{"id":"https://openalex.org/W4415345775","doi":"https://doi.org/10.1097/01.tp.0001170344.34555.47","title":"PS4.2: 3D bioprinted pancreatic organoids: A functional platform for cell therapy and regenerative applications.","display_name":"PS4.2: 3D bioprinted pancreatic organoids: A functional platform for cell therapy and regenerative applications.","publication_year":2025,"publication_date":"2025-10-01","ids":{"openalex":"https://openalex.org/W4415345775","doi":"https://doi.org/10.1097/01.tp.0001170344.34555.47"},"language":"en","primary_location":{"id":"doi:10.1097/01.tp.0001170344.34555.47","doi":"https://doi.org/10.1097/01.tp.0001170344.34555.47","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0001170344.34555.47","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075690140","display_name":"Marta Klak","orcid":"https://orcid.org/0000-0003-3901-586X","observed_orcids":["https://orcid.org/0000-0003-3901-586X"]},"institutions":[{"id":"https://openalex.org/I4405282422","display_name":"Fundacja Bada\u0144 i Rozwoju Nauki","ror":"https://ror.org/05tcth672","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4405282422"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marta Klak","raw_affiliation_strings":["Foundation of Research and Science Development, Warsaw, Poland","Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation of Research and Science Development, Warsaw, Poland","institution_ids":["https://openalex.org/I4405282422"]},{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118245088","display_name":"Katarzyna Wozniak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Wozniak","raw_affiliation_strings":["Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5120062091","display_name":"Daria Kostrzewa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daria Kostrzewa","raw_affiliation_strings":["Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084197424","display_name":"Dominika Ujazdowska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dominika Ujazdowska","raw_affiliation_strings":["Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041885344","display_name":"Kinga Rusinek","orcid":"https://orcid.org/0000-0001-6704-7127","observed_orcids":["https://orcid.org/0000-0001-6704-7127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kinga Rusinek","raw_affiliation_strings":["Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083143044","display_name":"Sylwester Doma\u0144ski","orcid":"https://orcid.org/0000-0002-8680-2180","observed_orcids":["https://orcid.org/0000-0002-8680-2180"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylwester Domanski","raw_affiliation_strings":["Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002245829","display_name":"Micha\u0142 Wszola","orcid":"https://orcid.org/0000-0001-5920-4065","observed_orcids":["https://orcid.org/0000-0001-5920-4065"]},"institutions":[{"id":"https://openalex.org/I4405282422","display_name":"Fundacja Bada\u0144 i Rozwoju Nauki","ror":"https://ror.org/05tcth672","country_code":"PL","type":"nonprofit","lineage":["https://openalex.org/I4405282422"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Michal Wszola","raw_affiliation_strings":["Foundation of Research and Science Development, Warsaw, Poland","Medispace Medical Centre, Warsaw, Poland","Polbionica S.A., Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foundation of Research and Science Development, Warsaw, Poland","institution_ids":["https://openalex.org/I4405282422"]},{"raw_affiliation_string":"Medispace Medical Centre, Warsaw, Poland","institution_ids":[]},{"raw_affiliation_string":"Polbionica S.A., Warsaw, Poland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"109","issue":"10S","first_page":"S9","last_page":"S9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.10090000182390213,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/3d-bioprinting","display_name":"3D bioprinting","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pancreatic-organoids","display_name":"pancreatic organoids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pancreatic-islets","display_name":"pancreatic islets","score":0.8769999742507935},{"id":"https://openalex.org/keywords/decellularized-extracellular-matrix","display_name":"decellularized extracellular matrix","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bioinks","display_name":"bioinks","score":0.8130000233650208},{"id":"https://openalex.org/keywords/gelatin-methacryloyl","display_name":"gelatin methacryloyl","score":0.9179999828338623},{"id":"https://openalex.org/keywords/hyaluronic-acid-methacrylate","display_name":"hyaluronic acid methacrylate","score":0.9729999899864197},{"id":"https://openalex.org/keywords/glucose-stimulated-insulin-secretion","display_name":"glucose-stimulated insulin secretion","score":0.7910000085830688},{"id":"https://openalex.org/keywords/beta-cell-function","display_name":"beta-cell function","score":0.6050000190734863},{"id":"https://openalex.org/keywords/pancreatic-alpha-cells","display_name":"alpha cells","score":0.734000027179718},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.796999990940094},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.6748999953269958},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5288000106811523},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.48339998722076416},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.47189998626708984},{"id":"https://openalex.org/C2994604686","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell function","level":3,"score":0.3935000002384186},{"id":"https://openalex.org/C2779718196","wikidata":"https://www.wikidata.org/wiki/Q17018741","display_name":"3D bioprinting","level":3,"score":0.32690000534057617},{"id":"https://openalex.org/C3019137385","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell survival","level":3,"score":0.29409998655319214},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.2734000086784363},{"id":"https://openalex.org/C110201527","wikidata":"https://www.wikidata.org/wiki/Q5508845","display_name":"Functional response","level":4,"score":0.2646999955177307},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.25540000200271606},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2526000142097473}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.tp.0001170344.34555.47","doi":"https://doi.org/10.1097/01.tp.0001170344.34555.47","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.tp.0001170344.34555.47","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310154684","https://openalex.org/W6980973636","https://openalex.org/W2907204040","https://openalex.org/W4411207009","https://openalex.org/W4302577033","https://openalex.org/W7027145240","https://openalex.org/W4284989008","https://openalex.org/W4224444053","https://openalex.org/W6980944777","https://openalex.org/W6989598667"],"abstract_inverted_index":{"Introduction:":[0],"Diabetes":[1],"mellitus":[2],"is":[3],"a":[4],"chronic,":[5],"globally":[6],"prevalent":[7],"disease":[8,60],"caused":[9],"by":[10,412],"dysfunction":[11],"of":[12,40,51,71,81,88,115,124,301,362,378,393],"pancreatic":[13,43,118,359],"islet":[14,22,372],"cells.":[15],"Standard":[16],"treatments,":[17],"including":[18],"insulin":[19,247,314,386],"therapy":[20],"and":[21,49,64,75,102,113,129,164,191,203,210,217,233,239,286,303,308,326,344,366,374,385,403,418],"transplantation,":[23],"do":[24],"not":[25],"fully":[26],"restore":[27],"physiological":[28,83],"glycemic":[29],"control":[30],"or":[31],"promote":[32],"tissue":[33],"regeneration.":[34],"This":[35,106,408],"has":[36,95],"fueled":[37],"the":[38,47,82,86,111,171,299,320,330,391],"development":[39],"3D":[41,116,140,357],"bioprinted":[42,117,358],"organoids":[44,69,360,395],"that":[45],"mimic":[46,122,370],"structure":[48],"function":[50],"native":[52,371],"islets.":[53],"These":[54,388],"constructs":[55],"offer":[56],"great":[57],"promise":[58],"for":[59,222,235,283,398,416],"modeling,":[61,400],"drug":[62,401],"testing,":[63],"regenerative":[65,406],"medicine.":[66],"Using":[67],"multicellular":[68],"composed":[70,361],"\u03b1,":[72,363],"\u03b2,":[73,364],"endothelial,":[74,365],"stromal":[76,327],"cells":[77,368],"allows":[78],"better":[79],"replication":[80],"microenvironment.":[84],"Moreover,":[85],"addition":[87],"decellularized":[89],"extracellular":[90],"matrix":[91],"(dECM)":[92],"to":[93,98,109,121,317],"bioinks":[94,127,260,380],"been":[96],"shown":[97],"improve":[99],"cell":[100,166,178,263,383],"viability":[101,112,228,255,270,384],"endocrine":[103],"function.":[104,375],"Aim:":[105],"study":[107,409],"aimed":[108],"evaluate":[110],"functionality":[114,242],"organoids,":[119],"designed":[120],"islets":[123],"Langerhans,":[125],"using":[126,142],"with":[128,175,265,319,324],"without":[130],"dECM.":[131,176],"Materials":[132],"&":[133],"Methods:":[134],"Organoids":[135,219],"were":[136,180,197,220],"fabricated":[137],"via":[138,245],"inkjet-based":[139],"bioprinting":[141],"two":[143],"bioink":[144],"formulations:":[145],"(1)":[146],"base":[147],"hydrogel":[148],"containing":[149],"10%":[150,165],"(w/v)":[151,156,162],"gelatin":[152],"methacrylate":[153,159],"(GELMA),":[154],"1%":[155],"hyaluronic":[157],"acid":[158],"(HAMA),":[160],"0.25%":[161],"LAP,":[163],"suspension":[167],"(5\u00d7106":[168],"cells/mL);":[169],"(2)":[170],"same":[172],"formulation":[173],"enriched":[174],"Four":[177],"types":[179],"used:":[181],"\u03b1TC-1":[182],"(\u03b1":[183],"cells),":[184,187,190],"\u03b2TC-tet":[185],"(\u03b2":[186],"HUVECs":[188,208],"(endothelial":[189],"L929":[192],"(fibroblasts).":[193],"Six":[194],"organoid":[195,252],"variants":[196,253,275],"created:":[198],"\u2022V1\u2013V2:":[199],"\u03b1TC-1:\u03b2TC-tet":[200,206,213],"(ratios":[201],"1:2":[202],"1:3)":[204],"\u2022V3\u2013V4:":[205],"+":[207,214],"(50%":[209,216],"25%)":[211,218],"\u2022V5\u2013V6:":[212],"HUVECs:L929":[215],"cultured":[221],"28":[223,257,335],"days.":[224,258],"Analyses":[225],"included":[226],"FDA/PI":[227,266],"staining,":[229,232],"microscopy,":[230],"H&E":[231],"immunohistochemistry":[234],"insulin,":[236],"glucagon,":[237],"CD31,":[238],"vimentin.":[240],"\u03b2-cell":[241,354],"was":[243,410],"assessed":[244],"glucose-stimulated":[246],"secretion":[248,332],"(GSIS).":[249],"Results:":[250],"All":[251,311],"maintained":[254],"throughout":[256],"dECM-enriched":[259],"significantly":[261,352],"improved":[262],"survival,":[264],"staining":[267],"indicating":[268],"near-complete":[269],"in":[271,315],"those":[272],"constructs.":[273],"Non-dECM":[274],"showed":[276,351],"slightly":[277],"lower":[278],"viability,":[279],"but":[280],"still":[281],"adequate":[282],"testing.":[284],"V5":[285],"V6":[287,321],"formed":[288],"spheroid-like":[289],"aggregates":[290],"as":[291,293,396],"early":[292],"day":[294,334],"7.":[295],"Immunohistochemical":[296],"analysis":[297],"confirmed":[298],"presence":[300],"\u03b1":[302],"\u03b2":[304],"cells,":[305],"endothelial":[306],"structures,":[307],"fibroblast":[309,367],"populations.":[310],"groups":[312],"secreted":[313],"response":[316],"glucose,":[318],"construct":[322],"(dECM-enriched,":[323],"vascular":[325],"cells)":[328],"demonstrating":[329],"highest":[331],"on":[333],"(170":[336],"ng/mL":[337],"under":[338],"high-glucose":[339],"conditions).":[340],"In":[341],"contrast,":[342],"V1":[343],"V2":[345],"(lacking":[346],"vascular/stromal":[347],"components":[348],"and/or":[349],"dECM)":[350],"reduced":[353],"functionality.":[355],"Conclusion:":[356],"successfully":[369],"architecture":[373],"The":[376,413],"use":[377],"dECM-enhanced":[379],"improves":[381],"both":[382],"secretion.":[387],"findings":[389],"support":[390],"potential":[392],"such":[394],"platforms":[397],"diabetes":[399],"screening,":[402],"future":[404],"cell-based":[405],"therapies.":[407],"funded":[411],"National":[414],"Centre":[415],"Research":[417],"Development:":[419],"TECHMATSTRATEG-III/0027/2019.":[420]},"counts_by_year":[{"year":2026,"cited_by_count":2}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2025-10-21T00:00:00"}
