{"id":"https://openalex.org/W4415345990","doi":"https://doi.org/10.1097/01.tp.0001170712.54699.4a","title":"P.10: Development of sodium fusidate-loaded microneedle dressing with improved wound healing.","display_name":"P.10: Development of sodium fusidate-loaded microneedle dressing with improved wound healing.","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415345990","doi":"https://doi.org/10.1097/01.tp.0001170712.54699.4a"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0001170712.54699.4a","doi":"https://doi.org/10.1097/01.tp.0001170712.54699.4a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0001170712.54699.4a","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Younseop Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Younseop Kim","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ga-Young Sim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ga-Young Sim","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085320396","display_name":"Chul hyun Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chul hyun Park","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045146037","display_name":"Minseok Kang","orcid":"https://orcid.org/0000-0003-2779-2063","observed_orcids":["https://orcid.org/0000-0003-2779-2063"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minseok Kang","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100706038","display_name":"Nahyun Kim","orcid":"https://orcid.org/0000-0001-9312-3939","observed_orcids":["https://orcid.org/0000-0001-9312-3939"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nahyun Kim","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100609750","display_name":"Dongho Lee","orcid":"https://orcid.org/0000-0003-4379-814X","observed_orcids":["https://orcid.org/0000-0003-4379-814X","https://orcid.org/0000-0002-5529-3053"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dongho Lee","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057344949","display_name":"Kyungho Baek","orcid":"https://orcid.org/0009-0006-1932-7224","observed_orcids":["https://orcid.org/0009-0006-1932-7224"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]},{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyungho Baek","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]},{"raw_affiliation_string":"Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan-si, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034418015","display_name":"Han\u2010Gon Choi","orcid":"https://orcid.org/0000-0002-2318-387X","observed_orcids":["https://orcid.org/0000-0002-2318-387X"]},"institutions":[{"id":"https://openalex.org/I4575257","display_name":"Hanyang University","ror":"https://ror.org/046865y68","country_code":"KR","type":"education","lineage":["https://openalex.org/I4575257"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Han-Gon Choi","raw_affiliation_strings":["Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacy & Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan-si, Korea","institution_ids":["https://openalex.org/I4575257"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040128343","display_name":"Sung Giu Jin","orcid":"https://orcid.org/0000-0003-1558-5155","observed_orcids":["https://orcid.org/0000-0003-1558-5155"]},"institutions":[{"id":"https://openalex.org/I89015989","display_name":"Dankook University","ror":"https://ror.org/058pdbn81","country_code":"KR","type":"education","lineage":["https://openalex.org/I89015989"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung Giu Jin","raw_affiliation_strings":["Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Engineering, Dankook University, Cheonan-si, Korea","institution_ids":["https://openalex.org/I89015989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":"10S","first_page":"S65","last_page":"S66"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sodium-fusidate","display_name":"sodium fusidate","score":0.9300000071525574},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.7549999952316284},{"id":"https://openalex.org/keywords/transdermal-drug-delivery","display_name":"transdermal drug delivery","score":0.9599999785423279},{"id":"https://openalex.org/keywords/hydrocolloid-dressing","display_name":"hydrocolloid dressing","score":0.7929999828338623},{"id":"https://openalex.org/keywords/chitosan","display_name":"chitosan","score":0.7400000095367432},{"id":"https://openalex.org/keywords/polyvinyl-alcohol","display_name":"polyvinyl alcohol","score":0.9089999794960022},{"id":"https://openalex.org/keywords/polyvinylpyrrolidone","display_name":"polyvinylpyrrolidone","score":0.8740000128746033},{"id":"https://openalex.org/keywords/amorphization","display_name":"amorphization","score":0.6069999933242798},{"id":"https://openalex.org/keywords/drug-release","display_name":"drug release","score":0.46799999475479126},{"id":"https://openalex.org/keywords/skin-permeation","display_name":"skin permeation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/staphylococcus-aureus-infection","display_name":"Staphylococcus aureus infection","score":0.8539999723434448},{"id":"https://openalex.org/keywords/wound-closure","display_name":"wound closure","score":0.4729999899864197},{"id":"https://openalex.org/keywords/hot-melt-coating","display_name":"hot-melt coating","score":0.6230000257492065}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6624000072479248},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.49079999327659607},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.4350000023841858},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4194999933242798},{"id":"https://openalex.org/C2909780792","wikidata":"https://www.wikidata.org/wiki/Q411030","display_name":"Sodium carboxymethylcellulose","level":3,"score":0.38749998807907104},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.302700012922287},{"id":"https://openalex.org/C2992618853","wikidata":"https://www.wikidata.org/wiki/Q422092","display_name":"Sodium alginate","level":3,"score":0.2939000129699707},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2993269979","wikidata":"https://www.wikidata.org/wiki/Q523536","display_name":"Wound dressing","level":2,"score":0.257099986076355},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.21940000355243683}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0001170712.54699.4a","doi":"https://doi.org/10.1097/01.tp.0001170712.54699.4a","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0001170712.54699.4a","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3061124477","https://openalex.org/W2601522533","https://openalex.org/W4392759229","https://openalex.org/W3093397621","https://openalex.org/W1990103595","https://openalex.org/W4406156235","https://openalex.org/W2006629406","https://openalex.org/W2172004779","https://openalex.org/W3007504960","https://openalex.org/W7130678529"],"abstract_inverted_index":{"Introduction:":[0],"Microneedle":[1],"(MN)":[2],"technology":[3],"is":[4,352],"a":[5,27,297,353,382],"promising":[6,354],"minimally":[7],"invasive":[8],"platform":[9],"for":[10,356,363],"transdermal":[11,358],"drug":[12,46],"delivery,":[13,47],"but":[14],"conventional":[15,344],"MNs":[16],"often":[17],"lack":[18],"adhesion":[19],"and":[20,39,51,57,93,104,117,134,138,144,184,198,215,223,231,251,279,285,307,334,360,366,373],"fixation.":[21],"To":[22],"address":[23],"this,":[24],"we":[25],"developed":[26],"sodium":[28],"fusidate":[29],"(SF)-loaded":[30],"double":[31,207,321],"layer":[32,83,208,322],"MN":[33,314],"dressing":[34,290,324],"that":[35],"improves":[36],"wound":[37,273,341,376],"fixation":[38],"promotes":[40],"healing.":[41],"The":[42,81,170,234],"SF-loaded":[43,320],"tip":[44,82],"enables":[45],"while":[48],"the":[49,186,313,391],"base":[50,108],"hydrocolloid":[52,289,316],"backing":[53],"provide":[54],"structural":[55],"support":[56],"moisture,":[58],"as":[59],"shown":[60],"in":[61,97,162,296,312,375],"vivo.":[62],"Methods:":[63],"Microneedles":[64],"were":[65,124,146],"fabricated":[66],"via":[67,200],"vacuum-assisted":[68],"micromolding":[69],"using":[70,131,155],"SLA":[71],"3D-printed":[72],"PDMS":[73],"molds":[74],"(~1994":[75],"\u03bcm,":[76],"7":[77],"\u00d7":[78],"2":[79,241],"array).":[80],"(500":[84],"\u03bcL)":[85],"contained":[86],"4%":[87,89],"PVA,":[88],"PVP,":[90,112],"2%":[91],"chitosan,":[92],"1%":[94],"lactic":[95],"acid":[96,177,267],"1:1":[98],"water:ethanol,":[99],"followed":[100],"by":[101,148,370,381],"vacuum":[102],"filling":[103],"drying.":[105],"A":[106],"flexible":[107],"(300":[109],"\u03bcL;":[110],"20%":[111],"10%":[113],"PVA)":[114],"was":[115,153,379],"added":[116],"dried":[118],"at":[119],"40":[120],"\u00b0C.":[121],"Hydrocolloid":[122],"dressings":[123],"hot-melt":[125],"coated":[126],"(100":[127],"\u00b0C,":[128],"0.5":[129],"mm)":[130],"SIS,":[132],"PIB,":[133],"PHR.":[135],"FTIR,":[136],"DSC,":[137],"XRD":[139,224],"confirmed":[140,218,248],"amorphization.":[141],"Drug":[142],"release":[143,239],"permeation":[145,259],"measured":[147],"HPLC.":[149],"In":[150,269],"vivo":[151,244],"healing":[152,293,336,342],"tested":[154,192],"S.":[156],"aureus\u2013infected":[157],"cut":[158,299],"or":[159],"stab":[160],"wounds":[161],"SD":[163],"rats.":[164],"Histology":[165,301],"used":[166],"H&E":[167],"staining.":[168],"Results:":[169],"final":[171],"formulation":[172,235],"(SF:PVP:PVA":[173],"=":[174,178],"4:10:40;":[175],"chitosan:lactic":[176],"2.5:5)":[179],"produced":[180],"sharp,":[181],"reproducible":[182],"tips":[183],"exhibited":[185],"highest":[187],"mechanical":[188,327],"strength":[189],"among":[190],"all":[191],"compositions.":[193],"Low-viscosity":[194],"chitosan":[195],"enhanced":[196,303,331],"elasticity":[197],"swelling":[199],"hydrogen":[201],"bonding":[202],"with":[203,288,315],"PVA.":[204],"This":[205,319],"optimized":[206],"structure":[209],"showed":[210,225,302],"superior":[211],"tensile":[212],"strength,":[213],"elongation,":[214],"conformability.":[216],"FTIR":[217],"SF":[219,238],"functional":[220],"groups;":[221],"DSC":[222],"crystalline":[226],"peak":[227],"loss,":[228],"indicating":[229],"amorphization":[230],"improved":[232,292,340],"solubility.":[233],"achieved":[236,272],"full":[237,249],"within":[240],"hours.":[242],"Ex":[243],"porcine":[245],"skin":[246,258,332,367],"tests":[247],"insertion":[250],"600":[252],"\u03bcm":[253],"penetration.":[254],"After":[255],"24":[256],"hours,":[257],"reached":[260],"213.45":[261],"\u03bcg/cm\u00b2,":[262],"over":[263,343],"10\u00d7":[264],"commercial":[265,283],"fusidic":[266],"gel.":[268],"vivo,":[270],"it":[271,351],"closure":[274],"rates":[275],"of":[276,386],"95.87%":[277],"(cut)":[278],"99.74%":[280],"(stab),":[281],"outperforming":[282],"patches":[284],"gels.":[286],"Co-application":[287],"further":[291],"to":[294],"98.6%":[295],"secondary":[298],"model.":[300],"epithelialization,":[304],"reduced":[305],"inflammation,":[306],"well-organized":[308],"granulation":[309,374],"tissue,":[310],"especially":[311],"group.":[317],"Conclusion:":[318],"microneedle":[323],"offers":[325],"strong":[326],"properties,":[328],"rapid":[329],"release,":[330],"permeability,":[333],"excellent":[335],"efficacy.":[337],"It":[338],"significantly":[339],"treatments.":[345],"With":[346],"its":[347],"modular,":[348],"biocompatible":[349],"design,":[350],"candidate":[355],"next-generation":[357],"therapy":[359],"shows":[361],"potential":[362],"regenerative":[364],"medicine":[365],"tissue":[368],"regeneration":[369],"promoting":[371],"re-epithelialization":[372],"environments.This":[377],"work":[378],"supported":[380],"National":[383],"Research":[384],"Foundation":[385],"Korea":[387],"(NRF)":[388],"grant":[389],"under":[390],"Korean":[392],"government":[393],"(MEST)":[394],"(No.":[395],"RS-2023-00208448).":[396]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-21T00:00:00"}