{"id":"https://openalex.org/W4415570281","doi":"https://doi.org/10.3390/biomedicines13112620","title":"Estrogen Receptors as Key Factors in Carcinogenesis","display_name":"Estrogen Receptors as Key Factors in Carcinogenesis","publication_year":2025,"publication_date":"2025-10-26","ids":{"openalex":"https://openalex.org/W4415570281","doi":"https://doi.org/10.3390/biomedicines13112620","pmid":"https://pubmed.ncbi.nlm.nih.gov/41301715","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12650284"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines13112620","doi":"https://doi.org/10.3390/biomedicines13112620","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines13112620","pdf_url":"https://www.mdpi.com/2227-9059/13/11/2620/pdf?version=1761464823","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/13/11/2620/pdf?version=1761464823","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093654041","display_name":"Oliwia Gruszka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Oliwia Gruszka","raw_affiliation_strings":["Department of Biotechnology and Genetic Engineering, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Genetic Engineering, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061254928","display_name":"Magdalena Jurzak","orcid":"https://orcid.org/0000-0002-7746-7333","observed_orcids":["https://orcid.org/0000-0002-7746-7333"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Jurzak","raw_affiliation_strings":["Department of Biotechnology and Genetic Engineering, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland"],"raw_orcid":"https://orcid.org/0000-0002-7746-7333","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Genetic Engineering, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland","institution_ids":["https://openalex.org/I166182418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061834347","display_name":"Ilona Anna Bednarek","orcid":"https://orcid.org/0000-0002-3003-5437","observed_orcids":["https://orcid.org/0000-0002-3003-5437"]},"institutions":[{"id":"https://openalex.org/I166182418","display_name":"Medical University of Silesia","ror":"https://ror.org/005k7hp45","country_code":"PL","type":"education","lineage":["https://openalex.org/I166182418"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Ilona Anna Bednarek","raw_affiliation_strings":["Department of Biotechnology and Genetic Engineering, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland"],"raw_orcid":"https://orcid.org/0000-0002-3003-5437","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Genetic Engineering, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055 Katowice, Poland","institution_ids":["https://openalex.org/I166182418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061834347","https://openalex.org/A5093654041"],"corresponding_institution_ids":["https://openalex.org/I166182418"],"apc_list":{"value":2600,"currency":"CHF","value_usd":3137},"apc_paid":{"value":2600,"currency":"CHF","value_usd":3137},"fwci":1.1446,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.68103448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"13","issue":"11","first_page":"2620","last_page":"2620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor","display_name":"estrogen receptor","score":0.9860000014305115},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.8920000195503235},{"id":"https://openalex.org/keywords/hormone-dependent-cancers","display_name":"hormone-dependent tumors","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9340000152587891},{"id":"https://openalex.org/keywords/estrogen-receptor-isoforms","display_name":"estrogen receptor isoforms","score":0.9079999923706055},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.8870000243186951},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.5260000228881836},{"id":"https://openalex.org/keywords/clonal-expansion","display_name":"clonal expansion","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6086999773979187},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5389999747276306},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5206999778747559},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.515500009059906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5019999742507935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5011000037193298},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.49549999833106995},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4650999903678894},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.3903999924659729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3840999901294708},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.3222000002861023},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.32030001282691956},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.311599999666214},{"id":"https://openalex.org/C140608501","wikidata":"https://www.wikidata.org/wiki/Q7318358","display_name":"Review article","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3084999918937683},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.30790001153945923},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.30640000104904175},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.2897000014781952},{"id":"https://openalex.org/C3018449070","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signalling pathways","level":3,"score":0.2896000146865845},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.2678000032901764},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.26010000705718994},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2526000142097473}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/biomedicines13112620","doi":"https://doi.org/10.3390/biomedicines13112620","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines13112620","pdf_url":"https://www.mdpi.com/2227-9059/13/11/2620/pdf?version=1761464823","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmid:41301715","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41301715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12650284","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12650284/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:2ac3024539194436aa3b48e7b0e20bb8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2ac3024539194436aa3b48e7b0e20bb8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 13, Iss 11, p 2620 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/biomedicines13112620","doi":"https://doi.org/10.3390/biomedicines13112620","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines13112620","pdf_url":"https://www.mdpi.com/2227-9059/13/11/2620/pdf?version=1761464823","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3215870064","display_name":null,"funder_award_id":"BNW-1-091/K/4/I","funder_id":"https://openalex.org/F4320326292","funder_display_name":"\u015al\u0105ski Uniwersytet Medyczny w Katowicach"},{"id":"https://openalex.org/G8406901479","display_name":null,"funder_award_id":"BNW-1-096/N/5/I","funder_id":"https://openalex.org/F4320326292","funder_display_name":"\u015al\u0105ski Uniwersytet Medyczny w Katowicach"}],"funders":[{"id":"https://openalex.org/F4320326292","display_name":"\u015al\u0105ski Uniwersytet Medyczny w Katowicach","ror":null},{"id":"https://openalex.org/F4320328948","display_name":"Uniwersytet \u015al\u0105ski w Katowicach","ror":"https://ror.org/0104rcc94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415570281.pdf","grobid_xml":"https://content.openalex.org/works/W4415570281.grobid-xml"},"referenced_works_count":272,"referenced_works":["https://openalex.org/W23842477","https://openalex.org/W1245681932","https://openalex.org/W1512690422","https://openalex.org/W1588468449","https://openalex.org/W1820219315","https://openalex.org/W1841022483","https://openalex.org/W1971555231","https://openalex.org/W1979376598","https://openalex.org/W1981467972","https://openalex.org/W1982388012","https://openalex.org/W1984728749","https://openalex.org/W1985232025","https://openalex.org/W1995416038","https://openalex.org/W1997726224","https://openalex.org/W2002051016","https://openalex.org/W2004795161","https://openalex.org/W2022102157","https://openalex.org/W2022977599","https://openalex.org/W2024132020","https://openalex.org/W2025327786","https://openalex.org/W2027044981","https://openalex.org/W2027515382","https://openalex.org/W2030676208","https://openalex.org/W2031113361","https://openalex.org/W2033853917","https://openalex.org/W2037790468","https://openalex.org/W2042602698","https://openalex.org/W2045389096","https://openalex.org/W2049623921","https://openalex.org/W2053174388","https://openalex.org/W2053252897","https://openalex.org/W2056404763","https://openalex.org/W2056475405","https://openalex.org/W2056967256","https://openalex.org/W2061671852","https://openalex.org/W2063284702","https://openalex.org/W2071993616","https://openalex.org/W2074619468","https://openalex.org/W2075443461","https://openalex.org/W2075786281","https://openalex.org/W2078150258","https://openalex.org/W2078836557","https://openalex.org/W2085921275","https://openalex.org/W2091564796","https://openalex.org/W2100531260","https://openalex.org/W2100877370","https://openalex.org/W2102138745","https://openalex.org/W2107519625","https://openalex.org/W2122861520","https://openalex.org/W2136403146","https://openalex.org/W2139093121","https://openalex.org/W2146352944","https://openalex.org/W2146615732","https://openalex.org/W2158344966","https://openalex.org/W2158558484","https://openalex.org/W2161566367","https://openalex.org/W2161977537","https://openalex.org/W2168631000","https://openalex.org/W2176222937","https://openalex.org/W2202862893","https://openalex.org/W2243467818","https://openalex.org/W2266639016","https://openalex.org/W2331825365","https://openalex.org/W2336058699","https://openalex.org/W2404884142","https://openalex.org/W2409571240","https://openalex.org/W2478846246","https://openalex.org/W2491547442","https://openalex.org/W2510039886","https://openalex.org/W2525695625","https://openalex.org/W2547801487","https://openalex.org/W2558048528","https://openalex.org/W2578132773","https://openalex.org/W2590461535","https://openalex.org/W2593628479","https://openalex.org/W2598753811","https://openalex.org/W2767660956","https://openalex.org/W2777085303","https://openalex.org/W2790097493","https://openalex.org/W2803975229","https://openalex.org/W2808444757","https://openalex.org/W2871159547","https://openalex.org/W2883915279","https://openalex.org/W2888888969","https://openalex.org/W2889541377","https://openalex.org/W2891700678","https://openalex.org/W2897226109","https://openalex.org/W2897481853","https://openalex.org/W2900064153","https://openalex.org/W2911209755","https://openalex.org/W2912212163","https://openalex.org/W2912410416","https://openalex.org/W2913627154","https://openalex.org/W2914371319","https://openalex.org/W2916860038","https://openalex.org/W2921913306","https://openalex.org/W2944317821","https://openalex.org/W2945564879","https://openalex.org/W2960070047","https://openalex.org/W2961382565","https://openalex.org/W2967966143","https://openalex.org/W2969927930","https://openalex.org/W2971872400","https://openalex.org/W2973927353","https://openalex.org/W2979761477","https://openalex.org/W2982091811","https://openalex.org/W2985055874","https://openalex.org/W2985832033","https://openalex.org/W2988773550","https://openalex.org/W2991466195","https://openalex.org/W3000766920","https://openalex.org/W3005410912","https://openalex.org/W3012639176","https://openalex.org/W3013561598","https://openalex.org/W3014547684","https://openalex.org/W3015634062","https://openalex.org/W3016395470","https://openalex.org/W3019462203","https://openalex.org/W3026431630","https://openalex.org/W3033801313","https://openalex.org/W3036320417","https://openalex.org/W3041664880","https://openalex.org/W3045200208","https://openalex.org/W3046376023","https://openalex.org/W3046518781","https://openalex.org/W3047352808","https://openalex.org/W3047869172","https://openalex.org/W3058545039","https://openalex.org/W3070792027","https://openalex.org/W3087593426","https://openalex.org/W3109161557","https://openalex.org/W3112209279","https://openalex.org/W3120684612","https://openalex.org/W3123151883","https://openalex.org/W3124676529","https://openalex.org/W3126656588","https://openalex.org/W3127344393","https://openalex.org/W3134053423","https://openalex.org/W3134347097","https://openalex.org/W3135442429","https://openalex.org/W3136164242","https://openalex.org/W3145610805","https://openalex.org/W3148213032","https://openalex.org/W3155105211","https://openalex.org/W3157136401","https://openalex.org/W3157710113","https://openalex.org/W3158138853","https://openalex.org/W3165542058","https://openalex.org/W3175971352","https://openalex.org/W3181323486","https://openalex.org/W3182224381","https://openalex.org/W3187534113","https://openalex.org/W3193378962","https://openalex.org/W3194182286","https://openalex.org/W3196153487","https://openalex.org/W3198119642","https://openalex.org/W3200601212","https://openalex.org/W3200709530","https://openalex.org/W3207318875","https://openalex.org/W3207509860","https://openalex.org/W3211004656","https://openalex.org/W3213105215","https://openalex.org/W3215719125","https://openalex.org/W4200081636","https://openalex.org/W4200191473","https://openalex.org/W4200463735","https://openalex.org/W4205658713","https://openalex.org/W4205724345","https://openalex.org/W4206666777","https://openalex.org/W4206812126","https://openalex.org/W4210659779","https://openalex.org/W4211001330","https://openalex.org/W4212924928","https://openalex.org/W4213197580","https://openalex.org/W4220681411","https://openalex.org/W4220868197","https://openalex.org/W4221046671","https://openalex.org/W4224112307","https://openalex.org/W4224922520","https://openalex.org/W4225001891","https://openalex.org/W4226146737","https://openalex.org/W4244519136","https://openalex.org/W4247951415","https://openalex.org/W4256389474","https://openalex.org/W4280626914","https://openalex.org/W4281805337","https://openalex.org/W4282006810","https://openalex.org/W4283393222","https://openalex.org/W4283714737","https://openalex.org/W4286615845","https://openalex.org/W4286629873","https://openalex.org/W4288749657","https://openalex.org/W4289951353","https://openalex.org/W4292180418","https://openalex.org/W4293860374","https://openalex.org/W4296675749","https://openalex.org/W4302009138","https://openalex.org/W4306925953","https://openalex.org/W4306926021","https://openalex.org/W4309157098","https://openalex.org/W4310191335","https://openalex.org/W4313889797","https://openalex.org/W4318185125","https://openalex.org/W4318822253","https://openalex.org/W4321372984","https://openalex.org/W4322719806","https://openalex.org/W4324129663","https://openalex.org/W4327956235","https://openalex.org/W4353066673","https://openalex.org/W4362615071","https://openalex.org/W4362667967","https://openalex.org/W4367693483","https://openalex.org/W4368377079","https://openalex.org/W4378714600","https://openalex.org/W4380480494","https://openalex.org/W4380577674","https://openalex.org/W4384203064","https://openalex.org/W4384338775","https://openalex.org/W4385064179","https://openalex.org/W4386649703","https://openalex.org/W4386884936","https://openalex.org/W4387033132","https://openalex.org/W4387139567","https://openalex.org/W4387457752","https://openalex.org/W4388735282","https://openalex.org/W4389516746","https://openalex.org/W4389570913","https://openalex.org/W4389836963","https://openalex.org/W4389944312","https://openalex.org/W4390673205","https://openalex.org/W4391004461","https://openalex.org/W4391404515","https://openalex.org/W4391997149","https://openalex.org/W4392038977","https://openalex.org/W4392159382","https://openalex.org/W4393251580","https://openalex.org/W4393257950","https://openalex.org/W4393340543","https://openalex.org/W4393935425","https://openalex.org/W4394704512","https://openalex.org/W4396561360","https://openalex.org/W4396658547","https://openalex.org/W4399167988","https://openalex.org/W4400356791","https://openalex.org/W4400664951","https://openalex.org/W4400928818","https://openalex.org/W4401197090","https://openalex.org/W4401204768","https://openalex.org/W4401215948","https://openalex.org/W4401922427","https://openalex.org/W4402228361","https://openalex.org/W4402561258","https://openalex.org/W4402574610","https://openalex.org/W4402814575","https://openalex.org/W4403612072","https://openalex.org/W4405483341","https://openalex.org/W4405498769","https://openalex.org/W4405724728","https://openalex.org/W4406900997","https://openalex.org/W4407729324","https://openalex.org/W4408173540","https://openalex.org/W4409329675","https://openalex.org/W4409344692","https://openalex.org/W4409398128","https://openalex.org/W4409769274","https://openalex.org/W4410300554","https://openalex.org/W4410588187","https://openalex.org/W4410824730","https://openalex.org/W4410974144","https://openalex.org/W4412678532","https://openalex.org/W4413094240","https://openalex.org/W4413240765"],"related_works":["https://openalex.org/W4224098211","https://openalex.org/W2361978992","https://openalex.org/W4387139567","https://openalex.org/W2152404439","https://openalex.org/W2116182095","https://openalex.org/W4386996041","https://openalex.org/W4404969960","https://openalex.org/W3158138853","https://openalex.org/W3201843140","https://openalex.org/W2065916615"],"abstract_inverted_index":{"Despite":[0],"continuous":[1],"advances":[2],"in":[3,80,104,197,203,214,229,265,286],"the":[4,9,16,29,57,71,74,81,94,105,118,129,140,145,154,178,189,194,204,207,215,221,230,236,249,259,262],"development":[5,82,130,267],"of":[6,14,22,28,59,67,83,86,90,107,131,136,144,156,180,193,206,217,232,238,251,261,280,289],"methodologies":[7,51],"for":[8,173],"diagnosis":[10],"and":[11,93,161,191,220],"therapeutic":[12,40,115,212],"treatment":[13,216],"cancer,":[15],"disease":[17],"remains":[18],"a":[19,77,101,113,125,277],"primary":[20],"cause":[21],"mortality":[23],"worldwide.":[24],"A":[25,64,133],"comprehensive":[26],"understanding":[27,279],"molecular":[30],"mechanisms":[31],"underlying":[32],"cancer":[33,233],"could":[34,45],"ultimately":[35],"lead":[36],"to":[37,49,62,123,153,275],"increasingly":[38],"effective":[39],"interventions.":[41],"One":[42],"approach":[43],"that":[44,52,139],"be":[46],"adopted":[47],"is":[48,70,100,167,268,273],"formulate":[50],"impede":[53],"cell":[54,98,159],"signalling":[55],"and/or":[56],"expression":[58],"genes":[60],"pivotal":[61],"carcinogenesis.":[63],"notable":[65],"example":[66],"this":[68,91],"strategy":[69],"focus":[72],"on":[73,97,128,187],"estrogen":[75,195,263],"receptor,":[76,92],"key":[78],"player":[79],"various":[84],"types":[85,288],"cancer.":[87,290],"The":[88,183],"deregulation":[89],"subsequent":[95,162],"impact":[96],"function,":[99],"critical":[102],"factor":[103],"progression":[106],"these":[108,218],"diseases.":[109],"This":[110,165],"renders":[111],"it":[112],"significant":[114,126],"target.":[116],"Furthermore,":[117],"microenvironment":[119,147],"has":[120],"been":[121],"demonstrated":[122],"exert":[124],"influence":[127],"cancers.":[132],"mounting":[134],"body":[135],"evidence":[137],"indicates":[138],"abnormal":[141],"physical":[142],"properties":[143],"tumour":[146,158],"can":[148],"induce":[149],"widespread":[150],"changes,":[151],"leading":[152],"selection":[155],"characteristic":[157],"abilities":[160],"clonal":[163],"proliferation.":[164],"process":[166],"accompanied":[168],"by":[169],"an":[170],"increased":[171],"capacity":[172],"invasive":[174],"growth":[175],"and,":[176],"notably,":[177],"induction":[179],"multidrug":[181],"resistance.":[182],"present":[184],"article":[185],"focuses":[186],"presenting":[188],"structure":[190],"role":[192,260],"receptor":[196,264],"selected":[198],"hormone-dependent":[199,255],"cancers,":[200,219],"its":[201,282],"involvement":[202],"formation":[205],"tumor":[208],"microenvironment,":[209],"currently":[210],"used":[211],"methods":[213],"challenges":[222],"associated":[223],"with":[224],"them.":[225],"Each":[226],"new":[227,240],"discovery":[228],"field":[231],"biology":[234],"offers":[235],"prospect":[237],"developing":[239],"potential":[241],"treatments,":[242],"including":[243],"targeted":[244],"therapies":[245],"aimed":[246],"at":[247],"improving":[248],"survival":[250],"patients":[252],"suffering":[253],"from":[254],"malignant":[256],"tumours.":[257],"Although":[258],"their":[266],"well":[269],"established,":[270],"further":[271],"research":[272],"required":[274],"develop":[276],"detailed":[278],"how":[281],"specific":[283],"isoforms":[284],"act":[285],"different":[287]},"counts_by_year":[{"year":2026,"cited_by_count":9}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2025-10-28T00:00:00"}