{"id":"https://openalex.org/W4415420150","doi":"https://doi.org/10.1186/s12967-025-07113-x","title":"Plasma multi-omics and machine learning reveal predictive biomarkers for type 2 diabetes and retinopathy in Qatar biobank cohort","display_name":"Plasma multi-omics and machine learning reveal predictive biomarkers for type 2 diabetes and retinopathy in Qatar biobank cohort","publication_year":2025,"publication_date":"2025-10-22","ids":{"openalex":"https://openalex.org/W4415420150","doi":"https://doi.org/10.1186/s12967-025-07113-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41126335","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12541984"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-025-07113-x","doi":"https://doi.org/10.1186/s12967-025-07113-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-07113-x","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07113-x","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07113-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091725873","display_name":"Ikhlak Ahmed","orcid":"https://orcid.org/0000-0002-5753-9627","observed_orcids":["https://orcid.org/0000-0002-5753-9627"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Ikhlak Ahmed","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008001574","display_name":"Ajaz Ahmad Bhat","orcid":"https://orcid.org/0000-0003-3079-5097","observed_orcids":["https://orcid.org/0000-0003-3079-5097"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Ajaz A. Bhat","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066214678","display_name":"Sujitha Padma Jeya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Sujitha Padma Jeya","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014040870","display_name":"Wilson K. M. Wong","orcid":"https://orcid.org/0000-0001-7736-6834","observed_orcids":["https://orcid.org/0000-0001-7736-6834"]},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wilson K. M. Wong","raw_affiliation_strings":["Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045296781","display_name":"Hana Q. Sadida","orcid":"https://orcid.org/0009-0003-2932-0323","observed_orcids":["https://orcid.org/0009-0003-2932-0323"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Hana Q. Sadida","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092181428","display_name":"Mya Polkamp","orcid":"https://orcid.org/0009-0002-8558-3315","observed_orcids":["https://orcid.org/0009-0002-8558-3315"]},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mya Polkamp","raw_affiliation_strings":["Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092181429","display_name":"Hrishikesh P. Hardikar","orcid":"https://orcid.org/0000-0002-4369-3623","observed_orcids":["https://orcid.org/0000-0002-4369-3623"]},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hrishikesh P. Hardikar","raw_affiliation_strings":["Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067221374","display_name":"Jyothi Lakshmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Jyothi Lakshmi","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107677533","display_name":"Sura Ahmed Hussain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Sura Ahmed Hussain","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012004673","display_name":"Evonne C. Chin-Smith","orcid":"https://orcid.org/0000-0002-1935-2941","observed_orcids":["https://orcid.org/0000-0002-1935-2941"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Evonne Chin-Smith","raw_affiliation_strings":["Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000625406","display_name":"Amaresh Kumar Ranjan","orcid":"https://orcid.org/0000-0001-7529-7409","observed_orcids":["https://orcid.org/0000-0001-7529-7409"]},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amaresh K. Ranjan","raw_affiliation_strings":["Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084593588","display_name":"Mugdha V. Joglekar","orcid":"https://orcid.org/0000-0001-5346-2266","observed_orcids":["https://orcid.org/0000-0001-5346-2266"]},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mugdha V. Joglekar","raw_affiliation_strings":["Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015293558","display_name":"Anandwardhan A. Hardikar","orcid":"https://orcid.org/0000-0001-5587-2090","observed_orcids":["https://orcid.org/0000-0001-5587-2090"]},"institutions":[{"id":"https://openalex.org/I63525965","display_name":"Western Sydney University","ror":"https://ror.org/03t52dk35","country_code":"AU","type":"education","lineage":["https://openalex.org/I63525965"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Anandwardhan A. Hardikar","raw_affiliation_strings":["Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Diabetes & Islet Biology Group, Western Sydney University School of Medicine, Campbelltown, NSW, 2560, Australia","institution_ids":["https://openalex.org/I63525965"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024723180","display_name":"Khalid Adnan Fakhro","orcid":"https://orcid.org/0000-0002-3150-1276","observed_orcids":["https://orcid.org/0000-0002-3150-1276"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]},{"id":"https://openalex.org/I4210144839","display_name":"Hamad bin Khalifa University","ror":"https://ror.org/03eyq4y97","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210144839"]},{"id":"https://openalex.org/I4210152471","display_name":"Weill Cornell Medical College in Qatar","ror":"https://ror.org/05v5hg569","country_code":"QA","type":"education","lineage":["https://openalex.org/I4210152471"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["QA","US"],"is_corresponding":false,"raw_author_name":"Khalid Fakhro","raw_affiliation_strings":["College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar","Department of Genetic Medicine, Weill Cornell Medical College, P.O. Box 24144, Doha, Qatar","Laboratory of Genomic Medicine, Metabolic and Mendelian Disorders Clinical Research Program, Sidra Medicine, Doha, Qatar"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar","institution_ids":["https://openalex.org/I4210144839"]},{"raw_affiliation_string":"Department of Genetic Medicine, Weill Cornell Medical College, P.O. Box 24144, Doha, Qatar","institution_ids":["https://openalex.org/I4210152471","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Laboratory of Genomic Medicine, Metabolic and Mendelian Disorders Clinical Research Program, Sidra Medicine, Doha, Qatar","institution_ids":["https://openalex.org/I4210130525"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080145722","display_name":"Ammira Al\u2010Shabeeb Akil","orcid":"https://orcid.org/0000-0001-5381-070X","observed_orcids":["https://orcid.org/0000-0001-5381-070X"]},"institutions":[{"id":"https://openalex.org/I4210130525","display_name":"Sidra Medical and Research Center","ror":"https://ror.org/03acdk243","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210130525"]}],"countries":["QA"],"is_corresponding":true,"raw_author_name":"Ammira Al-Shabeeb Akil","raw_affiliation_strings":["Metabolic and Mendelian Disorders Translational Research Program, Sidra Medicine, PO Box 26999, Doha, State of Qatar. aakil@sidra.org","Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar. aakil@sidra.org","Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar"],"raw_orcid":"https://orcid.org/0000-0001-5381-070X","affiliations":[{"raw_affiliation_string":"Metabolic and Mendelian Disorders Translational Research Program, Sidra Medicine, PO Box 26999, Doha, State of Qatar. aakil@sidra.org","institution_ids":["https://openalex.org/I4210130525"]},{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar. aakil@sidra.org","institution_ids":["https://openalex.org/I4210130525"]},{"raw_affiliation_string":"Precision Genomics and Translational Omics Lab, Sidra Medicine, 26999, Doha, State of Qatar","institution_ids":["https://openalex.org/I4210130525"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5080145722"],"corresponding_institution_ids":["https://openalex.org/I4210130525"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":1.122,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72929873,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":98},"biblio":{"volume":"23","issue":"1","first_page":"1159","last_page":"1159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.19850000739097595,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.19850000739097595,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.11959999799728394,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.11540000140666962,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/plasma-biomarkers","display_name":"plasma biomarkers","score":0.8019999861717224},{"id":"https://openalex.org/keywords/multi-omics","display_name":"multi-omics","score":0.6480000019073486},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mir-29c","display_name":"miR-29c","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiopoietin-2","display_name":"angiopoietin-2","score":0.9290000200271606},{"id":"https://openalex.org/keywords/placental-growth-factor","display_name":"placental growth factor","score":0.925000011920929},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.871999979019165},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.7089999914169312},{"id":"https://openalex.org/keywords/vascular-complications","display_name":"vascular complications","score":0.6809999942779541},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.9399999976158142},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.5860000252723694},{"id":"https://openalex.org/keywords/middle-eastern-populations","display_name":"Middle Eastern populations","score":0.8709999918937683},{"id":"https://openalex.org/keywords/qatar-biobank","display_name":"Qatar Biobank","score":0.9120000004768372},{"id":"https://openalex.org/keywords/random-forest","display_name":"random forest","score":0.49900001287460327},{"id":"https://openalex.org/keywords/shap","display_name":"SHAP","score":0.7860000133514404},{"id":"https://openalex.org/keywords/penalized-regression","display_name":"penalized regression","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.9064000248908997},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7443000078201294},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6802999973297119},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.6272000074386597},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.5719000101089478},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.557699978351593},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5246000289916992},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.4796999990940094},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4648999869823456},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.4187999963760376},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.4049000144004822},{"id":"https://openalex.org/C2910068830","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 Diabetes Mellitus","level":3,"score":0.38119998574256897},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3675000071525574},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3603000044822693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3598000109195709},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.3587999939918518},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3303999900817871},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3248000144958496},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.304500013589859},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.28940001130104065},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.28529998660087585},{"id":"https://openalex.org/C46578552","wikidata":"https://www.wikidata.org/wiki/Q2725393","display_name":"Global health","level":3,"score":0.28189998865127563},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.28049999475479126},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.2669999897480011},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.26660001277923584},{"id":"https://openalex.org/C3018472363","wikidata":"https://www.wikidata.org/wiki/Q177323","display_name":"Low and middle income countries","level":3,"score":0.2540999948978424},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25060001015663147}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000095028","descriptor_name":"Multiomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003930","descriptor_name":"Diabetic Retinopathy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011780","descriptor_name":"Qatar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D018070","descriptor_name":"Biological Specimen Banks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12967-025-07113-x","doi":"https://doi.org/10.1186/s12967-025-07113-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-07113-x","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07113-x","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12541984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12541984","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12541984/pdf/12967_2025_Article_7113.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Transl Med","raw_type":"Text"},{"id":"pmh:oai:europepmc.org:11349798","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12541984","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41126335","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41126335","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of translational medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:47820db8174d4f87a7515f4715661155","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/47820db8174d4f87a7515f4715661155","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Translational Medicine, Vol 23, Iss 1, Pp 1-15 (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12967-025-07113-x","doi":"https://doi.org/10.1186/s12967-025-07113-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-025-07113-x","pdf_url":"https://translational-medicine.biomedcentral.com/counter/pdf/10.1186/s12967-025-07113-x","source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G6008865513","display_name":null,"funder_award_id":"SDR100002","funder_id":"https://openalex.org/F4320319020","funder_display_name":"Sidra Medicine"},{"id":"https://openalex.org/G661701314","display_name":null,"funder_award_id":"NPRP9-229-3-041","funder_id":"https://openalex.org/F4320332753","funder_display_name":"Qatar National Research Fund"}],"funders":[{"id":"https://openalex.org/F4320319020","display_name":"Sidra Medicine","ror":"https://ror.org/03acdk243"},{"id":"https://openalex.org/F4320321038","display_name":"Fonds National de la Recherche Luxembourg","ror":"https://ror.org/039z13y21"},{"id":"https://openalex.org/F4320332753","display_name":"Qatar National Research Fund","ror":"https://ror.org/01svaqq28"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415420150.pdf","grobid_xml":"https://content.openalex.org/works/W4415420150.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1965468991","https://openalex.org/W1972722625","https://openalex.org/W1985222413","https://openalex.org/W1995141720","https://openalex.org/W2035994012","https://openalex.org/W2060698866","https://openalex.org/W2084225291","https://openalex.org/W2120356115","https://openalex.org/W2138480916","https://openalex.org/W2139414224","https://openalex.org/W2144776559","https://openalex.org/W2161068194","https://openalex.org/W2164279176","https://openalex.org/W2169038597","https://openalex.org/W2183554697","https://openalex.org/W2461088034","https://openalex.org/W2531587846","https://openalex.org/W2552818781","https://openalex.org/W2601773977","https://openalex.org/W2611138580","https://openalex.org/W2751247414","https://openalex.org/W2899281139","https://openalex.org/W2946434438","https://openalex.org/W2951072693","https://openalex.org/W3127111365","https://openalex.org/W3134975174","https://openalex.org/W3159150149","https://openalex.org/W3165693653","https://openalex.org/W3211863631","https://openalex.org/W4210537487","https://openalex.org/W4282946697","https://openalex.org/W4319158047","https://openalex.org/W4321372219","https://openalex.org/W4323039471","https://openalex.org/W4323921351","https://openalex.org/W4385466054","https://openalex.org/W4391690935","https://openalex.org/W4396232519"],"related_works":["https://openalex.org/W4416228590","https://openalex.org/W7168146963","https://openalex.org/W2948598541","https://openalex.org/W3132986119","https://openalex.org/W2931511392","https://openalex.org/W7153447803","https://openalex.org/W7135063275","https://openalex.org/W3035558492","https://openalex.org/W4409661761","https://openalex.org/W4394847452"],"abstract_inverted_index":{"Type":[0],"2":[1,295],"diabetes":[2,296],"(T2D)":[3,297],"and":[4,28,34,55,64,77,112,138,148,174,191,202,216,243,252,261,290,298,318,332,337,362],"its":[5,65,363],"vascular":[6,89,229],"complications,":[7],"including":[8,207],"diabetic":[9],"retinopathy":[10],"(DR),":[11],"are":[12],"escalating":[13],"in":[14,21,41,67,82,94,105,179,245,281,303,311,339],"prevalence":[15,20],"globally,":[16],"with":[17,62,87,115,132,165,228,234],"disproportionately":[18],"high":[19,328],"Middle":[22,69,246,284,305,341],"Eastern":[23,70,247,285,306,342],"populations,":[24],"where":[25],"genetic":[26],"predispositions":[27],"lifestyle":[29],"factors":[30],"intersect.":[31],"Early":[32],"detection":[33,260],"precise":[35],"risk":[36,130,239],"stratification":[37,240],"remain":[38],"critical":[39],"challenges":[40],"this":[42,267],"region.":[43],"We":[44],"hypothesised":[45],"that":[46],"an":[47,95,166],"integrated":[48],"plasma":[49],"multi-omics":[50,232],"profile;":[51],"comprising":[52],"microRNA,":[53],"mRNA,":[54],"protein":[56,78,333],"biomarkers,":[57,206],"could":[58],"accurately":[59],"distinguish":[60],"individuals":[61,107],"T2D":[63,111,114,181,201,242,361],"complications":[66,280],"a":[68,88,197,282,304,340],"cohort.":[71,286],"A":[72,185],"candidate":[73],"panel":[74],"of":[75,168,172,177],"mRNA":[76],"biomarkers":[79,102,257,334],"identified":[80,195],"from":[81,117,183,344],"vitro":[83,312],"hyperglycaemia":[84],"models,":[85],"along":[86],"microRNA":[90],"signature":[91],"previously":[92],"defined":[93],"Australian":[96],"cohort,":[97],"was":[98,127,194],"evaluated.":[99],"These":[100],"multiomic":[101],"were":[103,151,225,335,353],"profiled":[104],"962":[106],"(492":[108],"controls,":[109],"434":[110],"36":[113],"DR)":[116],"the":[118,141,270],"Qatar":[119,345],"Biobank":[120,346],"(QBB).":[121],"Random":[122,159],"Forest":[123,160],"machine":[124,235],"learning":[125,236],"workflow":[126],"used":[128,152,354],"for":[129,200,241,258,272,293,359],"stratification,":[131],"model":[133],"performance":[134],"assessed":[135],"by":[136],"accuracy":[137,176],"area":[139],"under":[140,316],"receiver":[142],"operating":[143],"characteristic":[144],"curve.":[145],"SHAP":[146],"analysis":[147],"penalised":[149],"regression":[150],"to":[153,321,326,355],"identify":[154,322,356],"key":[155,357],"discriminative":[156],"biomarkers.":[157],"The":[158,249,308],"classifier":[161],"achieved":[162],"robust":[163],"performance,":[164],"AUC":[167],"0.83,":[169],"F1":[170],"score":[171],"0.78,":[173],"overall":[175],"0.76":[178],"distinguishing":[180],"cases":[182],"controls.":[184],"regulatory":[186],"axis":[187,251],"involving":[188],"miR-29c":[189],"(protective)":[190],"PROM1":[192],"(risk-promoting)":[193],"as":[196],"central":[198],"driver":[199],"DR":[203,244],"progression.":[204],"Protein":[205],"ANGPT2":[208],"(fold":[209,218],"change":[210,219],"=":[211,214,220,223,348],"1.64,":[212],"p-value":[213,222],"3.8e\u221203)":[215],"PlGF":[217],"0.66,":[221],"3.7e\u221202),":[224],"significantly":[226],"associated":[227,253],"complications.":[230,364],"Integrating":[231],"data":[233],"enables":[237],"accurate":[238],"populations.":[248],"miR-29c\u2013PROM1":[250],"proteins":[254],"represent":[255],"promising":[256],"early":[259,323],"targeted":[262],"intervention.":[263],"Leveraging":[264],"QBB":[265],"resources,":[266],"study":[268,309],"lays":[269],"groundwork":[271],"precision":[273],"health":[274],"initiatives":[275],"aimed":[276],"at":[277],"mitigating":[278],"diabetes-related":[279],"high-risk":[283],"Integrated":[287],"Biomarker":[288],"Discovery":[289],"Validation":[291],"Workflow":[292],"type":[294],"T2D-related":[299],"Diabetic":[300],"Retinopathy":[301],"(DR)":[302],"Cohort.":[307],"integrates":[310],"endothelial":[313],"cell":[314],"assays":[315],"normoglycemic":[317],"hyperglycemic":[319],"conditions":[320],"molecular":[324],"responses":[325],"sustained":[327],"glucose.":[329],"Candidate":[330],"miRNA":[331],"selected":[336],"validated":[338],"cohort":[343],"(n":[347],"962).":[349],"Machine":[350],"learning-based":[351],"approaches":[352],"biomarkeres":[358],"predicting":[360]},"counts_by_year":[{"year":2026,"cited_by_count":4}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2025-10-24T00:00:00"}