{"id":"https://openalex.org/W4415604658","doi":"https://doi.org/10.3389/fcell.2025.1623814","title":"FGF2 supports NANOG expression via pyruvate dehydrogenase\u2013dependent histone acetylation under low oxygen conditions","display_name":"FGF2 supports NANOG expression via pyruvate dehydrogenase\u2013dependent histone acetylation under low oxygen conditions","publication_year":2025,"publication_date":"2025-10-28","ids":{"openalex":"https://openalex.org/W4415604658","doi":"https://doi.org/10.3389/fcell.2025.1623814","pmid":"https://pubmed.ncbi.nlm.nih.gov/41230500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12602506"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2025.1623814","doi":"https://doi.org/10.3389/fcell.2025.1623814","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2025.1623814","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1623814/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1623814/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003999875","display_name":"Petr Fojt\u00edk","orcid":"https://orcid.org/0000-0003-0188-0022","observed_orcids":["https://orcid.org/0000-0003-0188-0022"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petr Fojt\u00edk","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066696007","display_name":"Martin \u0160enfluk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Martin Senfluk","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053619151","display_name":"Kate\u0159ina Holomkov\u00e1","orcid":"https://orcid.org/0000-0002-5133-4946","observed_orcids":["https://orcid.org/0000-0002-5133-4946"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Katerina Holomkova","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013550266","display_name":"Anton Salykin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Anton Salykin","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022860253","display_name":"Jana Gregorov\u00e1","orcid":"https://orcid.org/0000-0002-3639-6559","observed_orcids":["https://orcid.org/0000-0002-3639-6559"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jana Gregorova","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043139384","display_name":"Pavel \u0160mak","orcid":"https://orcid.org/0000-0001-8610-5601","observed_orcids":["https://orcid.org/0000-0001-8610-5601"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Pavel Smak","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086992295","display_name":"Ond\u0159ej Pe\u0161","orcid":"https://orcid.org/0000-0002-1325-0418","observed_orcids":["https://orcid.org/0000-0002-1325-0418"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ondrej Pes","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084144300","display_name":"Jan Ra\u0161ka","orcid":"https://orcid.org/0000-0001-7957-0214","observed_orcids":["https://orcid.org/0000-0001-7957-0214"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Raska","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045033302","display_name":"Deborah Beckerov\u00e1","orcid":"https://orcid.org/0000-0002-6238-7365","observed_orcids":["https://orcid.org/0000-0002-6238-7365"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Deborah Beckerova","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021726103","display_name":"Monika \u0160t\u011btkov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Monika Stetkova","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011789826","display_name":"Petr Skl\u00e1dal","orcid":"https://orcid.org/0000-0002-3868-5725","observed_orcids":["https://orcid.org/0000-0002-3868-5725"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Petr Skladal","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064310351","display_name":"Miroslava Sedl\u00e1\u010dkov\u00e1","orcid":"https://orcid.org/0000-0002-9874-2285","observed_orcids":["https://orcid.org/0000-0002-9874-2285"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Miroslava Sedlackova","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049557870","display_name":"Ale\u0161 Hampl","orcid":"https://orcid.org/0000-0002-8963-9235","observed_orcids":["https://orcid.org/0000-0002-8963-9235"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ales Hampl","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031390336","display_name":"D\u00e1\u0161a Boha\u010diakov\u00e1","orcid":"https://orcid.org/0000-0002-9538-6668","observed_orcids":["https://orcid.org/0000-0002-9538-6668"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Dasa Bohaciakova","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059927382","display_name":"Stjepan Uldrijan","orcid":"https://orcid.org/0000-0001-8316-2539","observed_orcids":["https://orcid.org/0000-0001-8316-2539"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Stjepan Uldrijan","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060018992","display_name":"Vladim\u00edr Rotrekl","orcid":"https://orcid.org/0000-0002-1298-0849","observed_orcids":["https://orcid.org/0000-0002-1298-0849"]},"institutions":[{"id":"https://openalex.org/I21449261","display_name":"Masaryk University","ror":"https://ror.org/02j46qs45","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21449261"]},{"id":"https://openalex.org/I4210114565","display_name":"International Clinical Research Center, St. Anne's University Hospital Brno","ror":"https://ror.org/027v97282","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]},{"id":"https://openalex.org/I4210136987","display_name":"St. Anne's University Hospital Brno","ror":"https://ror.org/049bjee35","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210136987"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Vladimir Rotrekl","raw_affiliation_strings":["Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czechia","institution_ids":["https://openalex.org/I21449261"]},{"raw_affiliation_string":"International Clinical Research Center (ICRC), St. Anne's University Hospital, Brno, Czechia","institution_ids":["https://openalex.org/I4210114565","https://openalex.org/I4210136987"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060018992"],"corresponding_institution_ids":["https://openalex.org/I21449261","https://openalex.org/I4210114565","https://openalex.org/I4210136987"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.4898,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.82153391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"13","issue":null,"first_page":"1623814","last_page":"1623814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf2-signaling","display_name":"FGF2 signaling","score":0.8349999785423279},{"id":"https://openalex.org/keywords/nanog","display_name":"Nanog","score":0.8489999771118164},{"id":"https://openalex.org/keywords/pyruvate-dehydrogenase","display_name":"pyruvate dehydrogenase","score":0.9419999718666077},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pluripotency","display_name":"pluripotency","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.6340000033378601},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8479999899864197},{"id":"https://openalex.org/keywords/acetyl-coa","display_name":"acetyl-CoA","score":0.6759999990463257},{"id":"https://openalex.org/keywords/aerobic-glycolysis","display_name":"aerobic glycolysis","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mek-erk-signaling","display_name":"MEK/ERK signaling","score":0.9430000185966492},{"id":"https://openalex.org/keywords/human-pluripotent-stem-cells","display_name":"human pluripotent stem cells","score":0.8320000171661377},{"id":"https://openalex.org/keywords/redox-signaling","display_name":"redox signaling","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6509000062942505},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.6424999833106995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5745000243186951},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.5266000032424927},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.4884999990463257},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4214000105857849},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.38499999046325684},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.3790999948978424},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.37139999866485596},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.35510000586509705},{"id":"https://openalex.org/C207701140","wikidata":"https://www.wikidata.org/wiki/Q420522","display_name":"Homeobox protein NANOG","level":5,"score":0.35120001435279846},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.3479999899864197},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.3294999897480011},{"id":"https://openalex.org/C10730799","wikidata":"https://www.wikidata.org/wiki/Q18030568","display_name":"PKM2","level":5,"score":0.3248000144958496},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.319599986076355},{"id":"https://openalex.org/C20251656","wikidata":"https://www.wikidata.org/wiki/Q162643","display_name":"Glycolysis","level":3,"score":0.3116999864578247},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2971000075340271},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2964000105857849},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.2630999982357025},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25780001282691956}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2025.1623814","doi":"https://doi.org/10.3389/fcell.2025.1623814","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2025.1623814","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1623814/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"doi:10.1101/2023.01.20.524871","doi":"https://doi.org/10.1101/2023.01.20.524871","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2023.01.20.524871","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2023/01/20/2023.01.20.524871.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11410957","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12602506","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41230500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41230500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ebe89b4faead46f283c7fd7dfd69f85e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ebe89b4faead46f283c7fd7dfd69f85e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 13 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2025.1623814","doi":"https://doi.org/10.3389/fcell.2025.1623814","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2025.1623814","pdf_url":"https://public-pages-files-2025.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1623814/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2351268093","display_name":"CETOCOEN Excellence","funder_award_id":"857560","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3184942225","display_name":"Multiscale quantum bio-imaging and spectroscopy","funder_award_id":"101070546","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320327186","display_name":"L\u00e9ka\u0159sk\u00e1 fakulta, Masarykova univerzita","ror":null},{"id":"https://openalex.org/F4320334322","display_name":"HORIZON EUROPE Framework Programme","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415604658.pdf","grobid_xml":"https://content.openalex.org/works/W4415604658.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W565843157","https://openalex.org/W1546273936","https://openalex.org/W1651083567","https://openalex.org/W1679088767","https://openalex.org/W1823204572","https://openalex.org/W1856939756","https://openalex.org/W1951419265","https://openalex.org/W1969836970","https://openalex.org/W1971581297","https://openalex.org/W1972782503","https://openalex.org/W1973248503","https://openalex.org/W1980429500","https://openalex.org/W1982298098","https://openalex.org/W1984770187","https://openalex.org/W1987285745","https://openalex.org/W1993824241","https://openalex.org/W1994404746","https://openalex.org/W1994759068","https://openalex.org/W1994863097","https://openalex.org/W1995338702","https://openalex.org/W1995833967","https://openalex.org/W2000157901","https://openalex.org/W2000624133","https://openalex.org/W2000697370","https://openalex.org/W2003975298","https://openalex.org/W2004989087","https://openalex.org/W2005833897","https://openalex.org/W2008946188","https://openalex.org/W2010394923","https://openalex.org/W2011646732","https://openalex.org/W2011653215","https://openalex.org/W2019019085","https://openalex.org/W2019367703","https://openalex.org/W2025192477","https://openalex.org/W2026214905","https://openalex.org/W2027705428","https://openalex.org/W2028268047","https://openalex.org/W2029223706","https://openalex.org/W2033938885","https://openalex.org/W2033958147","https://openalex.org/W2035049195","https://openalex.org/W2038074574","https://openalex.org/W2043457504","https://openalex.org/W2043549608","https://openalex.org/W2045387875","https://openalex.org/W2045410354","https://openalex.org/W2047685803","https://openalex.org/W2049555359","https://openalex.org/W2063395944","https://openalex.org/W2064178384","https://openalex.org/W2072844557","https://openalex.org/W2073212505","https://openalex.org/W2080411308","https://openalex.org/W2084201375","https://openalex.org/W2101572834","https://openalex.org/W2111406434","https://openalex.org/W2112104218","https://openalex.org/W2117623697","https://openalex.org/W2127629715","https://openalex.org/W2131750155","https://openalex.org/W2132619798","https://openalex.org/W2134724797","https://openalex.org/W2135881241","https://openalex.org/W2142806844","https://openalex.org/W2144575277","https://openalex.org/W2146070554","https://openalex.org/W2148332948","https://openalex.org/W2158074192","https://openalex.org/W2163102268","https://openalex.org/W2168330194","https://openalex.org/W2277468569","https://openalex.org/W2291598966","https://openalex.org/W2292259030","https://openalex.org/W2318121458","https://openalex.org/W2346976868","https://openalex.org/W2402705657","https://openalex.org/W2516724335","https://openalex.org/W2521029421","https://openalex.org/W2564474486","https://openalex.org/W2568510753","https://openalex.org/W2578505993","https://openalex.org/W2593816418","https://openalex.org/W2619437071","https://openalex.org/W2735175936","https://openalex.org/W2740928018","https://openalex.org/W2752067270","https://openalex.org/W2783114553","https://openalex.org/W2795140951","https://openalex.org/W2802720142","https://openalex.org/W2807936922","https://openalex.org/W2884914467","https://openalex.org/W2893385376","https://openalex.org/W2902109548","https://openalex.org/W2902256938","https://openalex.org/W2903847535","https://openalex.org/W2937511191","https://openalex.org/W2941869121","https://openalex.org/W2944224779","https://openalex.org/W2945027985","https://openalex.org/W2947873326","https://openalex.org/W2952265240","https://openalex.org/W2955111823","https://openalex.org/W2962404533","https://openalex.org/W2963097804","https://openalex.org/W2976160240","https://openalex.org/W3004418456","https://openalex.org/W3006012565","https://openalex.org/W3006937932","https://openalex.org/W3008592960","https://openalex.org/W3013352992","https://openalex.org/W3033550003","https://openalex.org/W3093962163","https://openalex.org/W3105639016","https://openalex.org/W3108422731","https://openalex.org/W3112489042","https://openalex.org/W3124200902","https://openalex.org/W3189164194","https://openalex.org/W3213309159","https://openalex.org/W4310568099","https://openalex.org/W4386590156","https://openalex.org/W4396734336"],"related_works":["https://openalex.org/W4317583953","https://openalex.org/W2945027985","https://openalex.org/W4310568099","https://openalex.org/W3138895093","https://openalex.org/W4416388863","https://openalex.org/W1547681285","https://openalex.org/W3124200902","https://openalex.org/W2977856809","https://openalex.org/W2072844557","https://openalex.org/W7008451498"],"abstract_inverted_index":{"Introduction:":[0],"The":[1],"safe":[2],"and":[3,14,22,32,40,73,82,112,126,134,142,150,164,197,239,257],"effective":[4],"application":[5],"of":[6,124,168,222,234,248],"human":[7],"pluripotent":[8],"stem":[9,254],"cells":[10],"(hPSCs)":[11],"in":[12,109,243],"research":[13],"regenerative":[15],"medicine":[16],"requires":[17],"precise":[18],"control":[19,221],"over":[20],"pluripotency":[21,74,130,170,223],"cell":[23,255],"fate.":[24],"Pluripotency":[25],"is":[26],"characterized":[27],"by":[28,49,98,139,148,153,224],"high":[29],"histone":[30,62,71,88,161],"acetylation":[31,72,89,163],"aerobic":[33],"glycolysis,":[34],"while":[35],"differentiation":[36,258],"involves":[37],"metabolic":[38,213],"remodeling":[39],"reduced":[41],"acetylation.":[42,63],"Pyruvate":[43],"dehydrogenase":[44],"(PDH)":[45],"links":[46],"these":[47],"processes":[48],"converting":[50],"glycolytic":[51],"pyruvate":[52],"into":[53],"acetyl":[54],"coenzyme":[55],"A":[56],"(Ac-CoA),":[57],"the":[58,166,169,219,232,245],"key":[59],"substrate":[60],"for":[61,252],"Methods:":[64],"We":[65],"investigated":[66],"how":[67],"PDH":[68,85,95,125,158,187,209],"activity":[69,188],"regulates":[70,186],"maintenance":[75],"under":[76,174,199],"physiologically":[77],"relevant":[78],"oxygen":[79,114,201,235],"levels":[80,133,152,202],"(5%":[81],"21%":[83],"O\u2082).":[84,204],"contribution":[86],"to":[87,107,120],"was":[90,195],"assessed":[91],"using":[92,117],"a":[93,180,211],"specific":[94],"inhibitor,":[96],"followed":[97],"rescue":[99],"experiments":[100],"with":[101,218,250],"acetyl-CoA":[102],"precursors.":[103],"hPSCs":[104],"were":[105,137],"exposed":[106],"variations":[108],"FGF2":[110],"signaling":[111,183,242],"reactive":[113],"species":[115],"(ROS)":[116],"H\u2082O\u2082":[118],"treatment":[119],"evaluate":[121],"redox-dependent":[122],"modulation":[123],"downstream":[127],"effects":[128],"on":[129],"factors.":[131],"Protein":[132],"post-translational":[135],"modifications":[136],"analyzed":[138],"Western":[140],"blotting":[141],"quantitative":[143],"PCR,":[144],"relative":[145],"metabolite":[146],"concentrations":[147],"LC-MS,":[149],"ROS":[151,237],"fluorescence":[154],"microscopy.":[155],"Results:":[156],"Active":[157],"promoted":[159],"global":[160],"H3":[162],"upregulated":[165],"expression":[167],"factor":[171,241],"NANOG,":[172],"specifically":[173],"5%":[175],"O\u2082.":[176],"Mechanistic":[177],"analysis":[178],"revealed":[179],"novel":[181],"FGF2-MEK1/2-ERK1/2-ROS":[182],"axis":[184],"that":[185],"through":[189],"redox-sensitive":[190,212],"mechanisms.":[191],"This":[192],"regulatory":[193],"pathway":[194],"oxygen-dependent":[196],"absent":[198],"atmospheric":[200],"(21%":[203],"Discussion:":[205],"These":[206],"findings":[207],"identify":[208],"as":[210],"switch":[214],"connecting":[215],"cellular":[216],"metabolism":[217],"epigenetic":[220],"modulating":[225],"Ac-CoA":[226],"availability.":[227],"Conclusion:":[228],"Our":[229],"study":[230],"highlights":[231],"importance":[233],"tension,":[236],"homeostasis,":[238],"growth":[240],"shaping":[244],"metabolic-epigenetic":[246],"landscape":[247],"hPSCs,":[249],"implications":[251],"optimizing":[253],"culture":[256],"protocols.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-28T00:00:00"}