{"id":"https://openalex.org/W4415670592","doi":"https://doi.org/10.1016/j.htct.2025.104469","title":"ETV6::RUNX1 FUSION IN ACUTE LYMPHOBLASTIC LEUKEMIA: FREQUENCY AND REGIONAL DISTRIBUTION IN THE STATE OF PAR\u00c1","display_name":"ETV6::RUNX1 FUSION IN ACUTE LYMPHOBLASTIC LEUKEMIA: FREQUENCY AND REGIONAL DISTRIBUTION IN THE STATE OF PAR\u00c1","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415670592","doi":"https://doi.org/10.1016/j.htct.2025.104469"},"language":"en","primary_location":{"id":"doi:10.1016/j.htct.2025.104469","doi":"https://doi.org/10.1016/j.htct.2025.104469","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2025.104469","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1016/j.htct.2025.104469","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"KB Rodrigues","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"KB Rodrigues","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":null,"display_name":"YS Santos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"YS Santos","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041727163","display_name":"Jaqueline Silva de Oliveira","orcid":"https://orcid.org/0000-0003-3221-9528","observed_orcids":["https://orcid.org/0000-0003-3221-9528","https://orcid.org/0009-0001-0013-2981"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"JCS Oliveira","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038300578","display_name":"MB Oliveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"MB Oliveira","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":null,"display_name":"\u00c1TM Tavares","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00c1TM Tavares","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042501654","display_name":"AV Wanderley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AV Wanderley","raw_affiliation_strings":["Hospital Oncol\u00f3gico Infantil Oct\u00e1vio Lobo (HOIOL), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Oncol\u00f3gico Infantil Oct\u00e1vio Lobo (HOIOL), Bel\u00e9m, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077854512","display_name":"LC Pantoja","orcid":"https://orcid.org/0009-0004-5275-7184","observed_orcids":["https://orcid.org/0009-0004-5275-7184"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LC Pantoja","raw_affiliation_strings":["Hospital Oncol\u00f3gico Infantil Oct\u00e1vio Lobo (HOIOL), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Oncol\u00f3gico Infantil Oct\u00e1vio Lobo (HOIOL), Bel\u00e9m, Brazil","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"MS Aquino","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"MS Aquino","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086217172","display_name":"BCM Khayat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"BCM Khayat","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043257848","display_name":"M S Bernardes","orcid":"https://orcid.org/0000-0001-7240-1434","observed_orcids":["https://orcid.org/0000-0001-7240-1434"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MM Bernardes","raw_affiliation_strings":["Hospital Oncol\u00f3gico Infantil Oct\u00e1vio Lobo (HOIOL), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Oncol\u00f3gico Infantil Oct\u00e1vio Lobo (HOIOL), Bel\u00e9m, Brazil","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058996435","display_name":"Andr\u00e9 Salim Khayat","orcid":"https://orcid.org/0000-0002-3451-6369","observed_orcids":["https://orcid.org/0000-0002-3451-6369"]},"institutions":[{"id":"https://openalex.org/I59606676","display_name":"Universidade Federal do Par\u00e1","ror":"https://ror.org/03q9sr818","country_code":"BR","type":"education","lineage":["https://openalex.org/I59606676"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"AS Khayat","raw_affiliation_strings":["Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidade Federal do Par\u00e1 (UFPA), Bel\u00e9m, Brazil","institution_ids":["https://openalex.org/I59606676"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33043607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"47","issue":null,"first_page":"104469","last_page":"104469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/etv6-runx1","display_name":"ETV6-RUNX1","score":0.9570000171661377},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9800000190734863},{"id":"https://openalex.org/keywords/regional-distribution","display_name":"regional distribution","score":0.7210000157356262},{"id":"https://openalex.org/keywords/para","display_name":"Par\u00e1","score":0.6710000038146973},{"id":"https://openalex.org/keywords/belem","display_name":"Bel\u00e9m","score":0.4339999854564667},{"id":"https://openalex.org/keywords/macapa","display_name":"Macap\u00e1","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.6990000009536743},{"id":"https://openalex.org/keywords/sex-distribution","display_name":"sex distribution","score":0.7879999876022339},{"id":"https://openalex.org/keywords/age-distribution","display_name":"age distribution","score":0.9649999737739563},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.5609999895095825},{"id":"https://openalex.org/keywords/npcr","display_name":"NPCR","score":0.5019999742507935},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"immunophenotyping","score":0.703000009059906},{"id":"https://openalex.org/keywords/northern-brazil","display_name":"Northern Brazil","score":0.421999990940094},{"id":"https://openalex.org/keywords/belem-metropolitan-region","display_name":"Bel\u00e9m metropolitan region","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.845300018787384},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.6588000059127808},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.5432999730110168},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5020999908447266},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.4830000102519989},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.4675000011920929},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.4528999924659729},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41760000586509705},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3919999897480011},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3522999882698059},{"id":"https://openalex.org/C32809988","wikidata":"https://www.wikidata.org/wiki/Q1071004","display_name":"Chi-square test","level":2,"score":0.33180001378059387},{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.3314000070095062},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.32280001044273376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C96608239","wikidata":"https://www.wikidata.org/wiki/Q1199823","display_name":"Statistical power","level":2,"score":0.28870001435279846},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2842000126838684},{"id":"https://openalex.org/C2778274637","wikidata":"https://www.wikidata.org/wiki/Q5510282","display_name":"Fusion transcript","level":4,"score":0.2734000086784363},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2709999978542328},{"id":"https://openalex.org/C1391233","wikidata":"https://www.wikidata.org/wiki/Q5382703","display_name":"Epidemiological method","level":3,"score":0.26809999346733093},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2678999900817871},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.2669000029563904},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C2776863199","wikidata":"https://www.wikidata.org/wiki/Q976388","display_name":"Acute leukemia","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.2556000053882599},{"id":"https://openalex.org/C2777267654","wikidata":"https://www.wikidata.org/wiki/Q3519023","display_name":"Test (biology)","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C65409693","wikidata":"https://www.wikidata.org/wiki/Q425265","display_name":"Statistical significance","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.2515000104904175},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.25119999051094055},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.htct.2025.104469","doi":"https://doi.org/10.1016/j.htct.2025.104469","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2025.104469","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.htct.2025.104469","doi":"https://doi.org/10.1016/j.htct.2025.104469","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.htct.2025.104469","pdf_url":null,"source":{"id":"https://openalex.org/S2898598332","display_name":"Hematology Transfusion and Cell Therapy","issn_l":"2531-1379","issn":["2531-1379","2531-1387"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","scielo"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hematology, Transfusion and Cell Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Acute":[0],"Lymphoblastic":[1],"Leukemia":[2],"(ALL)":[3],"accounts":[4],"for":[5,67,144,168,327,482],"about":[6],"75%":[7],"of":[8,16,23,77,83,147,157,184,218,225,234,264,318,329,336,347,422,444,449,453,458,471,515],"leukemia":[9],"cases.":[10,25,332],"In":[11,288],"Northern":[12,521],"Brazil,":[13],"the":[14,21,27,41,54,75,78,103,145,158,182,189,223,230,243,290,307,322,341,344,354,363,372,379,390,406,420,423,442,447,450,456,463,469,480,493,513,516,520],"state":[15],"Par\u00e1":[17,84],"ranks":[18],"second":[19],"in":[20,81,172,198,222,254,282,298,386,392,410,429,441,473,490,519],"number":[22],"ALL":[24,99,430],"Among":[26,306],"genetic":[28],"alterations":[29],"frequently":[30],"associated":[31,59],"with":[32,60,88,98,155,340,505],"ALL,":[33],"gene":[34,132],"fusions":[35],"such":[36,120,204],"as":[37,121,205,426,466,468],"ETV6::RUNX1,":[38],"resulting":[39],"from":[40,95,128,138,165,267],"translocation":[42],"between":[43,113,251],"chromosomes":[44],"12":[45],"and":[46,57,85,90,115,124,140,188,207,310,316,394,405,446,462,475,484],"21,":[47],"t(12;21),":[48],"stand":[49],"out.":[50],"This":[51,70,396],"fusion":[52,80,133,425],"is":[53,58,338,414],"most":[55],"common":[56],"a":[61,294,360,376,383,427],"favorable":[62],"prognosis,":[63],"making":[64,496],"it":[65,497],"crucial":[66],"guiding":[68],"treatment.":[69],"study":[71,244,418],"aims":[72],"to":[73,180,194,239,269,402,432,460,487,511],"evaluate":[74,195],"incidence":[76],"ETV6::RUNX1":[79,169,231,424],"municipalities":[82,491],"its":[86,433],"association":[87],"sex":[89],"age.":[91,200],"Data":[92,164],"were":[93,126,170,209,236,259],"collected":[94],"patients":[96,139,166,220,265,337],"diagnosed":[97],"by":[100,150,160,186,301],"immunophenotyping":[101],"at":[102],"Oct\u00e1vio":[104],"Lobo":[105],"Children\u2019s":[106],"Oncology":[107],"Hospital,":[108],"who":[109],"signed":[110],"informed":[111],"consent":[112],"2023":[114],"June":[116],"2025.":[117],"Epidemiological":[118],"data,":[119],"sex,":[122],"age,":[123],"municipality,":[125,187],"retrieved":[127],"medical":[129],"records.":[130],"For":[131,500],"analysis,":[134],"RNA":[135],"was":[136,178,192,247],"extracted":[137],"converted":[141],"into":[142],"cDNA":[143],"detection":[146],"molecular":[148,403,483],"biomarkers":[149],"nPCR,":[151],"using":[152,213],"specific":[153],"primers,":[154],"visualization":[156],"products":[159],"agarose":[161],"gel":[162],"electrophoresis.":[163],"positive":[167,331],"used":[171,193],"statistical":[173,369],"analyses.":[174],"The":[175,261,275,333,356,436],"chi-square":[176,291,373],"test":[177,191,277,292,358,374],"performed":[179],"assess":[181],"frequency":[183],"cases":[185,472],"ANOVA":[190,276,357],"significant":[196,249,280,296,384,439],"differences":[197,440],"patient":[199],"Other":[201],"descriptive":[202],"statistics,":[203],"mode":[206],"mean,":[208],"also":[210],"applied,":[211],"all":[212,330],"RStudio":[214],"12.1.":[215],"A":[216],"total":[217],"56":[219],"participated":[221],"study,":[224],"which":[226],"33":[227],"children":[228],"presented":[229,359],"fusion;":[232],"9":[233],"these":[235,411],"excluded":[237],"due":[238,431],"missing":[240],"data.":[241],"During":[242],"period,":[245],"there":[246],"no":[248,279,368],"predominance":[250],"sexes,":[252],"except":[253],"2024,":[255],"when":[256],"approximately":[257],"63%":[258],"male.":[260],"mean":[262,334],"age":[263,283,335],"ranged":[266],"6":[268],"7":[270],"years":[271],"(SD":[272],"=":[273,286,304],"4.12).":[274],"showed":[278,375],"difference":[281,297,385],"distribution":[284,300,443,518],"(p":[285,303],"0.791).":[287],"contrast,":[289],"indicated":[293],"statistically":[295],"case":[299,387],"municipality":[302],"0.04585).":[305],"municipalities,":[308],"Bel\u00e9m":[309,323,393,454,474],"Macap\u00e1":[311],"stood":[312],"out,":[313],"concentrating":[314],"29.17%":[315],"16.67%":[317],"cases,":[319,445],"respectively.":[320],"Furthermore,":[321],"Metropolitan":[324,451],"Region":[325,452],"accounted":[326],"one-third":[328],"consistent":[339],"literature,":[342],"despite":[343],"standard":[345],"deviation":[346],"4.12":[348],"years,":[349],"indicating":[350,367,382],"considerable":[351],"variation":[352],"around":[353],"mean.":[355],"value":[361],"above":[362],"significance":[364,380],"level":[365],"(0.05),":[366],"difference.":[370],"Conversely,":[371],"p-value":[377],"below":[378],"level,":[381],"distribution,":[388],"highlighting":[389],"concentration":[391,470],"Macap\u00e1.":[395,476],"finding":[397],"may":[398],"reflect":[399],"greater":[400],"access":[401,459],"diagnosis":[404,461,489],"oncology":[407,464],"reference":[408],"network":[409],"cities.":[412],"It":[413],"concluded":[415],"that":[416],"this":[417,501],"highlights":[419],"relevance":[421],"biomarker":[428],"high":[434],"incidence.":[435],"analysis":[437],"revealed":[438],"representation":[448],"suggests":[455],"influence":[457],"network,":[465],"well":[467],"These":[477],"results":[478],"reinforce":[479],"need":[481],"epidemiological":[485],"mapping":[486],"expand":[488],"outside":[492],"metropolitan":[494],"area,":[495],"more":[498],"accessible.":[499],"purpose,":[502],"multicenter":[503],"studies":[504],"broader":[506],"regional":[507],"coverage":[508],"are":[509],"necessary":[510],"deepen":[512],"understanding":[514],"fusion\u2019s":[517],"region.":[522]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-29T00:00:00"}