{"id":"https://openalex.org/W4415549491","doi":"https://doi.org/10.1681/asn.2025jbnp5nm8","title":"Evaluation of In Vitro Thrombogenicity Among Different Dialyzer Membranes","display_name":"Evaluation of In Vitro Thrombogenicity Among Different Dialyzer Membranes","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415549491","doi":"https://doi.org/10.1681/asn.2025jbnp5nm8"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2025jbnp5nm8","doi":"https://doi.org/10.1681/asn.2025jbnp5nm8","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025jbnp5nm8","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073186406","display_name":"Robert Nitschel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Nitschel","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Sankt Wendel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Sankt Wendel, Germany;","institution_ids":["https://openalex.org/I90589149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046342878","display_name":"Adam M. Zawada","orcid":"https://orcid.org/0000-0001-9353-2943","observed_orcids":["https://orcid.org/0000-0001-9353-2943"]},"institutions":[{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Adam M. Zawada","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Sankt Wendel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Sankt Wendel, Germany;","institution_ids":["https://openalex.org/I90589149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058541247","display_name":"Bettina Griesshaber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bettina Griesshaber","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Bad Homburg, HE, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Bad Homburg, HE, Germany;","institution_ids":["https://openalex.org/I90589149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029339457","display_name":"Manuela Stauss\u2010Grabo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Manuela Stauss-Grabo","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Bad Homburg, HE, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Bad Homburg, HE, Germany;","institution_ids":["https://openalex.org/I90589149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086133898","display_name":"Craig D. Kamerath","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768216","display_name":"Fresenius Medical Care North America (United States)","ror":"https://ror.org/05rs7tq63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108778","https://openalex.org/I4210125924","https://openalex.org/I4391768216","https://openalex.org/I90589149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig D Kamerath","raw_affiliation_strings":["Fresenius Medical Care North America, Ogden, Utah, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care North America, Ogden, Utah, United States","institution_ids":["https://openalex.org/I4391768216"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nathan S Crook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768216","display_name":"Fresenius Medical Care North America (United States)","ror":"https://ror.org/05rs7tq63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108778","https://openalex.org/I4210125924","https://openalex.org/I4391768216","https://openalex.org/I90589149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan S Crook","raw_affiliation_strings":["Fresenius Medical Care North America, Ogden, Utah, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care North America, Ogden, Utah, United States","institution_ids":["https://openalex.org/I4391768216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094354196","display_name":"Skyler Boyington","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4391768216","display_name":"Fresenius Medical Care North America (United States)","ror":"https://ror.org/05rs7tq63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108778","https://openalex.org/I4210125924","https://openalex.org/I4391768216","https://openalex.org/I90589149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skyler Boyington","raw_affiliation_strings":["Fresenius Medical Care North America, Ogden, Utah, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care North America, Ogden, Utah, United States","institution_ids":["https://openalex.org/I4391768216"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025771896","display_name":"James Paul Kennedy","orcid":"https://orcid.org/0000-0002-9083-672X","observed_orcids":["https://orcid.org/0000-0002-9083-672X"]},"institutions":[{"id":"https://openalex.org/I4391768216","display_name":"Fresenius Medical Care North America (United States)","ror":"https://ror.org/05rs7tq63","country_code":"US","type":"company","lineage":["https://openalex.org/I4210108778","https://openalex.org/I4210125924","https://openalex.org/I4391768216","https://openalex.org/I90589149"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Paul Kennedy","raw_affiliation_strings":["Fresenius Medical Care North America, Ogden, Utah, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care North America, Ogden, Utah, United States","institution_ids":["https://openalex.org/I4391768216"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071117955","display_name":"Ansgar Erlenk\u00f6tter","orcid":"https://orcid.org/0009-0005-9559-8109","observed_orcids":["https://orcid.org/0009-0005-9559-8109"]},"institutions":[{"id":"https://openalex.org/I90589149","display_name":"Fresenius Medical Care (Germany)","ror":"https://ror.org/04sk0bj73","country_code":"DE","type":"company","lineage":["https://openalex.org/I90589149"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ansgar Erlenkoetter","raw_affiliation_strings":["Fresenius Medical Care Deutschland GmbH, Sankt Wendel, Germany;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fresenius Medical Care Deutschland GmbH, Sankt Wendel, Germany;","institution_ids":["https://openalex.org/I90589149"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.7509999871253967,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10641","display_name":"Central Venous Catheters and Hemodialysis","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.048500001430511475,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dialysis-membranes","display_name":"dialysis membranes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/thrombogenicity","display_name":"thrombogenicity","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hemocompatibility","display_name":"hemocompatibility","score":0.9150000214576721},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.9120000004768372},{"id":"https://openalex.org/keywords/platelet-activation","display_name":"platelet activation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/beta-thromboglobulin","display_name":"beta-thromboglobulin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/thrombin-antithrombin-complex","display_name":"thrombin-antithrombin complex","score":0.9660000205039978},{"id":"https://openalex.org/keywords/platelet-adsorption","display_name":"platelet adsorption","score":0.7820000052452087},{"id":"https://openalex.org/keywords/polysulfone-membranes","display_name":"polysulfone membranes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/polyethersulfone-membranes","display_name":"polyethersulfone membranes","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2776649359","wikidata":"https://www.wikidata.org/wiki/Q7798338","display_name":"Thrombogenicity","level":3,"score":0.9258999824523926},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7123000025749207},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6934000253677368},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6033999919891357},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.4894999861717224},{"id":"https://openalex.org/C50817676","wikidata":"https://www.wikidata.org/wiki/Q7880534","display_name":"Ultrafiltration (renal)","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3944999873638153},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.3774999976158142},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36980000138282776},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3447999954223633},{"id":"https://openalex.org/C155515750","wikidata":"https://www.wikidata.org/wiki/Q1059955","display_name":"Synthetic membrane","level":3,"score":0.3001999855041504},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2888000011444092},{"id":"https://openalex.org/C2909460087","wikidata":"https://www.wikidata.org/wiki/Q408032","display_name":"Edetic Acid","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.262800008058548},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C199091049","wikidata":"https://www.wikidata.org/wiki/Q5270638","display_name":"Dialysis tubing","level":3,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2025jbnp5nm8","doi":"https://doi.org/10.1681/asn.2025jbnp5nm8","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025jbnp5nm8","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7131629359","https://openalex.org/W1973373331","https://openalex.org/W2417481431","https://openalex.org/W1977482122","https://openalex.org/W2884757555","https://openalex.org/W2069596103","https://openalex.org/W2529448068","https://openalex.org/W2160536402","https://openalex.org/W4283790760","https://openalex.org/W2034280269"],"abstract_inverted_index":{"Background:":[0],"Dialyzer":[1],"membranes":[2,35,151],"exert":[3],"thrombogenic":[4],"potential":[5],"which":[6],"contributes":[7],"to":[8,82,138,142,240,287],"clotting":[9,295],"risk":[10],"during":[11],"dialysis":[12,34],"treatments,":[13],"necessitating":[14],"systemic":[15],"anticoagulation.":[16],"The":[17,258],"two":[18],"major":[19],"components":[20],"involved":[21],"in":[22],"this":[23,148],"process":[24],"are":[25,285],"plasmatic":[26,104,246,278],"coagulation":[27,105],"and":[28,124,155,194,282],"platelet":[29,95,140,166,238,270],"activation.":[30,271],"Hydrophilic":[31],"modification":[32,67,293],"of":[33,68,291],"improve":[36],"the":[37,44,55,59,65,69,143,150,232,241,254,289],"hemocompatibility":[38],"profile,":[39],"as":[40,80,101,103],"previously":[41],"shown":[42],"for":[43,277],"novel":[45],"FX":[46,70,115,161,242],"CorAL":[47,71,162,243],"dialyzer":[48,72,85,145],"with":[49,92,157,231,236],"increased":[50,266],"polyvinylpyrrolidone":[51],"(PVP)":[52],"content":[53],"on":[54,77,294],"blood-side":[56],"surface.":[57],"In":[58,88],"present":[60,259],"study":[61,261],"we":[62],"investigated":[63,110,226,255],"if":[64],"hydrophilic":[66,292],"has":[73],"a":[74,89,158],"positive":[75],"impact":[76,290],"in-vitro":[78,260],"thrombogenicity":[79],"compared":[81],"other":[83,225],"synthetic":[84],"membranes.":[86,146],"Methods:":[87],"recirculation":[90],"setup":[91],"human":[93],"blood,":[94],"activation":[96],"(platelet":[97],"counts,":[98],"\u03b2-thromboglobulin":[99],"[\u03b2-TG])":[100],"well":[102],"(thrombin\u2013antithrombin":[106],"complex":[107],"[TAT])":[108],"were":[109,152,251,275],"among":[111],"polysulfone-based":[112],"(FX":[113,169,198],"CorAL,":[114],"CorDiax,":[116],"Optiflux":[117],"[all":[118],"Fresenius":[119,301],"Medical":[120,302],"Care],":[121],"xevonta":[122],"[B.Braun])":[123],"polyethersulfone-based":[125],"dialyzers":[126],"(ELISIO":[127],"[Nipro],":[128],"Revaclear,":[129],"Theranova":[130],"[both":[131],"Baxter]).":[132],"Additionally,":[133],"fluorescence":[134,233],"microscopy":[135,234],"was":[136],"used":[137],"visualize":[139],"adsorption":[141,239],"different":[144],"For":[147],"purpose,":[149],"cut":[153],"open":[154],"stained":[156],"CD41a-FITC.":[159],"Results:":[160],"showed":[163],"significantly":[164],"lower":[165,195],"count":[167],"reduction":[168],"CorDiax:":[170,199],"3.8":[171],"fold,":[172,176,180,184,188,192,201,205,209,213,217,221],"p<0.001;":[173,177,181,185],"Optiflux:":[174,203],"4.7":[175],"xevonta:":[178],"4.3":[179],"ELISIO:":[182,211],"3.5":[183],"Revaclear:":[186,215],"2.8":[187],"p=0.003;":[189],"Theranova:":[190,219],"4.2":[191],"p<0.001)":[193],"\u03b2-TG":[196],"levels":[197],"5.9":[200],"p=0.006;":[202],"5.8":[204],"p=0.005;":[206],"xevonta;":[207],"4.8":[208],"p=0.021;":[210],"4.6":[212],"p=0.020;":[214],"2.9":[216],"p=0.051;":[218],"6.3":[220],"p=0.045)":[222],"than":[223],"all":[224],"dialyzers.":[227,256],"These":[228],"results":[229],"correlated":[230],"images,":[235],"lowest":[237],"membrane.":[244],"Regarding":[245],"coagulation,":[247,279],"no":[248,273],"significant":[249],"differences":[250,274],"observed":[252,276],"between":[253],"Conclusion:":[257],"supports":[262],"previous":[263],"findings":[264],"that":[265],"membrane":[267],"hydrophilicity":[268],"reduces":[269],"As":[272],"further":[280],"experimental":[281],"clinical":[283],"studies":[284],"needed":[286],"evaluate":[288],"risk.":[296],"Funding:":[297],"Commercial":[298],"Support":[299],"-":[300],"Care":[303],"Deutschland":[304],"GmbH":[305]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-25T00:00:00"}