{"id":"https://openalex.org/W4415367609","doi":"https://doi.org/10.1109/ius62464.2025.11201811","title":"First Exploration of H-scan Ultrasound Imaging in Diabetic Foot: A Feasibility Study","display_name":"First Exploration of H-scan Ultrasound Imaging in Diabetic Foot: A Feasibility Study","publication_year":2025,"publication_date":"2025-09-15","ids":{"openalex":"https://openalex.org/W4415367609","doi":"https://doi.org/10.1109/ius62464.2025.11201811"},"language":"en","primary_location":{"id":"doi:10.1109/ius62464.2025.11201811","doi":"https://doi.org/10.1109/ius62464.2025.11201811","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ius62464.2025.11201811","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Ultrasonics Symposium (IUS)","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093630814","display_name":"Emilio J. Ochoa","orcid":"https://orcid.org/0000-0002-2707-542X","observed_orcids":["https://orcid.org/0000-0002-2707-542X"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilio J. Ochoa","raw_affiliation_strings":["University of Rochester,Department of Biomedical Engineering,New York,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester,Department of Biomedical Engineering,New York,USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111231335","display_name":"Gilmer A. Flores Barrera","orcid":"https://orcid.org/0009-0003-0263-9967","observed_orcids":["https://orcid.org/0009-0003-0263-9967"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gilmer Flores Barrera","raw_affiliation_strings":["University of Rochester,Department of Biomedical Engineering,New York,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester,Department of Biomedical Engineering,New York,USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099161852","display_name":"Cristina Orihuela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65285256","display_name":"Pontificia Universidad Cat\u00f3lica del Per\u00fa","ror":"https://ror.org/00013q465","country_code":"PE","type":"education","lineage":["https://openalex.org/I65285256"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Cristina Orihuela","raw_affiliation_strings":["Pontificia Universidad Católica del Perú,Laboratorio de Imágenes Médicas,Lima,Perú"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontificia Universidad Católica del Perú,Laboratorio de Imágenes Médicas,Lima,Perú","institution_ids":["https://openalex.org/I65285256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052485316","display_name":"Itamar Salazar-Reque","orcid":"https://orcid.org/0000-0003-4991-0446","observed_orcids":["https://orcid.org/0000-0003-4991-0446"]},"institutions":[{"id":"https://openalex.org/I65285256","display_name":"Pontificia Universidad Cat\u00f3lica del Per\u00fa","ror":"https://ror.org/00013q465","country_code":"PE","type":"education","lineage":["https://openalex.org/I65285256"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Itamar Salazar-Reque","raw_affiliation_strings":["Pontificia Universidad Católica del Perú,Laboratorio de Imágenes Médicas,Lima,Perú"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontificia Universidad Católica del Perú,Laboratorio de Imágenes Médicas,Lima,Perú","institution_ids":["https://openalex.org/I65285256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024337857","display_name":"Stefano E. Romero","orcid":"https://orcid.org/0000-0001-6092-1395","observed_orcids":["https://orcid.org/0000-0001-6092-1395"]},"institutions":[{"id":"https://openalex.org/I65285256","display_name":"Pontificia Universidad Cat\u00f3lica del Per\u00fa","ror":"https://ror.org/00013q465","country_code":"PE","type":"education","lineage":["https://openalex.org/I65285256"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Stefano E. Romero","raw_affiliation_strings":["Pontificia Universidad Católica del Perú,Laboratorio de Procesamiento Digital de Señales,Lima,Perú"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pontificia Universidad Católica del Perú,Laboratorio de Procesamiento Digital de Señales,Lima,Perú","institution_ids":["https://openalex.org/I65285256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024070122","display_name":"Roozbeh Naemi","orcid":"https://orcid.org/0000-0002-2998-2883","observed_orcids":["https://orcid.org/0000-0002-2998-2883"]},"institutions":[{"id":"https://openalex.org/I54459138","display_name":"University of Salford","ror":"https://ror.org/01tmqtf75","country_code":"GB","type":"education","lineage":["https://openalex.org/I54459138"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roozbeh Naemi","raw_affiliation_strings":["University of Salford,Center for Human Movement and Rehabilitation,Manchester,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Salford,Center for Human Movement and Rehabilitation,Manchester,UK","institution_ids":["https://openalex.org/I54459138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051879325","display_name":"Kevin J. Parker","orcid":"https://orcid.org/0000-0002-6313-6605","observed_orcids":["https://orcid.org/0000-0002-6313-6605"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Parker","raw_affiliation_strings":["University of Rochester,Department of Electrical and Computer Engineering,New York,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester,Department of Electrical and Computer Engineering,New York,USA","institution_ids":["https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065434634","display_name":"Benjam\u00edn Casta\u00f1eda","orcid":"https://orcid.org/0000-0002-1913-0636","observed_orcids":["https://orcid.org/0000-0002-1913-0636"]},"institutions":[{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Castaneda","raw_affiliation_strings":["University of Rochester,Department of Biomedical Engineering,New York,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rochester,Department of Biomedical Engineering,New York,USA","institution_ids":["https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52978208,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10727","display_name":"Ultrasound Imaging and Elastography","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot","display_name":"diabetic foot","score":0.9919999837875366},{"id":"https://openalex.org/keywords/plantar-soft-tissue","display_name":"plantar soft tissue","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tissue-microstructure","display_name":"tissue microstructure","score":0.7889999747276306},{"id":"https://openalex.org/keywords/scatterer-size","display_name":"scatterer size","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ultrasound-elastography","display_name":"ultrasound elastography","score":0.6729999780654907},{"id":"https://openalex.org/keywords/diabetic-foot-ulcer-risk","display_name":"diabetic foot ulcer risk","score":0.6159999966621399},{"id":"https://openalex.org/keywords/metatarsal-heads","display_name":"metatarsal heads","score":0.7770000100135803},{"id":"https://openalex.org/keywords/heel","display_name":"heel","score":0.8349999785423279},{"id":"https://openalex.org/keywords/tissue-stiffness","display_name":"tissue stiffness","score":0.6079999804496765},{"id":"https://openalex.org/keywords/non-invasive-imaging","display_name":"non-invasive imaging","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8075000047683716},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.7796000242233276},{"id":"https://openalex.org/C2986892559","wikidata":"https://www.wikidata.org/wiki/Q234904","display_name":"Ultrasound imaging","level":3,"score":0.6398000121116638},{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.629800021648407},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.47099998593330383},{"id":"https://openalex.org/C2777690781","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Elastography","level":3,"score":0.46810001134872437},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.46480000019073486},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4016999900341034},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3666999936103821},{"id":"https://openalex.org/C2777248721","wikidata":"https://www.wikidata.org/wiki/Q174647","display_name":"Heel","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C2909095640","wikidata":"https://www.wikidata.org/wiki/Q1324974","display_name":"Ultrasound elastography","level":4,"score":0.3253999948501587},{"id":"https://openalex.org/C2910547128","wikidata":"https://www.wikidata.org/wiki/Q5454211","display_name":"First metatarsal","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C2776204877","wikidata":"https://www.wikidata.org/wiki/Q477415","display_name":"Amputation","level":2,"score":0.304500013589859},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.25040000677108765}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/ius62464.2025.11201811","doi":"https://doi.org/10.1109/ius62464.2025.11201811","is_oa":false,"landing_page_url":"https://doi.org/10.1109/ius62464.2025.11201811","pdf_url":null,"source":{"id":"https://openalex.org/S4393917990","display_name":"IEEE International Ultrasonics Symposium","issn_l":"1948-5719","issn":["1948-5719"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["jufo-1","norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"conference"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"2025 IEEE International Ultrasonics Symposium (IUS)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2023232745","https://openalex.org/W2057960423","https://openalex.org/W2127510940","https://openalex.org/W2400208957","https://openalex.org/W2621829755","https://openalex.org/W2792937837","https://openalex.org/W2894847031","https://openalex.org/W2979395232","https://openalex.org/W3022376905","https://openalex.org/W3024181893","https://openalex.org/W3093907388","https://openalex.org/W3209941512","https://openalex.org/W4390481560","https://openalex.org/W4405522021","https://openalex.org/W4408119788"],"related_works":["https://openalex.org/W6981829849","https://openalex.org/W2487492721","https://openalex.org/W4412615928","https://openalex.org/W2807869577","https://openalex.org/W3199432810","https://openalex.org/W4412072047","https://openalex.org/W3068177998","https://openalex.org/W2411858830","https://openalex.org/W3093907388","https://openalex.org/W7095770415"],"abstract_inverted_index":{"Diabetic":[0],"foot":[1,226],"complications":[2],"are":[3],"a":[4,57,69,115,144,217],"leading":[5],"cause":[6],"of":[7,20,72,89,131,138,213],"morbidity":[8],"and":[9,17,93,107,111,120,220],"lower-limb":[10],"amputation":[11],"worldwide,":[12],"largely":[13],"driven":[14],"by":[15],"structural":[16],"mechanical":[18],"alterations":[19,194],"plantar":[21,38,86,197],"soft":[22,87],"tissues.":[23],"Reverberant":[24],"shear":[25],"wave":[26],"ultrasound":[27,54,98,215],"elastography":[28],"has":[29],"shown":[30],"potential":[31],"in":[32,36,152,195],"detecting":[33],"increased":[34],"stiffness":[35,41],"diabetic":[37,91,196,225],"tissue;":[39],"however,":[40],"alone":[42],"does":[43],"not":[44],"fully":[45],"capture":[46],"microstructural":[47,193],"remodeling":[48],"at":[49,102,156,178,200],"the":[50,85,136,157,179,207,211],"scatterer":[51],"level.":[52],"H-scan":[53,82,189,214],"imaging":[55,83,190],"is":[56],"scatterer-size\u2013sensitive":[58],"technique":[59],"that":[60,188],"encodes":[61],"frequency-dependent":[62],"backscatter":[63],"information":[64],"into":[65],"color":[66],"maps,":[67],"providing":[68],"novel":[70],"means":[71],"assessing":[73],"tissue":[74],"microarchitecture.":[75],"In":[76],"this":[77],"feasibility":[78,212],"study,":[79],"we":[80],"applied":[81],"to":[84],"tissues":[88],"10":[90],"patients":[92],"3":[94],"healthy":[95],"controls.":[96],"Radiofrequency":[97],"data":[99],"were":[100,176],"acquired":[101],"clinically":[103,221],"relevant":[104],"sites":[105],"(1st":[106],"3rd":[108,158],"metatarsal":[109,159,181],"heads":[110],"heel),":[112],"processed":[113],"using":[114],"256-filter":[116],"Gaussian":[117],"convolution":[118],"algorithm,":[119],"analyzed":[121],"with":[122,154],"an":[123],"automated":[124],"region-of-interest":[125],"detection":[126],"method.":[127],"The":[128],"intensity-weighted":[129],"percentage":[130],"red":[132],"pixels":[133],"(IWPred),":[134],"representing":[135],"prevalence":[137],"larger":[139],"scatterers,":[140],"was":[141],"extracted":[142],"as":[143,216],"quantitative":[145],"biomarker.":[146],"Results":[147],"showed":[148],"significantly":[149],"higher":[150],"IWPredvalues":[151],"participants":[153],"diabetes":[155],"head":[160,182],"for":[161,224],"both":[162],"feet":[163],"(left:":[164],"p":[165,169],"\u2264":[166,170],"0.002,":[167],"right:":[168],"0.001),":[171],"while":[172],"no":[173],"significant":[174],"differences":[175],"observed":[177],"1st":[180],"or":[183],"heel.":[184],"These":[185],"findings":[186],"suggest":[187],"can":[191],"detect":[192],"tissues,":[198],"particularly":[199],"high-risk":[201],"ulceration":[202],"sites.":[203],"This":[204],"study":[205],"provides":[206],"first":[208],"evidence":[209],"supporting":[210],"non-invasive,":[218],"rapid,":[219],"deployable":[222],"tool":[223],"risk":[227],"assessment.":[228]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2025-10-21T00:00:00"}