{"id":"https://openalex.org/W4415529327","doi":"https://doi.org/10.1002/9781394214532.ch6","title":"Applications of Alginate\u2010Based Nanoparticles","display_name":"Applications of Alginate\u2010Based Nanoparticles","publication_year":2025,"publication_date":"2025-10-24","ids":{"openalex":"https://openalex.org/W4415529327","doi":"https://doi.org/10.1002/9781394214532.ch6"},"language":"en","primary_location":{"id":"doi:10.1002/9781394214532.ch6","doi":"https://doi.org/10.1002/9781394214532.ch6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781394214532.ch6","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers in Functional Foods and Drugs","raw_type":"other"},"volume":{"id":"https://openalex.org/W4415529386","display_name":"Polymers in Functional Foods and Drugs"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5120128452","display_name":"Aisha Qatawneh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153921779","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149","country_code":"JO","type":"education","lineage":["https://openalex.org/I153921779"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Aisha Qatawneh","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan","institution_ids":["https://openalex.org/I153921779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013385681","display_name":"Iman A. Mansi","orcid":"https://orcid.org/0000-0001-6905-5446","observed_orcids":["https://orcid.org/0000-0001-6905-5446"]},"institutions":[{"id":"https://openalex.org/I157392197","display_name":"Hashemite University","ror":"https://ror.org/04a1r5z94","country_code":"JO","type":"education","lineage":["https://openalex.org/I157392197"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Iman A. Mansi","raw_affiliation_strings":["Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, Jordan","institution_ids":["https://openalex.org/I157392197"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120128450","display_name":"Suha Telfah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104941359","display_name":"Al-Ahliyya Amman University","ror":"https://ror.org/00xddhq60","country_code":"JO","type":"education","lineage":["https://openalex.org/I104941359"]},{"id":"https://openalex.org/I153921779","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149","country_code":"JO","type":"education","lineage":["https://openalex.org/I153921779"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Suha Telfah","raw_affiliation_strings":["Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan","Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan","institution_ids":["https://openalex.org/I104941359"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan","institution_ids":["https://openalex.org/I153921779"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016459724","display_name":"Najlaa Saadi Ismael","orcid":"https://orcid.org/0000-0003-0858-6686","observed_orcids":["https://orcid.org/0000-0003-0858-6686"]},"institutions":[{"id":"https://openalex.org/I153687341","display_name":"Zarqa University","ror":"https://ror.org/01wf1es90","country_code":"JO","type":"education","lineage":["https://openalex.org/I153687341"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Najlaa Saadi Ismael","raw_affiliation_strings":["Department of Basic and Clinical Medical Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic and Clinical Medical Sciences, Faculty of Dentistry, Zarqa University, Zarqa, Jordan","institution_ids":["https://openalex.org/I153687341"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026535577","display_name":"Mohammad Abunuwar","orcid":"https://orcid.org/0000-0003-2639-4725","observed_orcids":["https://orcid.org/0000-0003-2639-4725"]},"institutions":[{"id":"https://openalex.org/I153921779","display_name":"Philadelphia University","ror":"https://ror.org/05mqvn149","country_code":"JO","type":"education","lineage":["https://openalex.org/I153921779"]},{"id":"https://openalex.org/I164218144","display_name":"Royal Scientific Society","ror":"https://ror.org/029nath19","country_code":"JO","type":"nonprofit","lineage":["https://openalex.org/I164218144"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Mohammad Abu Nuwar","raw_affiliation_strings":["Biocatalysis and Biosynthesis Research Unit, Research for Industry Center, Royal Scientific Society, Amman, Jordan","Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biocatalysis and Biosynthesis Research Unit, Research for Industry Center, Royal Scientific Society, Amman, Jordan","institution_ids":["https://openalex.org/I164218144"]},{"raw_affiliation_string":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan","institution_ids":["https://openalex.org/I153921779"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"209","last_page":"243"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.35839998722076416,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.29100000858306885,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alginate-nanoparticles","display_name":"alginate nanoparticles","score":0.9779999852180481},{"id":"https://openalex.org/keywords/drug-delivery-systems","display_name":"drug delivery systems","score":0.8199999928474426},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8100000023841858},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.8920000195503235},{"id":"https://openalex.org/keywords/biomedical-imaging","display_name":"biomedical imaging","score":0.8809999823570251},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.949999988079071},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6980000138282776},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.8690000176429749},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ionic-gelation","display_name":"ionic gelation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/covalent-cross-linking","display_name":"covalent cross-linking","score":0.9020000100135803},{"id":"https://openalex.org/keywords/emulsification","display_name":"emulsification","score":0.9860000014305115},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.5379999876022339}],"concepts":[{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.652400016784668},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.5358999967575073},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5307999849319458},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4690999984741211},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.4336000084877014},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.4309999942779541},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.39259999990463257},{"id":"https://openalex.org/C31499863","wikidata":"https://www.wikidata.org/wiki/Q905762","display_name":"Silver nanoparticle","level":3,"score":0.3662000000476837},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.3537999987602234},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.3409000039100647},{"id":"https://openalex.org/C2778648169","wikidata":"https://www.wikidata.org/wiki/Q967768","display_name":"Compatibility (geochemistry)","level":2,"score":0.3179999887943268},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C2780165375","wikidata":"https://www.wikidata.org/wiki/Q2102907","display_name":"PLGA","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28600001335144043},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.26930001378059387},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.260699987411499},{"id":"https://openalex.org/C15083742","wikidata":"https://www.wikidata.org/wiki/Q261659","display_name":"Nanomedicine","level":3,"score":0.25600001215934753},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781394214532.ch6","doi":"https://doi.org/10.1002/9781394214532.ch6","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781394214532.ch6","pdf_url":null,"source":{"id":"https://openalex.org/S4306464293","display_name":"Wiley eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers in Functional Foods and Drugs","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9846000075340271,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1603496397","https://openalex.org/W2794869591","https://openalex.org/W3035645369","https://openalex.org/W3196322830","https://openalex.org/W4292854268","https://openalex.org/W4362638291"],"related_works":["https://openalex.org/W4377092754","https://openalex.org/W7154744218","https://openalex.org/W3208774227","https://openalex.org/W2384658817","https://openalex.org/W4309043714","https://openalex.org/W3043924941","https://openalex.org/W4403983451","https://openalex.org/W4224139121","https://openalex.org/W3194311530","https://openalex.org/W4362638291"],"abstract_inverted_index":{"ALG-NPs":[0,70,119],"have":[1,177],"been":[2,180],"applied":[3],"in":[4,32,74,100,122],"various":[5],"areas":[6],"of":[7,30,68,112,118,153,194,200,207],"biomedical":[8,38],"area":[9],"due":[10,60],"to":[11,102,128,166,190],"their":[12],"compatibility":[13],"with":[14,156],"biological":[15],"systems,":[16,35],"degradation":[17],"abilities,":[18],"and":[19,25,40,49,58,78,108,162,174,204],"noncarcinogenic":[20],"nature.":[21],"Extracted":[22],"from":[23,82],"algae":[24],"bacteria,":[26],"there":[27],"are":[28,97,120],"applications":[29],"alginates":[31],"drug":[33,73,81,105],"delivery":[34],"wound":[36,143],"healing,":[37,144],"imaging,":[39],"cancer":[41,113],"treatment.":[42,114],"Alginates":[43],"can":[44,126],"be":[45],"formed":[46],"into":[47],"gels":[48],"nanoparticles":[50,95,154],"using":[51,136],"methods":[52],"likes":[53],"ionic":[54],"gelation,":[55],"covalent":[56],"cross-linking,":[57],"emulsification":[59],"its":[61],"chemical":[62],"structure.":[63],"Besides":[64],"enhancing":[65],"the":[66,72,80,104,110,145,159,164,185,192,198,201,205],"solubility":[67],"drugs,":[69],"deliver":[71],"a":[75,149],"controlled":[76],"manner":[77],"protect":[79],"degradation,":[83],"which":[84,125],"make":[85],"them":[86],"suitable":[87],"for":[88,187,210],"targeting":[89],"specific":[90],"tissues":[91],"or":[92,134,140],"cells.":[93],"These":[94],"themselves":[96],"also":[98],"coadministered":[99],"order":[101],"tackle":[103],"resistance":[106],"problem":[107],"enhance":[109],"effectiveness":[111],"Moreover,":[115],"new":[116],"concepts":[117],"appearing":[121],"antibacterial":[123],"therapy,":[124],"help":[127],"prevent":[129],"AMR":[130],"by":[131,135],"delivering":[132],"antibiotics":[133],"metals":[137],"like":[138],"silver":[139],"zinc.":[141],"In":[142],"alginate-based":[146],"dressing":[147],"has":[148],"therapeutic":[150],"role":[151],"because":[152],"associated":[155],"it,":[157],"shortening":[158],"healing":[160],"time":[161],"lessening":[163],"susceptibility":[165],"infections.":[167],"However,":[168],"some":[169],"questions":[170],"regarding":[171],"stability,":[172],"biotransformation,":[173],"clinical":[175],"applicability":[176],"not":[178],"yet":[179],"answered.":[181],"There":[182],"is,":[183],"however,":[184],"need":[186],"future":[188],"research":[189],"embrace":[191],"enhancement":[193],"different":[195],"formulation":[196],"techniques,":[197],"stability":[199],"end":[202],"products,":[203],"management":[206],"these":[208],"issues":[209],"more":[211],"extensive":[212],"medical":[213],"utility.":[214]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2025-10-25T00:00:00"}