{"id":"https://openalex.org/W4415476255","doi":"https://doi.org/10.1681/asn.2025wvk84ch3","title":"Peritoneal Dialysis in ADPKD","display_name":"Peritoneal Dialysis in ADPKD","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415476255","doi":"https://doi.org/10.1681/asn.2025wvk84ch3"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2025wvk84ch3","doi":"https://doi.org/10.1681/asn.2025wvk84ch3","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025wvk84ch3","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020100598","display_name":"Samantha Gunning","orcid":"https://orcid.org/0000-0003-4738-7356","observed_orcids":["https://orcid.org/0000-0003-4738-7356"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha Gunning","raw_affiliation_strings":["The University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States;","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083076868","display_name":"Rita L. McGill","orcid":"https://orcid.org/0000-0003-3856-8550","observed_orcids":["https://orcid.org/0000-0003-3856-8550"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita L. McGill","raw_affiliation_strings":["The University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States;","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113036319","display_name":"Arlene B. Chapman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlene B. Chapman","raw_affiliation_strings":["The University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Chicago Division of the Biological Sciences, Chicago, Illinois, United States;","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027394675","display_name":"Pranav Sandilya Garimella","orcid":"https://orcid.org/0000-0002-6016-4715","observed_orcids":["https://orcid.org/0000-0002-6016-4715"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pranav S. Garimella","raw_affiliation_strings":["University of California San Diego, La Jolla, California, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California San Diego, La Jolla, California, United States","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.32867003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.8407999873161316,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases","score":0.14149999618530273,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/peritoneal-dialysis","display_name":"peritoneal dialysis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/autosomal-dominant-polycystic-kidney-disease","display_name":"autosomal dominant polycystic kidney disease","score":1.0},{"id":"https://openalex.org/keywords/hemodialysis","display_name":"hemodialysis","score":0.6869999766349792},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9309999942779541},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8859999775886536},{"id":"https://openalex.org/keywords/treatment-outcomes","display_name":"treatment outcomes","score":0.5339999794960022},{"id":"https://openalex.org/keywords/home-dialysis","display_name":"home dialysis","score":0.597000002861023},{"id":"https://openalex.org/keywords/cystic-kidney-disease","display_name":"cystic kidney disease","score":0.7490000128746033},{"id":"https://openalex.org/keywords/dialysis-modality","display_name":"dialysis modality","score":0.5099999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9140999913215637},{"id":"https://openalex.org/C2776266639","wikidata":"https://www.wikidata.org/wiki/Q2732398","display_name":"Autosomal dominant polycystic kidney disease","level":3,"score":0.836899995803833},{"id":"https://openalex.org/C2779056158","wikidata":"https://www.wikidata.org/wiki/Q1756474","display_name":"Peritoneal dialysis","level":2,"score":0.7975999712944031},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.5522000193595886},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.5411999821662903},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5260999798774719},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.511900007724762},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.4706999957561493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45089998841285706},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.45019999146461487},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4447000026702881},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C2780145431","wikidata":"https://www.wikidata.org/wiki/Q15443105","display_name":"Polycystic kidney disease","level":3,"score":0.3700000047683716},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3149000108242035},{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C2779541074","wikidata":"https://www.wikidata.org/wiki/Q185643","display_name":"Renal replacement therapy","level":2,"score":0.28290000557899475},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.2651999890804291}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2025wvk84ch3","doi":"https://doi.org/10.1681/asn.2025wvk84ch3","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025wvk84ch3","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171921272","https://openalex.org/W2790152636","https://openalex.org/W2407712516","https://openalex.org/W1861653355","https://openalex.org/W2126405397","https://openalex.org/W2810489634","https://openalex.org/W7140287590","https://openalex.org/W2728190189","https://openalex.org/W2023667981","https://openalex.org/W1829483591"],"abstract_inverted_index":{"Background:":[0],"Peritoneal":[1],"dialysis":[2,291],"(PD)":[3],"is":[4,61,288],"a":[5,74,269,289],"convenient,":[6],"home-based":[7],"form":[8],"of":[9,66,77,158,191,197,232,272],"dialysis.":[10],"Patients":[11],"with":[12,24,83,155,260],"autosomal":[13],"dominant":[14],"polycystic":[15],"kidney":[16,85,302],"disease":[17,86],"(ADPKD)":[18],"are":[19,249],"often":[20],"optimal":[21],"PD":[22,40,127,186,211,223,237,255,287],"candidates":[23],"good":[25],"family":[26],"support,":[27],"health":[28],"literacy,":[29],"and":[30,51,55,128,134,150,218,267],"few":[31],"comorbid":[32,151,221],"conditions.":[33,222],"However,":[34],"clinicians":[35],"may":[36],"hesitate":[37],"to":[38,57,94,126,130,195,209,253],"choose":[39],"for":[41,53,104,140,230,293,301],"ADPKD":[42,67,165,192,204,234,240,294],"patients":[43,68,79,166,199,205],"given":[44],"their":[45],"organomegaly,":[46],"possible":[47],"increased":[48,261],"intraabdominal":[49],"pressure,":[50],"concerns":[52],"complications":[54],"ability":[56],"tolerate":[58],"PD.":[59,70],"Little":[60],"known":[62],"about":[63],"clinical":[64],"outcomes":[65,248],"undergoing":[69],"Methods:":[71],"We":[72],"analyzed":[73],"retrospective":[75],"cohort":[76],"all":[78],"\u226530":[80],"years":[81],"old":[82],"cystic":[84],"in":[87,167,189,239],"the":[88,116,168,201,227,283],"US":[89,284],"Renal":[90],"Data":[91],"System":[92],"up":[93],"12/2021,":[95],"followed":[96],"till":[97],"death":[98],"or":[99,299],"1/2023.":[100],"A":[101],"time-dependent":[102],"variable":[103],"modality":[105],"[PD,":[106],"hemodialysis":[107],"(HD),":[108],"transplant":[109],"(Tx)]":[110],"was":[111,115,173,181,224,241,257],"created.":[112],"HD":[113],"exposure":[114,187,212,238,256],"reference":[117],"category,":[118],"enabling":[119],"hazard":[120],"ratios":[121],"based":[122],"on":[123],"days":[124],"exposed":[125],"proximity":[129],"outcome":[131],"events":[132],"(death":[133],"Tx).":[135],"Cox":[136],"models":[137],"were":[138,163,177,206,215],"adjusted":[139],"age,":[141],"sex,":[142],"race,":[143],"BMI,":[144],"albumin,":[145,146],"hemoglobin,":[147],"time":[148],"period,":[149],"conditions":[152],"at":[153],"inclusion,":[154],"multiple":[156],"imputation":[157],"missing":[159],"data.":[160],"Results:":[161],"There":[162],"84,053":[164],"analytical":[169],"dataset.":[170],"Mean":[171],"age":[172],"56\u00b112":[174],"years;":[175],"47%":[176],"female.":[178],"Median":[179,236],"follow-up":[180],"82":[182],"(IQR:":[183,243],"37-154)":[184],"months.":[185,245],"occurred":[188],"27%":[190],"patients,":[193,295],"compared":[194],"29%":[196],"non-ADPKD":[198],"during":[200],"study":[202],"period.":[203],"more":[207],"likely":[208],"have":[210],"if":[213],"they":[214],"female,":[216],"younger,":[217],"had":[219,268],"fewer":[220],"inititated":[225],"within":[226],"first":[228],"year":[229],"86%":[231],"PD-exposed":[233],"patients.":[235],"20":[242],"8,39)":[244],"Ten-year":[246],"treatment":[247],"shown":[250],"(figure).":[251],"Compared":[252],"HD,":[254],"not":[258],"associated":[259],"mortality":[262],"(HR:":[263,274],"1.03,":[264],"95%CI=0.99-1.06,":[265],"P=0.13)":[266],"higher":[270],"likelihood":[271],"Tx":[273],"1.11":[275],"(95%CI=1.07-1.14,":[276],"P<0.001).":[277],"Conclusion:":[278],"Retrospective":[279],"national":[280],"data":[281],"from":[282],"indicate":[285],"that":[286],"viable":[290],"option":[292],"without":[296],"compromising":[297],"survival":[298],"opportunities":[300],"Tx.":[303]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-23T00:00:00"}