{"id":"https://openalex.org/W4415554385","doi":"https://doi.org/10.1016/j.surg.2025.109702","title":"A novel therapeutic approach to adrenocortical carcinoma repurposing fingolimod to target sphingolipid metabolism in metastatic disease","display_name":"A novel therapeutic approach to adrenocortical carcinoma repurposing fingolimod to target sphingolipid metabolism in metastatic disease","publication_year":2025,"publication_date":"2025-10-23","ids":{"openalex":"https://openalex.org/W4415554385","doi":"https://doi.org/10.1016/j.surg.2025.109702","pmid":"https://pubmed.ncbi.nlm.nih.gov/41136313","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12911514"},"language":"en","primary_location":{"id":"doi:10.1016/j.surg.2025.109702","doi":"https://doi.org/10.1016/j.surg.2025.109702","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.surg.2025.109702","pdf_url":"https://www.surgjournal.com/article/S0039-6060(25)00554-9/pdf","source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.surgjournal.com/article/S0039-6060(25)00554-9/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075065118","display_name":"Chitra Subramanian","orcid":"https://orcid.org/0000-0003-1871-2834","observed_orcids":["https://orcid.org/0000-0003-1871-2834"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chitra Subramanian","raw_affiliation_strings":["Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL"],"raw_orcid":"https://orcid.org/0000-0003-1871-2834","affiliations":[{"raw_affiliation_string":"Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014118600","display_name":"Kelli McNamara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelli McNamara","raw_affiliation_strings":["Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102986266","display_name":"Daniel L. Hess","orcid":"https://orcid.org/0000-0002-2476-3921","observed_orcids":["https://orcid.org/0000-0002-2476-3921"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Hess","raw_affiliation_strings":["Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023026672","display_name":"Seth W. Croslow","orcid":"https://orcid.org/0009-0001-2360-2472","observed_orcids":["https://orcid.org/0009-0001-2360-2472"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seth Wyatt Croslow","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023319670","display_name":"Yanqi Tan","orcid":"https://orcid.org/0009-0000-5302-547X","observed_orcids":["https://orcid.org/0009-0000-5302-547X"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanqi Tan","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036041546","display_name":"Katja Kiseljak\u2010Vassiliades","orcid":"https://orcid.org/0000-0003-3341-582X","observed_orcids":["https://orcid.org/0000-0003-3341-582X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katja Kiseljak-Vassiliades","raw_affiliation_strings":["Department of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz School of Medicine, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076835766","display_name":"Margaret E. Wierman","orcid":"https://orcid.org/0000-0002-7634-1093","observed_orcids":["https://orcid.org/0000-0002-7634-1093"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret E. Wierman","raw_affiliation_strings":["Department of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz School of Medicine, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz School of Medicine, Aurora, CO","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006238710","display_name":"Jonathan V. Sweedler","orcid":"https://orcid.org/0000-0003-3107-9922","observed_orcids":["https://orcid.org/0000-0003-3107-9922"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan V. Sweedler","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057675169","display_name":"Mark Steven Cohen","orcid":"https://orcid.org/0000-0002-2517-0757","observed_orcids":["https://orcid.org/0000-0002-2517-0757"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark S. Cohen","raw_affiliation_strings":["Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL; Department of Surgery, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL. Electronic address: meddean@illinois.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical and Translational Science, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL; Department of Surgery, Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, IL. Electronic address: meddean@illinois.edu","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5057675169"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":{"value":4130,"currency":"USD","value_usd":4130},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39774626,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"189","issue":null,"first_page":"109702","last_page":"109702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.07750000059604645,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.07609999924898148,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenocortical-carcinoma","display_name":"adrenocortical carcinoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.996999979019165},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8809999823570251},{"id":"https://openalex.org/keywords/sphingolipid-metabolism","display_name":"sphingolipid metabolism","score":1.0},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5730000138282776},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ceramide","display_name":"ceramide","score":0.5509999990463257},{"id":"https://openalex.org/keywords/sphingomyelin","display_name":"sphingomyelin","score":0.800000011920929},{"id":"https://openalex.org/keywords/oxygen-consumption-rate","display_name":"oxygen consumption rate","score":0.5479999780654907},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.6349999904632568},{"id":"https://openalex.org/keywords/h295r-cells","display_name":"H295R cells","score":0.8100000023841858},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9002000093460083},{"id":"https://openalex.org/C2781399356","wikidata":"https://www.wikidata.org/wiki/Q918285","display_name":"Adrenocortical carcinoma","level":2,"score":0.8062000274658203},{"id":"https://openalex.org/C2776036978","wikidata":"https://www.wikidata.org/wiki/Q425137","display_name":"Fingolimod","level":3,"score":0.8001000285148621},{"id":"https://openalex.org/C2776735609","wikidata":"https://www.wikidata.org/wiki/Q417465","display_name":"Mitotane","level":3,"score":0.6105999946594238},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.583899974822998},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5160999894142151},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5001000165939331},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4706999957561493},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.4681999981403351},{"id":"https://openalex.org/C61705674","wikidata":"https://www.wikidata.org/wiki/Q410395","display_name":"Sphingolipid","level":2,"score":0.4564000070095062},{"id":"https://openalex.org/C2778384578","wikidata":"https://www.wikidata.org/wiki/Q16930687","display_name":"Therapeutic approach","level":3,"score":0.39430001378059387},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3772999942302704},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.37119999527931213},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.35440000891685486},{"id":"https://openalex.org/C2775976807","wikidata":"https://www.wikidata.org/wiki/Q241150","display_name":"Aminoglutethimide","level":5,"score":0.353300005197525},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.32989999651908875},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.31220000982284546},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31060001254081726},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3093999922275543},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.2863999903202057},{"id":"https://openalex.org/C2778129406","wikidata":"https://www.wikidata.org/wiki/Q2507454","display_name":"Adrenal insufficiency","level":2,"score":0.27970001101493835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27900001406669617},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.2709999978542328},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2632000148296356},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2590000033378601},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.2540999948978424},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25270000100135803}],"mesh":[{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000081243","descriptor_name":"Sphingosine 1 Phosphate Receptor Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000081243","descriptor_name":"Sphingosine 1 Phosphate Receptor Modulators","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000306","descriptor_name":"Adrenal Cortex Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018268","descriptor_name":"Adrenocortical Carcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018268","descriptor_name":"Adrenocortical Carcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018268","descriptor_name":"Adrenocortical Carcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018268","descriptor_name":"Adrenocortical Carcinoma","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.surg.2025.109702","doi":"https://doi.org/10.1016/j.surg.2025.109702","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.surg.2025.109702","pdf_url":"https://www.surgjournal.com/article/S0039-6060(25)00554-9/pdf","source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"},{"id":"pmid:41136313","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41136313","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12911514","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12911514/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.surg.2025.109702","doi":"https://doi.org/10.1016/j.surg.2025.109702","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.surg.2025.109702","pdf_url":"https://www.surgjournal.com/article/S0039-6060(25)00554-9/pdf","source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2073281747","display_name":"Biomaterials for treatment of head and neck cancer","funder_award_id":"R01CA173292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5267332074","display_name":"Optimization and Investigation of Cruentaren A analogs","funder_award_id":"R01CA216919","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000904769","display_name":"Engineering the Next Generation of Safer Hsp90 Inhibitors","funder_award_id":"R01CA270147","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415554385.pdf","grobid_xml":"https://content.openalex.org/works/W4415554385.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1543068333","https://openalex.org/W1859298280","https://openalex.org/W1994625058","https://openalex.org/W2009667972","https://openalex.org/W2059486645","https://openalex.org/W2059779476","https://openalex.org/W2065685530","https://openalex.org/W2072709644","https://openalex.org/W2093713748","https://openalex.org/W2118779298","https://openalex.org/W2298824475","https://openalex.org/W2596100941","https://openalex.org/W2622678979","https://openalex.org/W2769383666","https://openalex.org/W2808884452","https://openalex.org/W2883682970","https://openalex.org/W2885027828","https://openalex.org/W2897002925","https://openalex.org/W2974072238","https://openalex.org/W3001874526","https://openalex.org/W3016255796","https://openalex.org/W3044908880","https://openalex.org/W3097153355","https://openalex.org/W3192913069","https://openalex.org/W4292166992","https://openalex.org/W4315641621","https://openalex.org/W4317937156","https://openalex.org/W4392019231","https://openalex.org/W4401716115","https://openalex.org/W4403539744","https://openalex.org/W4404824788"],"related_works":["https://openalex.org/W2298824475","https://openalex.org/W3192913069","https://openalex.org/W4315641621","https://openalex.org/W4410262680","https://openalex.org/W3022312226","https://openalex.org/W4285006015","https://openalex.org/W2101105526","https://openalex.org/W4280530016","https://openalex.org/W2468617656","https://openalex.org/W4396741769"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Patients":[1],"with":[2,134,145,169,273],"advanced":[3],"adrenocortical":[4,18,56,121,124,248,288],"carcinoma":[5,19,57,63,122,125,142,196,249],"have":[6],"poor":[7],"survival":[8],"and":[9,42,58,77,84,116,127,160,162,167,184,203,213,235,255,258],"show":[10],"elevated":[11],"steroid":[12,30],"production.":[13],"Lipid":[14,229],"metabolic":[15,94],"profiling":[16,230],"of":[17,25,111,137,151,158,165,179,201],"has":[20],"revealed":[21],"that":[22,46],"the":[23,80,120,135,177,199],"upregulation":[24,157],"sphingolipid":[26,48,253],"metabolism,":[27,49],"which":[28,221],"regulates":[29],"synthesis,":[31],"is":[32],"linked":[33],"to":[34],"worse":[35],"overall":[36],"survival.":[37],"Therefore,":[38],"fingolimod,":[39],"a":[40,51,148,163,208,283],"Food":[41],"Drug":[43],"Administration-approved":[44],"drug":[45],"targets":[47],"represents":[50],"promising":[52],"option":[53],"for":[54,119],"targeting":[55,252],"metastatic":[59,260],"spread.":[60],"METHODS:":[61],"Adrenocortical":[62,141,195],"cell":[64,74],"lines":[65],"were":[66],"cultured":[67],"in":[68,107,173,198,211,247,262,265,271,287],"an":[69,156],"appropriate":[70],"medium.":[71],"Cell-TiterGlo":[72],"assessed":[73],"viability.":[75],"Western-blot":[76],"RNA-sequencing":[78],"examined":[79],"targeted":[81],"pathways.":[82],"Migration":[83],"invasion":[85,214,261],"using":[86],"decellularized":[87],"extracellular":[88,205,219],"matrix":[89,206],"evaluated":[90],"metastasis.":[91],"Seahorse":[92],"measured":[93],"flux.":[95],"Reverse":[96],"transcription-polymerase":[97],"chain":[98],"reaction":[99],"determined":[100],"steroidogenic":[101],"genes.":[102],"Mass":[103],"spectrometry":[104],"analyzed":[105],"alterations":[106],"sphingolipids.":[108],"RESULTS:":[109],")":[110],"7.044":[112],"\u03bcmol/L,":[113,115],"5.588":[114],"9.992":[117],"\u03bcmol/L":[118],"1,":[123],"2,":[126],"NCI-H295R,":[128],"respectively.":[129],"Fingolimod":[130,244],"showed":[131,147,207],"synergistic":[132],"effect":[133],"standard":[136],"care":[138],"treatment":[139],"mitotane.":[140],"cells":[143,197,216,250],"treated":[144],"fingolimod":[146,193,227],"dose-dependent":[149],"cleavage":[150],"poly":[152],"(ADP-ribose)":[153],"polymerase":[154],"(PARP),":[155],"LC3-II":[159],"p-ERK,":[161],"downregulation":[164,178],"p-Akt":[166],"p-P65":[168],"no":[170],"appreciable":[171],"change":[172],"total":[174],"proteins.":[175],"Furthermore,":[176],"oxygen":[180],"consumption":[181],"rate,":[182],"steroidogenic,":[183],"transforming":[185],"growth":[186],"factor-\u03b2":[187],"pathway":[188],"genes":[189],"was":[190,222],"noted":[191],"after":[192,226],"treatment.":[194,228],"presence":[200],"liver":[202,257],"lung":[204,259],"2-fold":[209],"increase":[210],"migration":[212],"over":[215],"without":[217],"liver/lung":[218],"matrix,":[220],"blocked":[223],"by":[224,251],">90%":[225],"indicated":[231],"ceramides,":[232],"ceramide":[233],"phospho-ethanolamines":[234],"ceramide-1-phosphate,":[236],"sphingomyelins,":[237],"triglycerides,":[238],"phosphatidylcholines":[239],"as":[240,282],"altered":[241],"lipids.":[242],"CONCLUSION:":[243],"induces":[245],"apoptosis":[246],"metabolism":[254],"prevents":[256],"vitro.":[263],"Further":[264],"vivo":[266],"validation":[267],"studies":[268],"alone":[269],"or":[270],"combination":[272],"immune":[274],"checkpoint":[275],"inhibitor":[276],"will":[277],"support":[278],"its":[279],"clinical":[280],"translation":[281],"novel":[284],"repurposed":[285],"therapy":[286],"carcinoma.":[289]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-26T00:00:00"}