{"id":"https://openalex.org/W4415474147","doi":"https://doi.org/10.1681/asn.2025xv4nkh80","title":"Modulation of PTH Affects the Action of Irisin on Bone in a Rat Model of CKD-MBD","display_name":"Modulation of PTH Affects the Action of Irisin on Bone in a Rat Model of CKD-MBD","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415474147","doi":"https://doi.org/10.1681/asn.2025xv4nkh80"},"language":"en","primary_location":{"id":"doi:10.1681/asn.2025xv4nkh80","doi":"https://doi.org/10.1681/asn.2025xv4nkh80","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025xv4nkh80","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101527728","display_name":"Hannah E. Wilson","orcid":"https://orcid.org/0009-0008-6520-9215","observed_orcids":["https://orcid.org/0009-0008-6520-9215"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hannah E. Wilson","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036155533","display_name":"Neal X. Chen","orcid":"https://orcid.org/0000-0002-3309-0802","observed_orcids":["https://orcid.org/0000-0002-3309-0802"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Neal X. Chen","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044149723","display_name":"Corinne E. Metzger","orcid":"https://orcid.org/0000-0002-2944-8082","observed_orcids":["https://orcid.org/0000-0002-2944-8082","https://orcid.org/0000-0003-4973-9642"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Corinne E. Metzger","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048725628","display_name":"Shruthi Srinivasan","orcid":"https://orcid.org/0009-0003-8523-6900","observed_orcids":["https://orcid.org/0009-0003-8523-6900"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shruthi Srinivasan","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018885816","display_name":"Kalisha D. O\u2019Neill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalisha O'Neill","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5098777304","display_name":"Karis L Blacklock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karis L Blacklock","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020221844","display_name":"Emily K. Matter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily K Matter","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080453305","display_name":"Matthew R. Allen","orcid":"https://orcid.org/0000-0002-1174-9004","observed_orcids":["https://orcid.org/0000-0002-1174-9004"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. Allen","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074659892","display_name":"Sharon M. Moe","orcid":"https://orcid.org/0000-0003-3562-9725","observed_orcids":["https://orcid.org/0000-0003-3562-9725"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon M. Moe","raw_affiliation_strings":["Indiana University School of Medicine, Indianapolis, Indiana, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Indianapolis, Indiana, United States","institution_ids":["https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.31375665,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"10S","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9750999808311462,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irisin","display_name":"irisin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8399999737739563},{"id":"https://openalex.org/keywords/ckd-mbd","display_name":"chronic kidney disease-mineral and bone disorder","score":0.9760000109672546},{"id":"https://openalex.org/keywords/fndc5","display_name":"FNDC5","score":0.9290000200271606},{"id":"https://openalex.org/keywords/myokines","display_name":"myokines","score":0.8360000252723694},{"id":"https://openalex.org/keywords/bone-turnover","display_name":"bone turnover","score":0.8159999847412109},{"id":"https://openalex.org/keywords/bone-formation-rate","display_name":"bone formation rate","score":0.7519999742507935},{"id":"https://openalex.org/keywords/calcium-supplementation","display_name":"calcium supplementation","score":0.4830000102519989},{"id":"https://openalex.org/keywords/p1np","display_name":"P1NP","score":0.5690000057220459},{"id":"https://openalex.org/keywords/mineral-apposition-rate","display_name":"mineral apposition rate","score":0.843999981880188},{"id":"https://openalex.org/keywords/soleus-muscle","display_name":"soleus muscle","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8981999754905701},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.881600022315979},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6035000085830688},{"id":"https://openalex.org/C64348721","wikidata":"https://www.wikidata.org/wiki/Q7247456","display_name":"Procollagen peptidase","level":2,"score":0.5968999862670898},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.588699996471405},{"id":"https://openalex.org/C117365660","wikidata":"https://www.wikidata.org/wiki/Q962589","display_name":"Myokine","level":3,"score":0.5781000256538391},{"id":"https://openalex.org/C206810289","wikidata":"https://www.wikidata.org/wiki/Q21118157","display_name":"FNDC5","level":4,"score":0.49059998989105225},{"id":"https://openalex.org/C117866178","wikidata":"https://www.wikidata.org/wiki/Q321056","display_name":"Apposition","level":2,"score":0.4487999975681305},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.40700000524520874},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38429999351501465},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38199999928474426},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.3393000066280365},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.32100000977516174},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.3188999891281128},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.311599999666214},{"id":"https://openalex.org/C2909674915","wikidata":"https://www.wikidata.org/wiki/Q1851434","display_name":"Bone histomorphometry","level":4,"score":0.2858000099658966},{"id":"https://openalex.org/C2776104385","wikidata":"https://www.wikidata.org/wiki/Q1954164","display_name":"Soleus muscle","level":3,"score":0.2667999863624573},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.2597000002861023},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.2572999894618988},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1681/asn.2025xv4nkh80","doi":"https://doi.org/10.1681/asn.2025xv4nkh80","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.2025xv4nkh80","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Despite":[1],"use":[2],"of":[3,20,46,132,183,278,287],"PTH-lowering":[4],"therapies,":[5],"fractures":[6],"in":[7,55,57,158,207,214,233,238,255,283,304],"CKD":[8,196],"patients":[9],"have":[10],"not":[11],"decreased,":[12],"indicating":[13],"other":[14],"factors":[15],"may":[16,274],"modulate":[17],"the":[18,44,133,187,215,239,257,276],"effect":[19,45,220,277],"PTH":[21,54,109,167,254,273],"on":[22,48,280],"bone.":[23],"One":[24],"such":[25],"factor":[26],"is":[27,221],"irisin,":[28],"a":[29,181,202,246,284,301],"myokine":[30],"produced":[31],"by":[32,129,146,191],"skeletal":[33],"muscle":[34],"from":[35],"its":[36],"precursor,":[37],"Fndc5.":[38],"This":[39],"study":[40],"sought":[41],"to":[42,85,195],"determine":[43],"irisin":[47,94,171,177,216,279],"bone":[49,123,184,281],"under":[50],"high":[51,272],"and":[52,79,110,169,212,253,261,297,300],"low":[53],"CKD-MBD":[56],"vivo.":[58],"Methods:":[59],"22":[60],"wk":[61],"male":[62],"Cy/+":[63],"rats,":[64],"which":[65],"model":[66,286],"progressive":[67],"CKD-MBD,":[68],"were":[69,103,118,144],"divided":[70],"into":[71],"4":[72],"groups.":[73,163],"Half":[74],"received":[75],"normal":[76],"drinking":[77],"water":[78,84],"half":[80,192],"2%":[81,164,174],"calcium":[82,165,175,227],"gluconate":[83],"continuously":[86,271],"suppress":[87],"PTH,":[88],"then":[89],"at":[90],"27":[91],"wks,":[92],"recombinant":[93],"injections":[95],"(i.p.":[96],"3x/wk,":[97],"30":[98],"\u00b5g/kg)":[99],"or":[100,149,160,241],"no":[101,156,231],"treatment":[102],"administered":[104],"for":[105],"5":[106],"wks.":[107],"Plasma":[108],"serum":[111],"procollagen":[112],"type":[113],"I":[114],"N-terminal":[115],"propeptide":[116],"(PINP)":[117],"assessed":[119,140],"via":[120,141,295],"ELISA.":[121],"Tb":[122],"formation":[124],"rate":[125,210],"(BFR)":[126],"was":[127,139,155,230,245],"determined":[128],"dynamic":[130],"histomorphometry":[131,199],"proximal":[134],"tibia.":[135],"Muscle":[136],"Fndc5":[137,234,251],"mRNA":[138,235,252],"qPCR.":[142],"Data":[143],"analyzed":[145],"one-way":[147],"ANOVA":[148],"simple":[150],"linear":[151],"regression.":[152],"Results:":[153],"There":[154,229],"difference":[157,232],"BUN":[159],"creatinine":[161],"b/w":[162,236],"suppressed":[166],"with":[168,226],"without":[170],"(1a).":[172],"Neither":[173],"nor":[176],"alone":[178],"affected":[179],"PINP,":[180],"marker":[182],"turnover,":[185],"but":[186,243],"combination":[188],"decreased":[189],"PINP":[190],"(p<0.0001)":[193],"compared":[194],"(1b).":[197],"Preliminary":[198],"(n=5)":[200],"indicates":[201],"trend":[203],"toward":[204],"an":[205],"increase":[206],"mineral":[208],"apposition":[209],"(MAR)":[211],"BFR":[213],"group.":[217],"However,":[218],"this":[219,293],"blunted":[222],"when":[223],"also":[224],"treated":[225],"(1c,d).":[228],"groups":[237],"soleus":[240,258],"EDL,":[242],"there":[244],"significant":[247],"negative":[248],"correlation":[249],"between":[250],"both":[256],"(p<0.0001,":[259],"r2=0.414)":[260],"EDL":[262],"(p=0.02,":[263],"r2=0.116)":[264],"(2a,b).":[265],"Conclusion:":[266],"These":[267],"data":[268],"indicate":[269],"that":[270],"blunt":[275],"turnover":[282],"rat":[285],"CKD-MBD.":[288],"Ongoing":[289],"studies":[290],"will":[291],"examine":[292],"interaction":[294],"\u00b5CT":[296],"mechanical":[298],"testing":[299],"potential":[302],"mechanism":[303],"vitro.":[305],"Funding:":[306],"NIDDK":[307,310,312],"Support":[308,313],"-":[309],"Support,":[311]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2025-10-23T00:00:00"}
