{"id":"https://openalex.org/W4415345971","doi":"https://doi.org/10.1097/01.tp.0001170772.26841.bb","title":"P.26: Nanoparticle-mediated delivery of alpha-1 antitrypsin reduces cytokine-induced inflammation affecting islet transplantation.","display_name":"P.26: Nanoparticle-mediated delivery of alpha-1 antitrypsin reduces cytokine-induced inflammation affecting islet transplantation.","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415345971","doi":"https://doi.org/10.1097/01.tp.0001170772.26841.bb"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0001170772.26841.bb","doi":"https://doi.org/10.1097/01.tp.0001170772.26841.bb","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0001170772.26841.bb","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111339492","display_name":"Matthew Massaad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Massaad","raw_affiliation_strings":["Medicine, BIDMC/Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, BIDMC/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039698143","display_name":"Hamid M. Abdolmaleky","orcid":"https://orcid.org/0000-0002-8872-5174","observed_orcids":["https://orcid.org/0000-0002-8872-5174"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hamid Mostafavi Abdlumaki","raw_affiliation_strings":["Medicine, BIDMC/Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, BIDMC/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045746547","display_name":"Wayne John Hawthorne","orcid":"https://orcid.org/0000-0001-8638-3468","observed_orcids":["https://orcid.org/0000-0001-8638-3468"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2803024705","display_name":"Westmead Hospital","ror":"https://ror.org/04gp5yv64","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2803024705","https://openalex.org/I4405259172"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wayne J Hawthorne","raw_affiliation_strings":["Surgery, Westmead Hospital, University of Sydney, Westmead, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgery, Westmead Hospital, University of Sydney, Westmead, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2803024705"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103526914","display_name":"Xuejun Wen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xuejun Wen","raw_affiliation_strings":["Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, United States","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008549906","display_name":"Giuseppe Pettinato","orcid":"https://orcid.org/0000-0001-6785-6370","observed_orcids":["https://orcid.org/0000-0001-6785-6370"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Giuseppe Pettinato","raw_affiliation_strings":["Medicine, BIDMC/Harvard Medical School, Boston, MA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine, BIDMC/Harvard Medical School, Boston, MA, United States","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.385718,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":"10S","first_page":"S75","last_page":"S76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-antitrypsin","display_name":"alpha-1-antitrypsin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/redox-responsive-nanoparticles","display_name":"redox-responsive nanoparticles","score":0.8379999995231628},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.765999972820282},{"id":"https://openalex.org/keywords/cytokine-mediated-inflammation","display_name":"cytokine-induced inflammation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7250000238418579},{"id":"https://openalex.org/keywords/islet-graft-survival","display_name":"islet graft survival","score":0.7609999775886536},{"id":"https://openalex.org/keywords/islet-apoptosis","display_name":"islet apoptosis","score":0.6069999933242798},{"id":"https://openalex.org/keywords/mitochondrial-function","display_name":"mitochondrial function","score":0.9240000247955322},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.9279999732971191},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/dextran-nanoparticles","display_name":"dextran nanoparticles","score":0.7749999761581421},{"id":"https://openalex.org/keywords/local-immunosuppression","display_name":"local immunosuppression","score":0.6439999938011169},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6570000052452087},{"id":"https://openalex.org/keywords/hypoglycemia","display_name":"hypoglycemia","score":0.6899999976158142}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7915999889373779},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.774399995803833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6748999953269958},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37279999256134033},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3118000030517578},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2759000062942505},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.26919999718666077},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20010000467300415},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.19990000128746033},{"id":"https://openalex.org/C2910341952","wikidata":"https://www.wikidata.org/wiki/Q570425","display_name":"Leukocyte Trafficking","level":4,"score":0.18970000743865967}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0001170772.26841.bb","doi":"https://doi.org/10.1097/01.tp.0001170772.26841.bb","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0001170772.26841.bb","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134317477","https://openalex.org/W2051683789","https://openalex.org/W1970127550","https://openalex.org/W2080799979","https://openalex.org/W2569262272","https://openalex.org/W2042882874","https://openalex.org/W3215906383","https://openalex.org/W2034092999","https://openalex.org/W2089929922","https://openalex.org/W3037319423"],"abstract_inverted_index":{"Introduction:":[0],"Type":[1],"1":[2],"diabetes":[3],"affects":[4],"millions":[5],"worldwide":[6],"and,":[7],"despite":[8],"treatment":[9,205,269],"advances,":[10],"many":[11],"patients":[12],"still":[13],"face":[14],"frequent,":[15],"dangerous":[16],"hypoglycemia":[17,24,36],"due":[18],"to":[19,79,127,151,186,209,242,246,280,314,325,337],"impaired":[20],"hormonal":[21],"responses":[22],"and":[23,33,44,52,86,108,125,141,160,164,171,180,189,231,257,319,330,344],"unawareness.":[25],"Allogeneic":[26],"islet":[27,129,327,342,350],"transplantation":[28,351],"can":[29],"restore":[30],"insulin":[31,199,271],"production":[32],"prevent":[34],"severe":[35],"in":[37,58,153,216,227,278,352],"these":[38],"high-risk":[39],"patients,":[40],"but":[41],"early":[42,316],"inflammation":[43],"oxidative":[45],"stress":[46],"limit":[47],"graft":[48,60,84,328],"success.":[49],"TNF-\u03b1":[50],"inhibitors":[51],"alpha-1":[53,116],"antitrypsin":[54,117],"have":[55],"shown":[56],"promise":[57],"enhancing":[59],"survival":[61,329],"by":[62,354],"modulating":[63],"immune":[64],"responses.":[65],"Our":[66],"study":[67],"introduces":[68],"a":[69,122,225,321],"proof-of-concept":[70],"strategy":[71,309],"using":[72,121,169],"A1AT-loaded,":[73],"redox-responsive":[74],"nanoparticles":[75,114],"co-transplanted":[76],"with":[77,146,177,237],"islets":[78,101,211,250,292],"locally":[80],"reduce":[81,315],"inflammation,":[82],"enhance":[83,326],"survival,":[85],"improve":[87],"engraftment":[88,343],"efficiency":[89,340],"while":[90,296],"reducing":[91,355],"the":[92,128,335,339,346,356,371],"side":[93],"effects":[94],"of":[95,304,341,349],"systemic":[96],"immunosuppression.":[97],"Methods:":[98],"Human":[99],"pancreatic":[100],"were":[102,119,148,167],"obtained":[103],"from":[104,293],"Prodo":[105],"Laboratories":[106],"Inc.":[107],"cultured":[109],"under":[110,212,275],"standard":[111],"conditions.":[112],"Redox-responsive":[113],"encapsulating":[115],"(SR-A1AT-NPs)":[118],"synthesized":[120],"dextran-based":[123],"formulation":[124],"applied":[126],"cultures":[130],"for":[131,218,369,373],"24":[132,219],"hours.":[133,220],"Nanoparticle":[134],"uptake":[135],"was":[136,184,195],"confirmed":[137],"via":[138,197],"fluorescent":[139],"labeling":[140],"confocal":[142],"microscopy.":[143],"Islets":[144],"pre-treated":[145],"SR-A1AT-NPs":[147,204,238,289],"subsequently":[149],"exposed":[150,245],"an":[152,305,311],"vitro":[154],"inflammatory":[155,294,317,360],"cocktail":[156],"(Cytomix:":[157],"TNF-\u03b1,":[158],"IL-1\u03b2,":[159],"IFN-":[161],"\u03b3).":[162],"Viability":[163],"mitochondrial":[165,253],"function":[166,273],"assessed":[168],"G6PD":[170],"MTT":[172],"assays,":[173],"respectively.":[174],"Flow":[175,221],"cytometry":[176,222],"Annexin":[178],"V":[179],"propidium":[181],"iodide":[182],"staining":[183],"performed":[185],"quantify":[187],"live/dead":[188],"early/late":[190],"apoptotic":[191,230],"populations.":[192],"Functional":[193],"integrity":[194],"evaluated":[196],"glucose-stimulated":[198],"secretion":[200],"(GSIS)":[201],"assays.":[202],"Results:":[203],"conferred":[206],"significant":[207],"protection":[208],"human":[210,291],"proinflammatory":[213,276],"conditions":[214,277],"whilst":[215,274],"culture":[217],"analysis":[223],"revealed":[224],"reduction":[226],"both":[228],"late":[229],"dead":[232],"cell":[233],"populations":[234],"when":[235],"treated":[236],"(Fig":[239],"1).":[240],"Compared":[241],"untreated":[243],"controls":[244],"cytokine":[247],"stress,":[248],"nanoparticle-treated":[249],"demonstrated":[251],"improved":[252],"activity,":[254],"reduced":[255],"cytotoxicity,":[256],"enhanced":[258,312],"viability":[259],"(Fig.":[260,283],"2A-B).":[261],"Additionally,":[262],"GSIS":[263],"assays":[264],"showed":[265],"that":[266,288],"AAT-loaded":[267],"nanoparticle":[268],"preserved":[270],"secretory":[272],"response":[279],"glucose":[281],"stimulation":[282],"2C).Conclusion:":[284],"These":[285],"findings":[286],"demonstrate":[287],"protect":[290],"injury":[295],"preserving":[297],"metabolic":[298],"function.":[299,331],"By":[300],"enabling":[301],"localized":[302],"delivery":[303],"immunomodulatory":[306],"agent,":[307],"this":[308,374],"provides":[310],"method":[313,324],"damage":[318],"offers":[320],"safer,":[322],"targeted":[323],"This":[332],"approach":[333],"has":[334],"potential":[336],"increase":[338],"broaden":[345],"clinical":[347],"applicability":[348],"T1D":[353,366],"instant":[357],"blood":[358],"mediated":[359],"reaction":[361],"(IBMIR).":[362],"We":[363],"thank":[364],"Breakthrough":[365],"(formerly":[367],"JDRF)":[368],"providing":[370],"funding":[372],"project.":[375]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-21T00:00:00"}