{"id":"https://openalex.org/W4415613636","doi":"https://doi.org/10.1177/09731296251384399","title":"Study on the Mechanism of Berberine Based on PI3K/mTOR/Autophagy Pathway to Ameliorate Sepsis-associated Encephalopathy Injury","display_name":"Study on the Mechanism of Berberine Based on PI3K/mTOR/Autophagy Pathway to Ameliorate Sepsis-associated Encephalopathy Injury","publication_year":2025,"publication_date":"2025-10-28","ids":{"openalex":"https://openalex.org/W4415613636","doi":"https://doi.org/10.1177/09731296251384399"},"language":"en","primary_location":{"id":"doi:10.1177/09731296251384399","doi":"https://doi.org/10.1177/09731296251384399","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09731296251384399","pdf_url":null,"source":{"id":"https://openalex.org/S40318847","display_name":"Pharmacognosy Magazine","issn_l":"0973-1296","issn":["0973-1296","0976-4062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-70"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Magazine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1177/09731296251384399","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100933769","display_name":"Yu Li","orcid":"https://orcid.org/0009-0005-5426-0136","observed_orcids":["https://orcid.org/0009-0005-5426-0136","https://orcid.org/0000-0002-3431-8266"]},"institutions":[{"id":"https://openalex.org/I4210122141","display_name":"People's Hospital of Xinjiang Uygur Autonomous Region","ror":"https://ror.org/02r247g67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122141"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Li","raw_affiliation_strings":["Department of Health Care Centers, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Care Centers, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I4210122141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101492879","display_name":"Wei Feng Du","orcid":"https://orcid.org/0000-0002-3628-3298","observed_orcids":["https://orcid.org/0000-0002-3628-3298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei Du","raw_affiliation_strings":["Department of Intensive Care Medicine, Zhejiang Qiushi Cardiovascular Disease Hospital, Hangzhou, Zhejiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, Zhejiang Qiushi Cardiovascular Disease Hospital, Hangzhou, Zhejiang, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086020578","display_name":"Shijun Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122141","display_name":"People's Hospital of Xinjiang Uygur Autonomous Region","ror":"https://ror.org/02r247g67","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122141"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijun Tang","raw_affiliation_strings":["Neurosurgery Centre, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurosurgery Centre, People\u2019s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I4210122141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065466424","display_name":"Yuan-Jia Yue","orcid":"https://orcid.org/0009-0009-4735-3974","observed_orcids":["https://orcid.org/0009-0009-4735-3974"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan-Jia Yue","raw_affiliation_strings":["Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China"],"raw_orcid":"https://orcid.org/0009-0009-4735-3974","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xing Rong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xing Rong","raw_affiliation_strings":["Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601276","display_name":"Hongxiang Wang","orcid":"https://orcid.org/0000-0002-2499-3604","observed_orcids":["https://orcid.org/0000-0002-2499-3604"]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxiang Wang","raw_affiliation_strings":["Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031474549","display_name":"Gaerma Dugujia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dugujia Gaerma","raw_affiliation_strings":["Department of Pharmacy, Urumqi Friendship Hospital, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Urumqi Friendship Hospital, Urumqi, Xinjiang, China","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Lin Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154093214","display_name":"Xinjiang Medical University","ror":"https://ror.org/01p455v08","country_code":"CN","type":"education","lineage":["https://openalex.org/I154093214"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Jiang","raw_affiliation_strings":["Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Xinjiang Medical University Hospital of Traditional Chinese Medicine, Urumqi, Xinjiang, China","institution_ids":["https://openalex.org/I154093214"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154093214"],"apc_list":{"value":1600,"currency":"USD","value_usd":1600},"apc_paid":{"value":1600,"currency":"USD","value_usd":1600},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.27542334,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"3","first_page":"1181","last_page":"1187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.03889999911189079,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberine","display_name":"berberine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/sepsis-associated-encephalopathy","display_name":"sepsis-associated encephalopathy","score":1.0},{"id":"https://openalex.org/keywords/pi3k-mtor-pathway","display_name":"PI3K/mTOR pathway","score":0.9010000228881836},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9480000138282776},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9380000233650208},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.503000020980835},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.722000002861023},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8109999895095825},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9860000014305115},{"id":"https://openalex.org/keywords/il-10","display_name":"IL-10","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.8579999804496765},{"id":"https://openalex.org/keywords/beclin-1","display_name":"Beclin-1","score":0.8040000200271606},{"id":"https://openalex.org/keywords/lc3","display_name":"LC3","score":0.9179999828338623},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2780116568","wikidata":"https://www.wikidata.org/wiki/Q176525","display_name":"Berberine","level":2,"score":0.8572999835014343},{"id":"https://openalex.org/C37753355","wikidata":"https://www.wikidata.org/wiki/Q911877","display_name":"Nissl body","level":3,"score":0.8125},{"id":"https://openalex.org/C196795494","wikidata":"https://www.wikidata.org/wiki/Q1624817","display_name":"TUNEL assay","level":3,"score":0.6700000166893005},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6412000060081482},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5562999844551086},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5105999708175659},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.4964999854564667},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.49410000443458557},{"id":"https://openalex.org/C154113507","wikidata":"https://www.wikidata.org/wiki/Q411149","display_name":"Terminal deoxynucleotidyl transferase","level":4,"score":0.4778999984264374},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4627000093460083},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.41850000619888306},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.39890000224113464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38920000195503235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33149999380111694},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32760000228881836},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.32580000162124634},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3165999948978424},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2890999913215637},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2705000042915344},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.26249998807907104}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1177/09731296251384399","doi":"https://doi.org/10.1177/09731296251384399","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09731296251384399","pdf_url":null,"source":{"id":"https://openalex.org/S40318847","display_name":"Pharmacognosy Magazine","issn_l":"0973-1296","issn":["0973-1296","0976-4062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-70"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Magazine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1177/09731296251384399","doi":"https://doi.org/10.1177/09731296251384399","is_oa":true,"landing_page_url":"https://doi.org/10.1177/09731296251384399","pdf_url":null,"source":{"id":"https://openalex.org/S40318847","display_name":"Pharmacognosy Magazine","issn_l":"0973-1296","issn":["0973-1296","0976-4062"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","poland-70"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacognosy Magazine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W2159754384","https://openalex.org/W2604636580","https://openalex.org/W2990015591","https://openalex.org/W2994724934","https://openalex.org/W3012996909","https://openalex.org/W3070104865","https://openalex.org/W3092107442","https://openalex.org/W3116180543","https://openalex.org/W3184056831","https://openalex.org/W4220897376","https://openalex.org/W4223542076","https://openalex.org/W4295346352","https://openalex.org/W4321601699","https://openalex.org/W4322763428","https://openalex.org/W4384694894","https://openalex.org/W4388948995","https://openalex.org/W4390711247"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Sepsis-associated":[1],"encephalopathy":[2,53],"(SAE)":[3],"is":[4,159],"a":[5],"major":[6],"cause":[7],"of":[8,30,36,43,45,51,59,67,72,77,83,104,141,152,245,288,290,301],"high":[9],"mortality,":[10],"and":[11,56,81,92,118,131,149,154,174,189,201,220,234,251,266,303],"no":[12],"specific":[13],"therapeutic":[14,307],"drugs":[15],"are":[16],"currently":[17],"available.":[18],"Berberine":[19],"has":[20],"been":[21],"well-documented":[22],"for":[23,298],"its":[24,28],"neuroprotective":[25],"effects,":[26],"but":[27],"mechanism":[29,42,140,287],"action":[31,44,289],"remains":[32],"unclear.":[33],"Objectives":[34],"Use":[35],"network":[37,60],"pharmacology":[38,61],"to":[39,62,126,137,162,207,261],"study":[40,284],"the":[41,49,64,70,139,166,181,186,190,196,226,229,256,262,273,279,286,294,299],"berberine":[46],"(BER)":[47],"in":[48,69,109,180,185,195,255,278],"treatment":[50,71,300],"sepsis-associated":[52],"(SAE).":[54],"Materials":[55],"Methods":[57],"Application":[58],"predict":[63],"signalling":[65,296],"pathway":[66,297],"BER":[68,105,158,182,204,257,291],"SAE.":[73],"The":[74,102],"mouse":[75],"model":[76],"SAE":[78,110,164,187,210,263,302],"was":[79,95,124,135,193,276],"constructed,":[80],"determination":[82],"tumour":[84],"necrosis":[85],"factor-\u03b1":[86],"(TNF-\u03b1),":[87],"interleukin-1\u03b2":[88],"(IL-1\u03b2),":[89],"interleukin-6":[90],"(IL-6)":[91],"interleukin-10":[93],"(IL-10)":[94],"done":[96],"by":[97,114],"enzyme-linked":[98],"immunosorbent":[99],"assay":[100],"(ELISA).":[101],"effects":[103],"on":[106,145,293],"neuronal":[107,128],"damage":[108],"mice":[111],"were":[112,177,205,232,253,271],"examined":[113],"haematoxylin-eosin":[115],"(HE)":[116],"staining":[117,200,203],"Nissl":[119,202],"staining.":[120],"Transmission":[121],"electron":[122,222],"microscopy":[123,223],"used":[125],"observe":[127],"autophagy":[129],"formation,":[130],"Western":[132,237],"blot":[133],"analysis":[134],"employed":[136],"explore":[138],"action.":[142],"Results":[143],"Based":[144],"Gene":[146],"Ontology":[147],"(GO)":[148],"Kyoto":[150],"Encyclopedia":[151],"Genes":[153],"Genomes":[155],"(KEGG)":[156],"analyses,":[157],"most":[160],"likely":[161],"treat":[163],"via":[165],"phosphatidylinositol-3":[167],"kinase":[168],"(PI3K)-Akt":[169],"pathway.":[170],"TNF-\u03b1,":[171],"IL-1\u03b2,":[172],"IL-6":[173],"IL-10":[175],"levels":[176],"significantly":[178,208],"lower":[179],"group":[183,258],"than":[184],"group,":[188],"opposite":[191,274],"trend":[192,275],"shown":[194,277],"3MA":[197,280],"group.":[198,281],"HE":[199],"found":[206],"reduce":[209],"injury;":[211],"terminal":[212],"deoxynucleotidyl":[213],"transferase":[214],"dUTP":[215],"nick":[216],"end":[217],"labelling":[218],"(TUNEL)":[219],"transmission":[221],"visualised":[224],"under":[225],"microscope":[227],"that":[228,241],"injured":[230],"cells":[231],"shrunken":[233],"apoptosis":[235],"occurred.":[236],"blotting":[238],"experiments":[239],"revealed":[240],"PI3K,":[242],"mammalian":[243],"target":[244],"rapamycin":[246],"(mTOR),":[247],"matrix":[248],"metalloprotein-9":[249],"(MMP-9)":[250],"p62":[252],"reduced":[254],"as":[259],"compared":[260],"group;":[264],"Beclin1":[265],"light":[267],"chain":[268],"3":[269],"(LC3)":[270],"elevated;":[272],"Conclusion":[282],"This":[283],"predicted":[285],"acting":[292],"PI3K/mTOR":[295],"linked":[304],"more":[305],"potential":[306],"targets.":[308]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-28T00:00:00"}