{"id":"https://openalex.org/W4415478229","doi":"https://doi.org/10.1101/2025.10.22.681652","title":"FTO does not function as an m 6 A eraser in AML: a reassessment using direct RNA nanopore sequencing","display_name":"FTO does not function as an m 6 A eraser in AML: a reassessment using direct RNA nanopore sequencing","publication_year":2025,"publication_date":"2025-10-23","ids":{"openalex":"https://openalex.org/W4415478229","doi":"https://doi.org/10.1101/2025.10.22.681652","pmid":"https://pubmed.ncbi.nlm.nih.gov/41279954","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12633362"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.22.681652","doi":"https://doi.org/10.1101/2025.10.22.681652","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.22.681652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.1101/2025.10.22.681652","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110602540","display_name":"Louise V. B. Nicholson","orcid":"https://orcid.org/0009-0005-8203-7249","observed_orcids":["https://orcid.org/0009-0005-8203-7249"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke S. Nicholson","raw_affiliation_strings":["Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 0065, USA"],"raw_orcid":"https://orcid.org/0009-0005-8203-7249","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 0065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021160928","display_name":"Catarina Guimar\u00e3es\u2010Teixeira","orcid":"https://orcid.org/0000-0003-2212-3872","observed_orcids":["https://orcid.org/0000-0003-2212-3872"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405256639","display_name":"Centro de Investiga\u00e7\u00e3o do Instituto Portugu\u00eas de Oncologia do Porto Francisco Gentil","ror":"https://ror.org/04cxp0t61","country_code":"PT","type":"facility","lineage":["https://openalex.org/I4210103180","https://openalex.org/I4405256639"]},{"id":"https://openalex.org/I4405260822","display_name":"RISE - Health Research Network","ror":"https://ror.org/04asa4p95","country_code":"PT","type":"other","lineage":["https://openalex.org/I4405260822"]}],"countries":["PT","US"],"is_corresponding":false,"raw_author_name":"Catarina Guimar\u00e3es-Teixeira","raw_affiliation_strings":["Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal","Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portu"],"raw_orcid":"https://orcid.org/0000-0003-2212-3872","affiliations":[{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portugal","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639","https://openalex.org/I4405260822"]},{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Cancer Biology and Epigenetics Group, Research Center of IPO Porto (CI-IPOP)/RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto)/Porto Comprehensive Cancer Center Raquel Seruca (Porto.CCC Raquel Seruca), Porto, Portu","institution_ids":["https://openalex.org/I4210111164","https://openalex.org/I4405256639","https://openalex.org/I4405260822"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108048994","display_name":"Jianheng Fox Liu","orcid":"https://orcid.org/0000-0003-0216-1951","observed_orcids":["https://orcid.org/0000-0003-0216-1951"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianheng Fox Liu","raw_affiliation_strings":["Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 0065, USA"],"raw_orcid":"https://orcid.org/0000-0003-0216-1951","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 0065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033204172","display_name":"Raymond Chien","orcid":"https://orcid.org/0009-0005-1731-2312","observed_orcids":["https://orcid.org/0009-0005-1731-2312"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]},{"id":"https://openalex.org/I4405253338","display_name":"Infectious Diseases Labs","ror":"https://ror.org/00jj11r28","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405253338","https://openalex.org/I4405254895"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Raymond Chien","raw_affiliation_strings":["Department of Anesthesiology, New Jersey Medical School, Newark, NJ 07103, USA","Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ 08854, USA","A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore 18648, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, New Jersey Medical School, Newark, NJ 07103, USA","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"raw_affiliation_string":"A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore 18648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4405253338"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159962679","display_name":"Jin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Xu","raw_affiliation_strings":["Department of Anesthesiology, New Jersey Medical School, Newark, NJ 07103, USA","Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA","Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ 08854, USA","Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 0065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, New Jersey Medical School, Newark, NJ 07103, USA","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 0065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021081745","display_name":"Hui Xian Poh","orcid":"https://orcid.org/0000-0003-4286-9217","observed_orcids":["https://orcid.org/0000-0003-4286-9217"]},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405253338","display_name":"Infectious Diseases Labs","ror":"https://ror.org/00jj11r28","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405253338","https://openalex.org/I4405254895"]}],"countries":["SG","US"],"is_corresponding":false,"raw_author_name":"Hui Xian Poh","raw_affiliation_strings":["A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore","Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-4286-9217","affiliations":[{"raw_affiliation_string":"A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore 138648, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4405253338"]},{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159841913","display_name":"Ying-Xian Pan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4390039302","display_name":"Rutgers Health","ror":"https://ror.org/029z02k15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Xian Pan","raw_affiliation_strings":["Department of Anesthesiology, New Jersey Medical School, Newark, NJ 07103, USA","Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA","Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ 08854, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, New Jersey Medical School, Newark, NJ 07103, USA","institution_ids":["https://openalex.org/I4402554120"]},{"raw_affiliation_string":"Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Rutgers Addiction Research Center, Brain Health Institute, Rutgers Health, Piscataway, NJ 08854, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039302"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046085522","display_name":"Samie R. Jaffrey","orcid":"https://orcid.org/0000-0003-3615-6958","observed_orcids":["https://orcid.org/0000-0003-3615-6958"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samie R. Jaffrey","raw_affiliation_strings":["Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-3615-6958","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5046085522"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fto-gene","display_name":"FTO","score":0.9020000100135803},{"id":"https://openalex.org/keywords/n6-methyladenosine-demethylation","display_name":"N6-methyladenosine demethylation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9850000143051147},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.8820000290870667},{"id":"https://openalex.org/keywords/rna-demethylase","display_name":"RNA demethylase","score":0.7799999713897705},{"id":"https://openalex.org/keywords/rna-demethylation","display_name":"RNA demethylation","score":0.4869999885559082},{"id":"https://openalex.org/keywords/leukemia-cell-lines","display_name":"leukemia cell lines","score":0.4000000059604645}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6251999735832214},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.6000000238418579},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5940999984741211},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5792999863624573},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.5561000108718872},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4571000039577484},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4194999933242798},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.4165000021457672},{"id":"https://openalex.org/C2780428817","wikidata":"https://www.wikidata.org/wiki/Q14912501","display_name":"FTO gene","level":5,"score":0.4052000045776367},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.40400001406669617},{"id":"https://openalex.org/C141795571","wikidata":"https://www.wikidata.org/wiki/Q580942","display_name":"Nanopore","level":2,"score":0.39910000562667847},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3919000029563904},{"id":"https://openalex.org/C144082473","wikidata":"https://www.wikidata.org/wiki/Q213185","display_name":"Stoichiometry","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.37400001287460327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34619998931884766},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.30570000410079956},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.2987000048160553},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29750001430511475},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.27959999442100525},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.27790001034736633},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2597000002861023},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.2540000081062317},{"id":"https://openalex.org/C2777553025","wikidata":"https://www.wikidata.org/wiki/Q25323683","display_name":"S-Nitrosylation","level":4,"score":0.25209999084472656}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1101/2025.10.22.681652","doi":"https://doi.org/10.1101/2025.10.22.681652","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.22.681652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41279954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41279954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11440758","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12633362","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1101/2025.10.22.681652","doi":"https://doi.org/10.1101/2025.10.22.681652","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.22.681652","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4000000059604645}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7191335144","display_name":"Ultra-sensitive multi-mode laser-scanning imaging system","funder_award_id":"1s10od030335-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000866283","display_name":"Mechanisms of epitranscriptomic regulation in cancer","funder_award_id":"R01CA186702","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000877619","display_name":"Center for Genomic Information Encoded by RNA Nucleotide Modifications","funder_award_id":"RM1HG011563","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G9000896688","display_name":"New mechanisms and technologies for understanding post-transcriptional gene regulation in neurons","funder_award_id":"R35NS111631","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W776567260","https://openalex.org/W2002458471","https://openalex.org/W2015696149","https://openalex.org/W2021341670","https://openalex.org/W2065847836","https://openalex.org/W2071930821","https://openalex.org/W2078964320","https://openalex.org/W2104706770","https://openalex.org/W2122958542","https://openalex.org/W2174471079","https://openalex.org/W2266287131","https://openalex.org/W2562211106","https://openalex.org/W2563912688","https://openalex.org/W2601913258","https://openalex.org/W2735132087","https://openalex.org/W2741508285","https://openalex.org/W2750801274","https://openalex.org/W2772792536","https://openalex.org/W2789843538","https://openalex.org/W2891713480","https://openalex.org/W2897591452","https://openalex.org/W2912048746","https://openalex.org/W2936790196","https://openalex.org/W2946217053","https://openalex.org/W2949112249","https://openalex.org/W2950063384","https://openalex.org/W2952109315","https://openalex.org/W2952121859","https://openalex.org/W2953460056","https://openalex.org/W2964849163","https://openalex.org/W2973421587","https://openalex.org/W2989499631","https://openalex.org/W2997965570","https://openalex.org/W3016950990","https://openalex.org/W3018119582","https://openalex.org/W3034923646","https://openalex.org/W3112049593","https://openalex.org/W3131055609","https://openalex.org/W3187232364","https://openalex.org/W3195602130","https://openalex.org/W3197583636","https://openalex.org/W4220674994","https://openalex.org/W4224288799","https://openalex.org/W4307500724","https://openalex.org/W4312155712","https://openalex.org/W4313454095","https://openalex.org/W4313529454","https://openalex.org/W4378379085","https://openalex.org/W4383499322","https://openalex.org/W4384200957","https://openalex.org/W4391174155","https://openalex.org/W4391229108","https://openalex.org/W4394363929","https://openalex.org/W4403810280","https://openalex.org/W4404732962","https://openalex.org/W4405559017","https://openalex.org/W4406485793","https://openalex.org/W4406955194","https://openalex.org/W4408249282","https://openalex.org/W4409000948","https://openalex.org/W4410077534","https://openalex.org/W4410551920","https://openalex.org/W4410809531","https://openalex.org/W4410831420","https://openalex.org/W4410949827","https://openalex.org/W4413116206","https://openalex.org/W4413258226","https://openalex.org/W4415103556","https://openalex.org/W4416823254","https://openalex.org/W7140089885"],"related_works":["https://openalex.org/W2580206882","https://openalex.org/W2937441886","https://openalex.org/W2891713480","https://openalex.org/W7127711575","https://openalex.org/W7161763236","https://openalex.org/W2990113494","https://openalex.org/W4382010715","https://openalex.org/W4411435400","https://openalex.org/W4321329582","https://openalex.org/W4400952902"],"abstract_inverted_index":{"SUMMARY":[0],"A":[1,54,61,132,157],"central":[2],"concept":[3],"in":[4,24,31,76,90,107,117,128,136,158],"epitranscriptomics":[5],"is":[6,28,40,101],"that":[7,58,93,148],"the":[8,102,114,161],"RNA":[9,48],"demethylase":[10],"FTO":[11,71,106,118,143,149,166],"acts":[12],"as":[13],"a":[14],"site-selective":[15],"eraser":[16],"of":[17,38,80,105,165,172],"N":[18,81],"6":[19,22,53,60,82,85,95,99,131,139,156,174],"-methyladenosine":[20],"(m":[21,84],"A)":[23],"specific":[25],"mRNAs.":[26],"This":[27],"most":[29],"well-established":[30],"acute":[32],"myeloid":[33],"leukemia":[34],"(AML),":[35],"where":[36],"demethylation":[37,171],"MYC":[39,65],"thought":[41],"to":[42,50,153],"promote":[43],"leukemogenesis.":[44],"Using":[45],"nanopore":[46],"direct":[47],"sequencing":[49],"quantify":[51],"m":[52,59,94,98,130,138,155,173],"transcriptome-wide,":[55],"we":[56],"find":[57],"stoichiometry,":[62],"including":[63],"at":[64],"-specific":[66],"sites,":[67],"remains":[68],"unaffected":[69],"by":[70,170],"knockdown":[72],"or":[73],"pharmacologic":[74],"inhibition":[75],"AML.":[77,108],"Conversely,":[78],"levels":[79,141],"-2\u2019-O-dimethyladenosine":[83],"Am)":[86],"are":[87,167],"markedly":[88],"increased":[89],"snRNAs,":[91],"indicating":[92],"Am,":[96],"not":[97],"A,":[100],"major":[103],"substrate":[104],"We":[109],"extend":[110],"these":[111],"results":[112],"outside":[113],"AML":[115],"context":[116],"knockout":[119],"brain":[120],"and":[121],"HEK293T":[122],"cells,":[123],"detecting":[124],"no":[125],"selective":[126],"increases":[127,135],"mRNA":[129],"but":[133],"widespread":[134],"snRNA":[137],"Am":[140],"following":[142],"depletion.":[144],"These":[145],"findings":[146],"suggest":[147],"has":[150],"minimal":[151],"ability":[152],"erase":[154],"mRNA.":[159],"Instead,":[160],"reported":[162],"biological":[163],"effects":[164],"likely":[168],"mediated":[169],"Am.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-23T00:00:00"}
