{"id":"https://openalex.org/W4415534724","doi":"https://doi.org/10.48048/tis.2025.10924","title":"Pharmacological Evaluation of F45 on the Cardiovascular System Using In Vitro, In Vivo Models and Molecular Dockings","display_name":"Pharmacological Evaluation of F45 on the Cardiovascular System Using In Vitro, In Vivo Models and Molecular Dockings","publication_year":2025,"publication_date":"2025-09-10","ids":{"openalex":"https://openalex.org/W4415534724","doi":"https://doi.org/10.48048/tis.2025.10924"},"language":"en","primary_location":{"id":"doi:10.48048/tis.2025.10924","doi":"https://doi.org/10.48048/tis.2025.10924","is_oa":true,"landing_page_url":"https://doi.org/10.48048/tis.2025.10924","pdf_url":"https://tis.wu.ac.th/index.php/tis/article/download/10924/1649","source":{"id":"https://openalex.org/S4210171953","display_name":"Trends in Sciences","issn_l":"2774-0226","issn":["2774-0226"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310319383","host_organization_name":"Walailak University","host_organization_lineage":["https://openalex.org/P4310319383"],"host_organization_lineage_names":["Walailak University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://tis.wu.ac.th/index.php/tis/article/download/10924/1649","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120130679","display_name":"Ikbolkhon Abdurazakova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287382","display_name":"Fergana Medical Institute of Public Health","ror":"https://ror.org/050ycf013","country_code":"UZ","type":"education","lineage":["https://openalex.org/I4405287382"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Ikbolkhon Abdurazakova","raw_affiliation_strings":["Fergana Medical Institute of Public Health, Fergana Region, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fergana Medical Institute of Public Health, Fergana Region, Uzbekistan","institution_ids":["https://openalex.org/I4405287382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090269481","display_name":"Zaynabiddinov Anvar Erkinjonovich","orcid":"https://orcid.org/0009-0007-1710-2037","observed_orcids":["https://orcid.org/0009-0007-1710-2037"]},"institutions":[{"id":"https://openalex.org/I1300976906","display_name":"Andijan State University","ror":"https://ror.org/00bad4666","country_code":"UZ","type":"education","lineage":["https://openalex.org/I1300976906"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Anvar Zaynabiddinov","raw_affiliation_strings":["Andijan State University, Andijan Region, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andijan State University, Andijan Region, Uzbekistan","institution_ids":["https://openalex.org/I1300976906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115078221","display_name":"Izzatullo Abdullaev","orcid":"https://orcid.org/0009-0009-9125-2476","observed_orcids":["https://orcid.org/0009-0009-9125-2476"]},"institutions":[{"id":"https://openalex.org/I1302269238","display_name":"Academy of Sciences Republic of Uzbekistan","ror":"https://ror.org/01xgfaw76","country_code":"UZ","type":"government","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4405266844"]},{"id":"https://openalex.org/I4210147271","display_name":"A.S.Sadykov Institute of Bioorganic Chemistry","ror":"https://ror.org/04b76w231","country_code":"UZ","type":"facility","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4210147271","https://openalex.org/I4405266844"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Izzatullo Abdullaev","raw_affiliation_strings":["A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan","institution_ids":["https://openalex.org/I1302269238","https://openalex.org/I4210147271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089815995","display_name":"\u041c\u0430\u0445\u043c\u0443\u0434\u043e\u0432 \u041b\u0430\u0437\u0438\u0437\u0431\u0435\u043a \u0423\u043c\u0430\u0440\u0436\u043e\u043d\u043e\u0432\u0438\u0447","orcid":"https://orcid.org/0000-0002-6819-6543","observed_orcids":["https://orcid.org/0000-0002-6819-6543"]},"institutions":[{"id":"https://openalex.org/I1302269238","display_name":"Academy of Sciences Republic of Uzbekistan","ror":"https://ror.org/01xgfaw76","country_code":"UZ","type":"government","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4405266844"]},{"id":"https://openalex.org/I4210147271","display_name":"A.S.Sadykov Institute of Bioorganic Chemistry","ror":"https://ror.org/04b76w231","country_code":"UZ","type":"facility","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4210147271","https://openalex.org/I4405266844"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Lazizbek Makhmudov","raw_affiliation_strings":["A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan","institution_ids":["https://openalex.org/I1302269238","https://openalex.org/I4210147271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002899710","display_name":"Ulugbek Gayibov","orcid":"https://orcid.org/0000-0003-1228-236X","observed_orcids":["https://orcid.org/0000-0003-1228-236X"]},"institutions":[{"id":"https://openalex.org/I1302269238","display_name":"Academy of Sciences Republic of Uzbekistan","ror":"https://ror.org/01xgfaw76","country_code":"UZ","type":"government","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4405266844"]},{"id":"https://openalex.org/I4210147271","display_name":"A.S.Sadykov Institute of Bioorganic Chemistry","ror":"https://ror.org/04b76w231","country_code":"UZ","type":"facility","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4210147271","https://openalex.org/I4405266844"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Ulugbek Gayibov","raw_affiliation_strings":["A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan","institution_ids":["https://openalex.org/I1302269238","https://openalex.org/I4210147271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005245924","display_name":"Sirojiddin Omonturdiev","orcid":"https://orcid.org/0000-0003-1630-7480","observed_orcids":["https://orcid.org/0000-0003-1630-7480"]},"institutions":[{"id":"https://openalex.org/I1302269238","display_name":"Academy of Sciences Republic of Uzbekistan","ror":"https://ror.org/01xgfaw76","country_code":"UZ","type":"government","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4405266844"]},{"id":"https://openalex.org/I4210147271","display_name":"A.S.Sadykov Institute of Bioorganic Chemistry","ror":"https://ror.org/04b76w231","country_code":"UZ","type":"facility","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4210147271","https://openalex.org/I4405266844"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Sirojiddin Omonturdiev","raw_affiliation_strings":["A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"A. S. Sadykov Institute of Bioorganic Chemistry of the Science Academy of Uzbekistan, Plant Cytoprotectors Laboratory and Pharamacology, Tashkent, Uzbekistan","institution_ids":["https://openalex.org/I1302269238","https://openalex.org/I4210147271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011234396","display_name":"Gafurjon Abdullayev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160547875","display_name":"Namangan State University","ror":"https://ror.org/00k8k8t47","country_code":"UZ","type":"education","lineage":["https://openalex.org/I160547875"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Gafurjon Abdullayev","raw_affiliation_strings":["Namangan State University, Namangan Region, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Namangan State University, Namangan Region, Uzbekistan","institution_ids":["https://openalex.org/I160547875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106586191","display_name":"Madina Xolmirzayeva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1300976906","display_name":"Andijan State University","ror":"https://ror.org/00bad4666","country_code":"UZ","type":"education","lineage":["https://openalex.org/I1300976906"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Madina Xolmirzayeva","raw_affiliation_strings":["Andijan State University, Andijan Region, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Andijan State University, Andijan Region, Uzbekistan","institution_ids":["https://openalex.org/I1300976906"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061988151","display_name":"Sherzod Niyatqobulovich Zhurakulov","orcid":"https://orcid.org/0000-0002-2857-946X","observed_orcids":["https://orcid.org/0000-0002-2857-946X"]},"institutions":[{"id":"https://openalex.org/I1302269238","display_name":"Academy of Sciences Republic of Uzbekistan","ror":"https://ror.org/01xgfaw76","country_code":"UZ","type":"government","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4405266844"]},{"id":"https://openalex.org/I4210147448","display_name":"Yunusov Institute of the Chemistry of Plant Substances","ror":"https://ror.org/05515rj28","country_code":"UZ","type":"facility","lineage":["https://openalex.org/I1302269238","https://openalex.org/I4210147448","https://openalex.org/I4405266844"]}],"countries":["UZ"],"is_corresponding":false,"raw_author_name":"Sherzod Zhurakulov","raw_affiliation_strings":["Institute of the Chemistry of Plant Substances, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of the Chemistry of Plant Substances, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan","institution_ids":["https://openalex.org/I1302269238","https://openalex.org/I4210147448"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3639,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.92372584,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"22","issue":"12","first_page":"10924","last_page":"10924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.8003000020980835,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.04490000009536743,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.020400000736117363,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasorelaxation","display_name":"vasorelaxation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.9390000104904175},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8560000061988831},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.6690000295639038},{"id":"https://openalex.org/keywords/receptor-operated-calcium-entry","display_name":"receptor-operated calcium entry","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nitric-oxide-signaling","display_name":"nitric oxide signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/endothelium-dependent-relaxation","display_name":"endothelium-dependent relaxation","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ca2-atpase","display_name":"Ca2+-ATPase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/na-ca2-exchanger","display_name":"Na+/Ca2+ exchanger","score":0.9599999785423279},{"id":"https://openalex.org/keywords/aortic-contraction","display_name":"aortic contraction","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.7833999991416931},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7563999891281128},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7142000198364258},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5999000072479248},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5835000276565552},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.5342000126838684},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5138000249862671},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.4733999967575073},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.47040000557899475},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.43799999356269836},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3882000148296356},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.37770000100135803},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.319599986076355},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.30160000920295715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2759000062942505},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.27149999141693115},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C3018795828","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Binding affinities","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.2599000036716461},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.2563000023365021}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.48048/tis.2025.10924","doi":"https://doi.org/10.48048/tis.2025.10924","is_oa":true,"landing_page_url":"https://doi.org/10.48048/tis.2025.10924","pdf_url":"https://tis.wu.ac.th/index.php/tis/article/download/10924/1649","source":{"id":"https://openalex.org/S4210171953","display_name":"Trends in Sciences","issn_l":"2774-0226","issn":["2774-0226"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310319383","host_organization_name":"Walailak University","host_organization_lineage":["https://openalex.org/P4310319383"],"host_organization_lineage_names":["Walailak University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.48048/tis.2025.10924","doi":"https://doi.org/10.48048/tis.2025.10924","is_oa":true,"landing_page_url":"https://doi.org/10.48048/tis.2025.10924","pdf_url":"https://tis.wu.ac.th/index.php/tis/article/download/10924/1649","source":{"id":"https://openalex.org/S4210171953","display_name":"Trends in Sciences","issn_l":"2774-0226","issn":["2774-0226"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20"],"host_organization":"https://openalex.org/P4310319383","host_organization_name":"Walailak University","host_organization_lineage":["https://openalex.org/P4310319383"],"host_organization_lineage_names":["Walailak University"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415534724.pdf","grobid_xml":"https://content.openalex.org/works/W4415534724.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7081944628","https://openalex.org/W4412695389","https://openalex.org/W4414583758","https://openalex.org/W7140315912","https://openalex.org/W3207478002","https://openalex.org/W3140694398","https://openalex.org/W2024866788","https://openalex.org/W7155562097","https://openalex.org/W7221313745","https://openalex.org/W4408919354"],"abstract_inverted_index":{"The":[0],"current":[1],"study":[2],"investigated":[3],"the":[4,10,161,241],"vasorelaxant":[5,215],"and":[6,22,37,49,114,140,146,154,169,175,183,227,260,287],"antihypertensive":[7,206,277,308],"potential":[8,304],"of":[9,17,30,68,108,136,225,254,282],"novel":[11],"compound":[12],"F-45":[13,26,57,69,109,137,165,195,255,283,296],"through":[14,223],"a":[15,90,197,204,275,306],"combination":[16],"in":[18,20,23,95,122,217,267],"vitro,":[19],"vivo,":[21],"silico":[24],"approaches.":[25],"demonstrated":[27,213],"significant":[28],"relaxation":[29,96,243],"rat":[31,219],"aortic":[32,220],"rings":[33],"pre-contracted":[34],"with":[35,89,208,279],"KCl":[36],"phenylephrine,":[38],"suggesting":[39,302],"its":[40,120,265,303],"capacity":[41],"to":[42,86,150,179,240,256],"inhibit":[43],"both":[44],"voltage-dependent":[45],"L-type":[46,226],"Ca2+":[47],"channels":[48],"receptor-operated":[50,228],"calcium":[51,124,229,268],"entry":[52],"mechanisms.":[53],"At":[54],"70":[55],"\u03bcM,":[56],"reduced":[58,138],"KCl-induced":[59],"contraction":[60,72],"by":[61,73,245],"84.0%":[62],"\u00b1":[63,75,92,144,148,152,156,173,177,181,185],"1.3%,":[64],"while":[65],"45":[66],"\u03bcM":[67],"inhibited":[70],"phenylephrine-induced":[71],"78.0%":[74],"2.2%.":[76],"Endothelium-denuded":[77],"experiments":[78,128,273],"confirmed":[79,274],"that":[80,133,194],"nitric":[81,234],"oxide":[82,235],"signaling":[83],"contributes":[84],"significantly":[85,238,284],"F-45-mediated":[87],"vasorelaxation,":[88],"35.0%":[91],"2.4%":[93],"reduction":[94],"observed":[97],"after":[98],"endothelial":[99],"removal.":[100],"Molecular":[101,247],"docking":[102,248],"studies":[103],"revealed":[104,250],"high":[105,251],"binding":[106,252],"affinities":[107,253],"for":[110,200],"Ca2+-ATPase":[111,257],"(\u22128.6":[112,258],"kcal/mol)":[113,259],"Sodium\\Calcium":[115],"Exchanger":[116],"(\u22126.8":[117,262],"kcal/mol),":[118,263],"supporting":[119,264],"role":[121,266],"modulating":[123],"transport.":[125],"In":[126,160,271,291],"vivo":[127,272],"using":[129],"tail-cuff":[130],"plethysmography":[131],"showed":[132],"50":[134,280],"mg/kg":[135,281],"SBP":[139,168],"DBP":[141,170],"from":[142,171],"132.5":[143],"12.3":[145],"94.3":[147],"9.1":[149],"96.8":[151],"9.4":[153],"65.3":[155],"6.4":[157],"mmHg,":[158],"respectively.":[159],"adrenaline-induced":[162,293],"hypertension":[163,294],"model,":[164,295],"decreased":[166],"elevated":[167,299],"140.8":[172],"14.2":[174],"104.3":[176],"10.3":[178],"90.0":[180],"8.7":[182],"61.5":[184],"6.0":[186],"mmHg":[187],"within":[188],"2":[189],"h.":[190],"These":[191],"findings":[192],"suggested":[193],"is":[196],"promising":[198],"candidate":[199],"further":[201],"development":[202],"as":[203,305],"natural":[205],"agent":[207],"multimodal":[209],"action.":[210],"HIGHLIGHTS":[211],"F45":[212],"potent":[214],"activity":[216],"isolated":[218],"rings,":[221],"primarily":[222],"inhibition":[224],"channels.":[230],"Endothelium-dependent":[231],"mechanisms,":[232],"especially":[233],"(NO)":[236],"signaling,":[237],"contributed":[239],"vascular":[242],"induced":[244],"F-45.":[246],"analysis":[249],"NCX":[261],"homeostasis":[269],"modulation.":[270],"dose-dependent":[276],"effect,":[278],"reducing":[285],"systolic":[286],"diastolic":[288],"blood":[289,300],"pressure.":[290],"an":[292],"rapidly":[297],"normalized":[298],"pressure,":[301],"fast-acting":[307],"agent.":[309],"GRAPHICAL":[310],"ABSTRACT":[311]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-25T00:00:00"}
