{"id":"https://openalex.org/W4415423402","doi":"https://doi.org/10.1093/ndt/gfaf116.1857","title":"#3908 Potential cardiovascular benefits of denosumab in kidney transplant recipients: a focus on aortic arch calcification","display_name":"#3908 Potential cardiovascular benefits of denosumab in kidney transplant recipients: a focus on aortic arch calcification","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415423402","doi":"https://doi.org/10.1093/ndt/gfaf116.1857"},"language":"en","primary_location":{"id":"doi:10.1093/ndt/gfaf116.1857","doi":"https://doi.org/10.1093/ndt/gfaf116.1857","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfaf116.1857","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002075968","display_name":"Woo Yeong Park","orcid":"https://orcid.org/0000-0003-2662-2898","observed_orcids":["https://orcid.org/0000-0003-2662-2898"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Woo Yeong Park","raw_affiliation_strings":["Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005659905","display_name":"Yaerim Kim","orcid":"https://orcid.org/0000-0003-1596-1528","observed_orcids":["https://orcid.org/0000-0003-1596-1528","https://orcid.org/0000-0002-1344-3455"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yaerim Kim","raw_affiliation_strings":["Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009056330","display_name":"Jin Hyuk Paek","orcid":"https://orcid.org/0000-0001-8875-1260","observed_orcids":["https://orcid.org/0000-0001-8875-1260"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jin Hyuk Paek","raw_affiliation_strings":["Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035246894","display_name":"Kyubok Jin","orcid":"https://orcid.org/0000-0002-7836-8863","observed_orcids":["https://orcid.org/0000-0002-7836-8863","https://orcid.org/0000-0002-4586-5062"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyubok Jin","raw_affiliation_strings":["Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042765875","display_name":"Seungyeup Han","orcid":"https://orcid.org/0000-0002-7561-6534","observed_orcids":["https://orcid.org/0000-0002-7561-6534"]},"institutions":[{"id":"https://openalex.org/I4405261187","display_name":"Keimyung University Dongsan Hospital","ror":"https://ror.org/04xxe0935","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I4210128080","https://openalex.org/I4405261187"]},{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seungyeup Han","raw_affiliation_strings":["Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology , Department of Internal Medicine, Keimyung University School of Medicine, Keimyung University Dongsan Hospital, Daegu, South Korea","institution_ids":["https://openalex.org/I4405261187","https://openalex.org/I52010207"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3474,"currency":"EUR","value_usd":3926},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"Supplement_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.08500000089406967,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":1.0},{"id":"https://openalex.org/keywords/kidney-transplant-recipients","display_name":"kidney transplant recipients","score":0.921999990940094},{"id":"https://openalex.org/keywords/aortic-arch-calcification","display_name":"aortic arch calcification","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.8510000109672546},{"id":"https://openalex.org/keywords/osteoporosis-treatment","display_name":"osteoporosis treatment","score":0.828000009059906},{"id":"https://openalex.org/keywords/calcification-score","display_name":"calcification score","score":0.5379999876022339},{"id":"https://openalex.org/keywords/graft-failure","display_name":"graft failure","score":0.8669999837875366},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":0.7720000147819519},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.7770000100135803},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9642000198364258},{"id":"https://openalex.org/C2776286101","wikidata":"https://www.wikidata.org/wiki/Q408283","display_name":"Denosumab","level":3,"score":0.8934999704360962},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.7071999907493591},{"id":"https://openalex.org/C68443243","wikidata":"https://www.wikidata.org/wiki/Q2786686","display_name":"Quartile","level":3,"score":0.5831999778747559},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.545199990272522},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.5145999789237976},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.46950000524520874},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.45820000767707825},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.4205999970436096},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.39899998903274536},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.39320001006126404},{"id":"https://openalex.org/C2776556354","wikidata":"https://www.wikidata.org/wiki/Q25339734","display_name":"Chronic kidney disease-mineral and bone disorder","level":4,"score":0.39089998602867126},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3319000005722046},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.3278000056743622},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.314300000667572},{"id":"https://openalex.org/C2775981168","wikidata":"https://www.wikidata.org/wiki/Q239027","display_name":"Calcinosis","level":3,"score":0.298799991607666},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.274399995803833},{"id":"https://openalex.org/C2778838027","wikidata":"https://www.wikidata.org/wiki/Q3622611","display_name":"Secondary hyperparathyroidism","level":4,"score":0.2728999853134155},{"id":"https://openalex.org/C2781285907","wikidata":"https://www.wikidata.org/wiki/Q616032","display_name":"Aortic arch","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C2909026278","wikidata":"https://www.wikidata.org/wiki/Q656261","display_name":"Hemodialysis Catheter","level":3,"score":0.25600001215934753}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/ndt/gfaf116.1857","doi":"https://doi.org/10.1093/ndt/gfaf116.1857","is_oa":false,"landing_page_url":"https://doi.org/10.1093/ndt/gfaf116.1857","pdf_url":null,"source":{"id":"https://openalex.org/S186113128","display_name":"Nephrology Dialysis Transplantation","issn_l":"0931-0509","issn":["0931-0509","1460-2385"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nephrology Dialysis Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391556443","https://openalex.org/W2621002777","https://openalex.org/W4404547440","https://openalex.org/W3111176885","https://openalex.org/W4364356447","https://openalex.org/W2808700131","https://openalex.org/W2808545087","https://openalex.org/W4396791883","https://openalex.org/W2796169635","https://openalex.org/W4396915822"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"and":[2,101,170,175,193,244,252],"Aims":[3],"Several":[4],"studies":[5,40],"have":[6,41],"identified":[7],"aortic":[8],"arch":[9],"calcification":[10,82,226],"(AoAC)":[11],"as":[12],"an":[13],"indicator":[14],"of":[15,26,65,75,121,162,202],"cardiovascular":[16,97,178,222],"disease":[17],"risk.":[18],"A":[19],"research":[20,239],"has":[21],"shown":[22],"that":[23],"long-term":[24],"use":[25,201],"denosumab,":[27],"a":[28,110,235],"treatment":[29,64],"for":[30,62],"osteoporosis,":[31],"can":[32],"improve":[33],"AoAC":[34,76,78,113,131,206],"in":[35,46,112,159,181,190,207,214],"hemodialysis":[36,215],"patients.":[37],"However,":[38],"similar":[39],"not":[42],"yet":[43],"been":[44],"performed":[45],"kidney":[47],"transplant":[48],"recipients":[49],"(KTRs).":[50],"Method":[51],"We":[52,71,93],"analyzed":[53],"98":[54],"KTRs":[55,108,208,232],"who":[56],"used":[57],"denosumab":[58,122,136,203],"every":[59],"6":[60],"months":[61],"the":[63,73,119,150,160,182,196],"osteoporosis":[66],"from":[67,141],"2018":[68],"to":[69,143,149,204,220,231],"2023.":[70],"assessed":[72],"severity":[74],"by":[77,81,224],"score,":[79],"calculated":[80],"parts":[83],"divided":[84],"16":[85],"*":[86],"100":[87],"(%)":[88],"with":[89],"simple":[90],"chest":[91],"X-ray.":[92],"investigated":[94],"biochemical":[95],"parameters,":[96],"event,":[98],"graft":[99,191],"failure":[100,192],"patient":[102,250],"death.":[103],"Results":[104],"Among":[105],"them,":[106],"48":[107],"showed":[109],"change":[111],"score.":[114],"The":[115,129,199],"mean":[116,130],"age":[117],"at":[118],"time":[120],"administration":[123,137],"was":[124],"63.5":[125],"\u00b1":[126],"6.8":[127],"years.":[128],"score":[132,151],"1":[133],"year":[134],"after":[135],"had":[138],"significantly":[139],"decreased":[140],"34.6%":[142],"32.2%":[144],"(P":[145],"=":[146],"0.034)":[147],"compared":[148],"before":[152],"denosumab.":[153],"There":[154,185],"were":[155,186],"no":[156,187],"significant":[157,188,236],"differences":[158,189],"levels":[161],"calcium,":[163],"phosphorus,":[164],"parathyroid":[165],"hormone,":[166],"vitamin":[167],"D,":[168],"creatinine,":[169],"tacrolimus":[171],"trough":[172],"between":[173],"pre-":[174],"post-denosumab.":[176],"No":[177],"events":[179],"occurred":[180],"study":[183],"population.":[184],"death":[194],"among":[195],"KTRs.":[197],"Conclusion":[198],"potential":[200,219],"reduce":[205],"is":[209],"promising.":[210],"While":[211],"initial":[212],"findings":[213],"patients":[216],"highlight":[217],"denosumab's":[218],"ameliorate":[221],"risks":[223],"improving":[225,249],"markers,":[227],"extending":[228],"this":[229],"application":[230],"could":[233,240],"offer":[234],"breakthrough.":[237],"Further":[238],"confirm":[241],"these":[242],"benefits":[243],"revolutionize":[245],"post-transplant":[246],"care,":[247],"ultimately":[248],"outcomes":[251],"longevity.":[253]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2025-10-24T00:00:00"}
