{"id":"https://openalex.org/W4415600767","doi":"https://doi.org/10.1038/s41573-025-01308-z","title":"Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety","display_name":"Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety","publication_year":2025,"publication_date":"2025-10-27","ids":{"openalex":"https://openalex.org/W4415600767","doi":"https://doi.org/10.1038/s41573-025-01308-z","pmid":"https://pubmed.ncbi.nlm.nih.gov/41145622"},"language":"en","primary_location":{"id":"doi:10.1038/s41573-025-01308-z","doi":"https://doi.org/10.1038/s41573-025-01308-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41573-025-01308-z","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A4293259/view","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022911613","display_name":"Christopher E. Goldring","orcid":"https://orcid.org/0000-0002-8951-2226","observed_orcids":["https://orcid.org/0000-0002-8951-2226","https://orcid.org/0009-0003-9645-6394"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Christopher E. Goldring","raw_affiliation_strings":["Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. C.E.P.Goldring@liverpool.ac.uk","Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"],"raw_orcid":"https://orcid.org/0000-0002-8951-2226","affiliations":[{"raw_affiliation_string":"Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. C.E.P.Goldring@liverpool.ac.uk","institution_ids":["https://openalex.org/I146655781"]},{"raw_affiliation_string":"Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074112347","display_name":"Giusy Russomanno","orcid":"https://orcid.org/0000-0002-3378-5524","observed_orcids":["https://orcid.org/0000-0002-3378-5524"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giusy Russomanno","raw_affiliation_strings":["Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"],"raw_orcid":"https://orcid.org/0000-0002-3378-5524","affiliations":[{"raw_affiliation_string":"Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089750423","display_name":"Carmen Pin","orcid":"https://orcid.org/0000-0001-8734-6167","observed_orcids":["https://orcid.org/0000-0001-8734-6167"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carmen Pin","raw_affiliation_strings":["Systems Medicine, Clinical Pharmacology and Safety Sciences, R&D Department, AstraZeneca, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0001-8734-6167","affiliations":[{"raw_affiliation_string":"Systems Medicine, Clinical Pharmacology and Safety Sciences, R&D Department, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008563172","display_name":"Panuwat Trairatphisan","orcid":"https://orcid.org/0000-0001-9015-5855","observed_orcids":["https://orcid.org/0000-0001-9015-5855"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]},{"id":"https://openalex.org/I4210128201","display_name":"AbbVie (Germany)","ror":"https://ror.org/03538jp08","country_code":"DE","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4210128201"]},{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Panuwat Trairatphisan","raw_affiliation_strings":["AbbVie Deutschland, Ludwigshafen, Germany","Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany","Sanofi Research and Development, Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9015-5855","affiliations":[{"raw_affiliation_string":"AbbVie Deutschland, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210128201"]},{"raw_affiliation_string":"Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]},{"raw_affiliation_string":"Sanofi Research and Development, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013350706","display_name":"Kylie A. Beattie","orcid":"https://orcid.org/0000-0002-8579-6321","observed_orcids":["https://orcid.org/0000-0002-8579-6321"]},"institutions":[{"id":"https://openalex.org/I4405268060","display_name":"GlaxoSmithKline Research & Development Limited (United Kingdom)","ror":"https://ror.org/05mayyh83","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268060"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kylie A. Beattie","raw_affiliation_strings":["GSK Research and Development, Stevenage, UK"],"raw_orcid":"https://orcid.org/0000-0002-8579-6321","affiliations":[{"raw_affiliation_string":"GSK Research and Development, Stevenage, UK","institution_ids":["https://openalex.org/I4405268060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036949685","display_name":"Ciar\u00e1n Fisher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268060","display_name":"GlaxoSmithKline Research & Development Limited (United Kingdom)","ror":"https://ror.org/05mayyh83","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268060"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ciar\u00e1n P. Fisher","raw_affiliation_strings":["GSK Research and Development, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK Research and Development, Stevenage, UK","institution_ids":["https://openalex.org/I4405268060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054199754","display_name":"Janet Pi\u00f1ero","orcid":"https://orcid.org/0000-0003-1244-7654","observed_orcids":["https://orcid.org/0000-0003-1244-7654"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Janet Pi\u00f1ero","raw_affiliation_strings":["MedBioinformatics Solutions SL, Barcelona, Spain","Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) and Dept. of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1244-7654","affiliations":[{"raw_affiliation_string":"MedBioinformatics Solutions SL, Barcelona, Spain","institution_ids":[]},{"raw_affiliation_string":"Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) and Dept. of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064989100","display_name":"Richard Brennan","orcid":"https://orcid.org/0000-0002-0449-2730","observed_orcids":["https://orcid.org/0000-0002-0449-2730"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J. Brennan","raw_affiliation_strings":["Sanofi Research and Development, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanofi Research and Development, Cambridge, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009698902","display_name":"Diana Clausznitzer","orcid":"https://orcid.org/0009-0008-4752-115X","observed_orcids":["https://orcid.org/0009-0008-4752-115X"]},"institutions":[{"id":"https://openalex.org/I4210128201","display_name":"AbbVie (Germany)","ror":"https://ror.org/03538jp08","country_code":"DE","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4210128201"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Diana Clausznitzer","raw_affiliation_strings":["AbbVie Deutschland, Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Deutschland, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210128201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049530044","display_name":"Ian M. Copple","orcid":"https://orcid.org/0000-0003-4101-1913","observed_orcids":["https://orcid.org/0000-0003-4101-1913"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian M. Copple","raw_affiliation_strings":["Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048229400","display_name":"Theo M. C. M. de Kok","orcid":"https://orcid.org/0000-0003-2102-3626","observed_orcids":["https://orcid.org/0000-0003-2102-3626"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Theo M. de Kok","raw_affiliation_strings":["Department of Translational Genomics, GROW Research Institute for Oncology and Developmental Biology, Universiteit Maastricht, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-2102-3626","affiliations":[{"raw_affiliation_string":"Department of Translational Genomics, GROW Research Institute for Oncology and Developmental Biology, Universiteit Maastricht, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046711791","display_name":"Carrie A. Duckworth","orcid":"https://orcid.org/0000-0001-9992-7540","observed_orcids":["https://orcid.org/0000-0001-9992-7540"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Carrie A. Duckworth","raw_affiliation_strings":["Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028427590","display_name":"Laura Ines Furlong","orcid":"https://orcid.org/0000-0002-9383-528X","observed_orcids":["https://orcid.org/0000-0002-9383-528X"]},"institutions":[{"id":"https://openalex.org/I170486558","display_name":"Universitat Pompeu Fabra","ror":"https://ror.org/04n0g0b29","country_code":"ES","type":"education","lineage":["https://openalex.org/I170486558"]},{"id":"https://openalex.org/I4210130874","display_name":"Hospital Del Mar","ror":"https://ror.org/03a8gac78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210130874"]},{"id":"https://openalex.org/I4210136145","display_name":"Municipal Institute for Medical Research","ror":"https://ror.org/039evc422","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210136145"]},{"id":"https://openalex.org/I4210156109","display_name":"Hospital del Mar Research Institute","ror":"https://ror.org/042nkmz09","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210156109","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura I. Furlong","raw_affiliation_strings":["MedBioinformatics Solutions SL, Barcelona, Spain","Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) and Dept. of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedBioinformatics Solutions SL, Barcelona, Spain","institution_ids":[]},{"raw_affiliation_string":"Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM) and Dept. of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain","institution_ids":["https://openalex.org/I170486558","https://openalex.org/I4210130874","https://openalex.org/I4210136145","https://openalex.org/I4210156109"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044694431","display_name":"Barbara F\u00fczi","orcid":"https://orcid.org/0000-0001-5395-7920","observed_orcids":["https://orcid.org/0000-0001-5395-7920"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Barbara F\u00fczi","raw_affiliation_strings":["Universit\u00e4t Wien, Wien, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e4t Wien, Wien, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050239570","display_name":"Attila G\u00e1bor","orcid":"https://orcid.org/0000-0002-0776-1182","observed_orcids":["https://orcid.org/0000-0002-0776-1182"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Attila Gabor","raw_affiliation_strings":["Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032556608","display_name":"Louis Gall","orcid":"https://orcid.org/0000-0002-1805-2357","observed_orcids":["https://orcid.org/0000-0002-1805-2357"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Louis Gall","raw_affiliation_strings":["Systems Medicine, Clinical Pharmacology and Safety Sciences, R&D Department, AstraZeneca, Cambridge, UK"],"raw_orcid":"https://orcid.org/0000-0002-1805-2357","affiliations":[{"raw_affiliation_string":"Systems Medicine, Clinical Pharmacology and Safety Sciences, R&D Department, AstraZeneca, Cambridge, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044367456","display_name":"Jan Georg Hengstler","orcid":"https://orcid.org/0000-0002-1427-5246","observed_orcids":["https://orcid.org/0000-0002-1427-5246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Hengstler","raw_affiliation_strings":["Forschungsgesellschaft f\u00fcr Arbeitsphysiologie und Arbeitsschutz e.V, Dortmund, Germany"],"raw_orcid":"https://orcid.org/0000-0002-1427-5246","affiliations":[{"raw_affiliation_string":"Forschungsgesellschaft f\u00fcr Arbeitsphysiologie und Arbeitsschutz e.V, Dortmund, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066783652","display_name":"Henning Hermjakob","orcid":"https://orcid.org/0000-0001-8479-0262","observed_orcids":["https://orcid.org/0000-0001-8479-0262"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Henning Hermjakob","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK"],"raw_orcid":"https://orcid.org/0000-0001-8479-0262","affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035752579","display_name":"Fiona M. I. Hunter","orcid":"https://orcid.org/0000-0001-7160-1880","observed_orcids":["https://orcid.org/0000-0001-7160-1880"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Fiona Hunter","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK"],"raw_orcid":"https://orcid.org/0000-0001-7160-1880","affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073937073","display_name":"Danyel G. J. Jennen","orcid":"https://orcid.org/0000-0002-8618-2487","observed_orcids":["https://orcid.org/0000-0002-8618-2487"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Danyel Jennen","raw_affiliation_strings":["Department of Translational Genomics, GROW Research Institute for Oncology and Developmental Biology, Universiteit Maastricht, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-8618-2487","affiliations":[{"raw_affiliation_string":"Department of Translational Genomics, GROW Research Institute for Oncology and Developmental Biology, Universiteit Maastricht, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033341707","display_name":"Mikko Koskinen","orcid":"https://orcid.org/0000-0003-2033-051X","observed_orcids":["https://orcid.org/0000-0003-2033-051X"]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mikko Koskinen","raw_affiliation_strings":["Orion Pharma, Orion Corporation, Espoo, Finland"],"raw_orcid":"https://orcid.org/0000-0003-2033-051X","affiliations":[{"raw_affiliation_string":"Orion Pharma, Orion Corporation, Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037018875","display_name":"Steven J. Kunnen","orcid":"https://orcid.org/0000-0001-9549-1719","observed_orcids":["https://orcid.org/0000-0001-9549-1719"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Steven J. Kunnen","raw_affiliation_strings":["Universiteit Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-9549-1719","affiliations":[{"raw_affiliation_string":"Universiteit Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067799700","display_name":"Lieve Lammens","orcid":"https://orcid.org/0000-0002-7683-8745","observed_orcids":["https://orcid.org/0000-0002-7683-8745"]},"institutions":[{"id":"https://openalex.org/I85459889","display_name":"Galapagos (Belgium)","ror":"https://ror.org/04e4j5d46","country_code":"BE","type":"company","lineage":["https://openalex.org/I85459889"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lieve Lammens","raw_affiliation_strings":["Galapagos NV, Mechelen, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Galapagos NV, Mechelen, Belgium","institution_ids":["https://openalex.org/I85459889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021965999","display_name":"Sebastian Lobentanzer","orcid":"https://orcid.org/0000-0003-3399-6695","observed_orcids":["https://orcid.org/0000-0003-3399-6695"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Lobentanzer","raw_affiliation_strings":["Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3399-6695","affiliations":[{"raw_affiliation_string":"Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004618989","display_name":"Marcel Mohr","orcid":"https://orcid.org/0000-0001-6553-8651","observed_orcids":["https://orcid.org/0000-0001-6553-8651"]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcel Mohr","raw_affiliation_strings":["Sanofi Research and Development, Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0001-6553-8651","affiliations":[{"raw_affiliation_string":"Sanofi Research and Development, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091104856","display_name":"Elisa Passini","orcid":"https://orcid.org/0000-0003-0116-6347","observed_orcids":["https://orcid.org/0000-0003-0116-6347"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]},{"id":"https://openalex.org/I4210136630","display_name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","ror":"https://ror.org/02w0kg036","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210136630"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elisa Passini","raw_affiliation_strings":["Department of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK","NC3Rs - National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, UK"],"raw_orcid":"https://orcid.org/0000-0003-0116-6347","affiliations":[{"raw_affiliation_string":"Department of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"NC3Rs - National Centre for the Replacement, Refinement and Reduction of Animals in Research, London, UK","institution_ids":["https://openalex.org/I4210136630"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033056161","display_name":"David Mark Pritchard","orcid":"https://orcid.org/0000-0001-7971-3561","observed_orcids":["https://orcid.org/0000-0001-7971-3561"]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"D. Mark Pritchard","raw_affiliation_strings":["Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"],"raw_orcid":"https://orcid.org/0000-0001-7971-3561","affiliations":[{"raw_affiliation_string":"Department of Molecular and Clinical Cancer Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024795670","display_name":"Rahuman S. Malik\u2010Sheriff","orcid":"https://orcid.org/0000-0003-0705-9809","observed_orcids":["https://orcid.org/0000-0003-0705-9809"]},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rahuman S. Malik-Sheriff","raw_affiliation_strings":["European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Hinxton, UK","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067810825","display_name":"Blanca Rodr\u00edguez","orcid":"https://orcid.org/0000-0001-6361-3339","observed_orcids":["https://orcid.org/0000-0001-6361-3339","https://orcid.org/0000-0002-3435-7388","https://orcid.org/0000-0002-5814-7190"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Blanca Rodr\u00edguez","raw_affiliation_strings":["Department of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, British Heart Foundation Centre of Research Excellence, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091307956","display_name":"Eric I. Rossman","orcid":"https://orcid.org/0000-0002-5285-6754","observed_orcids":["https://orcid.org/0000-0002-5285-6754"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric I. Rossman","raw_affiliation_strings":["GSK, Collegeville, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"GSK, Collegeville, PA, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005499510","display_name":"Julio S\u00e1ez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-8552-8976","observed_orcids":["https://orcid.org/0000-0002-8552-8976"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julio Saez-Rodr\u00edguez","raw_affiliation_strings":["Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8552-8976","affiliations":[{"raw_affiliation_string":"Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102966370","display_name":"Friedemann Schmidt","orcid":"https://orcid.org/0000-0003-0265-0974","observed_orcids":["https://orcid.org/0000-0003-0265-0974"]},"institutions":[{"id":"https://openalex.org/I4210138838","display_name":"Sanofi (Germany)","ror":"https://ror.org/03ytdtb31","country_code":"DE","type":"company","lineage":["https://openalex.org/I3018075036","https://openalex.org/I4210138838"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Friedemann Schmidt","raw_affiliation_strings":["Sanofi Research and Development, Frankfurt am Main, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0265-0974","affiliations":[{"raw_affiliation_string":"Sanofi Research and Development, Frankfurt am Main, Germany","institution_ids":["https://openalex.org/I4210138838"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083272657","display_name":"Rowena L. C. Sison-Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I146655781","display_name":"University of Liverpool","ror":"https://ror.org/04xs57h96","country_code":"GB","type":"education","lineage":["https://openalex.org/I146655781"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rowena Sison-Young","raw_affiliation_strings":["Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Drug Safety Science, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK","institution_ids":["https://openalex.org/I146655781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083230265","display_name":"Inari Soininen","orcid":"https://orcid.org/0000-0002-2428-5245","observed_orcids":["https://orcid.org/0000-0002-2428-5245"]},"institutions":[{"id":"https://openalex.org/I4210107945","display_name":"Synapse (Spain)","ror":"https://ror.org/01n0jwg88","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210107945"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Inari Soininen","raw_affiliation_strings":["Synapse Research Management Partners, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0002-2428-5245","affiliations":[{"raw_affiliation_string":"Synapse Research Management Partners, Madrid, Spain","institution_ids":["https://openalex.org/I4210107945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111968550","display_name":"Sean C. MacKenzie Turner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128201","display_name":"AbbVie (Germany)","ror":"https://ror.org/03538jp08","country_code":"DE","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4210128201"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sean Turner","raw_affiliation_strings":["AbbVie Deutschland, Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AbbVie Deutschland, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210128201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081295579","display_name":"Bob van de Water","orcid":"https://orcid.org/0000-0002-5839-2380","observed_orcids":["https://orcid.org/0000-0002-5839-2380"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bob van de Water","raw_affiliation_strings":["Universiteit Leiden, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiteit Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049073682","display_name":"J. G. Coen van Hasselt","orcid":"https://orcid.org/0000-0002-1664-7314","observed_orcids":["https://orcid.org/0000-0002-1664-7314"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johan G. C. van Hasselt","raw_affiliation_strings":["Universiteit Leiden, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-1664-7314","affiliations":[{"raw_affiliation_string":"Universiteit Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088550744","display_name":"Filippo Venezia","orcid":"https://orcid.org/0000-0003-1091-4255","observed_orcids":["https://orcid.org/0000-0003-1091-4255"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Filippo Venezia","raw_affiliation_strings":["Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079846911","display_name":"Jeffrey A. Willy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I61970326","display_name":"Vertex Pharmaceuticals (United States)","ror":"https://ror.org/00anb1726","country_code":"US","type":"company","lineage":["https://openalex.org/I61970326"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Willy","raw_affiliation_strings":["Vertex Pharmaceuticals, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vertex Pharmaceuticals, Boston, MA, USA","institution_ids":["https://openalex.org/I61970326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113829375","display_name":"Derek J. Leishman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I168537998","display_name":"Eli Lilly (United States)","ror":"https://ror.org/01qat3289","country_code":"US","type":"company","lineage":["https://openalex.org/I168537998"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek J. Leishman","raw_affiliation_strings":["Eli Lilly and Company, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eli Lilly and Company, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I168537998"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015505628","display_name":"James L. Stevens","orcid":"https://orcid.org/0009-0006-9593-5299","observed_orcids":["https://orcid.org/0009-0006-9593-5299"]},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"James L. Stevens","raw_affiliation_strings":["Universiteit Leiden, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universiteit Leiden, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062315572","display_name":"Lo\u00efc Laplanche","orcid":"https://orcid.org/0000-0002-6082-9430","observed_orcids":["https://orcid.org/0000-0002-6082-9430"]},"institutions":[{"id":"https://openalex.org/I4210128201","display_name":"AbbVie (Germany)","ror":"https://ror.org/03538jp08","country_code":"DE","type":"company","lineage":["https://openalex.org/I2948539688","https://openalex.org/I4210128201"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Loic Laplanche","raw_affiliation_strings":["AbbVie Deutschland, Ludwigshafen, Germany. loic.laplanche@abbvie.com","AbbVie Deutschland, Ludwigshafen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6082-9430","affiliations":[{"raw_affiliation_string":"AbbVie Deutschland, Ludwigshafen, Germany. loic.laplanche@abbvie.com","institution_ids":["https://openalex.org/I4210128201"]},{"raw_affiliation_string":"AbbVie Deutschland, Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210128201"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":24,"corresponding_author_ids":["https://openalex.org/A5022911613","https://openalex.org/A5062315572"],"corresponding_institution_ids":["https://openalex.org/I146655781","https://openalex.org/I4210128201"],"apc_list":null,"apc_paid":null,"fwci":1.2148,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.76972625,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"2","first_page":"138","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.6884999871253967,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.12839999794960022,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.051899999380111694,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-systems-toxicology","display_name":"quantitative systems toxicology","score":1.0},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-safety-prediction","display_name":"drug safety prediction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7870000004768372},{"id":"https://openalex.org/keywords/gastrointestinal-toxicity","display_name":"gastrointestinal toxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/nephrotoxicity","display_name":"nephrotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/safety-risk-assessment","display_name":"safety risk assessment","score":0.4020000100135803}],"concepts":[{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.6765999794006348},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6132000088691711},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.555899977684021},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5467000007629395},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5217000246047974},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.4465999901294708},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4000999927520752},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.3953999876976013},{"id":"https://openalex.org/C539667460","wikidata":"https://www.wikidata.org/wiki/Q2414942","display_name":"Management science","level":1,"score":0.358599990606308},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3328999876976013},{"id":"https://openalex.org/C2993432071","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug reaction","level":3,"score":0.32350000739097595},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.32190001010894775},{"id":"https://openalex.org/C2992092908","wikidata":"https://www.wikidata.org/wiki/Q45959","display_name":"Drug toxicity","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.311599999666214},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2621000111103058}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41573-025-01308-z","doi":"https://doi.org/10.1038/s41573-025-01308-z","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41573-025-01308-z","pdf_url":null,"source":{"id":"https://openalex.org/S186543748","display_name":"Nature Reviews Drug Discovery","issn_l":"1474-1776","issn":["1474-1776","1474-1784"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"journal-article"},{"id":"pmid:41145622","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41145622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature reviews. Drug discovery","raw_type":"Journal Article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_4287220","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/4287220","pdf_url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A4293259/view","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:alma.31UKB_LEU:9940745522602711","doi":null,"is_oa":false,"landing_page_url":"https://scholarlypublications.universiteitleiden.nl/download/1887/4287220/1?col=81522199340002711","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Reviews Drug Discovery, Vol. 25, p. 138-153","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/08f0f5b8-1911-4271-afba-f975a68cc243","doi":null,"is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/08f0f5b8-1911-4271-afba-f975a68cc243","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/a986c7c1-8ffb-47b9-95c5-f843411ae995","doi":null,"is_oa":false,"landing_page_url":"https://research.birmingham.ac.uk/en/publications/a986c7c1-8ffb-47b9-95c5-f843411ae995","pdf_url":null,"source":{"id":"https://openalex.org/S4306402634","display_name":"University of Birmingham Research Portal (University of Birmingham)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79619799","host_organization_name":"University of Birmingham","host_organization_lineage":["https://openalex.org/I79619799"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_4287220","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1887/4287220","pdf_url":"https://scholarlypublications.universiteitleiden.nl/access/item%3A4293259/view","source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Reviews Drug Discovery","raw_type":"Article / Letter to editor"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G302012681","display_name":null,"funder_award_id":"116030","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G4971574390","display_name":"Human in silico clinical trials in post myocardial infarction: mechanistic investigations into phenotypic electromechanical variability and response to treatment","funder_award_id":"214290/Z/18/Z","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G8435999542","display_name":"Translational quantitative systems toxicology to improve the understanding of the safety of medicines - Sofia: 116030","funder_award_id":"116030","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8652874512","display_name":"Human in silico clinical trials in post myocardial infarction: mechanistic investigations into phenotypic electromechanical variability and response to treatment","funder_award_id":"214290","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415600767.pdf","grobid_xml":"https://content.openalex.org/works/W4415600767.grobid-xml"},"referenced_works_count":135,"referenced_works":["https://openalex.org/W1951340309","https://openalex.org/W1967105697","https://openalex.org/W1969578015","https://openalex.org/W1970401253","https://openalex.org/W1976385056","https://openalex.org/W1977247095","https://openalex.org/W1996198135","https://openalex.org/W2014372847","https://openalex.org/W2049400198","https://openalex.org/W2074062695","https://openalex.org/W2077470692","https://openalex.org/W2089133581","https://openalex.org/W2097132306","https://openalex.org/W2125060052","https://openalex.org/W2145578524","https://openalex.org/W2146402650","https://openalex.org/W2146435848","https://openalex.org/W2147670638","https://openalex.org/W2154274753","https://openalex.org/W2171913567","https://openalex.org/W2187933120","https://openalex.org/W2236915829","https://openalex.org/W2302501749","https://openalex.org/W2309887917","https://openalex.org/W2314927739","https://openalex.org/W2328527542","https://openalex.org/W2346104824","https://openalex.org/W2417773983","https://openalex.org/W2474430381","https://openalex.org/W2559592274","https://openalex.org/W2583486331","https://openalex.org/W2586869611","https://openalex.org/W2588796969","https://openalex.org/W2607063313","https://openalex.org/W2736354893","https://openalex.org/W2739866241","https://openalex.org/W2742474789","https://openalex.org/W2752492383","https://openalex.org/W2754002459","https://openalex.org/W2759966391","https://openalex.org/W2761612793","https://openalex.org/W2765161617","https://openalex.org/W2765851831","https://openalex.org/W2766644123","https://openalex.org/W2767352418","https://openalex.org/W2767891136","https://openalex.org/W2794392575","https://openalex.org/W2804500674","https://openalex.org/W2808180679","https://openalex.org/W2810085300","https://openalex.org/W2818868381","https://openalex.org/W2887856756","https://openalex.org/W2888983844","https://openalex.org/W2898112071","https://openalex.org/W2900090807","https://openalex.org/W2901254075","https://openalex.org/W2911340671","https://openalex.org/W2911749694","https://openalex.org/W2919261374","https://openalex.org/W2939552562","https://openalex.org/W2955636224","https://openalex.org/W2974351167","https://openalex.org/W2979725482","https://openalex.org/W2987425683","https://openalex.org/W2991137874","https://openalex.org/W3000689139","https://openalex.org/W3001465925","https://openalex.org/W3007299786","https://openalex.org/W3009425599","https://openalex.org/W3010152544","https://openalex.org/W3010974323","https://openalex.org/W3017407477","https://openalex.org/W3025324242","https://openalex.org/W3027042213","https://openalex.org/W3032110249","https://openalex.org/W3037410842","https://openalex.org/W3037567159","https://openalex.org/W3037765138","https://openalex.org/W3042519486","https://openalex.org/W3047209293","https://openalex.org/W3081007712","https://openalex.org/W3092554711","https://openalex.org/W3121769697","https://openalex.org/W3132502413","https://openalex.org/W3139353354","https://openalex.org/W3150252631","https://openalex.org/W3158731091","https://openalex.org/W3159130852","https://openalex.org/W3163628301","https://openalex.org/W3164967630","https://openalex.org/W3168038426","https://openalex.org/W3175801695","https://openalex.org/W3207512142","https://openalex.org/W3210331473","https://openalex.org/W4205379795","https://openalex.org/W4212773093","https://openalex.org/W4214774216","https://openalex.org/W4223410988","https://openalex.org/W4238048406","https://openalex.org/W4249825282","https://openalex.org/W4280523654","https://openalex.org/W4282560006","https://openalex.org/W4285076926","https://openalex.org/W4285085624","https://openalex.org/W4302283814","https://openalex.org/W4308211581","https://openalex.org/W4308510590","https://openalex.org/W4309306035","https://openalex.org/W4313204097","https://openalex.org/W4319436536","https://openalex.org/W4319826836","https://openalex.org/W4362700935","https://openalex.org/W4366245953","https://openalex.org/W4379185345","https://openalex.org/W4381682293","https://openalex.org/W4383102053","https://openalex.org/W4386153826","https://openalex.org/W4386193636","https://openalex.org/W4386268611","https://openalex.org/W4386697152","https://openalex.org/W4388039224","https://openalex.org/W4389487965","https://openalex.org/W4392093351","https://openalex.org/W4392662555","https://openalex.org/W4396928989","https://openalex.org/W4396999070","https://openalex.org/W4398171276","https://openalex.org/W4402135271","https://openalex.org/W4403461931","https://openalex.org/W4403537182","https://openalex.org/W4404391562","https://openalex.org/W4404553681","https://openalex.org/W4407828216","https://openalex.org/W4408535832","https://openalex.org/W4410860056"],"related_works":["https://openalex.org/W4403604862","https://openalex.org/W4413112804","https://openalex.org/W4403461931","https://openalex.org/W2148853709","https://openalex.org/W3177116930","https://openalex.org/W3161651438","https://openalex.org/W2945983369","https://openalex.org/W3000689139","https://openalex.org/W4404318906","https://openalex.org/W2912429526"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":22}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2025-10-28T00:00:00"}