{"id":"https://openalex.org/W4415549336","doi":"https://doi.org/10.1681/asn.2025p5jt3ezh","title":"Selective Peroxisome Proliferator-Activated Receptor-\u03b1 (PPAR\u03b1) Modulator Inhibits Cyst Enlargement in PKD","display_name":"Selective Peroxisome Proliferator-Activated Receptor-\u03b1 (PPAR\u03b1) Modulator Inhibits Cyst Enlargement in PKD","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415549336","doi":"https://doi.org/10.1681/asn.2025p5jt3ezh"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2025p5jt3ezh","doi":"https://doi.org/10.1681/asn.2025p5jt3ezh","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025p5jt3ezh","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085702157","display_name":"Yuhei Noda","orcid":"https://orcid.org/0009-0000-5131-995X","observed_orcids":["https://orcid.org/0009-0000-5131-995X"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuhei Noda","raw_affiliation_strings":["Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074150136","display_name":"Noritoshi Kato","orcid":"https://orcid.org/0000-0003-3924-6887","observed_orcids":["https://orcid.org/0000-0003-3924-6887"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noritoshi Kato","raw_affiliation_strings":["Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011614733","display_name":"Yoshinari Yasuda","orcid":"https://orcid.org/0000-0002-7448-3397","observed_orcids":["https://orcid.org/0000-0002-7448-3397"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshinari Yasuda","raw_affiliation_strings":["Gifu Daigaku, Gifu, Gifu Prefecture, Japan","Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifu Daigaku, Gifu, Gifu Prefecture, Japan","institution_ids":["https://openalex.org/I42405503"]},{"raw_affiliation_string":"Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050564961","display_name":"Shoichi Maruyama","orcid":"https://orcid.org/0000-0002-8858-632X","observed_orcids":["https://orcid.org/0000-0002-8858-632X"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoichi Maruyama","raw_affiliation_strings":["Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya Daigaku Daigakuin Igakukei Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan;","institution_ids":["https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22947549,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/pemafibrate","display_name":"pemafibrate","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pparalpha-modulator","display_name":"PPAR\u03b1 modulator","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cystic-kidney-disease","display_name":"cystic kidney disease","score":0.6759999990463257},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/liver-cysts","display_name":"liver cysts","score":0.9110000133514404},{"id":"https://openalex.org/keywords/renal-function","display_name":"renal function","score":0.550000011920929},{"id":"https://openalex.org/keywords/peroxisomes","display_name":"peroxisomes","score":0.6129999756813049}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5562999844551086},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5015000104904175},{"id":"https://openalex.org/C127078168","wikidata":"https://www.wikidata.org/wiki/Q138639","display_name":"Peroxisome","level":3,"score":0.47780001163482666},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.4049000144004822},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3465999960899353},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.32850000262260437},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.31189998984336853},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3061999976634979},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29589998722076416},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28220000863075256},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.27869999408721924},{"id":"https://openalex.org/C2779131090","wikidata":"https://www.wikidata.org/wiki/Q3331086","display_name":"Mesangial cell","level":3,"score":0.27320000529289246},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703000009059906},{"id":"https://openalex.org/C2910266098","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator","level":4,"score":0.26019999384880066},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2508000135421753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2025p5jt3ezh","doi":"https://doi.org/10.1681/asn.2025p5jt3ezh","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025p5jt3ezh","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7140297931","https://openalex.org/W2754464449","https://openalex.org/W3026832836","https://openalex.org/W2072299848","https://openalex.org/W2154820433","https://openalex.org/W2099274614","https://openalex.org/W2159414038","https://openalex.org/W4283385888","https://openalex.org/W7096207706","https://openalex.org/W2560689216"],"abstract_inverted_index":{"Background:":[0],"Autosomal":[1],"dominant":[2],"polycystic":[3,19],"kidney":[4,20,184,213,239,249,288],"disease":[5,21,289],"(ADPKD)":[6],"is":[7,32,36,71,84,132,137],"one":[8,37],"of":[9,38,51,57,82,222,247,258,281,286,310],"the":[10,25,39,49,55,134,199,220,256,305],"most":[11],"frequent":[12],"single-gene":[13],"disorders.":[14],"Nevertheless,":[15],"therapeutic":[16,29],"agents":[17],"for":[18,27,43,300],"remain":[22],"limited,":[23],"and":[24,54,116,136,159,164,179,190,201,205,212,261,290,308],"search":[26],"new":[28],"intervention":[30],"points":[31],"essential.":[33],"The":[34,61,278],"peroxisome":[35,74],"intracellular":[40],"organelles":[41],"responsible":[42],"cellular":[44,291],"metabolic":[45,130],"functions":[46,192],"such":[47],"as":[48,296],"oxidation":[50],"fatty":[52],"acids":[53],"removal":[56],"reactive":[58],"oxygen":[59],"species.":[60],"interactions":[62],"with":[63,253],"mitochondria":[64],"have":[65],"also":[66,269],"been":[67,96,107],"increasingly":[68],"emphasized.":[69],"It":[70],"known":[72],"that":[73],"proliferator-activated":[75],"receptor-\u03b1":[76],"(PPAR\u03b1)":[77],"activity,":[78],"a":[79,92,123,172,182,244,297],"nuclear":[80],"receptor":[81],"peroxisome,":[83],"decreased":[85],"during":[86],"renal":[87,100,114,144,158,208,225,259,263],"cyst":[88,101,226],"enlargement.":[89],"Although":[90],"fenofibrate,":[91],"PPAR\u03b1":[93,125,150],"modulator,":[94,126,151],"has":[95,104],"reported":[97],"to":[98,111,142,153,181],"suppress":[99],"enlargement,":[102],"it":[103],"not":[105],"yet":[106],"applied":[108],"clinically":[109],"due":[110],"concerns":[112],"about":[113],"metabolism":[115],"nephrotoxicity.":[117],"This":[118],"study":[119],"focused":[120],"on":[121,157,224],"pemafibrate,":[122,152],"selective":[124,149],"because":[127],"its":[128,155,294],"main":[129],"pathway":[131],"in":[133,162,165,198,231,237,271,272,283],"liver":[135],"generally":[138,235],"considered":[139],"less":[140],"likely":[141],"cause":[143],"dysfunction.":[145],"We":[146,302],"used":[147,236],"this":[148],"evaluate":[154,304],"effects":[156,280],"hepatic":[160,191,210],"cysts":[161,260],"vitro":[163,273],"vivo":[166,170],"trials.":[167],"Methods:":[168],"In":[169,216,243],"study,":[171],"mixed":[173],"diet":[174],"was":[175,268],"prepared":[176],"using":[177],"pemafibrate":[178,202,223,254,282,311],"administered":[180],"cystic":[183,238,248,287],"rat":[185,245],"model":[186,246],"(PCK":[187],"rat).":[188],"Renal":[189],"were":[193],"evaluated":[194,207,219],"by":[195],"blood":[196],"tests":[197],"control":[200],"treated":[203],"groups,":[204],"we":[206,218],"cysts,":[209,211],"fibrosis":[214],"histologically.":[215],"vitro,":[217],"effect":[221],"enlargement":[227],"under":[228],"3D":[229,274],"culture":[230,275],"MDCK2":[232],"cells,":[233],"which":[234],"suppression":[240],"experiments.":[241],"Results:":[242],"disease,":[250],"long-term":[251],"treatment":[252,299],"suppressed":[255],"growth":[257],"improved":[262],"function.":[264],"Cyst":[265],"size":[266],"reduction":[267],"observed":[270],"experiment.":[276],"Conclusion:":[277],"favorable":[279],"animal":[284],"models":[285],"experiments":[292],"demonstrated":[293],"potential":[295],"clinical":[298],"ADPKD.":[301],"will":[303],"optimal":[306],"dosage":[307],"toxicity":[309],"treatment.":[312],"Funding:":[313],"Commercial":[314],"Support":[315],"-":[316],"Kowa":[317],"Company,":[318],"Ltd.,":[319],"Tokyo,":[320],"Japan.":[321]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-25T00:00:00"}