{"id":"https://openalex.org/W4415401125","doi":"https://doi.org/10.1016/j.bmcl.2025.130441","title":"Triscationic bolaamphiphilic QACs \u2013 optimizing antibacterial therapeutic indices","display_name":"Triscationic bolaamphiphilic QACs \u2013 optimizing antibacterial therapeutic indices","publication_year":2025,"publication_date":"2025-10-21","ids":{"openalex":"https://openalex.org/W4415401125","doi":"https://doi.org/10.1016/j.bmcl.2025.130441","pmid":"https://pubmed.ncbi.nlm.nih.gov/41130327","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13180305"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmcl.2025.130441","doi":"https://doi.org/10.1016/j.bmcl.2025.130441","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2025.130441","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13180305/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115904462","display_name":"Johanna Y. D. Asante","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7863295","display_name":"Villanova University","ror":"https://ror.org/02g7kd627","country_code":"US","type":"education","lineage":["https://openalex.org/I7863295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johanna Y.D. Asante","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Villanova University, Villanova, PA 19085, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Villanova University, Villanova, PA 19085, USA","institution_ids":["https://openalex.org/I7863295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094021923","display_name":"Elise L. Bezold","orcid":"https://orcid.org/0009-0002-2721-284X","observed_orcids":["https://orcid.org/0009-0002-2721-284X"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise L. Bezold","raw_affiliation_strings":["Department of Chemistry, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023759374","display_name":"William M. Wuest","orcid":"https://orcid.org/0000-0002-5198-7744","observed_orcids":["https://orcid.org/0000-0002-5198-7744"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William M. Wuest","raw_affiliation_strings":["Department of Chemistry, Emory University, Atlanta, GA 30322, USA. Electronic address: wwuest@emory.edu","Department of Chemistry, Emory University, Atlanta, GA 30322, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Emory University, Atlanta, GA 30322, USA. Electronic address: wwuest@emory.edu","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Chemistry, Emory University, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088835744","display_name":"Kevin P. C. Minbiole","orcid":"https://orcid.org/0000-0003-4263-9833","observed_orcids":["https://orcid.org/0000-0003-4263-9833"]},"institutions":[{"id":"https://openalex.org/I7863295","display_name":"Villanova University","ror":"https://ror.org/02g7kd627","country_code":"US","type":"education","lineage":["https://openalex.org/I7863295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin P.C. Minbiole","raw_affiliation_strings":["Department of Chemistry and Biochemistry, Villanova University, Villanova, PA 19085, USA. Electronic address: kevin.minbiole@villanova.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, Villanova University, Villanova, PA 19085, USA. Electronic address: kevin.minbiole@villanova.edu","institution_ids":["https://openalex.org/I7863295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5023759374","https://openalex.org/A5088835744"],"corresponding_institution_ids":["https://openalex.org/I150468666","https://openalex.org/I7863295"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.2959,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.46586439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"131","issue":null,"first_page":"130441","last_page":"130441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12526","display_name":"Antimicrobial agents and applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10721","display_name":"Surfactants and Colloidal Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quaternary-ammonium-salts","display_name":"quaternary ammonium compounds","score":0.8809999823570251},{"id":"https://openalex.org/keywords/bolaamphiphiles","display_name":"bolaamphiphiles","score":0.9480000138282776},{"id":"https://openalex.org/keywords/phloroglucinol","display_name":"phloroglucinol","score":0.8320000171661377},{"id":"https://openalex.org/keywords/imidazolium","display_name":"imidazolium","score":0.9070000052452087},{"id":"https://openalex.org/keywords/antibacterial-agents","display_name":"antibacterial agents","score":0.765999972820282},{"id":"https://openalex.org/keywords/surface-disinfectants","display_name":"surface disinfectants","score":0.9470000267028809},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7839999794960022},{"id":"https://openalex.org/keywords/minimum-inhibitory-concentration","display_name":"minimum inhibitory concentration","score":0.7860000133514404},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"therapeutic index","score":0.9350000023841858},{"id":"https://openalex.org/keywords/bacterial-resistance","display_name":"bacterial resistance","score":0.5910000205039978},{"id":"https://openalex.org/keywords/gram-positive-bacteria","display_name":"Gram-positive bacteria","score":0.8330000042915344},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":1.0}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8080000281333923},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.5855000019073486},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.5751000046730042},{"id":"https://openalex.org/C183882617","wikidata":"https://www.wikidata.org/wiki/Q3046749","display_name":"Cationic polymerization","level":2,"score":0.5371999740600586},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5058000087738037},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4763000011444092},{"id":"https://openalex.org/C2781221799","wikidata":"https://www.wikidata.org/wiki/Q73984","display_name":"Disinfectant","level":2,"score":0.46959999203681946},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.4350000023841858},{"id":"https://openalex.org/C2780104969","wikidata":"https://www.wikidata.org/wiki/Q4774530","display_name":"Antibacterial activity","level":3,"score":0.43389999866485596},{"id":"https://openalex.org/C2779870022","wikidata":"https://www.wikidata.org/wiki/Q190901","display_name":"Ammonium","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.36469998955726624},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.35920000076293945},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.3582000136375427},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.3472000062465668},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31349998712539673},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.3100000023841858},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.30410000681877136},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.2955999970436096},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28949999809265137},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.28780001401901245},{"id":"https://openalex.org/C2991667435","wikidata":"https://www.wikidata.org/wiki/Q334951","display_name":"Carbon chain","level":2,"score":0.2838999927043915},{"id":"https://openalex.org/C140205800","wikidata":"https://www.wikidata.org/wiki/Q5860","display_name":"Carbon fibers","level":3,"score":0.2752000093460083},{"id":"https://openalex.org/C2778883795","wikidata":"https://www.wikidata.org/wiki/Q804517","display_name":"Pathogenic bacteria","level":3,"score":0.27489998936653137},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.2720000147819519},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.26840001344680786},{"id":"https://openalex.org/C2776460385","wikidata":"https://www.wikidata.org/wiki/Q420060","display_name":"Hydrochloride","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2630999982357025},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.2522999942302704}],"mesh":[{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000644","descriptor_name":"Quaternary Ammonium Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006094","descriptor_name":"Gram-Positive Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.bmcl.2025.130441","doi":"https://doi.org/10.1016/j.bmcl.2025.130441","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmcl.2025.130441","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:41130327","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41130327","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13180305","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13180305/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorg Med Chem Lett","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:13180305","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13180305/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorg Med Chem Lett","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4709533116","display_name":"MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer to Enhance Undergraduate Research and Teaching at a Primarily Undergraduate Institution","funder_award_id":"1827930","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5844639341","display_name":"The Development of Novel Disinfectants to Overcome Bacterial Resistance","funder_award_id":"R15AI185860","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000889584","display_name":"Atlanta Network for Training In KUH Scientific Research (ATLANTIS)","funder_award_id":"TL1DK136047","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000912635","display_name":"Natural Product-Inspired Approaches Toward The Development Of Antivirulence And Species-Specific Inhibitors","funder_award_id":"R35GM119426","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320307779","display_name":"Roche","ror":"https://ror.org/00by1q217"},{"id":"https://openalex.org/F4320310358","display_name":"Achievement Rewards for College Scientists Foundation","ror":"https://ror.org/054awkm93"},{"id":"https://openalex.org/F4320333988","display_name":"Roche Diagnostics","ror":null},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1913181687","https://openalex.org/W1988405733","https://openalex.org/W2024726158","https://openalex.org/W2039414773","https://openalex.org/W2062851027","https://openalex.org/W2135465392","https://openalex.org/W2253785489","https://openalex.org/W2418802035","https://openalex.org/W2509594258","https://openalex.org/W2525225058","https://openalex.org/W2567630585","https://openalex.org/W2797473538","https://openalex.org/W2943908740","https://openalex.org/W3124273426","https://openalex.org/W3136344797","https://openalex.org/W3140095290","https://openalex.org/W3163511067","https://openalex.org/W3201745797","https://openalex.org/W4206093396","https://openalex.org/W4211017567","https://openalex.org/W4248560660","https://openalex.org/W4309503005","https://openalex.org/W4311243824","https://openalex.org/W4311439503","https://openalex.org/W4320888629","https://openalex.org/W4365451869","https://openalex.org/W4375951215","https://openalex.org/W4403230281","https://openalex.org/W4403685427","https://openalex.org/W4406457965","https://openalex.org/W4406474059","https://openalex.org/W4415249659"],"related_works":["https://openalex.org/W4406457965","https://openalex.org/W4403713646","https://openalex.org/W7133518019","https://openalex.org/W4392242155","https://openalex.org/W3123083876","https://openalex.org/W4319657180","https://openalex.org/W7036345529","https://openalex.org/W4415249659","https://openalex.org/W2418802035","https://openalex.org/W4321605124"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2025-10-22T00:00:00"}