{"id":"https://openalex.org/W4415354592","doi":"https://doi.org/10.1016/j.molmet.2025.102274","title":"Increased TGF-\u03b2/Activin-Smad2 signaling is associated with pancreatic \u03b2-cell dysfunction and glucose intolerance in gestational diabetes mellitus","display_name":"Increased TGF-\u03b2/Activin-Smad2 signaling is associated with pancreatic \u03b2-cell dysfunction and glucose intolerance in gestational diabetes mellitus","publication_year":2025,"publication_date":"2025-10-18","ids":{"openalex":"https://openalex.org/W4415354592","doi":"https://doi.org/10.1016/j.molmet.2025.102274","pmid":"https://pubmed.ncbi.nlm.nih.gov/41115652","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12902259"},"language":"en","primary_location":{"id":"doi:10.1016/j.molmet.2025.102274","doi":"https://doi.org/10.1016/j.molmet.2025.102274","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2025.102274","pdf_url":null,"source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.molmet.2025.102274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082227002","display_name":"Tal\u00eda Boronat\u2010Belda","orcid":"https://orcid.org/0000-0002-6548-5251","observed_orcids":["https://orcid.org/0000-0002-6548-5251"]},"institutions":[{"id":"https://openalex.org/I111262870","display_name":"Universitat de Miguel Hern\u00e1ndez d'Elx","ror":"https://ror.org/01azzms13","country_code":"ES","type":"education","lineage":["https://openalex.org/I111262870"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Tal\u00eda Boronat-Belda","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain","institution_ids":["https://openalex.org/I111262870","https://openalex.org/I4405253163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009128948","display_name":"Hilda Ferrero","orcid":"https://orcid.org/0000-0001-7960-7523","observed_orcids":["https://orcid.org/0000-0001-7960-7523"]},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Hilda Ferrero","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, Alicante, Spain","institution_ids":["https://openalex.org/I130194489","https://openalex.org/I4405253163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028548927","display_name":"Sergi Soriano","orcid":"https://orcid.org/0000-0001-9844-7027","observed_orcids":["https://orcid.org/0000-0001-9844-7027"]},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergi Soriano","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, Alicante, Spain","institution_ids":["https://openalex.org/I130194489","https://openalex.org/I4405253163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116372306","display_name":"Elena Ribes-Garc\u00eda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137487","display_name":"Hospital Universitario del Vinalop\u00f3","ror":"https://ror.org/03gtg9w20","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137487"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Ribes-Garc\u00eda","raw_affiliation_strings":["Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario del Vinalop\u00f3, Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario del Vinalop\u00f3, Elche, Spain","institution_ids":["https://openalex.org/I4210137487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049889538","display_name":"R Betoret Gustems","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137487","display_name":"Hospital Universitario del Vinalop\u00f3","ror":"https://ror.org/03gtg9w20","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137487"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rub\u00e9n Betoret-Gustems","raw_affiliation_strings":["Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario del Vinalop\u00f3, Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario del Vinalop\u00f3, Elche, Spain","institution_ids":["https://openalex.org/I4210137487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116372308","display_name":"Daniel Mart\u00ednez-Ba\u00f1\u00f3n","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137487","display_name":"Hospital Universitario del Vinalop\u00f3","ror":"https://ror.org/03gtg9w20","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137487"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Daniel Mart\u00ednez-Ba\u00f1\u00f3n","raw_affiliation_strings":["Laboratorio Ribera Lab Hospital Universitario del Vinalop\u00f3, Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratorio Ribera Lab Hospital Universitario del Vinalop\u00f3, Elche, Spain","institution_ids":["https://openalex.org/I4210137487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116372309","display_name":"M\u00f3nica Serrano-Selva","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137487","display_name":"Hospital Universitario del Vinalop\u00f3","ror":"https://ror.org/03gtg9w20","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210137487"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"M\u00f3nica Serrano-Selva","raw_affiliation_strings":["Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario del Vinalop\u00f3, Elche, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Ginecolog\u00eda y Obstetricia, Hospital Universitario del Vinalop\u00f3, Elche, Spain","institution_ids":["https://openalex.org/I4210137487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021082772","display_name":"Juan Mart\u00ednez\u2010Pinna","orcid":"https://orcid.org/0000-0003-0777-2049","observed_orcids":["https://orcid.org/0000-0003-0777-2049"]},"institutions":[{"id":"https://openalex.org/I130194489","display_name":"University of Alicante","ror":"https://ror.org/05t8bcz72","country_code":"ES","type":"education","lineage":["https://openalex.org/I130194489"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Mart\u00ednez-Pinna","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, Alicante, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; Departamento de Fisiolog\u00eda, Gen\u00e9tica y Microbiolog\u00eda, Universidad de Alicante, Alicante, Spain","institution_ids":["https://openalex.org/I130194489","https://openalex.org/I4405253163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091100404","display_name":"\u00c1ngel Nadal","orcid":"https://orcid.org/0000-0003-4178-2152","observed_orcids":["https://orcid.org/0000-0003-4178-2152"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"\u00c1ngel Nadal","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain","Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4405253163"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4210115082","https://openalex.org/I4405253163"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048567884","display_name":"Iv\u00e1n Quesada","orcid":"https://orcid.org/0000-0002-9808-514X","observed_orcids":["https://orcid.org/0000-0002-9808-514X"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210115082","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red","ror":"https://ror.org/02g87qh62","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Iv\u00e1n Quesada","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain","Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4405253163"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4210115082","https://openalex.org/I4405253163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016039990","display_name":"Paloma Alonso\u2010Magdalena","orcid":"https://orcid.org/0000-0003-1065-5388","observed_orcids":["https://orcid.org/0000-0003-1065-5388"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210092133","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Diabetes y Enfermedades Metab\u00f3licas Asociadas","ror":"https://ror.org/00dwgct76","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4405253163","display_name":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE)","ror":"https://ror.org/00c87jq02","country_code":"ES","type":"education","lineage":["https://openalex.org/I4405253163"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Paloma Alonso-Magdalena","raw_affiliation_strings":["Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: palonso@umh.es","Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III. Electronic address: palonso@umh.es"],"raw_orcid":"https://orcid.org/0000-0003-1065-5388","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: palonso@umh.es","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4405253163"]},{"raw_affiliation_string":"Instituto de Investigaci\u00f3n, Desarrollo e Innovaci\u00f3n en Biotecnolog\u00eda Sanitaria de Elche (IDiBE), Universidad Miguel Hern\u00e1ndez de Elche, Elche, Spain; CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM), Instituto de Salud Carlos III. Electronic address: palonso@umh.es","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4405253163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5016039990"],"corresponding_institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210092133","https://openalex.org/I4405253163"],"apc_list":{"value":4270,"currency":"USD","value_usd":4270},"apc_paid":{"value":4270,"currency":"USD","value_usd":4270},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.29376924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"103","issue":null,"first_page":"102274","last_page":"102274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10673","display_name":"Gestational Diabetes Research and Management","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gestational-diabetes-mellitus","display_name":"gestational diabetes mellitus","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.9300000071525574},{"id":"https://openalex.org/keywords/smad2","display_name":"Smad2","score":0.7480000257492065},{"id":"https://openalex.org/keywords/activin-a","display_name":"activin A","score":0.7549999952316284},{"id":"https://openalex.org/keywords/inhibin","display_name":"inhibin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/beta-cell-dysfunction","display_name":"beta-cell dysfunction","score":0.9190000295639038},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.753000020980835},{"id":"https://openalex.org/keywords/impaired-glucose-tolerance","display_name":"impaired glucose tolerance","score":0.9679999947547913},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8140000104904175},{"id":"https://openalex.org/keywords/beta-cell-proliferation","display_name":"beta-cell proliferation","score":0.8809999823570251},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.5609999895095825},{"id":"https://openalex.org/keywords/type-2-diabetes-prevention","display_name":"type 2 diabetes prevention","score":0.8180000185966492},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7213000059127808},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7071999907493591},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.7041000127792358},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6858999729156494},{"id":"https://openalex.org/C2779434492","wikidata":"https://www.wikidata.org/wiki/Q126691","display_name":"Gestational diabetes","level":4,"score":0.604200005531311},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5939000248908997},{"id":"https://openalex.org/C3018667095","wikidata":"https://www.wikidata.org/wiki/Q3455903","display_name":"Glucose homeostasis","level":4,"score":0.5357000231742859},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.48069998621940613},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4293999969959259},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4226999878883362},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.3424000144004822},{"id":"https://openalex.org/C2780833929","wikidata":"https://www.wikidata.org/wiki/Q1501412","display_name":"Glucose tolerance test","level":4,"score":0.304500013589859},{"id":"https://openalex.org/C2780352109","wikidata":"https://www.wikidata.org/wiki/Q728309","display_name":"Pancreatic hormone","level":4,"score":0.266400009393692}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016640","descriptor_name":"Diabetes, Gestational","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018149","descriptor_name":"Glucose Intolerance","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D028341","descriptor_name":"Activins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051899","descriptor_name":"Smad2 Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1016/j.molmet.2025.102274","doi":"https://doi.org/10.1016/j.molmet.2025.102274","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2025.102274","pdf_url":null,"source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},{"id":"doi:10.1101/2025.02.16.638404","doi":"https://doi.org/10.1101/2025.02.16.638404","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.02.16.638404","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:11709173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12902259","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:41115652","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41115652","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12902259","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12902259/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Metab","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:7c6750291be8481ca09b135aa6d81d0e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/7c6750291be8481ca09b135aa6d81d0e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Metabolism, Vol 103, Iss , Pp 102274- (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.molmet.2025.102274","doi":"https://doi.org/10.1016/j.molmet.2025.102274","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.molmet.2025.102274","pdf_url":null,"source":{"id":"https://openalex.org/S2764545133","display_name":"Molecular Metabolism","issn_l":"2212-8778","issn":["2212-8778"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9907000064849854,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4181769387","display_name":null,"funder_award_id":"PID2020-113112RB-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G4388077840","display_name":null,"funder_award_id":"UNISALUT 2022","funder_id":"https://openalex.org/F4320330239","funder_display_name":"Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana"},{"id":"https://openalex.org/G593054264","display_name":null,"funder_award_id":"MICIU/AEI/ 10.13039/501,100,011,033 /","funder_id":"https://openalex.org/F4320315062","funder_display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades"},{"id":"https://openalex.org/G6474471406","display_name":null,"funder_award_id":"PID2023-146795OB-I00","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"}],"funders":[{"id":"https://openalex.org/F307140202","display_name":"Universidad Miguel Hern\u00e1ndez","ror":"https://ror.org/01azzms13"},{"id":"https://openalex.org/F4320315062","display_name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","ror":null},{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320330239","display_name":"Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana","ror":"https://ror.org/0116vew40"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":"https://ror.org/003x0zc53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W341888715","https://openalex.org/W1580414593","https://openalex.org/W1920128393","https://openalex.org/W1970098795","https://openalex.org/W1970404346","https://openalex.org/W1995275529","https://openalex.org/W1996448199","https://openalex.org/W1996857104","https://openalex.org/W2000674600","https://openalex.org/W2009961905","https://openalex.org/W2011220884","https://openalex.org/W2015874443","https://openalex.org/W2020798714","https://openalex.org/W2035940741","https://openalex.org/W2047791249","https://openalex.org/W2051372978","https://openalex.org/W2055836967","https://openalex.org/W2059979075","https://openalex.org/W2074895831","https://openalex.org/W2077411765","https://openalex.org/W2078021951","https://openalex.org/W2094134871","https://openalex.org/W2124624343","https://openalex.org/W2125472394","https://openalex.org/W2126028578","https://openalex.org/W2132708527","https://openalex.org/W2135022068","https://openalex.org/W2146161926","https://openalex.org/W2156865358","https://openalex.org/W2163904778","https://openalex.org/W2180804111","https://openalex.org/W2254975421","https://openalex.org/W2258832448","https://openalex.org/W2321023278","https://openalex.org/W2418640715","https://openalex.org/W2588473406","https://openalex.org/W2806500078","https://openalex.org/W2827733148","https://openalex.org/W2898266729","https://openalex.org/W2956138079","https://openalex.org/W2980216650","https://openalex.org/W3012106142","https://openalex.org/W3016572394","https://openalex.org/W3044762644","https://openalex.org/W3064462073","https://openalex.org/W3085480888","https://openalex.org/W3089169813","https://openalex.org/W3110337409","https://openalex.org/W3113755912","https://openalex.org/W3118384087","https://openalex.org/W3122503354","https://openalex.org/W3133706516","https://openalex.org/W3185611478","https://openalex.org/W3204443300","https://openalex.org/W3211550430","https://openalex.org/W4200161781","https://openalex.org/W4205324281","https://openalex.org/W4214586565","https://openalex.org/W4224127973","https://openalex.org/W4240986128","https://openalex.org/W4306385318","https://openalex.org/W4319335650","https://openalex.org/W4353071739","https://openalex.org/W4377087983","https://openalex.org/W4379054666","https://openalex.org/W4386788919","https://openalex.org/W4388284381","https://openalex.org/W4389080843","https://openalex.org/W4393118076","https://openalex.org/W4402170335"],"related_works":["https://openalex.org/W2951464792","https://openalex.org/W7168049922","https://openalex.org/W3204443300","https://openalex.org/W2952872214","https://openalex.org/W2051372978","https://openalex.org/W2121767013","https://openalex.org/W3113755912","https://openalex.org/W4292939295","https://openalex.org/W2992112108","https://openalex.org/W3173882765"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Gestational":[2],"diabetes":[3,21,42,264],"mellitus":[4],"(GDM)":[5],"is":[6],"the":[7,16,38,57,110,123,226],"most":[8],"common":[9],"metabolic":[10],"disease":[11],"during":[12,259],"pregnancy":[13,260],"and":[14,25,36,81,101,114,136,148,154,170,177,206,235,258,268,276,300],"increases":[15],"prevalence":[17],"of":[18,32,41,60,93,112,127,187,193,209,217,228,240,293],"type":[19],"2":[20],"in":[22,67,99,175,196,201,225,265,274,289],"both":[23],"mothers":[24],"offspring.":[26],"GDM":[27,48,68,87,119,129,142],"management":[28],"provides":[29],"a":[30,86,222,246],"window":[31],"opportunity":[33],"to":[34,75,231,262,285],"prevent":[35],"lower":[37],"global":[39],"burden":[40],"across":[43],"life.":[44],"Molecular":[45],"mechanisms":[46],"underlying":[47],"are":[49,272],"poorly":[50],"defined.":[51],"In":[52],"this":[53,70,241],"study,":[54],"we":[55],"explore":[56],"potential":[58],"involvement":[59],"transforming":[61],"growth":[62],"factor":[63],"beta":[64],"(TGF-\u03b2)":[65],"signaling":[66,106,165,185,195,242,283,295],"as":[69,183],"pathway":[71,220,243],"has":[72],"been":[73],"reported":[74],"affect":[76],"pancreatic":[77,137,188,198,203,218,281,297],"\u03b2-cell":[78,138,156,204,298],"development,":[79],"proliferation":[80],"identity.":[82],"Methods":[83],"We":[84],"developed":[85],"animal":[88,120],"model.":[89],"Serum":[90],"circulating":[91],"levels":[92,172,271],"TGF\u03b2":[94,105],"family":[95],"ligands":[96],"were":[97,173],"measured":[98],"mice":[100,143,176,277],"human":[102,128,178,275],"GDM.":[103,251],"Pancreatic":[104],"was":[107,160],"investigated":[108],"at":[109],"level":[111],"gene":[113],"protein":[115],"expression.":[116],"Results":[117],"Our":[118,212],"model":[121],"recapitulates":[122],"main":[124],"pathophysiological":[125],"features":[126],"including":[130],"glucose":[131,233],"intolerance,":[132],"decreased":[133,155],"insulin":[134,146,237,287],"sensitivity":[135],"malfunction.":[139],"Islets":[140],"from":[141],"showed":[144],"impaired":[145],"secretion":[147,288],"content,":[149],"altered":[150],"ion":[151],"channel":[152],"activity,":[153],"replication":[157],"rate.":[158],"This":[159],"accompanied":[161],"by":[162],"increased":[163,273],"Smad2":[164,189,219,282,294],"activation.":[166,190],"Elevated":[167],"serum":[168,270],"activin-A":[169],"inhibin":[171,269],"found":[174],"GDM,":[179,229],"suggesting":[180],"their":[181],"role":[182,224],"upstream":[184],"transducers":[186],"Pharmacological":[191],"inhibition":[192],"TGF\u03b2/Activin-Smad2":[194],"mouse":[197],"islets":[199],"resulted":[200],"improved":[202],"function":[205,299],"regeneration":[207],"capacity":[208],"\u03b2-cells.":[210],"Conclusions":[211],"data":[213],"disclose":[214],"that":[215],"disruption":[216],"plays":[221],"critical":[223],"pathogenesis":[227],"contributing":[230],"abnormal":[232],"homeostasis":[234],"inadequate":[236,286],"secretion.":[238],"Attenuation":[239],"could":[244],"represent":[245],"putative":[247],"therapeutic":[248],"target":[249],"for":[250],"Highlights":[252],"High":[253],"fat":[254],"diet":[255],"just":[256],"before":[257],"leads":[261],"gestational":[263,278,290],"mice.":[266],"Activin":[267],"diabetes.":[279,291],"Enhanced":[280],"contributes":[284],"Inhibition":[292],"improves":[296],"proliferation.":[301]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2025-10-20T00:00:00"}