{"id":"https://openalex.org/W4415549461","doi":"https://doi.org/10.1681/asn.2025y9na19bw","title":"An Uncommon Presentation of a Rare Disease: Membranous-Like Glomerulopathy with Masked IgG Kappa Deposits (MGMID)","display_name":"An Uncommon Presentation of a Rare Disease: Membranous-Like Glomerulopathy with Masked IgG Kappa Deposits (MGMID)","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415549461","doi":"https://doi.org/10.1681/asn.2025y9na19bw"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2025y9na19bw","doi":"https://doi.org/10.1681/asn.2025y9na19bw","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025y9na19bw","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080270931","display_name":"Zedrick Aguirre","orcid":"https://orcid.org/0009-0003-3227-6052","observed_orcids":["https://orcid.org/0009-0003-3227-6052"]},"institutions":[{"id":"https://openalex.org/I4210146450","display_name":"AtlantiCare","ror":"https://ror.org/03vdj0f87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zedrick Aguirre","raw_affiliation_strings":["AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States","institution_ids":["https://openalex.org/I4210146450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054046874","display_name":"Sahil S Mamtani","orcid":"https://orcid.org/0000-0002-7348-1541","observed_orcids":["https://orcid.org/0000-0002-7348-1541"]},"institutions":[{"id":"https://openalex.org/I4210146450","display_name":"AtlantiCare","ror":"https://ror.org/03vdj0f87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahil Mamtani","raw_affiliation_strings":["AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States","institution_ids":["https://openalex.org/I4210146450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083195926","display_name":"Nitin Behl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146450","display_name":"AtlantiCare","ror":"https://ror.org/03vdj0f87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitin Behl","raw_affiliation_strings":["AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States","institution_ids":["https://openalex.org/I4210146450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036505756","display_name":"Jayant Goda Shastri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146450","display_name":"AtlantiCare","ror":"https://ror.org/03vdj0f87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210146450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay G. Shastri","raw_affiliation_strings":["AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AtlantiCare Regional Medical Center Atlantic City Campus, Atlantic City, New Jersey, United States","institution_ids":["https://openalex.org/I4210146450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210146450"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atypical-presentation","display_name":"atypical presentation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/elderly-male","display_name":"elderly man","score":0.8889999985694885},{"id":"https://openalex.org/keywords/nephrotic-range-proteinuria","display_name":"nephrotic-range proteinuria","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hematuria","display_name":"hematuria","score":0.859000027179718},{"id":"https://openalex.org/keywords/antiphospholipid-antibodies","display_name":"antiphospholipid antibodies","score":0.8149999976158142},{"id":"https://openalex.org/keywords/anti-dsdna-antibodies","display_name":"anti-dsDNA antibodies","score":0.7509999871253967},{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":0.8339999914169312},{"id":"https://openalex.org/keywords/intravenous-immunoglobulin","display_name":"intravenous immunoglobulin","score":0.9750000238418579},{"id":"https://openalex.org/keywords/corticosteroids","display_name":"corticosteroids","score":0.6759999990463257},{"id":"https://openalex.org/keywords/glomerular-disease","display_name":"glomerular disease","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8804000020027161},{"id":"https://openalex.org/C2780199430","wikidata":"https://www.wikidata.org/wiki/Q3347169","display_name":"Glomerulopathy","level":4,"score":0.6201000213623047},{"id":"https://openalex.org/C2781087799","wikidata":"https://www.wikidata.org/wiki/Q7312483","display_name":"Renal biopsy","level":3,"score":0.6158000230789185},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6148999929428101},{"id":"https://openalex.org/C2779561371","wikidata":"https://www.wikidata.org/wiki/Q570197","display_name":"Proteinuria","level":3,"score":0.4749999940395355},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4690999984741211},{"id":"https://openalex.org/C2779701055","wikidata":"https://www.wikidata.org/wiki/Q929833","display_name":"Rare disease","level":3,"score":0.4316999912261963},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4090000092983246},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.3677999973297119},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.3547999858856201},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.3522000014781952},{"id":"https://openalex.org/C2780368995","wikidata":"https://www.wikidata.org/wiki/Q605006","display_name":"Glomerulonephritis","level":3,"score":0.3386000096797943},{"id":"https://openalex.org/C2775998817","wikidata":"https://www.wikidata.org/wiki/Q1509367","display_name":"Rapidly progressive glomerulonephritis","level":4,"score":0.31040000915527344},{"id":"https://openalex.org/C2780439664","wikidata":"https://www.wikidata.org/wiki/Q7535376","display_name":"Skin biopsy","level":3,"score":0.30570000410079956},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28200000524520874},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.2799000144004822},{"id":"https://openalex.org/C2778474638","wikidata":"https://www.wikidata.org/wiki/Q575241","display_name":"Immune complex","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C2910809950","wikidata":"https://www.wikidata.org/wiki/Q1534492","display_name":"Microhematuria","level":4,"score":0.2718000113964081},{"id":"https://openalex.org/C2778674544","wikidata":"https://www.wikidata.org/wiki/Q1414805","display_name":"Systemic disease","level":3,"score":0.27079999446868896},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26820001006126404},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.26179999113082886},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.26159998774528503},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2574000060558319},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C2777601897","wikidata":"https://www.wikidata.org/wiki/Q3409113","display_name":"Presentation (obstetrics)","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2025y9na19bw","doi":"https://doi.org/10.1681/asn.2025y9na19bw","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025y9na19bw","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4403811430","https://openalex.org/W4416067006","https://openalex.org/W4396995160","https://openalex.org/W4397041267","https://openalex.org/W4396990002","https://openalex.org/W4416066923","https://openalex.org/W4396993503","https://openalex.org/W7116936742","https://openalex.org/W4416066779","https://openalex.org/W4396995327"],"abstract_inverted_index":{"Introduction:":[0],"Membranous-like":[1],"glomerulopathy":[2],"with":[3,58,98,114,176,252],"masked":[4],"IgG":[5,38],"kappa":[6,39],"deposits":[7,18,35],"(MGMID)":[8],"is":[9,79,239,273],"a":[10,89,95,154,229],"rare":[11,90],"glomerular":[12,16],"disease":[13,49,208],"characterized":[14],"by":[15],"immune":[17],"that":[19],"are":[20,43,68,287],"not":[21,80],"detected":[22],"on":[23,29,187],"routine":[24],"immunofluorescence":[25],"(IF),":[26],"but":[27],"appear":[28],"paraffin":[30],"IF.":[31],"On":[32],"Electron":[33],"Microscopy,":[34],"stain":[36],"for":[37,131,190,263],"light":[40],"chains":[41],"and":[42,55,62,109,120,127,147,159,165,178,218,243,250,261,278,284],"usually":[44],"subepithelial":[45],"or":[46],"mesangial.":[47],"The":[48,221],"primarily":[50],"affects":[51,210],"females":[52],"under":[53],"40":[54],"typically":[56],"presents":[57],"nephrotic-range":[59],"proteinuria,":[60],"hematuria,":[61,119],"preserved":[63],"complement":[64],"levels.":[65],"PLA2R":[66],"antibodies":[67],"consistently":[69],"negative.":[70],"Although":[71,255],"some":[72],"patients":[73],"have":[74],"positive":[75,148],"autoimmune":[76,82,224],"serologies,":[77],"MGMID":[78,93,201,267,272],"clearly":[81],"in":[83,94,181,202],"nature.":[84],"Case":[85],"Description:":[86],"We":[87],"report":[88],"case":[91,195],"of":[92,124,200,223],"77-year-old":[96],"male":[97],"paroxysmal":[99],"atrial":[100],"fibrillation,":[101],"CAD":[102],"s/p":[103],"CABG,":[104],"mechanical":[105],"aortic":[106],"valve":[107],"replacement,":[108],"progressive":[110],"CKD.":[111],"He":[112],"presented":[113],"worsening":[115],"renal":[116,155,173],"function,":[117],"microscopic":[118],"24-hour":[121],"urine":[122],"protein":[123],"3.2":[125],"g/day":[126],"was":[128,157,161,185],"being":[129],"evaluated":[130],"SLE.":[132],"Serologic":[133],"workup":[134],"showed":[135],"indeterminate":[136],"anti-dsDNA,":[137],"initially":[138],"negative":[139],"ANA":[140],"(later":[141],"repeated":[142],"as":[143,269],"positive),":[144],"low":[145],"C3/C4,":[146],"antiphospholipid":[149],"antibodies.":[150],"Due":[151],"to":[152,289],"thrombocytopenia,":[153],"biopsy":[156,169],"delayed":[158],"he":[160,184],"given":[162],"IV":[163],"dexamethasone":[164],"IVIG.":[166],"Once":[167],"stabilized,":[168],"confirmed":[170],"MGMID.":[171],"Coincidentally,":[172],"function":[174],"improved":[175,268],"IVIG":[177],"steroids.":[179],"After":[180],"hospital":[182],"treatment,":[183,242],"discharged":[186],"mycophenolate":[188,262],"mofetil":[189],"ongoing":[191],"immunosuppression.":[192],"Discussion:":[193],"This":[194],"highlights":[196],"an":[197,203],"atypical":[198],"presentation":[199],"elderly":[204],"male.":[205],"While":[206],"the":[207,266],"classically":[209],"young":[211],"females,":[212],"this":[213],"patient":[214,257],"demonstrated":[215],"typical":[216],"clinical":[217],"histologic":[219],"findings.":[220],"presence":[222],"markers":[225],"raises":[226],"questions":[227],"about":[228],"potential":[230],"immune-mediated":[231],"component,":[232],"though":[233],"definitive":[234],"mechanisms":[235],"remain":[236],"unclear.":[237],"There":[238],"no":[240],"established":[241],"reported":[244],"therapies":[245],"include":[246],"RAAS":[247],"blockade,":[248],"steroids,":[249,259],"immunosuppressants":[251],"variable":[253],"outcomes.":[254],"our":[256],"received":[258],"IVIG,":[260],"SLE,":[264],"incidentally,":[265],"well.":[270],"As":[271],"increasingly":[274],"recognized,":[275],"broader":[276],"age":[277],"gender":[279],"presentations":[280],"may":[281],"become":[282],"apparent,":[283],"further":[285],"studies":[286],"needed":[288],"define":[290],"optimal":[291],"management":[292],"strategies.":[293]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-25T00:00:00"}