{"id":"https://openalex.org/W4415550942","doi":"https://doi.org/10.1016/j.ymthe.2026.05.029","title":"Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells","display_name":"Directing fratricide within T cell products using an anti-uPAR chimeric antigen receptor to drive the production of potent therapeutic cells","publication_year":2026,"publication_date":"2026-06-03","ids":{"openalex":"https://openalex.org/W4415550942","doi":"https://doi.org/10.1016/j.ymthe.2026.05.029","pmid":"https://pubmed.ncbi.nlm.nih.gov/41279709","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12633439"},"language":"en","primary_location":{"id":"doi:10.1016/j.ymthe.2026.05.029","doi":"https://doi.org/10.1016/j.ymthe.2026.05.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.05.029","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13555585/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015387119","display_name":"Lauren E. Sarko","orcid":"https://orcid.org/0000-0003-0154-8564","observed_orcids":["https://orcid.org/0000-0003-0154-8564"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2802999273","display_name":"Wisconsin Institutes for Discovery","ror":"https://ror.org/05gbven85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802999273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lauren E. Sarko","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2802999273"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120136377","display_name":"David Givand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Givand","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120136379","display_name":"Brendan Rattin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2802999273","display_name":"Wisconsin Institutes for Discovery","ror":"https://ror.org/05gbven85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802999273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brendan Rattin","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2802999273"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120136378","display_name":"Claire Shepley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Shepley","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anna Tommasi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2802999273","display_name":"Wisconsin Institutes for Discovery","ror":"https://ror.org/05gbven85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802999273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Tommasi","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2802999273"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Allen Attar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I2802999273","display_name":"Wisconsin Institutes for Discovery","ror":"https://ror.org/05gbven85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2802999273"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen Attar","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I2802999273"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rachel Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Taylor","raw_affiliation_strings":["Biomedical Research Model Services, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Model Services, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120136380","display_name":"Benjamin Kutler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Kutler","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Roshini M. Traynor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roshini M. Traynor","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anika Upadhyaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anika Upadhyaya","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mackenzie Mnuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mackenzie Mnuk","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cavin Gehrke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cavin Gehrke","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115037760","display_name":"Nat Murren","orcid":"https://orcid.org/0009-0001-4885-0050","observed_orcids":["https://orcid.org/0009-0001-4885-0050"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Murren","raw_affiliation_strings":["Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin","institution_ids":["https://openalex.org/I1304256225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016691718","display_name":"Tyler Kent Ulland","orcid":"https://orcid.org/0000-0002-6507-4989","observed_orcids":["https://orcid.org/0000-0002-6507-4989"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210153600","display_name":"Evolved Analytics (United States)","ror":"https://ror.org/04c504j29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler K. Ulland","raw_affiliation_strings":["Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","Evolved Analytics, LLC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Pathology Program, University of Wisconsin-Madison, Madison, WI, USA; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Evolved Analytics, LLC","institution_ids":["https://openalex.org/I4210153600"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054397260","display_name":"Christian M. Capitini","orcid":"https://orcid.org/0000-0002-2276-6731","observed_orcids":["https://orcid.org/0000-0002-2276-6731"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian M. Capitini","raw_affiliation_strings":["Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","University of Wisconsin-Madison"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037838194","display_name":"Theresa Kotanchek","orcid":"https://orcid.org/0000-0002-0417-8864","observed_orcids":["https://orcid.org/0000-0002-0417-8864"]},"institutions":[{"id":"https://openalex.org/I4210153600","display_name":"Evolved Analytics (United States)","ror":"https://ror.org/04c504j29","country_code":"US","type":"company","lineage":["https://openalex.org/I4210153600"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Theresa Kotanchek","raw_affiliation_strings":["Evolved Analytics LLC, Rancho Santa Fe, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolved Analytics LLC, Rancho Santa Fe, CA, USA","institution_ids":["https://openalex.org/I4210153600"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087358894","display_name":"Krishanu Saha","orcid":"https://orcid.org/0000-0003-2837-0858","observed_orcids":["https://orcid.org/0000-0003-2837-0858"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"funder","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Krishanu Saha","raw_affiliation_strings":["Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: ksaha@wisc.edu"],"raw_orcid":"https://orcid.org/0000-0003-2837-0858","affiliations":[{"raw_affiliation_string":"Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, WI, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA; Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Electronic address: ksaha@wisc.edu","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087358894"],"corresponding_institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.8954,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.84571751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"34","issue":"9","first_page":"5190","last_page":"5206"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor","display_name":"chimeric antigen receptor","score":0.8730000257492065},{"id":"https://openalex.org/keywords/upar","display_name":"uPAR","score":0.8080000281333923},{"id":"https://openalex.org/keywords/urokinase-receptor","display_name":"urokinase receptor","score":0.9110000133514404},{"id":"https://openalex.org/keywords/t-cell-reprogramming","display_name":"T cell reprogramming","score":0.6629999876022339},{"id":"https://openalex.org/keywords/crispr-gene-editing","display_name":"CRISPR gene editing","score":0.8050000071525574},{"id":"https://openalex.org/keywords/car-t-cell-manufacturing","display_name":"CAR T cell manufacturing","score":0.7979999780654907},{"id":"https://openalex.org/keywords/gd2","display_name":"GD2","score":0.5759999752044678},{"id":"https://openalex.org/keywords/memory-like-t-cells","display_name":"memory-like T cells","score":0.824999988079071},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6304000020027161},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.6291000247001648},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5311999917030334},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.46790000796318054},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4641999900341034},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3885999917984009},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38089999556541443},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3650999963283539},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3625999987125397},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3562999963760376},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.3555999994277954},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3495999872684479},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.34869998693466187},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3343999981880188},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.3181000053882599},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.30320000648498535},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26030001044273376},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.25859999656677246},{"id":"https://openalex.org/C108249834","wikidata":"https://www.wikidata.org/wiki/Q3922363","display_name":"Antigen processing","level":5,"score":0.2556999921798706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25220000743865967},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.25060001015663147}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.ymthe.2026.05.029","doi":"https://doi.org/10.1016/j.ymthe.2026.05.029","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ymthe.2026.05.029","pdf_url":null,"source":{"id":"https://openalex.org/S51596929","display_name":"Molecular Therapy","issn_l":"1525-0016","issn":["1525-0016","1525-0024"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Therapy","raw_type":"journal-article"},{"id":"doi:10.1101/2025.10.24.684419","doi":"https://doi.org/10.1101/2025.10.24.684419","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2025.10.24.684419","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41279709","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41279709","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmid:42237538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42237538","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular therapy : the journal of the American Society of Gene Therapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13555585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13555585/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13555585","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13555585/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Ther","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3802479825","display_name":"Multi-color Benchtop Flow Cytometer","funder_award_id":"S10RR025483","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G9000858571","display_name":"Biotechnology Training Program","funder_award_id":"T32GM135066","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000860577","display_name":"Label-free imaging of CAR T cell metabolism","funder_award_id":"R01CA278051","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000863878","display_name":"Graduate Training in Cellular and Molecular Pathogenesis of Human Diseases","funder_award_id":"T32GM135119","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000870050","display_name":"UW Comprehensive Cancer Center Support","funder_award_id":"P30CA014520","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000883303","display_name":"Assembly of Novel Gene Editing Particles to Understand Genome Surgery in Patient-Derived Cells","funder_award_id":"R35GM119644","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000911325","display_name":"\u00df-hydroxybutyrate inhibition of pathology in Alzheimer's disease","funder_award_id":"R01AG083883","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306555","display_name":"Wisconsin Alumni Research Foundation","ror":"https://ror.org/00hwxbz16"},{"id":"https://openalex.org/F4320308906","display_name":"St. Baldrick's Foundation","ror":"https://ror.org/03h1gea69"},{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320316231","display_name":"Midwest Athletes Against Childhood Cancer","ror":"https://ror.org/028yrea10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334547","display_name":"Grainger Institute for Engineering, University of Wisconsin-Madison","ror":null},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W576867606","https://openalex.org/W1548496378","https://openalex.org/W1884466283","https://openalex.org/W2026252733","https://openalex.org/W2066186103","https://openalex.org/W2092565468","https://openalex.org/W2137154569","https://openalex.org/W2148757319","https://openalex.org/W2149471961","https://openalex.org/W2167413291","https://openalex.org/W2567664749","https://openalex.org/W2589417329","https://openalex.org/W2591706731","https://openalex.org/W2790491347","https://openalex.org/W2795785271","https://openalex.org/W2818540548","https://openalex.org/W2944669426","https://openalex.org/W2947301297","https://openalex.org/W2951049045","https://openalex.org/W2951153979","https://openalex.org/W2954713933","https://openalex.org/W2956092422","https://openalex.org/W3034215145","https://openalex.org/W3035751258","https://openalex.org/W3036603151","https://openalex.org/W3038090972","https://openalex.org/W3041156479","https://openalex.org/W3120950503","https://openalex.org/W3148729173","https://openalex.org/W3150736119","https://openalex.org/W3154185160","https://openalex.org/W3155375284","https://openalex.org/W3164849376","https://openalex.org/W3165628776","https://openalex.org/W4211083170","https://openalex.org/W4224255508","https://openalex.org/W4281288994","https://openalex.org/W4281694109","https://openalex.org/W4282966989","https://openalex.org/W4285742411","https://openalex.org/W4295009108","https://openalex.org/W4295022868","https://openalex.org/W4311887602","https://openalex.org/W4317390676","https://openalex.org/W4324101854","https://openalex.org/W4385858278","https://openalex.org/W4386031016","https://openalex.org/W4387378477","https://openalex.org/W4388880158","https://openalex.org/W4391169172","https://openalex.org/W4392958947","https://openalex.org/W4394680557","https://openalex.org/W4396653330","https://openalex.org/W4399525128","https://openalex.org/W4401891075","https://openalex.org/W4403159071","https://openalex.org/W4403216233","https://openalex.org/W4405481661","https://openalex.org/W4406362844","https://openalex.org/W4407150819","https://openalex.org/W4407684469","https://openalex.org/W4408040503","https://openalex.org/W4408718964","https://openalex.org/W4409980972","https://openalex.org/W4410785218","https://openalex.org/W4412728064"],"related_works":["https://openalex.org/W4306319214","https://openalex.org/W7124430261","https://openalex.org/W2984445276","https://openalex.org/W2948809937","https://openalex.org/W3038090972","https://openalex.org/W2794149319","https://openalex.org/W3117758135","https://openalex.org/W7214515963","https://openalex.org/W4308378129","https://openalex.org/W4295022868"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2025-10-26T00:00:00"}