{"id":"https://openalex.org/W4415438504","doi":"https://doi.org/10.7554/elife.108742.1","title":"Suppression of interferon signaling via small molecule modulation of TFAM","display_name":"Suppression of interferon signaling via small molecule modulation of TFAM","publication_year":2025,"publication_date":"2025-10-22","ids":{"openalex":"https://openalex.org/W4415438504","doi":"https://doi.org/10.7554/elife.108742.1"},"language":"en","primary_location":{"id":"doi:10.7554/elife.108742.1","doi":"https://doi.org/10.7554/elife.108742.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108742.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.108742.1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068554597","display_name":"Dionisia P. Sideris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dionisia P Sideris","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007857979","display_name":"Hsuan Lee","orcid":"https://orcid.org/0000-0001-6818-3243","observed_orcids":["https://orcid.org/0000-0001-6818-3243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hsuan Lee","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061546028","display_name":"Lyndsay Olson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyndsay Olson","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047456909","display_name":"Kalyan C. Nallaparaju","orcid":"https://orcid.org/0009-0006-1952-2505","observed_orcids":["https://orcid.org/0009-0006-1952-2505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kalyan Nallaparaju","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019766432","display_name":"Keiichiro Okuyama","orcid":"https://orcid.org/0009-0007-9519-3333","observed_orcids":["https://orcid.org/0009-0007-9519-3333"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiichiro Okuyama","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050447186","display_name":"Jeff Ciavarri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeff Ciavarri","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Medicinal Chemistry"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Medicinal Chemistry","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032437502","display_name":"Robert Lafyatis","orcid":"https://orcid.org/0000-0002-9398-5034","observed_orcids":["https://orcid.org/0000-0002-9398-5034"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Lafyatis","raw_affiliation_strings":["Division of Rheumatology and Clinical Immunology, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Rheumatology and Clinical Immunology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076006747","display_name":"Mads Breum Larsen","orcid":"https://orcid.org/0000-0001-5361-0898","observed_orcids":["https://orcid.org/0000-0001-5361-0898"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mads B Larsen","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085684503","display_name":"Bo Lin","orcid":"https://orcid.org/0000-0002-2108-2696","observed_orcids":["https://orcid.org/0000-0002-2108-2696"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Lin","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064234531","display_name":"Irene Alfaras","orcid":"https://orcid.org/0000-0002-2073-9641","observed_orcids":["https://orcid.org/0000-0002-2073-9641"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene Alfaras","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050602232","display_name":"Jason R. Kennerdell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason R Kennerdell","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103504958","display_name":"Toren Finkel","orcid":"https://orcid.org/0000-0002-5265-7982","observed_orcids":["https://orcid.org/0000-0002-5265-7982"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Toren Finkel","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC","Department of Medicine, Division of Cardiology, University of Pittsburgh","Generian Pharmaceuticals"],"raw_orcid":"https://orcid.org/0000-0002-5265-7982","affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Medicine, Division of Cardiology, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Generian Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390796","display_name":"Yuan Liu","orcid":"https://orcid.org/0000-0001-5031-7514","observed_orcids":["https://orcid.org/0000-0001-5031-7514"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuan Liu","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC","Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh","Generian Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Generian Pharmaceuticals","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087456017","display_name":"Bill B. Chen","orcid":"https://orcid.org/0000-0003-2695-5107","observed_orcids":["https://orcid.org/0000-0003-2695-5107"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bill B Chen","raw_affiliation_strings":["Aging Institute, University of Pittsburgh/UPMC","Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh","Generian Pharmaceuticals","Vascular Medicine Institute, University of Pittsburgh"],"raw_orcid":"https://orcid.org/0000-0003-2695-5107","affiliations":[{"raw_affiliation_string":"Aging Institute, University of Pittsburgh/UPMC","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Generian Pharmaceuticals","institution_ids":[]},{"raw_affiliation_string":"Vascular Medicine Institute, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007956428","display_name":"Lin Lyu","orcid":"https://orcid.org/0000-0001-9771-0110","observed_orcids":["https://orcid.org/0000-0001-9771-0110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lin Lyu","raw_affiliation_strings":["Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology"],"raw_orcid":"https://orcid.org/0000-0001-9771-0110","affiliations":[{"raw_affiliation_string":"Astellas Pharmaceuticals Inc., Oncology Research, Cancer Biology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.06960000097751617,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tfam","display_name":"TFAM","score":0.9509999752044678},{"id":"https://openalex.org/keywords/small-molecule-activators","display_name":"small molecule activators","score":0.9100000262260437},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cgas-sting-pathway","display_name":"cGAS-STING pathway","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mitochondrial-dna","display_name":"mitochondrial DNA","score":0.5669999718666077},{"id":"https://openalex.org/keywords/mtdna-release","display_name":"mtDNA release","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mitochondrial-dna-copy-number","display_name":"mitochondrial DNA copy number","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.6230000257492065},{"id":"https://openalex.org/keywords/melas","display_name":"MELAS","score":0.9399999976158142},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.9480000138282776},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.8870000243186951},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C169415338","wikidata":"https://www.wikidata.org/wiki/Q18031951","display_name":"TFAM","level":4,"score":0.9945999979972839},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6830999851226807},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5616000294685364},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5573999881744385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5509999990463257},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.47920000553131104},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.4219000041484833},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.41909998655319214},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.4074999988079071},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.37119999527931213},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36579999327659607},{"id":"https://openalex.org/C77445288","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivator","level":4,"score":0.336899995803833},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.31360000371932983},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C2778480876","wikidata":"https://www.wikidata.org/wiki/Q21112674","display_name":"PARP1","level":5,"score":0.2924000024795532},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2770000100135803},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2766999900341034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2669999897480011},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.26440000534057617},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2603999972343445},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2556999921798706}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.108742.1","doi":"https://doi.org/10.7554/elife.108742.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108742.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.108742.1","doi":"https://doi.org/10.7554/elife.108742.1","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.108742.1","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323024","display_name":"Astellas Pharma","ror":"https://ror.org/01cjash87"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1968197570","https://openalex.org/W1971082641","https://openalex.org/W1972645332","https://openalex.org/W2021652408","https://openalex.org/W2035232303","https://openalex.org/W2121594663","https://openalex.org/W2790688909","https://openalex.org/W2808681120","https://openalex.org/W2967460951","https://openalex.org/W2969924591","https://openalex.org/W2995171541","https://openalex.org/W3008007446","https://openalex.org/W3145334405","https://openalex.org/W3197077697","https://openalex.org/W3205710654","https://openalex.org/W3213307544","https://openalex.org/W4214766070","https://openalex.org/W4220854412","https://openalex.org/W4221068778","https://openalex.org/W4244513330","https://openalex.org/W4360852432","https://openalex.org/W4362459424","https://openalex.org/W4386579497","https://openalex.org/W4388460235","https://openalex.org/W4388483815","https://openalex.org/W4389304453","https://openalex.org/W4389614457","https://openalex.org/W4394567462","https://openalex.org/W4398784869"],"related_works":["https://openalex.org/W4411870896","https://openalex.org/W2028339345","https://openalex.org/W2141852665","https://openalex.org/W4389609689","https://openalex.org/W3215386094","https://openalex.org/W2154802086","https://openalex.org/W7095430614","https://openalex.org/W2019671050","https://openalex.org/W4283693551","https://openalex.org/W3197077697"],"abstract_inverted_index":{"The":[0],"mitochondrial":[1,9,15,27,43,200],"transcription":[2],"factor":[3],"A":[4],"(TFAM)":[5],"is":[6,32],"essential":[7],"for":[8,88,94],"genome":[10],"maintenance.":[11],"It":[12],"binds":[13],"to":[14,63],"DNA":[16],"(mtDNA)":[17],"and":[18,23,45,71,123,173],"determines":[19],"the":[20,26,69,74,142,187],"abundance,":[21],"packaging":[22],"stability":[24],"of":[25,50,66,73,119,131,176,190],"genome.":[28],"Because":[29],"its":[30],"function":[31],"tightly":[33],"associated":[34],"with":[35,107],"mtDNA,":[36],"TFAM":[37,54,58,82,103,120,156,194],"has":[38,60,158],"a":[39,85,132,162,174],"protective":[40],"role":[41],"in":[42,117,129,149,153,169,179,196],"diseases":[44],"supportive":[46],"studies":[47],"demonstrate":[48,112],"reversal":[49],"disease":[51,151,163],"phenotypes":[52],"by":[53,137,199],"overexpression.":[55],"In":[56],"addition,":[57],"deficiency":[59],"been":[61,97,159],"shown":[62],"cause":[64],"release":[65],"mtDNA":[67,124,133,139],"into":[68,141],"cytosol":[70],"activation":[72],"cGAS/STING":[75],"innate":[76],"immune":[77],"response":[78,136],"pathway.":[79],"As":[80],"such,":[81],"presents":[83],"as":[84,161],"unique":[86],"target":[87],"therapeutic":[89,188],"intervention,":[90],"but":[91],"limited":[92],"efforts":[93],"activators":[95,195],"have":[96],"reported.":[98],"Herein":[99],"we":[100,145],"disclose":[101],"novel":[102],"small":[104,192],"molecule":[105,193],"modulators":[106],"sub-micromolar":[108],"activity.":[109],"Our":[110],"results":[111,128,185],"that":[113],"these":[114],"compounds":[115],"result":[116],"increase":[118],"protein":[121],"levels":[122],"copy":[125],"number.":[126],"This":[127],"inhibition":[130],"stress-mediated":[134],"inflammatory":[135],"preventing":[138],"escape":[140],"cytosol.":[143],"Furthermore,":[144],"see":[146],"beneficial":[147],"effects":[148],"cellular":[150],"models":[152],"which":[154],"boosting":[155],"activity":[157],"advanced":[160],"modifying":[164],"strategy":[165],"including":[166],"improved":[167],"energetics":[168],"MELAS":[170],"cybrid":[171],"cells":[172],"decrease":[175],"fibrotic":[177],"markers":[178],"Systemic":[180],"Sclerosis":[181],"(SSc)":[182],"fibroblasts.":[183],"These":[184],"highlight":[186],"potential":[189],"using":[191],"indications":[197],"characterized":[198],"dysfunction.":[201]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-24T00:00:00"}