{"id":"https://openalex.org/W4415385083","doi":"https://doi.org/10.1021/acs.jmedchem.5c02216","title":"Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain","display_name":"Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain","publication_year":2025,"publication_date":"2025-10-21","ids":{"openalex":"https://openalex.org/W4415385083","doi":"https://doi.org/10.1021/acs.jmedchem.5c02216","pmid":"https://pubmed.ncbi.nlm.nih.gov/41116332","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12621258"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.5c02216","doi":"https://doi.org/10.1021/acs.jmedchem.5c02216","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5c02216","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c02216?ref=article_openPDF","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c02216?ref=article_openPDF","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000506509","display_name":"Tomoteru Yamasaki","orcid":"https://orcid.org/0000-0001-7773-3665","observed_orcids":["https://orcid.org/0000-0001-7773-3665"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoteru Yamasaki","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7773-3665","affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042859239","display_name":"Norio Ohyabu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Norio Ohyabu","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103856138","display_name":"Takeshi Wakabayashi","orcid":"https://orcid.org/0009-0003-0861-0874","observed_orcids":["https://orcid.org/0009-0003-0861-0874"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Wakabayashi","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":"https://orcid.org/0009-0003-0861-0874","affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003050236","display_name":"Ignacio Ib\u00e1\u00f1ez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ignacio Iba\u0301n\u0303ez","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kouichi Iwanaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouichi Iwanaga","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022184748","display_name":"Satoshi Yamamoto","orcid":"https://orcid.org/0000-0001-6408-626X","observed_orcids":["https://orcid.org/0000-0001-6408-626X"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Yamamoto","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110328253","display_name":"Masahiko Hattori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Hattori","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027348243","display_name":"Taku Sugita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taku Sugita","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110014764","display_name":"Michiko Terada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Michiko Terada","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052777624","display_name":"Tomohiro Onishi","orcid":"https://orcid.org/0000-0003-0633-9323","observed_orcids":["https://orcid.org/0000-0003-0633-9323"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro Onishi","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sho Sato","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sho Sato","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102932433","display_name":"Yohei Kosugi","orcid":"https://orcid.org/0000-0001-9318-4723","observed_orcids":["https://orcid.org/0000-0001-9318-4723"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yohei Kosugi","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0001-9318-4723","affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062363884","display_name":"Akihiro Takano","orcid":"https://orcid.org/0000-0002-3034-7721","observed_orcids":["https://orcid.org/0000-0002-3034-7721"]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akihiro Takano","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , Chuo-ku , ,","Takeda Pharmaceutical Company Limited, Chuo-ku, Osaka 540-8645, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , Chuo-ku , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Chuo-ku, Osaka 540-8645, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001482204","display_name":"Paul S. Mcquade","orcid":"https://orcid.org/0000-0003-0282-0208","observed_orcids":["https://orcid.org/0000-0003-0282-0208"]},"institutions":[{"id":"https://openalex.org/I4210140176","display_name":"Takeda (United States)","ror":"https://ror.org/03bygaq51","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Paul McQuade","raw_affiliation_strings":["Takeda Development Center Americas, Inc. , , ,","Takeda Development Center Americas, Inc., Cambridge, Massachusetts 02142, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Development Center Americas, Inc. , , ,","institution_ids":["https://openalex.org/I4210140176","https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Development Center Americas, Inc., Cambridge, Massachusetts 02142, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021495006","display_name":"Takamitsu Maru","orcid":"https://orcid.org/0000-0002-9540-9276","observed_orcids":["https://orcid.org/0000-0002-9540-9276"]},"institutions":[{"id":"https://openalex.org/I4405264295","display_name":"Axcelead Drug Discovery Partners Inc. (Japan)","ror":"https://ror.org/01gy5eb25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264295"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takamitsu Maru","raw_affiliation_strings":["Axcelead Drug Discovery Partners, Inc. , , ,","Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa 251-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axcelead Drug Discovery Partners, Inc. , , ,","institution_ids":["https://openalex.org/I4405264295"]},{"raw_affiliation_string":"Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa 251-0012, Japan","institution_ids":["https://openalex.org/I4405264295"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Naomi Inui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405264295","display_name":"Axcelead Drug Discovery Partners Inc. (Japan)","ror":"https://ror.org/01gy5eb25","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405264295"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naomi Inui","raw_affiliation_strings":["Axcelead Drug Discovery Partners, Inc. , , ,","Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa 251-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Axcelead Drug Discovery Partners, Inc. , , ,","institution_ids":["https://openalex.org/I4405264295"]},{"raw_affiliation_string":"Axcelead Drug Discovery Partners, Inc., Fujisawa, Kanagawa 251-0012, Japan","institution_ids":["https://openalex.org/I4405264295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065064887","display_name":"Masayuki Fujinaga","orcid":"https://orcid.org/0000-0002-0418-229X","observed_orcids":["https://orcid.org/0000-0002-0418-229X"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masayuki Fujinaga","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0002-0418-229X","affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060170998","display_name":"Wakana Mori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Wakana Mori","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066421492","display_name":"Yuji Nagai","orcid":"https://orcid.org/0000-0001-7005-0749","observed_orcids":["https://orcid.org/0000-0001-7005-0749"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Nagai","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060847562","display_name":"Chie Seki","orcid":"https://orcid.org/0000-0002-3222-7125","observed_orcids":["https://orcid.org/0000-0002-3222-7125"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chie Seki","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shoko Uchida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shoko Uchida","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059642319","display_name":"Takafumi Minamimoto","orcid":"https://orcid.org/0000-0003-4305-0174","observed_orcids":["https://orcid.org/0000-0003-4305-0174"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takafumi Minamimoto","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002819177","display_name":"Makoto Higuchi","orcid":"https://orcid.org/0000-0002-3934-5810","observed_orcids":["https://orcid.org/0000-0002-3934-5810"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Higuchi","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061261134","display_name":"Makoto Fushimi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I44892455","display_name":"Takeda (Japan)","ror":"https://ror.org/04hjbmv12","country_code":"JP","type":"company","lineage":["https://openalex.org/I44892455"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Fushimi","raw_affiliation_strings":["Takeda Pharmaceutical Company Limited , , ,","Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited , , ,","institution_ids":["https://openalex.org/I44892455"]},{"raw_affiliation_string":"Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa 251-8555, Japan","institution_ids":["https://openalex.org/I44892455"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030087345","display_name":"Ming\u2010Rong Zhang","orcid":"https://orcid.org/0000-0002-3001-9605","observed_orcids":["https://orcid.org/0000-0002-3001-9605"]},"institutions":[{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ming-Rong Zhang","raw_affiliation_strings":["National Institute for Quantum Science and Technology , Inage-ku , ,","National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan"],"raw_orcid":"https://orcid.org/0000-0002-3001-9605","affiliations":[{"raw_affiliation_string":"National Institute for Quantum Science and Technology , Inage-ku , ,","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"National Institute for Quantum Science and Technology, Inage-ku, Chiba 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5030087345","https://openalex.org/A5042859239"],"corresponding_institution_ids":["https://openalex.org/I4210114217","https://openalex.org/I44892455"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.4415,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.47558978,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"68","issue":"21","first_page":"23375","last_page":"23388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.8529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hdac6","display_name":"HDAC6","score":0.9639999866485596},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.8169999718666077},{"id":"https://openalex.org/keywords/pyrazoles","display_name":"pyrazole derivatives","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fluorine-18-radiolabeling","display_name":"fluorine-18 radiolabeling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/non-human-primate-brain","display_name":"non-human primate brain","score":0.890999972820282},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.8309999704360962},{"id":"https://openalex.org/keywords/brain-distribution","display_name":"brain distribution","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C23681527","wikidata":"https://www.wikidata.org/wiki/Q18034953","display_name":"HDAC6","level":5,"score":0.8607000112533569},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.7932999730110168},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7574999928474426},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.6072999835014343},{"id":"https://openalex.org/C3018809729","wikidata":"https://www.wikidata.org/wiki/Q7380","display_name":"Nonhuman primate","level":2,"score":0.48539999127388},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.4327999949455261},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.4171999990940094},{"id":"https://openalex.org/C2776202225","wikidata":"https://www.wikidata.org/wiki/Q3569101","display_name":"Histone deacetylase inhibitor","level":5,"score":0.4056999981403351},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.39879998564720154},{"id":"https://openalex.org/C112390072","wikidata":"https://www.wikidata.org/wiki/Q4955834","display_name":"Brain positron emission tomography","level":4,"score":0.3831000030040741},{"id":"https://openalex.org/C2777807558","wikidata":"https://www.wikidata.org/wiki/Q4914764","display_name":"Biodistribution","level":3,"score":0.36410000920295715},{"id":"https://openalex.org/C2778172261","wikidata":"https://www.wikidata.org/wiki/Q3796563","display_name":"Imaging agent","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.33469998836517334},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33379998803138733},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.30550000071525574},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C202100949","wikidata":"https://www.wikidata.org/wiki/Q3229","display_name":"Positron","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28189998865127563},{"id":"https://openalex.org/C2779415379","wikidata":"https://www.wikidata.org/wiki/Q903539","display_name":"Radioactive tracer","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C85240754","wikidata":"https://www.wikidata.org/wiki/Q14914420","display_name":"HDAC1","level":5,"score":0.2596000134944916},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2587999999523163}],"mesh":[{"descriptor_ui":"D000073864","descriptor_name":"Histone Deacetylase 6","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000073864","descriptor_name":"Histone Deacetylase 6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005462","descriptor_name":"Fluorine Radioisotopes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1021/acs.jmedchem.5c02216","doi":"https://doi.org/10.1021/acs.jmedchem.5c02216","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5c02216","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c02216?ref=article_openPDF","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:11429604","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12621258","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41116332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41116332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12621258","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12621258/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Chem","raw_type":"Text"},{"id":"pmh:oai:irdb.nii.ac.jp:01116:0007229338","doi":null,"is_oa":false,"landing_page_url":"https://repo.qst.go.jp/records/2001909","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal article"},{"id":"pmh:oai:repo.qst.go.jp:02001909","doi":null,"is_oa":false,"landing_page_url":"https://repo.qst.go.jp/records/2001909","pdf_url":null,"source":{"id":"https://openalex.org/S4377196694","display_name":"QST-Repository (National Institutes for Quantum and Radiological Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210114217","host_organization_name":"National Institutes for Quantum Science and Technology","host_organization_lineage":["https://openalex.org/I4210114217"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1021/acs.jmedchem.5c02216","doi":"https://doi.org/10.1021/acs.jmedchem.5c02216","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.5c02216","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.5c02216?ref=article_openPDF","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2041494519","display_name":"Development of PET probes for cyclic nucleotide phosphodiesterases 7","funder_award_id":"23K27558","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2169187199","display_name":"In vivo\u5236\u5fa1\u306b\u5411\u3051\u305f\u4eba\u5de5\u30ea\u30ac\u30f3\u30c9\u30fb\u53d7\u5bb9\u4f53\u30da\u30a2\u8a2d\u8a08\u306e\u5b66\u7406\u69cb\u7bc9","funder_award_id":"24H00492","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2963015916","display_name":null,"funder_award_id":"21zf0127003h001","funder_id":"https://openalex.org/F4320311405","funder_display_name":"Japan Agency for Medical Research and Development"},{"id":"https://openalex.org/G3153944560","display_name":null,"funder_award_id":"21zf0127003h001","funder_id":"https://openalex.org/F4320338247","funder_display_name":"Moonshot Research and Development Program"},{"id":"https://openalex.org/G3374338189","display_name":null,"funder_award_id":"23K27558","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3530270314","display_name":"Development of Radio-Senolytics for Imaging and Deleting Senescent Cells","funder_award_id":"24K21295","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3691837540","display_name":null,"funder_award_id":"24K21295","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G3786735645","display_name":null,"funder_award_id":"23H02867","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4737930782","display_name":null,"funder_award_id":"24H00492","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6167594335","display_name":null,"funder_award_id":"23K07122","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G6646357127","display_name":null,"funder_award_id":"23H02867","funder_id":"https://openalex.org/F4320320912","funder_display_name":"Ministry of Education, Culture, Sports, Science and Technology"},{"id":"https://openalex.org/G7404568463","display_name":"PET study for AMPA-TARPg8 complex in epilepsy.","funder_award_id":"23K07122","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7619541072","display_name":null,"funder_award_id":"21zf0127003h001","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320338247","display_name":"Moonshot Research and Development Program","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415385083.pdf","grobid_xml":"https://content.openalex.org/works/W4415385083.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1985808875","https://openalex.org/W1992000457","https://openalex.org/W2005408062","https://openalex.org/W2014298739","https://openalex.org/W2016509332","https://openalex.org/W2016575780","https://openalex.org/W2063017390","https://openalex.org/W2082385708","https://openalex.org/W2152754744","https://openalex.org/W2173587209","https://openalex.org/W2323389052","https://openalex.org/W2406409992","https://openalex.org/W2520844524","https://openalex.org/W2746780129","https://openalex.org/W2753058178","https://openalex.org/W2984173135","https://openalex.org/W3042200676","https://openalex.org/W3125404244","https://openalex.org/W3142292409","https://openalex.org/W3184053383","https://openalex.org/W3209375497","https://openalex.org/W4225139566","https://openalex.org/W4281479594","https://openalex.org/W4392473141","https://openalex.org/W4402729576","https://openalex.org/W4412860214"],"related_works":["https://openalex.org/W3125404244","https://openalex.org/W3012050366","https://openalex.org/W2997230048","https://openalex.org/W4392473141","https://openalex.org/W4405624056","https://openalex.org/W4281479594","https://openalex.org/W3042200676","https://openalex.org/W2753058178","https://openalex.org/W1979743501","https://openalex.org/W7015591324"],"abstract_inverted_index":{"Abstract":[0],"Histone":[1],"deacetylase":[2],"6":[3],"(HDAC6)":[4],"is":[5,120],"a":[6,26,97,121],"crucial":[7],"target":[8],"for":[9,34,125],"the":[10,16,53,77,83,93,111],"development":[11],"of":[12,18,28,55,73,80,95,100,114],"pharmaceuticals":[13],"used":[14],"in":[15,52,59,82,106],"treatment":[17],"neurodegenerative":[19],"disorders.":[20],"Here,":[21],"we":[22],"identified":[23],"16a":[24],"as":[25],"candidate":[27],"positron":[29],"emission":[30],"tomography":[31],"(PET)":[32],"tracer":[33,124],"HDAC6":[35,43,60,81,126],"imaging":[36,127],"from":[37],"pyrazole":[38],"derivatives,":[39],"which":[40],"showed":[41],"strong":[42],"affinity":[44],"(Kd":[45],"=":[46],"1.66":[47],"nM)":[48],"and":[49],"higher":[50],"accumulation":[51,105],"brain":[54],"wild-type":[56],"mice":[57],"than":[58],"knockout":[61],"mice.":[62],"Following":[63],"radiolabeling":[64],"with":[65,68,116],"fluorine-18,":[66],"PET":[67,107,123],"[18F]16a":[69,115,119],"exhibited":[70],"heterogeneous":[71],"uptake":[72],"radioactivity,":[74],"corresponding":[75],"to":[76],"biological":[78],"distribution":[79],"monkey":[84],"brain.":[85],"These":[86],"radioactive":[87,104],"distributions":[88],"were":[89],"homogeneously":[90],"diminished":[91],"by":[92],"preadministration":[94],"ACY-775,":[96],"potent":[98],"inhibitor":[99],"HDAC6,":[101],"suggesting":[102],"that":[103,128],"images":[108],"could":[109],"reflect":[110],"specific":[112],"binding":[113],"HDAC6.":[117],"Thus,":[118],"promising":[122],"motivates":[129],"future":[130],"clinical":[131],"research.":[132]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2025-10-22T00:00:00"}
