org/0000-0003-1205-4340","observed_orcids":["https://orcid.org/0000-0003-1205-4340"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ingredy Lopes dos Santos","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011562167","display_name":"D\u00e9bora Caroline do Nascimento Rodrigues","orcid":"https://orcid.org/0000-0002-1171-8013","observed_orcids":["https://orcid.org/0000-0002-1171-8013"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"D\u00e9bora Caroline do Nascimento Rodrigues","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018052637","display_name":"Maria Lu\u00edsa Lima Barreto do Nascimento","orcid":"https://orcid.org/0000-0002-2242-3392","observed_orcids":["https://orcid.org/0000-0002-2242-3392"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Lu\u00edsa Lima Barreto do Nascimento","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074249487","display_name":"Micaely Lorrana Pereira Concei\u00e7\u00e3o","orcid":"https://orcid.org/0000-0001-8492-6721","observed_orcids":["https://orcid.org/0000-0001-8492-6721"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Micaely Lorrana Pereira Concei\u00e7\u00e3o","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062693038","display_name":"Milena Monteiro de Freitas","orcid":"https://orcid.org/0000-0003-4227-5419","observed_orcids":["https://orcid.org/0000-0003-4227-5419"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Milena Monteiro de Freitas","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036821414","display_name":"Gabriel da Silva Fernandes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Gabriel da Silva Fernandes","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rita de C\u00e1ssia de Lima Sousa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Rita de C\u00e1ssia de Lima Sousa","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011880631","display_name":"Railson Pereira Souza","orcid":"https://orcid.org/0000-0002-2996-4511","observed_orcids":["https://orcid.org/0000-0002-2996-4511"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Railson Pereira Souza","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031323398","display_name":"Irislene Costa Pereira","orcid":"https://orcid.org/0000-0001-8993-2020","observed_orcids":["https://orcid.org/0000-0001-8993-2020"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Irislene Costa Pereira","raw_affiliation_strings":["Metabolic Diseases, Exercise and Nutrition Research Group (Domen), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Diseases, Exercise and Nutrition Research Group (Domen), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103786189","display_name":"Francisco Leonardo Torres-Leal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Francisco Leonardo Torres-Leal","raw_affiliation_strings":["Metabolic Diseases, Exercise and Nutrition Research Group (Domen), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolic Diseases, Exercise and Nutrition Research Group (Domen), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003940287","display_name":"Luciano da Silva Lopes","orcid":"https://orcid.org/0000-0002-7702-7258","observed_orcids":["https://orcid.org/0000-0002-7702-7258"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciano da Silva Lopes","raw_affiliation_strings":["Laboratory of Experimental Neurochemistry Research (Lapnex), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Neurochemistry Research (Lapnex), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil","institution_ids":["https://openalex.org/I3121799822"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100619388","display_name":"Paulo Michel Pinheiro Ferreira","orcid":"https://orcid.org/0000-0001-6862-6497","observed_orcids":["https://orcid.org/0000-0001-6862-6497"]},"institutions":[{"id":"https://openalex.org/I3121799822","display_name":"Universidade Federal do Piau\u00ed","ror":"https://ror.org/00kwnx126","country_code":"BR","type":"education","lineage":["https://openalex.org/I3121799822"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Paulo Michel Pinheiro Ferreira","raw_affiliation_strings":["Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil. Electronic address: pmpf@ufpi.edu.br"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piau\u00ed, Teresina, Brazil. Electronic address: pmpf@ufpi.edu.br","institution_ids":["https://openalex.org/I3121799822"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100619388"],"corresponding_institution_ids":["https://openalex.org/I3121799822"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.2643,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37948718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"304","issue":null,"first_page":"115153","last_page":"115153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.7099999785423279,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.18469999730587006,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.05429999902844429,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/depression-in-cancer-patients","display_name":"cancer-related depression","score":0.828000009059906},{"id":"https://openalex.org/keywords/sarcoma","display_name":"sarcoma","score":0.6629999876022339},{"id":"https://openalex.org/keywords/sarcoma-180","display_name":"sarcoma 180","score":0.7940000295639038},{"id":"https://openalex.org/keywords/animal-models-of-depression","display_name":"animal models of depression","score":0.7940000295639038},{"id":"https://openalex.org/keywords/antidepressants","display_name":"antidepressants","score":0.5509999990463257},{"id":"https://openalex.org/keywords/amitriptyline","display_name":"amitriptyline","score":0.9980000257492065},{"id":"https://openalex.org/keywords/fluoxetine","display_name":"fluoxetine","score":1.0},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7620000243186951},{"id":"https://openalex.org/keywords/nitrosative-stress","display_name":"nitrosative stress","score":0.8899999856948853},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9679999947547913},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"prefrontal cortex","score":0.8199999928474426},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":1.0},{"id":"https://openalex.org/keywords/tail-suspension-test","display_name":"tail suspension test","score":0.800000011920929},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.9399999976158142},{"id":"https://openalex.org/keywords/sucrose-preference","display_name":"sucrose preference","score":0.9440000057220459},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.4519999921321869}],"concepts":[{"id":"https://openalex.org/C2776134451","wikidata":"https://www.wikidata.org/wiki/Q422244","display_name":"Fluoxetine","level":4,"score":0.7146999835968018},{"id":"https://openalex.org/C2779085643","wikidata":"https://www.wikidata.org/wiki/Q7096029","display_name":"Open field","level":2,"score":0.6575999855995178},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.6187000274658203},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.5564000010490417},{"id":"https://openalex.org/C2780216858","wikidata":"https://www.wikidata.org/wiki/Q58397","display_name":"Amitriptyline","level":2,"score":0.5562000274658203},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.48100000619888306},{"id":"https://openalex.org/C2778875871","wikidata":"https://www.wikidata.org/wiki/Q4764954","display_name":"Animal models of depression","level":4,"score":0.47209998965263367},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4546000063419342},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4510999917984009},{"id":"https://openalex.org/C2778941446","wikidata":"https://www.wikidata.org/wiki/Q545365","display_name":"Anhedonia","level":3,"score":0.4090999960899353},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.3939000070095062},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3919999897480011},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35530000925064087},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3506999909877777},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.33390000462532043},{"id":"https://openalex.org/C2781001258","wikidata":"https://www.wikidata.org/wiki/Q7676084","display_name":"Tail suspension test","level":5,"score":0.31610000133514404},{"id":"https://openalex.org/C2779145073","wikidata":"https://www.wikidata.org/wiki/Q58396","display_name":"Imipramine","level":3,"score":0.3061000108718872},{"id":"https://openalex.org/C131783052","wikidata":"https://www.wikidata.org/wiki/Q7333746","display_name":"Righting reflex","level":3,"score":0.2994999885559082},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.2962999939918518},{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.2957000136375427},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2928999960422516},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.27959999442100525},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.27950000762939453},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.27790001034736633},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.2775000035762787},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.27230000495910645},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C173586616","wikidata":"https://www.wikidata.org/wiki/Q5359685","display_name":"Elevated plus maze","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.2556000053882599}],"mesh":[{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000639","descriptor_name":"Amitriptyline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005473","descriptor_name":"Fluoxetine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D012509","descriptor_name":"Sarcoma","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.physbeh.2025.115153","doi":"https://doi.org/10.1016/j.physbeh.2025.115153","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.physbeh.2025.115153","pdf_url":null,"source":{"id":"https://openalex.org/S167407068","display_name":"Physiology & Behavior","issn_l":"0031-9384","issn":["0031-9384","1873-507X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","erih-plus","jufo-1","ki-jl-1","medline","norway-2","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & Behavior","raw_type":"journal-article"},{"id":"pmid:41173117","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41173117","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology & behavior","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":104,"referenced_works":["https://openalex.org/W936804720","https://openalex.org/W1771974095","https://openalex.org/W1884392588","https://openalex.org/W1977657096","https://openalex.org/W1982655221","https://openalex.org/W1987990233","https://openalex.org/W1992507729","https://openalex.org/W1993465912","https://openalex.org/W2002050752","https://openalex.org/W2004947150","https://openalex.org/W2013586266","https://openalex.org/W2014099101","https://openalex.org/W2019450798","https://openalex.org/W2021566700","https://openalex.org/W2025972014","https://openalex.org/W2028392177","https://openalex.org/W2037111632","https://openalex.org/W2053028505","https://openalex.org/W2053054955","https://openalex.org/W2058072416","https://openalex.org/W2061212294","https://openalex.org/W2067698502","https://openalex.org/W2069692485","https://openalex.org/W2073924899","https://openalex.org/W2088762260","https://openalex.org/W2089299823","https://openalex.org/W2090999800","https://openalex.org/W2094364556","https://openalex.org/W2094470988","https://openalex.org/W2099725757","https://openalex.org/W2115510970","https://openalex.org/W2118233432","https://openalex.org/W2153592313","https://openalex.org/W2194350630","https://openalex.org/W2205794177","https://openalex.org/W2322169434","https://openalex.org/W2394910669","https://openalex.org/W2422260867","https://openalex.org/W2472941396","https://openalex.org/W2498283353","https://openalex.org/W2570263642","https://openalex.org/W2582369321","https://openalex.org/W2595110790","https://openalex.org/W2611578710","https://openalex.org/W2634470894","https://openalex.org/W2661742777","https://openalex.org/W2734700058","https://openalex.org/W2754697483","https://openalex.org/W2762156928","https://openalex.org/W2767036716","https://openalex.org/W2791538403","https://openalex.org/W2791745894","https://openalex.org/W2793943160","https://openalex.org/W2806621502","https://openalex.org/W2807729355","https://openalex.org/W2808053923","https://openalex.org/W2865698779","https://openalex.org/W2904244708","https://openalex.org/W2905365975","https://openalex.org/W2908813817","https://openalex.org/W2913447439","https://openalex.org/W2913563045","https://openalex.org/W2915070982","https://openalex.org/W2926367082","https://openalex.org/W2947838984","https://openalex.org/W2956190082","https://openalex.org/W2976315735","https://openalex.org/W2981928697","https://openalex.org/W2995925857","https://openalex.org/W3041587291","https://openalex.org/W3092176105","https://openalex.org/W3093637677","https://openalex.org/W3107429808","https://openalex.org/W3122927608","https://openalex.org/W3135176112","https://openalex.org/W3138421735","https://openalex.org/W3154330664","https://openalex.org/W3189676709","https://openalex.org/W3197166860","https://openalex.org/W3208866670","https://openalex.org/W3213918117","https://openalex.org/W4205742491","https://openalex.org/W4206995814","https://openalex.org/W4224264316","https://openalex.org/W4250447799","https://openalex.org/W4282839499","https://openalex.org/W4291017243","https://openalex.org/W4292865316","https://openalex.org/W4297826660","https://openalex.org/W4300687942","https://openalex.org/W4309403786","https://openalex.org/W4320491888","https://openalex.org/W4360604211","https://openalex.org/W4366133647","https://openalex.org/W4388424066","https://openalex.org/W4389670234","https://openalex.org/W4391508379","https://openalex.org/W4393305779","https://openalex.org/W4396931845","https://openalex.org/W4401513698","https://openalex.org/W4402324046","https://openalex.org/W4402998150","https://openalex.org/W4404364815","https://openalex.org/W4411249549"],"related_works":["https://openalex.org/W936804720","https://openalex.org/W1963482332","https://openalex.org/W71613833","https://openalex.org/W7168428661","https://openalex.org/W2375286030","https://openalex.org/W2490578007","https://openalex.org/W2094364556","https://openalex.org/W2353701824","https://openalex.org/W2339173498","https://openalex.org/W2053028505"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-30T00:00:00"}