{"id":"https://openalex.org/W4415519805","doi":"https://doi.org/10.1016/j.jtho.2025.09.819","title":"P3.03.21 Aptamer-Drug Conjugates for Leptomeningeal Carcinomatosis and Cancer-Associated Cachexia in Lung Cancer","display_name":"P3.03.21 Aptamer-Drug Conjugates for Leptomeningeal Carcinomatosis and Cancer-Associated Cachexia in Lung Cancer","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415519805","doi":"https://doi.org/10.1016/j.jtho.2025.09.819"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtho.2025.09.819","doi":"https://doi.org/10.1016/j.jtho.2025.09.819","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2025.09.819","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1016/j.jtho.2025.09.819","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026893117","display_name":"E.P.-Y. Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"E.P.-Y. Lin","raw_affiliation_strings":["Taipei Medical University, Taipei/TW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University, Taipei/TW","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"B-T. Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"B-T. Huang","raw_affiliation_strings":["Taipei Medical University, Taipei/TW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University, Taipei/TW","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":null,"display_name":"C-L. Yeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"C-L. Yeh","raw_affiliation_strings":["Taipei Medical University, Taipei/TW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University, Taipei/TW","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102152955","display_name":"Y. L. Tseng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Y-T. Tseng","raw_affiliation_strings":["Taipei Medical University, Taipei/TW"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taipei Medical University, Taipei/TW","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062656698","display_name":"Yu Shyr","orcid":"https://orcid.org/0000-0003-2086-9670","observed_orcids":["https://orcid.org/0000-0003-2086-9670"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Shyr","raw_affiliation_strings":["Vanderbilt University Medical Center, Nashville/TN/USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University Medical Center, Nashville/TN/USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.12493141,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"10","first_page":"S437","last_page":"S437"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.23569999635219574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aptamer-drug-conjugates","display_name":"aptamer-drug conjugates","score":0.9919999837875366},{"id":"https://openalex.org/keywords/leptomeningeal-metastasis","display_name":"leptomeningeal metastasis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cancer-cachexia","display_name":"cancer cachexia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9229999780654907},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9789000153541565},{"id":"https://openalex.org/C2777704314","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cachexia","level":3,"score":0.8075000047683716},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.7294999957084656},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5299000144004822},{"id":"https://openalex.org/C3020092424","wikidata":"https://www.wikidata.org/wiki/Q6003455","display_name":"Cancer cachexia","level":4,"score":0.520799994468689},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4756999909877777},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3718000054359436},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3709999918937683},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36059999465942383},{"id":"https://openalex.org/C2776206344","wikidata":"https://www.wikidata.org/wiki/Q837583","display_name":"Carcinosis","level":5,"score":0.3547999858856201},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.33230000734329224},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3061999976634979},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtho.2025.09.819","doi":"https://doi.org/10.1016/j.jtho.2025.09.819","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2025.09.819","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtho.2025.09.819","doi":"https://doi.org/10.1016/j.jtho.2025.09.819","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2025.09.819","pdf_url":null,"source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7222212704","https://openalex.org/W4388045790","https://openalex.org/W4214584275","https://openalex.org/W4243215441","https://openalex.org/W2915274177","https://openalex.org/W4403101646","https://openalex.org/W3082149391","https://openalex.org/W4235538497","https://openalex.org/W7132582630","https://openalex.org/W6941142628"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2025-10-24T00:00:00"}