{"id":"https://openalex.org/W4415380272","doi":"https://doi.org/10.64719/pb.4121","title":"Donepezil for Cognitive Decline Following Coronary Artery Bypass Surgery: A Pilot Randomized Controlled Trial","display_name":"Donepezil for Cognitive Decline Following Coronary Artery Bypass Surgery: A Pilot Randomized Controlled Trial","publication_year":2025,"publication_date":"2025-08-12","ids":{"openalex":"https://openalex.org/W4415380272","doi":"https://doi.org/10.64719/pb.4121","mag":"12160871","pmid":"https://pubmed.ncbi.nlm.nih.gov/17514186"},"language":"en","primary_location":{"id":"doi:10.64719/pb.4121","doi":"https://doi.org/10.64719/pb.4121","is_oa":false,"landing_page_url":"https://doi.org/10.64719/pb.4121","pdf_url":null,"source":{"id":"https://openalex.org/S5407052355","display_name":"Psychopharmacology Bulletin","issn_l":"0048-5764","issn":["0048-5764","2472-2448"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111699918","display_name":"Pudugramam Murali Doraiswamy","orcid":"https://orcid.org/0000-0003-0697-3893","observed_orcids":["https://orcid.org/0000-0003-0697-3893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Murali Doraiswamy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"MD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109903512","display_name":"Michael A. Babyak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Babyak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"PhD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PhD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077339824","display_name":"Therese Hennig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Therese Hennig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"PA-C","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PA-C","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076113047","display_name":"RANAK B. TRIVEDI","orcid":"https://orcid.org/0000-0003-4114-912X","observed_orcids":["https://orcid.org/0000-0003-4114-912X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranak Trivedi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"PhD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PhD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055415791","display_name":"William D. White","orcid":"https://orcid.org/0000-0002-2969-2798","observed_orcids":["https://orcid.org/0000-0002-2969-2798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William D. White","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"MPH","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MPH","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010756522","display_name":"Joseph P. Mathew","orcid":"https://orcid.org/0000-0002-3815-4131","observed_orcids":["https://orcid.org/0000-0002-3815-4131","https://orcid.org/0000-0002-0202-5354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph P. Mathew","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"MD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008148833","display_name":"Mark F. Newman","orcid":"https://orcid.org/0000-0003-4851-015X","observed_orcids":["https://orcid.org/0000-0003-4851-015X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark F. Newman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"MD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"and James A. Blumenthal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"and James A. Blumenthal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"PhD","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PhD","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5937,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.7021397,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"40","issue":"2","first_page":"54","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5273000001907349,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5273000001907349,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.17440000176429749,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donepezil","display_name":"donepezil","score":1.0},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.7229999899864197},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8059999942779541},{"id":"https://openalex.org/keywords/vascular-mild-cognitive-impairment","display_name":"vascular mild cognitive impairment","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cholinergic-therapy","display_name":"cholinergic therapy","score":0.6169999837875366},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.8309999704360962},{"id":"https://openalex.org/keywords/postoperative-cognitive-dysfunction","display_name":"postoperative cognitive dysfunction","score":0.6499999761581421},{"id":"https://openalex.org/keywords/executive-function","display_name":"executive function","score":0.6110000014305115},{"id":"https://openalex.org/keywords/psychomotor-speed","display_name":"psychomotor speed","score":0.8679999709129333},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2780904820","wikidata":"https://www.wikidata.org/wiki/Q415081","display_name":"Donepezil","level":4,"score":0.9429000020027161},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.7483999729156494},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6739000082015991},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6539999842643738},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.6323000192642212},{"id":"https://openalex.org/C164953862","wikidata":"https://www.wikidata.org/wiki/Q7256440","display_name":"Psychomotor learning","level":3,"score":0.6155999898910522},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.5394999980926514},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.453000009059906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41909998655319214},{"id":"https://openalex.org/C89798072","wikidata":"https://www.wikidata.org/wiki/Q1141779","display_name":"Wechsler Adult Intelligence Scale","level":3,"score":0.4185999929904938},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4124999940395355},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.37779998779296875},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3587000072002411},{"id":"https://openalex.org/C2780566141","wikidata":"https://www.wikidata.org/wiki/Q3065932","display_name":"Cognitive disorder","level":4,"score":0.32440000772476196},{"id":"https://openalex.org/C100660578","wikidata":"https://www.wikidata.org/wiki/Q18733","display_name":"Recall","level":2,"score":0.31700000166893005},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.2994000017642975},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C36668950","wikidata":"https://www.wikidata.org/wiki/Q5500279","display_name":"Free recall","level":3,"score":0.29409998655319214},{"id":"https://openalex.org/C204243189","wikidata":"https://www.wikidata.org/wiki/Q1363085","display_name":"Randomization","level":3,"score":0.28040000796318054},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.2669000029563904}],"mesh":[{"descriptor_ui":"D000077265","descriptor_name":"Donepezil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002315","descriptor_name":"Cardiopulmonary Bypass","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008570","descriptor_name":"Memory, Short-Term","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D011183","descriptor_name":"Postoperative Complications","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011939","descriptor_name":"Mental Recall","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014888","descriptor_name":"Wechsler Scales","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018697","descriptor_name":"Nootropic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.64719/pb.4121","doi":"https://doi.org/10.64719/pb.4121","is_oa":false,"landing_page_url":"https://doi.org/10.64719/pb.4121","pdf_url":null,"source":{"id":"https://openalex.org/S5407052355","display_name":"Psychopharmacology Bulletin","issn_l":"0048-5764","issn":["0048-5764","2472-2448"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["medline","poland-20","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology Bulletin","raw_type":"journal-article"},{"id":"pmid:17514186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17514186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology bulletin","raw_type":"Journal Article"},{"id":"mag:12160871","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17514186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G3448895845","display_name":"AGING AND COGNITION AFTER CARDIAC SURGERY","funder_award_id":"R01AG009663","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393397460","https://openalex.org/W2010768107","https://openalex.org/W2122306903","https://openalex.org/W2127608917","https://openalex.org/W2094009584","https://openalex.org/W4235256111","https://openalex.org/W2415247095","https://openalex.org/W2112583510","https://openalex.org/W1990936268","https://openalex.org/W2073836906"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"study":[2],"the":[3,74,111,116,157,166,203],"effect":[4,149],"of":[5,82,165,220,235,244,255],"donepezil":[6,51,108,155,209],"in":[7,59,104,258],"treating":[8],"patients":[9,134,142,186],"with":[10,23,50,110,140,147],"cognitive":[11,38,69,93,206,214,261],"decline":[12,29,207],"following":[13],"coronary":[14],"artery":[15],"bypass":[16],"graft":[17],"(CABG)":[18],"surgery.":[19],"METHODS:":[20],"Forty-four":[21],"patients,":[22],"at":[24,30,35],"least":[25,36],"a":[26,60,136],"0.5":[27],"SD":[28],"1":[31],"year":[32],"post-CABG":[33,204],"on":[34,115,143,231],"one":[37],"domain":[39],"compared":[40,139],"to":[41,48,53,107,252],"their":[42,105],"pre-CABG":[43],"baseline":[44],"score,":[45],"were":[46,156],"randomized":[47,65],"treatment":[49,99,180],"(titrated":[52],"10":[54],"mg":[55],"daily)":[56],"or":[57],"placebo":[58,141],"12-week":[61],"double-blind,":[62],"single":[63],"center,":[64],"study.":[66],"A":[67],"composite":[68,92,213],"change":[70],"score":[71],"served":[72],"as":[73,131,238],"primary":[75],"outcome.":[76],"Secondary":[77,101],"outcome":[78,94],"measures":[79,102,195],"included":[80],"tests":[81],"memory,":[83],"attention,":[84],"psychomotor":[85],"speed,":[86],"and":[87,121,151,160,174,193,226,242],"executive":[88],"function.":[89],"RESULTS:":[90],"The":[91],"did":[95,196,210],"not":[96,197,211],"show":[97],"significant":[98,137,229],"effects.":[100],"varied":[103],"sensitivity":[106],"effects":[109,113,192,230,257],"largest":[112],"seen":[114],"Wechsler":[117],"Visual":[118],"Memory":[119],"Scale-Delayed":[120],"Immediate":[122],"recall":[123],"tests.":[124],"More":[125,182],"than":[126,184],"twice":[127],"(52%":[128],"vs.":[129],"22%)":[130],"many":[132],"donepezil-treated":[133,183],"showed":[135,178],"improvement":[138],"Delayed":[144],"recall.":[145],"Tests":[146],"weak":[148],"sizes":[150],"minimal":[152],"trends":[153],"favoring":[154],"Boston":[158],"Naming":[159],"Digit":[161,170],"Symbol.":[162],"However,":[163],"most":[164],"other":[167,190],"instruments":[168],"(e.g.,":[169],"Span,":[171],"Trails":[172],"B,":[173],"Controlled":[175],"Word":[176],"Association)":[177],"no":[179,228],"benefits.":[181],"placebo-treated":[185],"experienced":[187],"diarrhea,":[188],"but":[189,216,250],"adverse":[191],"safety":[194],"differ":[198],"between":[199],"groups.":[200],"CONCLUSION:":[201],"In":[202],"mild":[205,260],"setting,":[208],"improve":[212],"performance":[215],"improved":[217],"some":[218],"aspects":[219],"memory.":[221],"Donepezil":[222],"was":[223],"well":[224],"tolerated":[225],"had":[227],"EKG":[232],"parameters.":[233],"Because":[234],"limitations":[236],"such":[237],"small":[239],"sample":[240],"size":[241],"multiplicity":[243],"tests,":[245],"these":[246],"findings":[247],"are":[248],"preliminary":[249],"add":[251],"our":[253],"knowledge":[254],"cholinergic":[256],"vascular":[259],"decline.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-22T00:00:00"}