{"id":"https://openalex.org/W4415436331","doi":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","title":"A comparative analysis of the expression of key proteins involved in the entry of coronavirus into different types of cell cultures","display_name":"A comparative analysis of the expression of key proteins involved in the entry of coronavirus into different types of cell cultures","publication_year":2025,"publication_date":"2025-10-20","ids":{"openalex":"https://openalex.org/W4415436331","doi":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33"},"language":"en","primary_location":{"id":"doi:10.58708/2074-2088.2025-3(35)-27-33","doi":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","is_oa":true,"landing_page_url":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","pdf_url":"https://medbio.ejournal.by/jour/article/download/460/465","source":{"id":"https://openalex.org/S4387289679","display_name":"Medical and Biological Problems of Life Activity","issn_l":"2074-2088","issn":["2074-2088"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Biological Problems of Life Activity","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://medbio.ejournal.by/jour/article/download/460/465","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076515643","display_name":"Elena G. Fomina","orcid":"https://orcid.org/0000-0003-3028-1176","observed_orcids":["https://orcid.org/0000-0003-3028-1176"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. G. Fomina","raw_affiliation_strings":["\u0413\u0423 \u00ab\u0420\u0426 \u0433\u0438\u0433\u0438\u0435\u043d\u044b, \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0413\u0423 \u00ab\u0420\u0426 \u0433\u0438\u0433\u0438\u0435\u043d\u044b, \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f\u00bb","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110723652","display_name":"E. E. Grigorieva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. E. Grigorieva","raw_affiliation_strings":["\u0413\u0423 \u00ab\u0420\u0426 \u0433\u0438\u0433\u0438\u0435\u043d\u044b, \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0413\u0423 \u00ab\u0420\u0426 \u0433\u0438\u0433\u0438\u0435\u043d\u044b, \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f\u00bb","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089022802","display_name":"\u0412.\u0412. \u0417\u0432\u0435\u0440\u043a\u043e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V. V. Zverko","raw_affiliation_strings":["\u0413\u0423 \u00ab\u0420\u0426 \u0433\u0438\u0433\u0438\u0435\u043d\u044b, \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u0413\u0423 \u00ab\u0420\u0426 \u0433\u0438\u0433\u0438\u0435\u043d\u044b, \u044d\u043f\u0438\u0434\u0435\u043c\u0438\u043e\u043b\u043e\u0433\u0438\u0438 \u0438 \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0435\u043d\u043d\u043e\u0433\u043e \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f\u00bb","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5120094881","display_name":"A. D. Korzheeva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. D. Korzheeva","raw_affiliation_strings":["\u041e\u041e\u041e \u00ab\u0410\u043b\u044c\u0433\u0438\u043c\u0435\u0434 \u0422\u0435\u0445\u043d\u043e\u00bb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u041e\u041e\u041e \u00ab\u0410\u043b\u044c\u0433\u0438\u043c\u0435\u0434 \u0422\u0435\u0445\u043d\u043e\u00bb","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"3","first_page":"27","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.972000002861023},{"id":"https://openalex.org/keywords/virus-entry","display_name":"viral entry","score":0.8169999718666077},{"id":"https://openalex.org/keywords/ace2-receptor","display_name":"ACE2 receptor","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tmprss2","display_name":"TMPRSS2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cathepsin-l","display_name":"cathepsin L","score":0.9959999918937683},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.6499999761581421},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cell-line-comparison","display_name":"cell line comparison","score":0.5879999995231628},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.8090000152587891},{"id":"https://openalex.org/keywords/vero-cells","display_name":"Vero cells","score":0.7329999804496765},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8809999823570251},{"id":"https://openalex.org/keywords/hek293t-cells","display_name":"HEK293T cells","score":0.902999997138977},{"id":"https://openalex.org/keywords/mdbk-cells","display_name":"MDBK cells","score":0.8640000224113464}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.7225000262260437},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7135000228881836},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.5835000276565552},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5454999804496765},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.5414999723434448},{"id":"https://openalex.org/C2780034444","wikidata":"https://www.wikidata.org/wiki/Q5052485","display_name":"Cathepsin L","level":4,"score":0.5388000011444092},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5304999947547913},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49970000982284546},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48919999599456787},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4878000020980835},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.4699000120162964},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.45980000495910645},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.44609999656677246},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.42010000348091125},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.4187999963760376},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.3887999951839447},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3873000144958496},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.37310001254081726},{"id":"https://openalex.org/C6045943","wikidata":"https://www.wikidata.org/wiki/Q21014462","display_name":"Immortalised cell line","level":3,"score":0.3723999857902527},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3630000054836273},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2778042024","wikidata":"https://www.wikidata.org/wiki/Q18032025","display_name":"TMPRSS2","level":5,"score":0.35280001163482666},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.3467000126838684},{"id":"https://openalex.org/C2777132095","wikidata":"https://www.wikidata.org/wiki/Q14906548","display_name":"Cathepsin G","level":4,"score":0.3208000063896179},{"id":"https://openalex.org/C28021979","wikidata":"https://www.wikidata.org/wiki/Q14911946","display_name":"Cathepsin B","level":3,"score":0.31540000438690186},{"id":"https://openalex.org/C2777807008","wikidata":"https://www.wikidata.org/wiki/Q87324999","display_name":"Serine protease","level":4,"score":0.30979999899864197},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3003999888896942},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.28769999742507935},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.28519999980926514},{"id":"https://openalex.org/C51618164","wikidata":"https://www.wikidata.org/wiki/Q5052484","display_name":"Cathepsin H","level":4,"score":0.26840001344680786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.58708/2074-2088.2025-3(35)-27-33","doi":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","is_oa":true,"landing_page_url":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","pdf_url":"https://medbio.ejournal.by/jour/article/download/460/465","source":{"id":"https://openalex.org/S4387289679","display_name":"Medical and Biological Problems of Life Activity","issn_l":"2074-2088","issn":["2074-2088"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Biological Problems of Life Activity","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.58708/2074-2088.2025-3(35)-27-33","doi":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","is_oa":true,"landing_page_url":"https://doi.org/10.58708/2074-2088.2025-3(35)-27-33","pdf_url":"https://medbio.ejournal.by/jour/article/download/460/465","source":{"id":"https://openalex.org/S4387289679","display_name":"Medical and Biological Problems of Life Activity","issn_l":"2074-2088","issn":["2074-2088"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical and Biological Problems of Life Activity","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415436331.pdf","grobid_xml":"https://content.openalex.org/works/W4415436331.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W2971662549","https://openalex.org/W3038741500","https://openalex.org/W3095926067","https://openalex.org/W3117882848","https://openalex.org/W3119087855","https://openalex.org/W3131417871","https://openalex.org/W3151076337","https://openalex.org/W3162284050","https://openalex.org/W3165852093","https://openalex.org/W3184513201","https://openalex.org/W3203433659","https://openalex.org/W3205930470","https://openalex.org/W4210579813","https://openalex.org/W4281763324"],"related_works":["https://openalex.org/W3173514762","https://openalex.org/W3092682742","https://openalex.org/W3044069820","https://openalex.org/W4382501132","https://openalex.org/W3048152115","https://openalex.org/W3134181354","https://openalex.org/W3043649968","https://openalex.org/W3017315642","https://openalex.org/W2775762540","https://openalex.org/W3193102476"],"abstract_inverted_index":{"The":[0,68,116,199],"expression":[1,59,69,122,147,175,205],"of":[2,18,27,44,65,71,111,119,148,172,202,240],"specific":[3],"receptors":[4],"and":[5,30,57,90,103,133,137,182,185,235],"proteases":[6],"in":[7,78,95,104,125,134,158,178,193,208],"each":[8],"cell":[9,32,97,105,130,163,167,188],"type":[10],"determines":[11],"the":[12,28,42,53,63,109,126,135,146,159,169,225,229],"relative":[13],"preference":[14],"for":[15,51,73,218],"different":[16,112],"modes":[17],"SARS-CoV-2":[19],"entry.":[20,67],"This":[21],"includes":[22],"entry":[23,37,81],"through":[24,38],"TMPRSS2-mediated":[25],"fusion":[26],"viral":[29,54,66],"host":[31,83],"membranes,":[33],"as":[34,36],"well":[35],"endocytosis,":[39],"which":[40],"involves":[41],"activity":[43],"cathepsin":[45,91],"L.":[46],"Cathepsin":[47],"L":[48],"is":[49],"responsible":[50],"cleaving":[52],"S":[55],"protein,":[56],"its":[58],"level":[60,70,118,171,201],"can":[61],"affect":[62],"efficiency":[64],"mRNA":[72,204],"three":[74],"key":[75],"proteins":[76],"involved":[77],"SARS":[79],"CoV-2":[80],"into":[82],"cells":[84,139,234],"(ACE2":[85],"receptor,":[86],"TMPRSS2":[87,173],"serine":[88],"protease,":[89],"L)":[92],"was":[93,123,151,176,191,206],"assessed":[94],"human":[96,127,166],"lines":[98,106],"from":[99,108,141],"various":[100,238],"tissues":[101],"(n=5),":[102],"derived":[107],"kidneys":[110],"animal":[113,162,187],"species":[114],"(n=7).":[115],"highest":[117,170],"ACE2":[120],"gene":[121,150,174],"observed":[124,177],"colon":[128],"adenocarcinoma":[129],"line":[131],"Caco-2,":[132],"Vero":[136],"VeroE6":[138],"(derived":[140],"African":[142],"green":[143],"monkey":[144],"kidneys),":[145],"this":[149],"more":[152],"than":[153,157],"four":[154],"times":[155],"higher":[156],"other":[160],"studied":[161],"lines.":[164],"Among":[165],"lines,":[168],"HEK293T":[179],"(embryonic":[180],"kidney)":[181,197],"Caco-2":[183],"cells,":[184],"among":[186],"cultures,":[189],"it":[190],"seen":[192],"MDBK":[194],"(domestic":[195],"bovine":[196],"cells.":[198,213,244],"maximum":[200],"CTSL":[203],"found":[207],"A549":[209],"(human":[210],"lung":[211],"cancer)":[212],"These":[214],"findings":[215],"are":[216],"important":[217],"selecting":[219],"a":[220],"model":[221],"system":[222],"to":[223,231,236],"study":[224],"pathways":[226],"used":[227],"by":[228],"virus":[230],"enter":[232],"target":[233],"investigate":[237],"aspects":[239],"SARS-CoV-2\u2019s":[241],"interaction":[242],"with":[243]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-24T00:00:00"}
