{"id":"https://openalex.org/W4415345478","doi":"https://doi.org/10.1101/2025.10.17.682671","title":"Molecular and cellular dynamics of measurable residual disease progression in myelodysplastic syndromes","display_name":"Molecular and cellular dynamics of measurable residual disease progression in myelodysplastic syndromes","publication_year":2025,"publication_date":"2025-10-19","ids":{"openalex":"https://openalex.org/W4415345478","doi":"https://doi.org/10.1101/2025.10.17.682671","pmid":"https://pubmed.ncbi.nlm.nih.gov/41279348","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/12633041"},"language":"en","primary_location":{"id":"doi:10.1101/2025.10.17.682671","doi":"https://doi.org/10.1101/2025.10.17.682671","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.17.682671","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/19/2025.10.17.682671.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/19/2025.10.17.682671.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101623680","display_name":"Yu-Hsiang Chen","orcid":"https://orcid.org/0000-0002-5598-4129","observed_orcids":["https://orcid.org/0000-0002-5598-4129","https://orcid.org/0000-0002-3316-797X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Hsiang Chen","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":"https://orcid.org/0000-0002-5598-4129","affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016323560","display_name":"Timothy Bi","orcid":"https://orcid.org/0000-0002-5237-7024","observed_orcids":["https://orcid.org/0000-0002-5237-7024"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Bi","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"UTHealth Houston Graduate School of Biomedical Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065843439","display_name":"Ming qing Xu","orcid":"https://orcid.org/0000-0001-7974-0658","observed_orcids":["https://orcid.org/0000-0001-7974-0658"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minhang Xu","raw_affiliation_strings":["Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA","Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA","Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jaehyun Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaehyun Lee","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100580282","display_name":"Wesley S. Lu","orcid":"https://orcid.org/0009-0007-5584-041X","observed_orcids":["https://orcid.org/0009-0007-5584-041X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wesley S. Lu","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113010283","display_name":"Mengchuan Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mengchuan Zhuang","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006537103","display_name":"Alejandro Marinos Velarde","orcid":"https://orcid.org/0000-0001-8179-5789","observed_orcids":["https://orcid.org/0000-0001-8179-5789"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Marinos Velarde","raw_affiliation_strings":["Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","The University of Texas Southwestern Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"The University of Texas Southwestern Medical Center","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013312057","display_name":"Dustin McCurry","orcid":"https://orcid.org/0000-0003-0585-3259","observed_orcids":["https://orcid.org/0000-0003-0585-3259"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dustin McCurry","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100334957","display_name":"Hui Yang","orcid":"https://orcid.org/0009-0002-2231-3430","observed_orcids":["https://orcid.org/0009-0002-2231-3430","https://orcid.org/0000-0003-2624-7899"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hui Yang","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029855695","display_name":"Gheath Alatrash","orcid":"https://orcid.org/0000-0002-7648-4377","observed_orcids":["https://orcid.org/0000-0002-7648-4377"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gheath Al-Atrash","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016928938","display_name":"Gabriela Rond\u00f3n","orcid":"https://orcid.org/0000-0003-3841-3567","observed_orcids":["https://orcid.org/0000-0003-3841-3567"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriela Rondon","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055885795","display_name":"Elizabeth J. Shpall","orcid":"https://orcid.org/0000-0003-3947-4126","observed_orcids":["https://orcid.org/0000-0003-3947-4126"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Shpall","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072687747","display_name":"Fatima Zahra Jelloul","orcid":"https://orcid.org/0000-0002-3791-3204","observed_orcids":["https://orcid.org/0000-0002-3791-3204"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fatima Zahra Jelloul","raw_affiliation_strings":["Department of Hematopathology, Division of Pathology & Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, Division of Pathology & Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042723341","display_name":"Frances Natalia Cervoni-Curet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances N. Cervoni-Curet","raw_affiliation_strings":["Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069659955","display_name":"Sassine Ghanem","orcid":"https://orcid.org/0000-0001-7295-0978","observed_orcids":["https://orcid.org/0000-0001-7295-0978"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]},{"id":"https://openalex.org/I4210151747","display_name":"Lifespan","ror":"https://ror.org/04yt1rh21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210151747"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sassine Ghanem","raw_affiliation_strings":["Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA","Lifespan Cancer Institute, Providence, RI 02903, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA","institution_ids":["https://openalex.org/I27804330"]},{"raw_affiliation_string":"Lifespan Cancer Institute, Providence, RI 02903, USA","institution_ids":["https://openalex.org/I4210151747"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060578744","display_name":"C\u00e9line Kerros","orcid":"https://orcid.org/0000-0002-7826-4167","observed_orcids":["https://orcid.org/0000-0002-7826-4167"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Celine Kerros","raw_affiliation_strings":["Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056807600","display_name":"Priya Koppikar","orcid":"https://orcid.org/0000-0002-4966-5826","observed_orcids":["https://orcid.org/0000-0002-4966-5826"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Koppikar","raw_affiliation_strings":["Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047806967","display_name":"Jeffrey J. Molldrem","orcid":"https://orcid.org/0000-0003-1196-1715","observed_orcids":["https://orcid.org/0000-0003-1196-1715"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Molldrem","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061026876","display_name":"Guillermo Garcia\u2010Manero","orcid":"https://orcid.org/0000-0002-3631-2482","observed_orcids":["https://orcid.org/0000-0002-3631-2482"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guillermo Garcia-Manero","raw_affiliation_strings":["Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033298605","display_name":"Ankit Patel","orcid":"https://orcid.org/0000-0001-9678-496X","observed_orcids":["https://orcid.org/0000-0001-9678-496X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ankit Patel","raw_affiliation_strings":["Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA","Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA","Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA","Rice University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical and Computer Engineering, Rice University, Houston, TX 77005, USA","institution_ids":["https://openalex.org/I74775410"]},{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Graduate Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Rice University","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057562254","display_name":"Pavan Bachireddy","orcid":"https://orcid.org/0000-0002-8698-4957","observed_orcids":["https://orcid.org/0000-0002-8698-4957"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Pavan Bachireddy","raw_affiliation_strings":["Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","The University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopoietic Biology & Malignancy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Lymphoma & Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Evolution of Cancer, Leukemia, and Immunity Post Stem Cell Transplant (ECLIPSE), The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5057562254"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/measurable-residual-disease","display_name":"minimal residual disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/relapse","display_name":"relapse","score":0.6809999942779541},{"id":"https://openalex.org/keywords/stem-cell-transplantation","display_name":"stem cell transplantation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/single-cell-multi-omics","display_name":"single-cell multi-omics","score":0.8610000014305115},{"id":"https://openalex.org/keywords/clonal-evolution","display_name":"clonal evolution","score":0.7950000166893005},{"id":"https://openalex.org/keywords/cell-state-transitions","display_name":"cell state transitions","score":0.9580000042915344},{"id":"https://openalex.org/keywords/ifn-gamma-response","display_name":"IFN-gamma response","score":0.6919999718666077},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8820000290870667},{"id":"https://openalex.org/keywords/t-cell-infiltration","display_name":"T cell infiltration","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5806000232696533},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5637000203132629},{"id":"https://openalex.org/C2780817109","wikidata":"https://www.wikidata.org/wiki/Q954625","display_name":"Myelodysplastic syndromes","level":3,"score":0.5601000189781189},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5206000208854675},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.49160000681877136},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.48829999566078186},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.44519999623298645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4406999945640564},{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.4392000138759613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4041000008583069},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.38449999690055847},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3709999918937683},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.35440000891685486},{"id":"https://openalex.org/C64618202","wikidata":"https://www.wikidata.org/wiki/Q3733697","display_name":"Genetic heterogeneity","level":4,"score":0.3330000042915344},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.33059999346733093},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32010000944137573},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3172000050544739},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2921999990940094},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C3020284061","wikidata":"https://www.wikidata.org/wiki/Q5194613","display_name":"Curative treatment","level":3,"score":0.2644999921321869},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.26109999418258667}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1101/2025.10.17.682671","doi":"https://doi.org/10.1101/2025.10.17.682671","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.17.682671","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/19/2025.10.17.682671.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:41279348","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41279348","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bioRxiv : the preprint server for biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2025.10.17.682671","doi":"https://doi.org/10.1101/2025.10.17.682671","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2025.10.17.682671","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2025/10/19/2025.10.17.682671.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3004623375","display_name":"Recruitment of First-Time, Tenure-Track Faculty Members","funder_award_id":"RR210008","funder_id":"https://openalex.org/F4320308129","funder_display_name":"Cancer Prevention and Research Institute of Texas"}],"funders":[{"id":"https://openalex.org/F4320306271","display_name":"Damon Runyon Cancer Research Foundation","ror":"https://ror.org/01gd7b947"},{"id":"https://openalex.org/F4320306799","display_name":"Pharmaceutical Research and Manufacturers of America Foundation","ror":"https://ror.org/01z88k350"},{"id":"https://openalex.org/F4320308129","display_name":"Cancer Prevention and Research Institute of Texas","ror":"https://ror.org/0003xa228"},{"id":"https://openalex.org/F4320310832","display_name":"Edward P. Evans Foundation","ror":"https://ror.org/03h22gm35"},{"id":"https://openalex.org/F4320313428","display_name":"Andrew Sabin Family Foundation","ror":"https://ror.org/02h7p8r46"},{"id":"https://openalex.org/F4320316669","display_name":"Break Through Cancer","ror":"https://ror.org/00a8me616"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415345478.pdf","grobid_xml":"https://content.openalex.org/works/W4415345478.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W1987383967","https://openalex.org/W2010847848","https://openalex.org/W2013781993","https://openalex.org/W2013921359","https://openalex.org/W2015182193","https://openalex.org/W2027950772","https://openalex.org/W2050676604","https://openalex.org/W2066277278","https://openalex.org/W2070982730","https://openalex.org/W2093845572","https://openalex.org/W2098258699","https://openalex.org/W2098979837","https://openalex.org/W2111724321","https://openalex.org/W2114104545","https://openalex.org/W2125792957","https://openalex.org/W2128348084","https://openalex.org/W2130410032","https://openalex.org/W2131558552","https://openalex.org/W2133682816","https://openalex.org/W2135177247","https://openalex.org/W2154851868","https://openalex.org/W2155096565","https://openalex.org/W2169456326","https://openalex.org/W2170970408","https://openalex.org/W2179438025","https://openalex.org/W2322005850","https://openalex.org/W2323326409","https://openalex.org/W2337848504","https://openalex.org/W2417094179","https://openalex.org/W2529241974","https://openalex.org/W2551607099","https://openalex.org/W2738685991","https://openalex.org/W2765151185","https://openalex.org/W2891092031","https://openalex.org/W2898648224","https://openalex.org/W2900956052","https://openalex.org/W2911989837","https://openalex.org/W2913402023","https://openalex.org/W2925256229","https://openalex.org/W2946682337","https://openalex.org/W2970840218","https://openalex.org/W2971091813","https://openalex.org/W2984472267","https://openalex.org/W2997280954","https://openalex.org/W2998901800","https://openalex.org/W3008206242","https://openalex.org/W3010838109","https://openalex.org/W3023290106","https://openalex.org/W3027643991","https://openalex.org/W3048598023","https://openalex.org/W3117986169","https://openalex.org/W3152371839","https://openalex.org/W3156682036","https://openalex.org/W3157353881","https://openalex.org/W3164692211","https://openalex.org/W3164839005","https://openalex.org/W3165899249","https://openalex.org/W3202418805","https://openalex.org/W3202649987","https://openalex.org/W3208070164","https://openalex.org/W3210860076","https://openalex.org/W4213457742","https://openalex.org/W4214880556","https://openalex.org/W4220906030","https://openalex.org/W4225731526","https://openalex.org/W4230833968","https://openalex.org/W4294770642","https://openalex.org/W4297241645","https://openalex.org/W4298143089","https://openalex.org/W4318755006","https://openalex.org/W4323544741","https://openalex.org/W4365482302","https://openalex.org/W4379184768","https://openalex.org/W4382632237","https://openalex.org/W4384198561","https://openalex.org/W4385453852","https://openalex.org/W4389765986","https://openalex.org/W4390038867","https://openalex.org/W4392099391","https://openalex.org/W4394837973","https://openalex.org/W4396558712","https://openalex.org/W4405653500","https://openalex.org/W4409851995","https://openalex.org/W4410897757"],"related_works":["https://openalex.org/W4417007969","https://openalex.org/W4402022603","https://openalex.org/W7133499686","https://openalex.org/W7134199600","https://openalex.org/W4417022235","https://openalex.org/W7170732190","https://openalex.org/W4417006180","https://openalex.org/W4390960089","https://openalex.org/W7133506343","https://openalex.org/W7132840959"],"abstract_inverted_index":{"Cancer":[0],"relapse":[1,103],"after":[2,74,104],"treatment":[3],"invariably":[4],"proceeds":[5],"from":[6],"the":[7,21,32,41,47,79,159],"persistence":[8,179],"and":[9,46,61,113,135,169,180],"progression":[10,118],"of":[11,44,91,161],"measurable":[12],"residual":[13],"disease":[14],"(MRD),":[15],"an":[16],"ultrasmall":[17],"malignant":[18],"population.":[19],"Despite":[20],"poor":[22],"prognostic":[23],"impact":[24],"established":[25],"by":[26,131,146],"increasingly":[27],"sensitive":[28],"MRD":[29,36,45,92,117,171,178],"detection":[30],"methods,":[31],"molecular":[33,48,89],"pathways":[34],"defining":[35],"remain":[37],"unknown.":[38],"To":[39],"identify":[40],"unique":[42],"features":[43],"forces":[49],"shaping":[50],"its":[51],"progression,":[52],"we":[53],"performed":[54],"single-cell":[55,163],"multi-omic":[56,164],"profiling":[57],"on":[58],"DNA,":[59],"RNA":[60],"protein":[62],"layers":[63],"for":[64,83,166],"a":[65,87,120,126,152],"longitudinal":[66],"patient":[67],"cohort":[68],"with":[69,94,108],"relapsed":[70],"myelodysplastic":[71],"syndromes":[72],"(MDS)":[73],"stem":[75],"cell":[76,136],"transplantation":[77],"(SCT),":[78],"only":[80],"curative":[81],"modality":[82],"MDS.":[84],"We":[85],"provide":[86],"comprehensive":[88],"portrait":[90],"cells":[93,140,145],"novel":[95],"markers,":[96],"shared":[97],"across":[98],"genetically":[99],"heterogeneous":[100],"patients.":[101],"MDS":[102],"SCT":[105],"manifested":[106],"universally":[107],"marked":[109],"phenotypic":[110],"evolution.":[111],"Genotype":[112],"phenotype":[114],"analyses":[115],"revealed":[116],"as":[119],"dynamic,":[121],"evolutionary":[122],"process":[123],"rather":[124],"than":[125],"static":[127],"expansionary":[128],"one,":[129],"driven":[130],"both":[132],"subclonal":[133],"sweeping":[134],"state":[137],"transitions.":[138],"Malignant":[139],"adapted":[141],"to":[142,150,176],"infiltrating":[143],"T":[144],"rewiring":[147],"IFN-\u03b3":[148],"responses":[149],"activate":[151],"key":[153],"immunoevasive":[154],"pathway.":[155],"Our":[156],"study":[157],"demonstrates":[158],"power":[160],"longitudinal,":[162],"analysis":[165],"identifying,":[167],"tracking,":[168],"understanding":[170],"cells,":[172],"opening":[173],"new":[174],"avenues":[175],"target":[177],"progression.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2025-10-21T00:00:00"}
