{"id":"https://openalex.org/W4415600593","doi":"https://doi.org/10.1007/978-3-031-99609-2_15","title":"Mural Cells, Microvessels, and Alzheimer\u2019s Disease","display_name":"Mural Cells, Microvessels, and Alzheimer\u2019s Disease","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4415600593","doi":"https://doi.org/10.1007/978-3-031-99609-2_15"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-99609-2_15","doi":"https://doi.org/10.1007/978-3-031-99609-2_15","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-99609-2_15","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-99609-2_15.pdf","source":{"id":"https://openalex.org/S4210174491","display_name":"Physiology in health and disease","issn_l":"2625-252X","issn":["2625-252X","2625-2538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology in Health and Disease","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4415600617","display_name":"Handbook of Microcirculation"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-99609-2_15.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066759296","display_name":"Stephanie K. Bonney","orcid":"https://orcid.org/0000-0002-9519-9272","observed_orcids":["https://orcid.org/0000-0002-9519-9272"]},"institutions":[{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie K. Bonney","raw_affiliation_strings":["Seattle Children\u2019s Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seattle Children\u2019s Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030494354","display_name":"Cara D. Nielson","orcid":"https://orcid.org/0000-0002-6238-7824","observed_orcids":["https://orcid.org/0000-0002-6238-7824"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cara D. Nielson","raw_affiliation_strings":["Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA","Seattle Children\u2019s Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Children\u2019s Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I4405262941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088648796","display_name":"Andy Y. Shih","orcid":"https://orcid.org/0000-0002-7839-392X","observed_orcids":["https://orcid.org/0000-0002-7839-392X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4405262941","display_name":"Seattle Children's Research Institute","ror":"https://ror.org/00cz0md82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1295499534","https://openalex.org/I4405262941"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andy Y. Shih","raw_affiliation_strings":["Department of Bioengineering, University of Washington, Seattle, WA, USA","Department of Pediatrics, University of Washington, Seattle, WA, USA","Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA","Seattle Children\u2019s Research Institute, Seattle, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Department of Pediatrics, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Seattle Children\u2019s Research Institute, Seattle, WA, USA","institution_ids":["https://openalex.org/I4405262941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5088648796"],"corresponding_institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4405262941"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.56433409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"693","last_page":"720"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.029899999499320984,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mural-cells","display_name":"mural cells","score":0.8420000076293945},{"id":"https://openalex.org/keywords/cerebrovascular-pathology","display_name":"cerebrovascular pathology","score":0.7820000052452087},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"cerebral blood flow","score":0.6980000138282776},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.9139999747276306},{"id":"https://openalex.org/keywords/neurovascular-unit","display_name":"neurovascular unit","score":0.765999972820282},{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.5410000085830688},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.8859999775886536},{"id":"https://openalex.org/keywords/amyloid-plaques","display_name":"amyloid plaques","score":0.7699999809265137},{"id":"https://openalex.org/keywords/neurofibrillary-tangles","display_name":"neurofibrillary tangles","score":0.9110000133514404},{"id":"https://openalex.org/keywords/microvascular-dysfunction","display_name":"microvascular dysfunction","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C111758988","wikidata":"https://www.wikidata.org/wiki/Q6937269","display_name":"Mural cell","level":4,"score":0.6690999865531921},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.6610000133514404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5967000126838684},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.592199981212616},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5874999761581421},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5633999705314636},{"id":"https://openalex.org/C2777799939","wikidata":"https://www.wikidata.org/wiki/Q1711381","display_name":"Perivascular space","level":2,"score":0.4180000126361847},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.41440001130104065},{"id":"https://openalex.org/C2780427682","wikidata":"https://www.wikidata.org/wiki/Q500446","display_name":"Pericyte","level":4,"score":0.40380001068115234},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3747999966144562},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.3709999918937683},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.3610000014305115},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.30140000581741333},{"id":"https://openalex.org/C2777427615","wikidata":"https://www.wikidata.org/wiki/Q954257","display_name":"Degenerative disease","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.27720001339912415},{"id":"https://openalex.org/C2777408375","wikidata":"https://www.wikidata.org/wiki/Q707810","display_name":"Arteriogenesis","level":3,"score":0.27140000462532043},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.26440000534057617},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.26409998536109924}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-99609-2_15","doi":"https://doi.org/10.1007/978-3-031-99609-2_15","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-99609-2_15","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-99609-2_15.pdf","source":{"id":"https://openalex.org/S4210174491","display_name":"Physiology in health and disease","issn_l":"2625-252X","issn":["2625-252X","2625-2538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology in Health and Disease","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.1007/978-3-031-99609-2_15","doi":"https://doi.org/10.1007/978-3-031-99609-2_15","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-99609-2_15","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-99609-2_15.pdf","source":{"id":"https://openalex.org/S4210174491","display_name":"Physiology in health and disease","issn_l":"2625-252X","issn":["2625-252X","2625-2538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Physiology in Health and Disease","raw_type":"book-chapter"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415600593.pdf","grobid_xml":"https://content.openalex.org/works/W4415600593.grobid-xml"},"referenced_works_count":177,"referenced_works":["https://openalex.org/W1177847716","https://openalex.org/W1540025214","https://openalex.org/W1562276199","https://openalex.org/W1567524252","https://openalex.org/W1640210388","https://openalex.org/W1745482744","https://openalex.org/W1780877458","https://openalex.org/W1883842978","https://openalex.org/W1957400240","https://openalex.org/W1968060691","https://openalex.org/W1973418567","https://openalex.org/W1975303418","https://openalex.org/W1977032052","https://openalex.org/W1980786936","https://openalex.org/W1981106800","https://openalex.org/W1983274002","https://openalex.org/W1983591080","https://openalex.org/W1983670592","https://openalex.org/W1985063020","https://openalex.org/W1994609866","https://openalex.org/W1994839798","https://openalex.org/W1999430398","https://openalex.org/W1999700051","https://openalex.org/W2001552996","https://openalex.org/W2004534322","https://openalex.org/W2011190955","https://openalex.org/W2016820608","https://openalex.org/W2019574826","https://openalex.org/W2020604254","https://openalex.org/W2024955728","https://openalex.org/W2029532449","https://openalex.org/W2029881431","https://openalex.org/W2030011352","https://openalex.org/W2031762899","https://openalex.org/W2034275438","https://openalex.org/W2038298070","https://openalex.org/W2042698075","https://openalex.org/W2049742542","https://openalex.org/W2052812301","https://openalex.org/W2053005839","https://openalex.org/W2055467683","https://openalex.org/W2056709516","https://openalex.org/W2056856515","https://openalex.org/W2063309386","https://openalex.org/W2069929255","https://openalex.org/W2069974562","https://openalex.org/W2070251027","https://openalex.org/W2073364218","https://openalex.org/W2074546602","https://openalex.org/W2074641979","https://openalex.org/W2083721622","https://openalex.org/W2083822803","https://openalex.org/W2084525950","https://openalex.org/W2087529125","https://openalex.org/W2088344008","https://openalex.org/W2089040344","https://openalex.org/W2090097368","https://openalex.org/W2094113864","https://openalex.org/W2107325549","https://openalex.org/W2109290881","https://openalex.org/W2120334927","https://openalex.org/W2121820797","https://openalex.org/W2123065255","https://openalex.org/W2126019582","https://openalex.org/W2132513225","https://openalex.org/W2138230197","https://openalex.org/W2138992210","https://openalex.org/W2146046417","https://openalex.org/W2147346575","https://openalex.org/W2149801164","https://openalex.org/W2152719134","https://openalex.org/W2159707179","https://openalex.org/W2162266981","https://openalex.org/W2163234334","https://openalex.org/W2167043901","https://openalex.org/W2167183660","https://openalex.org/W2167527439","https://openalex.org/W2169199162","https://openalex.org/W2170235570","https://openalex.org/W2172610621","https://openalex.org/W2187829723","https://openalex.org/W2255860951","https://openalex.org/W2270752438","https://openalex.org/W2288877230","https://openalex.org/W2298163613","https://openalex.org/W2399776559","https://openalex.org/W2415637550","https://openalex.org/W2461766912","https://openalex.org/W2463189234","https://openalex.org/W2474981734","https://openalex.org/W2485924810","https://openalex.org/W2554203130","https://openalex.org/W2565314027","https://openalex.org/W2582407848","https://openalex.org/W2583122146","https://openalex.org/W2596832374","https://openalex.org/W2596892842","https://openalex.org/W2613121599","https://openalex.org/W2615239588","https://openalex.org/W2615918291","https://openalex.org/W2623854426","https://openalex.org/W2626061308","https://openalex.org/W2736715037","https://openalex.org/W2741752826","https://openalex.org/W2763985063","https://openalex.org/W2782416724","https://openalex.org/W2786318872","https://openalex.org/W2789420223","https://openalex.org/W2793877399","https://openalex.org/W2807046484","https://openalex.org/W2808454816","https://openalex.org/W2809129903","https://openalex.org/W2810209650","https://openalex.org/W2897433925","https://openalex.org/W2899281139","https://openalex.org/W2904598213","https://openalex.org/W2911147760","https://openalex.org/W2911407981","https://openalex.org/W2912592608","https://openalex.org/W2913113106","https://openalex.org/W2934416369","https://openalex.org/W2949897197","https://openalex.org/W2951514146","https://openalex.org/W2958522695","https://openalex.org/W2964787846","https://openalex.org/W2969832889","https://openalex.org/W2973051664","https://openalex.org/W2976940088","https://openalex.org/W2984045917","https://openalex.org/W2993316870","https://openalex.org/W2995183059","https://openalex.org/W3000062832","https://openalex.org/W3003596505","https://openalex.org/W3003618703","https://openalex.org/W3007815224","https://openalex.org/W3013784088","https://openalex.org/W3023320726","https://openalex.org/W3034077561","https://openalex.org/W3034765977","https://openalex.org/W3044090570","https://openalex.org/W3082690496","https://openalex.org/W3090440882","https://openalex.org/W3123867917","https://openalex.org/W3127042286","https://openalex.org/W3128032280","https://openalex.org/W3130987271","https://openalex.org/W3131331170","https://openalex.org/W3131922807","https://openalex.org/W3155992342","https://openalex.org/W3160045421","https://openalex.org/W3160628817","https://openalex.org/W3162551739","https://openalex.org/W3164345316","https://openalex.org/W3170603847","https://openalex.org/W3176700643","https://openalex.org/W3181691429","https://openalex.org/W3182913217","https://openalex.org/W3192234794","https://openalex.org/W3193538660","https://openalex.org/W3206871822","https://openalex.org/W4206957222","https://openalex.org/W4210649675","https://openalex.org/W4213366162","https://openalex.org/W4220857895","https://openalex.org/W4220916851","https://openalex.org/W4226058222","https://openalex.org/W4226267268","https://openalex.org/W4285396516","https://openalex.org/W4292836783","https://openalex.org/W4295902280","https://openalex.org/W4303415616","https://openalex.org/W4312075225","https://openalex.org/W4321440681","https://openalex.org/W4321612260","https://openalex.org/W4378980569","https://openalex.org/W4387253054","https://openalex.org/W4401120087"],"related_works":["https://openalex.org/W1957400240","https://openalex.org/W4408387186","https://openalex.org/W2044677267","https://openalex.org/W2034716506","https://openalex.org/W2897950992","https://openalex.org/W4220888995","https://openalex.org/W2227592214","https://openalex.org/W2954237632","https://openalex.org/W4413821570","https://openalex.org/W2047841882"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-28T00:00:00"}