{"id":"https://openalex.org/W4415608279","doi":"https://doi.org/10.1364/opticaopen.30460610","title":"Predicting Wrist Osteoporosis from excised human finger bones using spatially offset Raman spectroscopy \u2013 A Cadaveric Study","display_name":"Predicting Wrist Osteoporosis from excised human finger bones using spatially offset Raman spectroscopy \u2013 A Cadaveric Study","publication_year":2025,"publication_date":"2025-10-28","ids":{"openalex":"https://openalex.org/W4415608279","doi":"https://doi.org/10.1364/opticaopen.30460610"},"language":"en","primary_location":{"id":"doi:10.1364/opticaopen.30460610","doi":"https://doi.org/10.1364/opticaopen.30460610","is_oa":true,"landing_page_url":"https://doi.org/10.1364/opticaopen.30460610","pdf_url":"https://preprints.opticaopen.org/articles/preprint/Predicting_Wrist_Osteoporosis_from_excised_human_finger_bones_using_spatially_offset_Raman_spectroscopy_A_Cadaveric_Study/30460610/1/files/59101370.pdf","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Optica Open","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://preprints.opticaopen.org/articles/preprint/Predicting_Wrist_Osteoporosis_from_excised_human_finger_bones_using_spatially_offset_Raman_spectroscopy_A_Cadaveric_Study/30460610/1/files/59101370.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103471531","display_name":"Mohammad Hosseini","orcid":"https://orcid.org/0000-0002-3508-0851","observed_orcids":["https://orcid.org/0000-0002-3508-0851"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Hosseini","raw_affiliation_strings":["The Institute of Optics , University of Rochester , 275 Hutchison Rd , Rochester , NY 14620 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Institute of Optics , University of Rochester , 275 Hutchison Rd , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015883705","display_name":"Sadia Afrin","orcid":"https://orcid.org/0000-0001-5063-9900","observed_orcids":["https://orcid.org/0000-0001-5063-9900","https://orcid.org/0009-0002-4899-4123"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SADIA AFRIN","raw_affiliation_strings":["Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117535944","display_name":"Anthony J. Yosick","orcid":"https://orcid.org/0000-0003-3980-8966","observed_orcids":["https://orcid.org/0000-0003-3980-8966"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANTHONY YOSICK","raw_affiliation_strings":["Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","The Center for Musculoskeletal Research , University of Rochester Medical Center , 601 Elmwood Avenue , Box 665 , Rochester , NY 14642 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"The Center for Musculoskeletal Research , University of Rochester Medical Center , 601 Elmwood Avenue , Box 665 , Rochester , NY 14642 , USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120157393","display_name":"EMMA SCHENKER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"EMMA SCHENKER","raw_affiliation_strings":["Department of Physics , University of Florida , Gainesville , FL 32611 , USA","The Institute of Optics , University of Rochester , 275 Hutchison Rd , Rochester , NY 14620 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics , University of Florida , Gainesville , FL 32611 , USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"The Institute of Optics , University of Rochester , 275 Hutchison Rd , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072046074","display_name":"Hani A. Awad","orcid":"https://orcid.org/0000-0003-2197-2610","observed_orcids":["https://orcid.org/0000-0003-2197-2610"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani Awad","raw_affiliation_strings":["Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","The Center for Musculoskeletal Research , University of Rochester Medical Center , 601 Elmwood Avenue , Box 665 , Rochester , NY 14642 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"The Center for Musculoskeletal Research , University of Rochester Medical Center , 601 Elmwood Avenue , Box 665 , Rochester , NY 14642 , USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000504474","display_name":"Andrew J. Berger","orcid":"https://orcid.org/0000-0001-5090-1198","observed_orcids":["https://orcid.org/0000-0001-5090-1198"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ANDREW BERGER","raw_affiliation_strings":["Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","The Institute of Optics , University of Rochester , 275 Hutchison Rd , Rochester , NY 14620 , USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering , University of Rochester , 207 Robert B. Goergen Hall , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]},{"raw_affiliation_string":"The Institute of Optics , University of Rochester , 275 Hutchison Rd , Rochester , NY 14620 , USA","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.019500000402331352,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopenia","display_name":"osteopenia","score":0.9269999861717224},{"id":"https://openalex.org/keywords/spatially-offset-raman-spectroscopy","display_name":"spatially offset Raman spectroscopy","score":0.9909999966621399},{"id":"https://openalex.org/keywords/finger-bones","display_name":"finger bones","score":0.8429999947547913},{"id":"https://openalex.org/keywords/proximal-phalanx","display_name":"proximal phalanx","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.5849999785423279},{"id":"https://openalex.org/keywords/mineral-to-matrix-ratio","display_name":"mineral-to-matrix ratio","score":0.8100000023841858},{"id":"https://openalex.org/keywords/partial-least-squares-regression","display_name":"partial least squares regression","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cadaveric-bone","display_name":"cadaveric bone","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.6389999985694885},{"id":"https://openalex.org/C2778216619","wikidata":"https://www.wikidata.org/wiki/Q185706","display_name":"Wrist","level":2,"score":0.6158000230789185},{"id":"https://openalex.org/C175696284","wikidata":"https://www.wikidata.org/wiki/Q986524","display_name":"Cadaveric spasm","level":2,"score":0.6040999889373779},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.5690000057220459},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5393000245094299},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.5322999954223633},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.45410001277923584},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.42410001158714294},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.3749000132083893},{"id":"https://openalex.org/C175291020","wikidata":"https://www.wikidata.org/wiki/Q1156822","display_name":"Offset (computer science)","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C91762617","wikidata":"https://www.wikidata.org/wiki/Q48422","display_name":"Cadaver","level":2,"score":0.36250001192092896},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.351500004529953},{"id":"https://openalex.org/C2776881184","wikidata":"https://www.wikidata.org/wiki/Q83360","display_name":"Thumb","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.2953999936580658},{"id":"https://openalex.org/C104709138","wikidata":"https://www.wikidata.org/wiki/Q1671540","display_name":"Intraclass correlation","level":3,"score":0.2890999913215637},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C2909959974","wikidata":"https://www.wikidata.org/wiki/Q1057892","display_name":"Proximal phalanx","level":2,"score":0.2840000092983246},{"id":"https://openalex.org/C2777781587","wikidata":"https://www.wikidata.org/wiki/Q1208242","display_name":"Finger joint","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C154020017","wikidata":"https://www.wikidata.org/wiki/Q520171","display_name":"Repeatability","level":2,"score":0.27639999985694885},{"id":"https://openalex.org/C2777286522","wikidata":"https://www.wikidata.org/wiki/Q900415","display_name":"Photoacoustic spectroscopy","level":3,"score":0.2720000147819519},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.26269999146461487},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.25540000200271606}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1364/opticaopen.30460610","doi":"https://doi.org/10.1364/opticaopen.30460610","is_oa":true,"landing_page_url":"https://doi.org/10.1364/opticaopen.30460610","pdf_url":"https://preprints.opticaopen.org/articles/preprint/Predicting_Wrist_Osteoporosis_from_excised_human_finger_bones_using_spatially_offset_Raman_spectroscopy_A_Cadaveric_Study/30460610/1/files/59101370.pdf","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Optica Open","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1364/opticaopen.30460610","doi":"https://doi.org/10.1364/opticaopen.30460610","is_oa":true,"landing_page_url":"https://doi.org/10.1364/opticaopen.30460610","pdf_url":"https://preprints.opticaopen.org/articles/preprint/Predicting_Wrist_Osteoporosis_from_excised_human_finger_bones_using_spatially_offset_Raman_spectroscopy_A_Cadaveric_Study/30460610/1/files/59101370.pdf","source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Optica Open","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415608279.pdf","grobid_xml":"https://content.openalex.org/works/W4415608279.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4388270339","https://openalex.org/W7133618604","https://openalex.org/W7202275986","https://openalex.org/W4323306815","https://openalex.org/W7124593196","https://openalex.org/W2995941800","https://openalex.org/W4393315275","https://openalex.org/W3209957860","https://openalex.org/W2002011169","https://openalex.org/W2113583319"],"abstract_inverted_index":{"Osteoporosis":[0],"and":[1,57,59,94,103,137,155,158,161,164,173,184,223,250],"osteopenia":[2,58],"remain":[3],"vastly":[4],"underdiagnosed.":[5],"Current":[6],"clinical":[7],"screening":[8],"relies":[9],"almost":[10],"exclusively":[11],"on":[12,70],"dual-energy":[13],"X-ray":[14],"absorptiometry":[15],"(DXA),":[16],"which":[17],"measures":[18],"bone":[19],"mineral":[20],"density":[21],"(BMD)":[22],"but":[23],"fails":[24],"to":[25,32,44,114,247],"capture":[26],"the":[27,71,74,78,86,115,121,132,178,185,197,207,264,269],"compositional":[28],"changes":[29,249],"that":[30,241,251],"lead":[31],"BMD":[33],"loss.":[34],"We":[35],"investigated":[36],"whether":[37],"Spatially":[38],"Offset":[39],"Raman":[40,64,253,274],"Spectroscopy":[41],"(SORS)":[42],"applied":[43],"excised":[45],"finger":[46],"bones":[47],"can":[48],"assess":[49],"subsurface":[50,273],"biochemical":[51,248],"markers":[52],"capable":[53],"of":[54,73,77,100,120,144,219,227,229,236,263],"diagnosing":[55],"osteoporosis":[56],"predicting":[60],"wrist":[61],"DXA":[62,213,261],"T-scores.":[63],"spectra":[65,113,119,209,254],"were":[66],"acquired":[67],"ex":[68],"vivo":[69],"mid-shaft":[72],"proximal":[75],"phalanx":[76],"second":[79],"digit":[80],"from":[81,106,206],"25":[82],"female":[83],"cadavers":[84],"spanning":[85],"three":[87,122],"T-score":[88,214,231],"categories":[89],"(n=8":[90],"normal,":[91],"n=6":[92],"osteopenic,":[93],"n=11":[95],"osteoporotic)":[96],"at":[97,125],"spatial":[98],"offsets":[99],"0,":[101],"3,":[102],"6":[104],"mm":[105],"a":[107,216,224,242,277],"laser":[108],"irradiation":[109],"spot.":[110],"After":[111],"normalizing":[112],"PO43-":[116],"peak,":[117],"group-averaged":[118],"categories,":[123],"measured":[124],"3-mm":[126,198,208],"offset,":[127],"showed":[128,168],"clear":[129],"differences":[130,170],"in":[131],"CO32-,":[133],"Amide":[134,138],"III,":[135],"CH2,":[136],"I":[139],"bands.":[140],"Quantitatively,":[141],"four":[142],"out":[143],"five":[145,166],"mineral-to-matrix":[146],"ratios":[147,167],"differed":[148],"significantly":[149],"(p":[150],"\u2264":[151],"0.05)":[152],"between":[153,159,171,192],"normal":[154,172],"osteopenic":[156,160],"bone,":[157,163],"osteoporotic":[162,174],"all":[165],"significant":[169],"bone.":[175],"In":[176],"contrast,":[177,183],"0-mm":[179],"offset":[180,187,244],"suffered":[181],"diminished":[182],"6-mm":[186],"did":[188],"not":[189],"enhance":[190],"discrimination":[191],"different":[193],"groups,":[194],"compared":[195],"with":[196,215],"offset.":[199],"A":[200],"leave-one-out,":[201],"partial-least-squares":[202],"regression":[203],"model":[204],"built":[205],"predicted":[210],"distal":[211],"radius":[212],"Pearson":[217],"correlation":[218],"r":[220],"=":[221],"0.85":[222],"root-mean-square":[225],"error":[226],"cross-validation":[228],"\u22481":[230],"units,":[232],"correctly":[233],"classifying":[234],"92%":[235],"specimens.":[237],"These":[238],"results":[239],"demonstrate":[240],"SORS":[243],"provides":[245],"sensitivity":[246],"phalangeal":[252],"might":[255],"serve":[256],"as":[257],"non-ionizing":[258],"surrogates":[259],"for":[260,271,282],"metrics":[262],"wrist.":[265],"The":[266],"findings":[267],"lay":[268],"groundwork":[270],"translating":[272],"spectroscopy":[275],"into":[276],"fast,":[278],"non-invasive":[279],"prescreening":[280],"tool":[281],"osteoporosis.":[283]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-28T00:00:00"}
