{"id":"https://openalex.org/W4415465436","doi":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","title":"Extraction of PCB18 (2,2',5-Trichlorobiphenyl) and Its Hydroxylated Metabolites from Animal Tissues v2 v1","display_name":"Extraction of PCB18 (2,2',5-Trichlorobiphenyl) and Its Hydroxylated Metabolites from Animal Tissues v2 v1","publication_year":2025,"publication_date":"2025-10-22","ids":{"openalex":"https://openalex.org/W4415465436","doi":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1"},"language":"en","primary_location":{"id":"doi:10.17504/protocols.io.14egnrr26l5d/v1","doi":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","pdf_url":"https://www.protocols.io/view/extraction-of-pcb18-2-2-39-5-trichlorobiphenyl-and-hdc7b22zp.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.protocols.io/view/extraction-of-pcb18-2-2-39-5-trichlorobiphenyl-and-hdc7b22zp.pdf","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048294684","display_name":"Xueshu Li","orcid":"https://orcid.org/0000-0002-0881-5381","observed_orcids":["https://orcid.org/0000-0002-0881-5381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xueshu Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119102625","display_name":"Sean Brobston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sean Brobston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5024042726","display_name":"Hans\u2010Joachim Lehmler","orcid":"https://orcid.org/0000-0001-9163-927X","observed_orcids":["https://orcid.org/0000-0001-9163-927X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Joachim Lehmler","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9163-927X","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxylated-pcb-metabolites","display_name":"hydroxylated PCB metabolites","score":0.8880000114440918},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tissue-extraction","display_name":"tissue extraction","score":0.7179999947547913},{"id":"https://openalex.org/keywords/liquid-liquid-extraction","display_name":"liquid-liquid extraction","score":0.902999997138977},{"id":"https://openalex.org/keywords/solid-phase-extraction-cleanup","display_name":"solid-phase extraction cleanup","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mouse-tissues","display_name":"mouse tissues","score":0.9150000214576721},{"id":"https://openalex.org/keywords/organochlorine-pollutants","display_name":"organochlorine contaminants","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.7911999821662903},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7342000007629395},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6488000154495239},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.5620999932289124},{"id":"https://openalex.org/C205345274","wikidata":"https://www.wikidata.org/wiki/Q873009","display_name":"Gas chromatography\u2013mass spectrometry","level":3,"score":0.43529999256134033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.397599995136261},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.34610000252723694},{"id":"https://openalex.org/C123460561","wikidata":"https://www.wikidata.org/wiki/Q677065","display_name":"Gas chromatography","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.3124000132083893},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.26980000734329224},{"id":"https://openalex.org/C95986675","wikidata":"https://www.wikidata.org/wiki/Q185168","display_name":"Quantitative analysis (chemistry)","level":2,"score":0.26489999890327454}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17504/protocols.io.14egnrr26l5d/v1","doi":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","pdf_url":"https://www.protocols.io/view/extraction-of-pcb18-2-2-39-5-trichlorobiphenyl-and-hdc7b22zp.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.17504/protocols.io.14egnrr26l5d/v1","doi":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","is_oa":true,"landing_page_url":"https://doi.org/10.17504/protocols.io.14egnrr26l5d/v1","pdf_url":"https://www.protocols.io/view/extraction-of-pcb18-2-2-39-5-trichlorobiphenyl-and-hdc7b22zp.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8785879452","display_name":"PCB-mediated dysbiosis of the gut microbiome: A missing link in PCB-mediated neurodevelopmental disorders?","funder_award_id":"R01ES031098","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000134533","display_name":"Iowa Superfund Research Program: Airborne PCBs: Sources, Exposures, Toxicities, Remediation","funder_award_id":"P42ES013661","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000321911","display_name":"Environmental factors in pathobiology of dementia: the role of PCB exposure, microbiome, and tissue barrier dysfunction","funder_award_id":"R01ES034691","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000866560","display_name":"Molecular and Cellular Basis of PCB Developmental Neurotoxicity","funder_award_id":"R01ES014901","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415465436.pdf","grobid_xml":"https://content.openalex.org/works/W4415465436.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4412723523","https://openalex.org/W4412936123","https://openalex.org/W4401382063","https://openalex.org/W4401518988","https://openalex.org/W2350714353","https://openalex.org/W2049194098","https://openalex.org/W2069682687","https://openalex.org/W2010690664","https://openalex.org/W2012225606","https://openalex.org/W1970504913"],"abstract_inverted_index":{"This":[0],"protocol":[1],"describes":[2],"a":[3],"method":[4],"for":[5],"extracting":[6],"PCB18":[7,27],"(2,2\u2032,5-trichlorobiphenyl)":[8],"and":[9,28],"its":[10],"monohydroxylated":[11],"metabolites":[12],"from":[13],"mouse":[14],"tissues":[15],"via":[16],"liquid-liquid":[17],"extraction":[18,22],"followed":[19],"by":[20,36],"solid-phase":[21],"cleanup.":[23],"The":[24],"levels":[25],"of":[26],"OH-PCB18s":[29],"in":[30],"the":[31],"tissue":[32],"are":[33],"subsequently":[34],"measured":[35],"gas":[37],"chromatography-tandem":[38],"mass":[39],"spectrometry.":[40]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2025-10-23T00:00:00"}
